Poly(ADP-ribose)glycosylhydrolase(PARG)is an enzyme involved in hydrolyzing the ribose–ribose bonds present in poly(ADP-ribose)(PAR),which are primarily found in the nucleus.Along with poly(ADP-ribose)polymerase,PARG...Poly(ADP-ribose)glycosylhydrolase(PARG)is an enzyme involved in hydrolyzing the ribose–ribose bonds present in poly(ADP-ribose)(PAR),which are primarily found in the nucleus.Along with poly(ADP-ribose)polymerase,PARG regulates the level of PAR in cells,playing a crucial role in DNA maintenance and repair processes.Recent studies have revealed elevated levels of PARG in various cancers,such as breast,liver,prostate,and esophageal cancers,indicating a link to unfavorable cancer outcomes.PARG is a significant molecular target for treating PAR-related cancers.This review provides a comprehensive overview of the physiological role of PARG and the development of its inhibitors,highlighting its potential as an innovative target for cancer treatment.展开更多
基金supported by grants from the National Natural Science Foundation of China(32271485)the Natural Science Foundation of Zhejiang Province(YXD23H0302)to J.J.+3 种基金as well as grants from the National Natural Science Foundation of China(82473195)the Natural Science Foundation of Zhejiang Province(LTGY23H160018)the Zhejiang Medical and Health Science and Technology Program(2024KY789)the Beijing Science and Technology Innovation Medical Development Foundation(KC2023-JX-0270-07)to Z.Y.
文摘Poly(ADP-ribose)glycosylhydrolase(PARG)is an enzyme involved in hydrolyzing the ribose–ribose bonds present in poly(ADP-ribose)(PAR),which are primarily found in the nucleus.Along with poly(ADP-ribose)polymerase,PARG regulates the level of PAR in cells,playing a crucial role in DNA maintenance and repair processes.Recent studies have revealed elevated levels of PARG in various cancers,such as breast,liver,prostate,and esophageal cancers,indicating a link to unfavorable cancer outcomes.PARG is a significant molecular target for treating PAR-related cancers.This review provides a comprehensive overview of the physiological role of PARG and the development of its inhibitors,highlighting its potential as an innovative target for cancer treatment.
