Objective:To explore the clinical efficacy and safety of Naomaili granules in the treatment of acute ischemic stroke.Methods:Eighty-eight patients were randomly divided into a treatment group and a control group,with ...Objective:To explore the clinical efficacy and safety of Naomaili granules in the treatment of acute ischemic stroke.Methods:Eighty-eight patients were randomly divided into a treatment group and a control group,with 44 patients in each group.The control group received conventional Western medicine treatment,while the treatment group was additionally administered Naomaili granules at 10g per time,3 times per day,for 20 days.Neurological function(NIHSS),activities of daily living(BI),inflammatory factors(hs-CRP,IL-6)levels,and adverse reactions were observed before and after treatment.Results:After 20 days of treatment,the NIHSS score of the treatment group decreased from(9.20±2.10)to(5.12±1.30),the BI index increased from(52.30±8.50)to(78.60±9.20),and hs-CRP and IL-6 decreased to(3.12±1.10)mg/L and(18.20±4.20)pg/mL,respectively,all significantly better than the control group(P<0.01).The incidence of adverse reactions in the treatment group was 4.55%,lower than the 15.91%in the control group(P<0.05).Conclusion:Naomaili granules can improve neurological function and living ability,reduce inflammatory response,and have good safety in patients with acute ischemic stroke.展开更多
Dysregulated inflammation after trauma or infection could result in the further disease and delayed tissue reconstruction.The conventional anti-inflammatory drug treatment suffers to the poor bioavailability and side ...Dysregulated inflammation after trauma or infection could result in the further disease and delayed tissue reconstruction.The conventional anti-inflammatory drug treatment suffers to the poor bioavailability and side effects.Herein,we developed an amphiphilic multifunctional poly(citrate-polyglycol-curcumin)(PCGC)nano oligomer with the robust anti-inflammatory activity for treating acute lung injury(ALI)and Methicillin-resistant staphylococcus aureus(MRSA)infected wound.PCGC demonstrated the sustained curcumin release,inherent photoluminescence,good cellular compatibility,hemocompatibility,robust antioxidant activity and enhanced cellular uptake.PCGC could efficiently scavenge nitrogen-based free radicals,oxygen-based free radicals,and intracellular oxygen species,enhance the endothelial cell migration and reduce the expression of pro-inflammatory factors through the NF-κB signal pathway.Combined the anti-inflammation and antioxidant properties,PCGC can shortened the inflammatory process.In animal model of ALI,PCGC was able to reduce the pulmonary edema,bronchial cell infiltration,and lung inflammation,while exhibiting rapid metabolic behavior in vivo.The MRSA-infection wound model showed that PCGC significantly reduced the expression of pro-inflammatory factors,promoted the angiogenesis and accelerated the wound healing.The transcriptome sequencing and molecular mechanism studies further demonstrated that PCGC could inhibit multiple inflammatory related pathways including TNFAIP3,IL-15RA,NF-κB.This work demonstrates that PCGC is efficient in resolving inflammation and promotes the prospect of application in inflammatory diseases as the drug-loaded therapeutic system.展开更多
The adsorption remediation of radioactive contamination from wastewater is scientifically and economically important.In this work,titanium dioxide-modified manganese dioxide(MnO_(2)@TiO_(2))was prepared by immobilizin...The adsorption remediation of radioactive contamination from wastewater is scientifically and economically important.In this work,titanium dioxide-modified manganese dioxide(MnO_(2)@TiO_(2))was prepared by immobilizing crystalline anatase titanium dioxide(TiO_(2))on the surface of alpha manganese dioxide nanowire(MnO_(2)).The base material MnO_(2) nanowire acted as a physical template for the vip TiO_(2),and the formed MnO_(2)@TiO_(2) composite exhibited a highly uniform core–shell nanorod structure.The MnO_(2)@TiO_(2) composite was investigated as an efficient adsorbent for the removal of U(Ⅵ)from aqueous solution.In the same system,MnO_(2)@TiO_(2) exhibited a much higher maximum adsorption capacity(105.3 mg g^(−1))for U(Ⅵ)as compared with MnO_(2)(13.3 mg g^(−1)),showing that the performance of the surface-modified MnO_(2) was greatly improved.The fitting results for kinetic and isothermal models manifested that U(Ⅵ)ion adsorption by MnO_(2)@TiO_(2) involved monolayer chemisorption.Characterization before and after adsorption was performed and the results compared and analyzed carefully,with the conclusion that there might be three kinds of interactions between U(Ⅵ)and MnO_(2)@TiO_(2) during the adsorption process,namely inner-sphere surface complexation,chemical precipitation,and electrostatic interaction.The low-cost,facile fabrication method and efficient performance endow the adsorbent MnO_(2)@TiO_(2) with a high potential for U(Ⅵ)removal from actual wastewater.展开更多
Uranium is of high concern in the field of environmental remediation because of its high fluidity,radioactivity,biological toxicity and long life.Removing U(VI)from wastewater is of great significance to both environm...Uranium is of high concern in the field of environmental remediation because of its high fluidity,radioactivity,biological toxicity and long life.Removing U(VI)from wastewater is of great significance to both environment and biology.Herein,the composite adsorbentα-MnO_(2)@LDHs composed ofα-MnO_(2) and layered double hydroxides(LDHs)was constructed,and U(VI)adsorption experiments under different conditions were systematically carried out.The results manifested that the maximum U(VI)removal capacity ofα-MnO_(2)@LDHs was 135.52 mg g^(-1) at 298 K through the formation of inner-sphere surface complexes and redox reactions.In particular,at 328 K,the removal amount reached 564.97 mg g^(-1),which suggested the potential to treat high-temperature radioactive wastewater.Furthermore,α-MnO_(2)@LDHs exhibited stability in a wide range of ionic strength(0.001-0.1 M)and pH(5.0-12.0),strong resistance to foreign ion interference,and rapid adsorption capacity.These madeα-MnO_(2)@LDHs an outstanding candidate for repair materials,and performed well even in simulated environments.In-depth and systematic spectra analysis revealed that the active functional groups were Al-and Mg-OH.Mn^(3+)and CO_(3)^(2-)also made important contributions to the combination of U(VI).This work might promote the development of MnO_(2) combined with various metal LDHs,providing a reference for designing excellent repair materials.展开更多
文摘Objective:To explore the clinical efficacy and safety of Naomaili granules in the treatment of acute ischemic stroke.Methods:Eighty-eight patients were randomly divided into a treatment group and a control group,with 44 patients in each group.The control group received conventional Western medicine treatment,while the treatment group was additionally administered Naomaili granules at 10g per time,3 times per day,for 20 days.Neurological function(NIHSS),activities of daily living(BI),inflammatory factors(hs-CRP,IL-6)levels,and adverse reactions were observed before and after treatment.Results:After 20 days of treatment,the NIHSS score of the treatment group decreased from(9.20±2.10)to(5.12±1.30),the BI index increased from(52.30±8.50)to(78.60±9.20),and hs-CRP and IL-6 decreased to(3.12±1.10)mg/L and(18.20±4.20)pg/mL,respectively,all significantly better than the control group(P<0.01).The incidence of adverse reactions in the treatment group was 4.55%,lower than the 15.91%in the control group(P<0.05).Conclusion:Naomaili granules can improve neurological function and living ability,reduce inflammatory response,and have good safety in patients with acute ischemic stroke.
基金National Natural Science Foundation of China(grant No.52172288)Young Talent Support Plan of Xi'an Jiaotong University of China(grant No.QY6J003)。
文摘Dysregulated inflammation after trauma or infection could result in the further disease and delayed tissue reconstruction.The conventional anti-inflammatory drug treatment suffers to the poor bioavailability and side effects.Herein,we developed an amphiphilic multifunctional poly(citrate-polyglycol-curcumin)(PCGC)nano oligomer with the robust anti-inflammatory activity for treating acute lung injury(ALI)and Methicillin-resistant staphylococcus aureus(MRSA)infected wound.PCGC demonstrated the sustained curcumin release,inherent photoluminescence,good cellular compatibility,hemocompatibility,robust antioxidant activity and enhanced cellular uptake.PCGC could efficiently scavenge nitrogen-based free radicals,oxygen-based free radicals,and intracellular oxygen species,enhance the endothelial cell migration and reduce the expression of pro-inflammatory factors through the NF-κB signal pathway.Combined the anti-inflammation and antioxidant properties,PCGC can shortened the inflammatory process.In animal model of ALI,PCGC was able to reduce the pulmonary edema,bronchial cell infiltration,and lung inflammation,while exhibiting rapid metabolic behavior in vivo.The MRSA-infection wound model showed that PCGC significantly reduced the expression of pro-inflammatory factors,promoted the angiogenesis and accelerated the wound healing.The transcriptome sequencing and molecular mechanism studies further demonstrated that PCGC could inhibit multiple inflammatory related pathways including TNFAIP3,IL-15RA,NF-κB.This work demonstrates that PCGC is efficient in resolving inflammation and promotes the prospect of application in inflammatory diseases as the drug-loaded therapeutic system.
基金financially supported by National Natural Science Foundation of China(11575211,11875028)the Fundamental Research Funds for the Central Universities(2017MS044).
文摘The adsorption remediation of radioactive contamination from wastewater is scientifically and economically important.In this work,titanium dioxide-modified manganese dioxide(MnO_(2)@TiO_(2))was prepared by immobilizing crystalline anatase titanium dioxide(TiO_(2))on the surface of alpha manganese dioxide nanowire(MnO_(2)).The base material MnO_(2) nanowire acted as a physical template for the vip TiO_(2),and the formed MnO_(2)@TiO_(2) composite exhibited a highly uniform core–shell nanorod structure.The MnO_(2)@TiO_(2) composite was investigated as an efficient adsorbent for the removal of U(Ⅵ)from aqueous solution.In the same system,MnO_(2)@TiO_(2) exhibited a much higher maximum adsorption capacity(105.3 mg g^(−1))for U(Ⅵ)as compared with MnO_(2)(13.3 mg g^(−1)),showing that the performance of the surface-modified MnO_(2) was greatly improved.The fitting results for kinetic and isothermal models manifested that U(Ⅵ)ion adsorption by MnO_(2)@TiO_(2) involved monolayer chemisorption.Characterization before and after adsorption was performed and the results compared and analyzed carefully,with the conclusion that there might be three kinds of interactions between U(Ⅵ)and MnO_(2)@TiO_(2) during the adsorption process,namely inner-sphere surface complexation,chemical precipitation,and electrostatic interaction.The low-cost,facile fabrication method and efficient performance endow the adsorbent MnO_(2)@TiO_(2) with a high potential for U(Ⅵ)removal from actual wastewater.
基金supported by National Natural Science Foundation of China(11575211,11875028).
文摘Uranium is of high concern in the field of environmental remediation because of its high fluidity,radioactivity,biological toxicity and long life.Removing U(VI)from wastewater is of great significance to both environment and biology.Herein,the composite adsorbentα-MnO_(2)@LDHs composed ofα-MnO_(2) and layered double hydroxides(LDHs)was constructed,and U(VI)adsorption experiments under different conditions were systematically carried out.The results manifested that the maximum U(VI)removal capacity ofα-MnO_(2)@LDHs was 135.52 mg g^(-1) at 298 K through the formation of inner-sphere surface complexes and redox reactions.In particular,at 328 K,the removal amount reached 564.97 mg g^(-1),which suggested the potential to treat high-temperature radioactive wastewater.Furthermore,α-MnO_(2)@LDHs exhibited stability in a wide range of ionic strength(0.001-0.1 M)and pH(5.0-12.0),strong resistance to foreign ion interference,and rapid adsorption capacity.These madeα-MnO_(2)@LDHs an outstanding candidate for repair materials,and performed well even in simulated environments.In-depth and systematic spectra analysis revealed that the active functional groups were Al-and Mg-OH.Mn^(3+)and CO_(3)^(2-)also made important contributions to the combination of U(VI).This work might promote the development of MnO_(2) combined with various metal LDHs,providing a reference for designing excellent repair materials.
