In this paper,three new polyoxometalates(POM)-based metal–organic complexes constructed from a new semi-rigid organic ligand N,N'-bis(4-pyrimidinecarboxamido)-1,2-cyclohexane(4-bpmah)H_(2)[Cu(4-bpmah)_(2)(SiMo_(1...In this paper,three new polyoxometalates(POM)-based metal–organic complexes constructed from a new semi-rigid organic ligand N,N'-bis(4-pyrimidinecarboxamido)-1,2-cyclohexane(4-bpmah)H_(2)[Cu(4-bpmah)_(2)(SiMo_(12)O_(40))(H_(2)O)_(2)]·2H_(2)O(1),H[Cu(4-bpmah)_(2)(PMo_(12)O_(4)0)(H_(2)O)_(2)]·2H_(2)O(2)and[Cu(4-bpmah)(H_(2)O)_(2)]·[Cu_(2)(TeMo_(6)O_(24))(H_(2)O)_(10)]·4H_(2)O(3)were synthesized by hydrothermal method.Single crystal X-ray analyses showed that complexes 1 and 2 were isostructural,in which the isolated Keggin-type[SiMo1_(2)O_(40)]^(4–)/[PMo_(12)O_(40)]^(3–)anions and[Cu(4-bpmah)_(2)(H_(2)O)2]^(2n+)units were expanded into 3D supramolecular structures through hydrogen bond interactions.In complex 3,the 1D[Cu(4-bpmah)(H_(2)O)_(2)]^(2n+)metal–organic chains and isolated[Cu_(2)(TeMo_(6)O_(24))(H_(2)O)_(10)]^(2n–)units were expanded into a 3D supramolecular framework by the hydrogen bond interactions.In this paper,carbon cloth working electrodes composited by the title complexes(1/CC,2/CC and 3/CC)were prepared and used as electrodes for supercapacitors.The performance of supercapacitors as well as the influence of electrolyte solution and title complexes quality load on the performance of supercapacitors were studied.Furthermore,the electrochemistry and electrocatalytic behaviors of complexes 1–3 bulk-modified carbon paste electrodes(1-CPE,2-CPE and 3-CPE)toward the reduction of KBrO_(3),KNO_(2),Cr(Ⅵ),as well as their sensing behaviors on Cr(Ⅵ)were investigated.展开更多
Heterodimerization of receptor tyrosine kinases(RTKs)plays unique roles in cell signaling and functions.However,engineering heterodimerization of multiple receptors remains largely unexplored.Herein,we developed an ap...Heterodimerization of receptor tyrosine kinases(RTKs)plays unique roles in cell signaling and functions.However,engineering heterodimerization of multiple receptors remains largely unexplored.Herein,we developed an aptamer-based DNA Nano-windmill(TA3)to regulate heterodimerization of three different RTK families,simultaneously activating fibroblast growth factor receptor 1(FGFR1),hepatocyte growth factor receptor(Met)and epidermal growth factor receptor(EGFR)signaling.It is the first DNA Nanowindmill that activates heterodimerization of FGFR1,Met and EGFR,leading to the down-stream signals transduction,such as the phosphorylation of protein kinase B(Akt)and extracellular regulated protein kinases(Erk),inducing the cell migration and proliferation.We further designed transformable DNA Nanowindmill(TMA)that can convert DNA Nano-windmill into DNA Nano-kite using complementary strands or small molecules to reduce the activation of specific receptor.We believe that the DNA Nano-windmill for heterodimerization of different RTK families have potential applications in biomedicine fields.展开更多
基金financially supported by the National Natural Science Foundation of China (Nos. 21971024, 21671025)Liaoning Revitalization Talents Program (No. XLYC1902011)
文摘In this paper,three new polyoxometalates(POM)-based metal–organic complexes constructed from a new semi-rigid organic ligand N,N'-bis(4-pyrimidinecarboxamido)-1,2-cyclohexane(4-bpmah)H_(2)[Cu(4-bpmah)_(2)(SiMo_(12)O_(40))(H_(2)O)_(2)]·2H_(2)O(1),H[Cu(4-bpmah)_(2)(PMo_(12)O_(4)0)(H_(2)O)_(2)]·2H_(2)O(2)and[Cu(4-bpmah)(H_(2)O)_(2)]·[Cu_(2)(TeMo_(6)O_(24))(H_(2)O)_(10)]·4H_(2)O(3)were synthesized by hydrothermal method.Single crystal X-ray analyses showed that complexes 1 and 2 were isostructural,in which the isolated Keggin-type[SiMo1_(2)O_(40)]^(4–)/[PMo_(12)O_(40)]^(3–)anions and[Cu(4-bpmah)_(2)(H_(2)O)2]^(2n+)units were expanded into 3D supramolecular structures through hydrogen bond interactions.In complex 3,the 1D[Cu(4-bpmah)(H_(2)O)_(2)]^(2n+)metal–organic chains and isolated[Cu_(2)(TeMo_(6)O_(24))(H_(2)O)_(10)]^(2n–)units were expanded into a 3D supramolecular framework by the hydrogen bond interactions.In this paper,carbon cloth working electrodes composited by the title complexes(1/CC,2/CC and 3/CC)were prepared and used as electrodes for supercapacitors.The performance of supercapacitors as well as the influence of electrolyte solution and title complexes quality load on the performance of supercapacitors were studied.Furthermore,the electrochemistry and electrocatalytic behaviors of complexes 1–3 bulk-modified carbon paste electrodes(1-CPE,2-CPE and 3-CPE)toward the reduction of KBrO_(3),KNO_(2),Cr(Ⅵ),as well as their sensing behaviors on Cr(Ⅵ)were investigated.
基金the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346)+1 种基金Shenzhen Science and Technology Program(No.SZBH202130)State Key Laboratory of Chemo/Biosensing and Chemometrics(No.20230762)。
文摘Heterodimerization of receptor tyrosine kinases(RTKs)plays unique roles in cell signaling and functions.However,engineering heterodimerization of multiple receptors remains largely unexplored.Herein,we developed an aptamer-based DNA Nano-windmill(TA3)to regulate heterodimerization of three different RTK families,simultaneously activating fibroblast growth factor receptor 1(FGFR1),hepatocyte growth factor receptor(Met)and epidermal growth factor receptor(EGFR)signaling.It is the first DNA Nanowindmill that activates heterodimerization of FGFR1,Met and EGFR,leading to the down-stream signals transduction,such as the phosphorylation of protein kinase B(Akt)and extracellular regulated protein kinases(Erk),inducing the cell migration and proliferation.We further designed transformable DNA Nanowindmill(TMA)that can convert DNA Nano-windmill into DNA Nano-kite using complementary strands or small molecules to reduce the activation of specific receptor.We believe that the DNA Nano-windmill for heterodimerization of different RTK families have potential applications in biomedicine fields.
