human-robot collaboration(HRC)is set to transform the manufacturing paradigm by leveraging the strengths of human flexibility and robot precision.The recent breakthrough of Large Language Models(LLMs)and Vision-Langua...human-robot collaboration(HRC)is set to transform the manufacturing paradigm by leveraging the strengths of human flexibility and robot precision.The recent breakthrough of Large Language Models(LLMs)and Vision-Language Models(VLMs)has motivated the preliminary explorations and adoptions of these models in the smart manufacturing field.However,despite the considerable amount of effort,existing research mainly focused on individual components without a comprehensive perspective to address the full potential of VLMs,especially for HRC in smart manufacturing scenarios.To fill the gap,this work offers a systematic review of the latest advance-ments and applications of VLMs in HRC for smart manu-facturing,which covers the fundamental architectures and pretraining methodologies of LLMs and VLMs,their applications in robotic task planning,navigation,and manipulation,and role in enhancing human-robot skill transfer through multimodal data integration.Lastly,the paper discusses current limitations and future research directions in VLM-based HRC,highlighting the trend in fully realizing the potential of these technologies for smart manufacturing.展开更多
Background Alzheimer's disease(AD)is a neurodegenerative disorder that affects the central nervous system.Silent information regulator sirtuin 1(SIRT1)may deacetylate and suppress forkhead box O(FOXO)activities to...Background Alzheimer's disease(AD)is a neurodegenerative disorder that affects the central nervous system.Silent information regulator sirtuin 1(SIRT1)may deacetylate and suppress forkhead box O(FOXO)activities to promote neuronal survival.FOXO1 is involved in the regulation of metabolism,senescence,stress response,and apoptosis.Moreover,endoplasmic reticulum stress(ERS)mediates cell apoptosis.Therefore,this study aimed to determine whether the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis in amyloid precursor protein/presenilin 1(APP/PS1)transgenic mice.MethodsWe used APP/PS1 transgenic mice to construct an in vivo AD model.Additionally,we usedβ-amyloid(Aβ)-incubated HT22 cells and primary neurons(PNs)for in vitro analyses.Cognitive function was assessed using novel object recognition,the Morris water maze,and fear conditioning.Discrepancies between wild-type(WT)and APP/PS1 transgenic mice were evaluated using an unpaired t test.In addition,one-way analysis of variance was conducted for behavioral assessments and other tests involving four distinct groups,followed by a Tukey's honestly significant difference test for post hoc pairwise comparisons.ResultsThe expression of SIRT1 was downregulated(in animal experiments,WT mice vs.APP/PS1 mice,n=3,p=0.002;in cell experiments,HT22 cells vs.HT22 cells+Aβ_(1−42),n=3,p=0.001;primary neurons vs.primary neurons+Aβ_(1−42),n=3,p<0.001),whereas FOXO1 acetylation was upregulated both in vivo and in vitro(in animal experiments,WT mice vs.APP/PS1 mice,n=3,p<0.001;in cell experiments,HT22 cells vs.HT22 cells+Aβ_(1−42),n=3,p=0.004;primary neurons vs.primary neurons+Aβ_(1−42),n=3,p<0.001),leading to cognitive dysfunction,Aβplaque deposition,and neuronal apoptosis.Quercetin,a SIRT1 agonist,reversed these changes(For SIRT1,APP/PS1 mice vs.Quercetin-treated APP/PS1 mice,n=3,p=0.014;HT22 cells+Aβ_(1−42)vs.HT22 cells+Aβ_(1−42)+Quercetin,n=3,p=0.003;primary neurons+Aβ_(1−42)vs.primary neurons+Aβ1−42+Quercetin,n=3,p=0.014.For ac-FOXO1,APP/PS1 mice vs.Quercetin-treated APP/PS1 mice,n=3,p<0.001;HT22 cells+Aβ_(1−42)vs.HT22 cells+Aβ_(1−42)+Quercetin,n=3,p=0.023;primary neurons+Aβ_(1−42)vs.primary neurons+Aβ_(1−42)+Quercetin,n=3,p=0.003).However,the FOXO1 antagonist AS1842856 invalidated the positive effects of quercetin in APP/PS1 transgenic mice(ac-FOXO1:Quercetin-treated APP/PS1 mice vs.AS1842856-treated APP/PS1 mice,n=3,p<0.001).Quercetin counteracted FOXO1 acetylation and ERS-mediated apoptosis.In contrast,AS1842856 promoted these processes in vivo and in vitro.Conclusion Our findings demonstrate that the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis.展开更多
Rapid growth and a vast transition of Chinese livestock industry driven by economic incentives make it become an important contributor on climate change over the last four decades.This study first analyzes the evolvin...Rapid growth and a vast transition of Chinese livestock industry driven by economic incentives make it become an important contributor on climate change over the last four decades.This study first analyzes the evolving lowcarbon livestock development policies and regulations,then an assessment and explanations of the achievements and non-achievements are provided.The findings reveal that China began to pay attention to low-carbon development policy starting in the early 1990s.However,only after the cyclic and green concept became the main sustainable development policy,China began to move seriously toward low-carbon livestock development.Several policy instruments were introduced,including moderate scale,feed optimization,manure resource utilization,facility and equipment allocation rate,energy conservation and substitution.Overall,achievements were made in introducing such policies.However,due to the large share of standard agriculture and regional resources,and environmental diversity,such policies may have little effect in practice.The divergence between the policies and actual practices are explained,and important policies applicable to all developing countries are also recommended.展开更多
基金Research Institute for Advanced Manufacturing(RIAM)of The Hong Kong Polytechnic University(1-CDJT)Intra-Faculty Interdisciplinary Project 2023/24(1-WZ4N)+6 种基金Research Committee of The Hong Kong Polytechnic UniversityState Key Laboratory of Intelligent Manufacturing Equipment and Technology,Huazhong University of Science and Technology(IMETKF2024010)Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHX/075/22GD)Innovation and Technology Commission(ITC)COMAC International Collaborative Research Project(COMAC-SFGS-2023-3148)General Research Fund from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project Nos.PolyU15210222 and PolyU15206723)Open access funding provided by the Hong Kong Polytechnic University.
文摘human-robot collaboration(HRC)is set to transform the manufacturing paradigm by leveraging the strengths of human flexibility and robot precision.The recent breakthrough of Large Language Models(LLMs)and Vision-Language Models(VLMs)has motivated the preliminary explorations and adoptions of these models in the smart manufacturing field.However,despite the considerable amount of effort,existing research mainly focused on individual components without a comprehensive perspective to address the full potential of VLMs,especially for HRC in smart manufacturing scenarios.To fill the gap,this work offers a systematic review of the latest advance-ments and applications of VLMs in HRC for smart manu-facturing,which covers the fundamental architectures and pretraining methodologies of LLMs and VLMs,their applications in robotic task planning,navigation,and manipulation,and role in enhancing human-robot skill transfer through multimodal data integration.Lastly,the paper discusses current limitations and future research directions in VLM-based HRC,highlighting the trend in fully realizing the potential of these technologies for smart manufacturing.
基金International Clinical Exchange Program of Health Commission of Zhejiang ProvinceNational Natural Science Foundation of China,Grant/Award Number:31900685+3 种基金Zhejiang Province Natural Science Foundation,Grant/Award Numbers:LTGY24H050004,LTGY23H050003Wenzhou Municipal Science and Technology Bureau of China,Grant/Award Number:Y2023065School Level Scientific Research Project of Wenzhou Medical University,Grant/Award Numbers:XY2022007,wyx2023101049Medical Innovation Discipline of Zhejiang Province,Grant/Award Number:Y2015。
文摘Background Alzheimer's disease(AD)is a neurodegenerative disorder that affects the central nervous system.Silent information regulator sirtuin 1(SIRT1)may deacetylate and suppress forkhead box O(FOXO)activities to promote neuronal survival.FOXO1 is involved in the regulation of metabolism,senescence,stress response,and apoptosis.Moreover,endoplasmic reticulum stress(ERS)mediates cell apoptosis.Therefore,this study aimed to determine whether the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis in amyloid precursor protein/presenilin 1(APP/PS1)transgenic mice.MethodsWe used APP/PS1 transgenic mice to construct an in vivo AD model.Additionally,we usedβ-amyloid(Aβ)-incubated HT22 cells and primary neurons(PNs)for in vitro analyses.Cognitive function was assessed using novel object recognition,the Morris water maze,and fear conditioning.Discrepancies between wild-type(WT)and APP/PS1 transgenic mice were evaluated using an unpaired t test.In addition,one-way analysis of variance was conducted for behavioral assessments and other tests involving four distinct groups,followed by a Tukey's honestly significant difference test for post hoc pairwise comparisons.ResultsThe expression of SIRT1 was downregulated(in animal experiments,WT mice vs.APP/PS1 mice,n=3,p=0.002;in cell experiments,HT22 cells vs.HT22 cells+Aβ_(1−42),n=3,p=0.001;primary neurons vs.primary neurons+Aβ_(1−42),n=3,p<0.001),whereas FOXO1 acetylation was upregulated both in vivo and in vitro(in animal experiments,WT mice vs.APP/PS1 mice,n=3,p<0.001;in cell experiments,HT22 cells vs.HT22 cells+Aβ_(1−42),n=3,p=0.004;primary neurons vs.primary neurons+Aβ_(1−42),n=3,p<0.001),leading to cognitive dysfunction,Aβplaque deposition,and neuronal apoptosis.Quercetin,a SIRT1 agonist,reversed these changes(For SIRT1,APP/PS1 mice vs.Quercetin-treated APP/PS1 mice,n=3,p=0.014;HT22 cells+Aβ_(1−42)vs.HT22 cells+Aβ_(1−42)+Quercetin,n=3,p=0.003;primary neurons+Aβ_(1−42)vs.primary neurons+Aβ1−42+Quercetin,n=3,p=0.014.For ac-FOXO1,APP/PS1 mice vs.Quercetin-treated APP/PS1 mice,n=3,p<0.001;HT22 cells+Aβ_(1−42)vs.HT22 cells+Aβ_(1−42)+Quercetin,n=3,p=0.023;primary neurons+Aβ_(1−42)vs.primary neurons+Aβ_(1−42)+Quercetin,n=3,p=0.003).However,the FOXO1 antagonist AS1842856 invalidated the positive effects of quercetin in APP/PS1 transgenic mice(ac-FOXO1:Quercetin-treated APP/PS1 mice vs.AS1842856-treated APP/PS1 mice,n=3,p<0.001).Quercetin counteracted FOXO1 acetylation and ERS-mediated apoptosis.In contrast,AS1842856 promoted these processes in vivo and in vitro.Conclusion Our findings demonstrate that the downregulation of SIRT1 expression exacerbates cognitive dysfunction by activating FOXO1 acetylation and promoting ERS-mediated apoptosis.
基金sponsored by the National Natural Science Foundation of China(42201329)the Key Project of the Establishment of National Dairy Technology Innovation Center(2021-National Dairy Innovation Center-2)+1 种基金the Central Public-Interest Scientific Institution Basic Research Fund(BSRF202104)the Agricultural Science and Technology Innovation Program.
文摘Rapid growth and a vast transition of Chinese livestock industry driven by economic incentives make it become an important contributor on climate change over the last four decades.This study first analyzes the evolving lowcarbon livestock development policies and regulations,then an assessment and explanations of the achievements and non-achievements are provided.The findings reveal that China began to pay attention to low-carbon development policy starting in the early 1990s.However,only after the cyclic and green concept became the main sustainable development policy,China began to move seriously toward low-carbon livestock development.Several policy instruments were introduced,including moderate scale,feed optimization,manure resource utilization,facility and equipment allocation rate,energy conservation and substitution.Overall,achievements were made in introducing such policies.However,due to the large share of standard agriculture and regional resources,and environmental diversity,such policies may have little effect in practice.The divergence between the policies and actual practices are explained,and important policies applicable to all developing countries are also recommended.
