Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cance...Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC.展开更多
In the published article1,the affiliation for the first author,Xingshcng Hu,is"Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences",we would like to update it to"Departmen...In the published article1,the affiliation for the first author,Xingshcng Hu,is"Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences",we would like to update it to"Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China".We apologize for the errors and for any confusion it may have caused.展开更多
Diffraction,inherently linked to angular spectrum and affected by spatiotemporal coupling effects,imposes a fundamental limit on wave packets propagation.This limitation is particularly acute for spatiotemporal vortex...Diffraction,inherently linked to angular spectrum and affected by spatiotemporal coupling effects,imposes a fundamental limit on wave packets propagation.This limitation is particularly acute for spatiotemporal vortex beams,where diffraction distorts the beam profile and splits topological charges.While spatiotemporal coupling engineering has enabled diffraction-free(or propagation-invariant)wave packet propagation,achieving stable vortex propagation remains a significant challenge due to inherent constraints of regular wave dispersion.Here,we overcome this challenge by tailoring the wave system’s dispersion to achieve both propagation-invariant behavior and stable vortex structures.We present the first experimental demonstration of propagation-invariant spatiotemporal vortex beams that maintain their spatiotemporal profiles and topological charges over extended propagation distances.The ability of these wave packets to stably carry diverse topological charges without splitting or deformation provides critical insights into spatiotemporal vortex dynamics and unlocks new possibilities for applications across optics,acoustics,and beyond.展开更多
基金supported by grant from the National Natural Science Foundation of China (Grant No.81502699)
文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC.
文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is"Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences",we would like to update it to"Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China".We apologize for the errors and for any confusion it may have caused.
基金supported by the National Key Research and Development Program of China(2023YFA1406900 and 2022YFA1404800)the National Natural Science Foundation of China(12234007,12321161645,12221004,T2394480,and T2394481)+1 种基金Science and Technology Commission of Shanghai Municipality(22142200400,21DZ1101500,2019SHZDZX01,and 23DZ2260100)China Postdoctoral Science Foundation(2022M720810 and 2022TQ0078).
文摘Diffraction,inherently linked to angular spectrum and affected by spatiotemporal coupling effects,imposes a fundamental limit on wave packets propagation.This limitation is particularly acute for spatiotemporal vortex beams,where diffraction distorts the beam profile and splits topological charges.While spatiotemporal coupling engineering has enabled diffraction-free(or propagation-invariant)wave packet propagation,achieving stable vortex propagation remains a significant challenge due to inherent constraints of regular wave dispersion.Here,we overcome this challenge by tailoring the wave system’s dispersion to achieve both propagation-invariant behavior and stable vortex structures.We present the first experimental demonstration of propagation-invariant spatiotemporal vortex beams that maintain their spatiotemporal profiles and topological charges over extended propagation distances.The ability of these wave packets to stably carry diverse topological charges without splitting or deformation provides critical insights into spatiotemporal vortex dynamics and unlocks new possibilities for applications across optics,acoustics,and beyond.
