Objectives:To evaluate the value of Xpert MTB/RIF in the diagnosis of pulmonary tuberculosis(PTB)in general hospitals,which are usually where patients first visit.Materials and methods:Presumptive PTB patients,based o...Objectives:To evaluate the value of Xpert MTB/RIF in the diagnosis of pulmonary tuberculosis(PTB)in general hospitals,which are usually where patients first visit.Materials and methods:Presumptive PTB patients,based on imaging results,in a general hospital in China,were enrolled from August 2015 to April 2017.The sensitivity and specificity of four tuberculosis(TB)detection methods,including sputum smear,Xpert MTB/RIF,T-SPOT.TB and TB-DNA were studied.To predict the effectiveness of the methods,different combinations were assessed using the receiver operating characteristic(ROC)curve.Results:283 PTB suspect patients were enrolled,81 of which were diagnosed as TB infections based on the golden standard.The TB detection rate for sputum smear was 11.7%(33/283).The respective sensitivity and specificity of Xpert MTB/RIF were 87.8%(71/81)and 99.5%(201/202).For the smear negative TB patients,the sensitivity of Xpert MTB/RIF was 79.2%(38/48).Combined with several methods,the Xpert MTB/RIF assay had the highest area under curve(AUC)value(0.913).Conclusions:Xpert MTB/RIF showed tremendous promise for early,rapid and accurate diagnosis of TB.Multicentre evaluation and adoption of Xpert MTB/RIF in general hospitals in China should be embraced and promoted in order to establish an effective TB identification system.展开更多
文摘Objectives:To evaluate the value of Xpert MTB/RIF in the diagnosis of pulmonary tuberculosis(PTB)in general hospitals,which are usually where patients first visit.Materials and methods:Presumptive PTB patients,based on imaging results,in a general hospital in China,were enrolled from August 2015 to April 2017.The sensitivity and specificity of four tuberculosis(TB)detection methods,including sputum smear,Xpert MTB/RIF,T-SPOT.TB and TB-DNA were studied.To predict the effectiveness of the methods,different combinations were assessed using the receiver operating characteristic(ROC)curve.Results:283 PTB suspect patients were enrolled,81 of which were diagnosed as TB infections based on the golden standard.The TB detection rate for sputum smear was 11.7%(33/283).The respective sensitivity and specificity of Xpert MTB/RIF were 87.8%(71/81)and 99.5%(201/202).For the smear negative TB patients,the sensitivity of Xpert MTB/RIF was 79.2%(38/48).Combined with several methods,the Xpert MTB/RIF assay had the highest area under curve(AUC)value(0.913).Conclusions:Xpert MTB/RIF showed tremendous promise for early,rapid and accurate diagnosis of TB.Multicentre evaluation and adoption of Xpert MTB/RIF in general hospitals in China should be embraced and promoted in order to establish an effective TB identification system.
