Ethanol(EtOH)is a common trigger for gastric mucosal diseases,and mitigating oxidative stress is essential for attenuating gastric mucosal damage.Capsaicin(CAP)has been identified as a potential agent to counteract ox...Ethanol(EtOH)is a common trigger for gastric mucosal diseases,and mitigating oxidative stress is essential for attenuating gastric mucosal damage.Capsaicin(CAP)has been identified as a potential agent to counteract oxidative damage in the gastric mucosa;however,its precise mechanism remains unclear.This study demonstrates that CAP alleviates EtOH-induced gastric mucosal injuries through two primary pathways:by suppressing the chemokine receptor 4(CCR4)/Src/p47phox axis,thereby reducing oxidative stress,and by inhibiting the phosphorylation and nuclear translocation of nuclear factor-κB p65(NF-κB)p65,resulting in diminished inflammatory responses.These findings elucidate the mechanistic pathways of CAP and provide a theoretical foundation for its potential therapeutic application in the treatment of gastric mucosal injuries.展开更多
基金supported by the High-level Talent Research Start-up Project Funding of Henan Academy of Sciences (No.252028037)。
文摘Ethanol(EtOH)is a common trigger for gastric mucosal diseases,and mitigating oxidative stress is essential for attenuating gastric mucosal damage.Capsaicin(CAP)has been identified as a potential agent to counteract oxidative damage in the gastric mucosa;however,its precise mechanism remains unclear.This study demonstrates that CAP alleviates EtOH-induced gastric mucosal injuries through two primary pathways:by suppressing the chemokine receptor 4(CCR4)/Src/p47phox axis,thereby reducing oxidative stress,and by inhibiting the phosphorylation and nuclear translocation of nuclear factor-κB p65(NF-κB)p65,resulting in diminished inflammatory responses.These findings elucidate the mechanistic pathways of CAP and provide a theoretical foundation for its potential therapeutic application in the treatment of gastric mucosal injuries.
