1Introduction The condenser plays a vital role in the operation of a thermal power generation unit.Its primary function is to remove the heat from the steam that is exhausted from the steam turbine,thereby condensing ...1Introduction The condenser plays a vital role in the operation of a thermal power generation unit.Its primary function is to remove the heat from the steam that is exhausted from the steam turbine,thereby condensing the steam into water.Additionally,it establishes and maintains a specific degree of vacuum at the exhaust port of the steam turbine,facilitating efficient operation of the turbine(Keshvarparast et al.,2020).The vacuum degree of the condenser is affected by physical factors such as steam-side resistance and heat-transfer efficiency.展开更多
α_(1)-Adrenergic receptor(AR)blockers can be effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms(BPH/LUTS),their usage is limited by cardiovascular-related side effects that are c...α_(1)-Adrenergic receptor(AR)blockers can be effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms(BPH/LUTS),their usage is limited by cardiovascular-related side effects that are caused by the subtype nonselective nature or low selectivity of many current drugs.We previously reported that phenylpiperazine analogues with amide and propane linker were moderateα_(1D/1A)adrenoceptor antagonists and exhibited better anti-BPH effect than lead compound naftopidil(NAF)in vivo,however,with modestα_(1D/1A)-subtype selectivity.Herein,we replaced propane moiety with2-hydroxypropanol linker and synthesized twenty-seven racemic derivatives with modified aromatic and hetero aromatic groups.Of these new compounds,quinoline surrogate 17 exhibited extremely weak antagonistic affinity onα_(1B)in both cell-based calcium assay and tissue-based functional assay,so that elicited significantα_(1A/1B)andα_(1D/1B)selectivity.Intriguingly,the R enantiomer of 17 preferentially displayed superior anti-BPH effect in rat model compared with S-17,supporting ligand regulates the receptor in a highly stereospecific manner.Finally,the computer-aided modelling research was also performed in order to deeply understand the unique binding mode of R-17 in complex withα_(1A)and the subtype receptor selectivity for R-17 was also rationalized in this study.Taken together,our work enriched the diversity of phenylpiperazines for the treatment of BPH/LUTS,and provided a basis for discovery ofα_(1D/1A)-selective ligands.展开更多
Triboelectric nanogenerators(TENGs)represent a promising technology for next generation human–computer interaction.The effective enhancement of induced charges are critical factors that determine the recognition accu...Triboelectric nanogenerators(TENGs)represent a promising technology for next generation human–computer interaction.The effective enhancement of induced charges are critical factors that determine the recognition accuracy of TENGbased tactile sensors.Here,we propose a magnetic fieldassisted TENG device utilizing waveform feature enrichment strategies to significantly enhance the tactile recognition accuracy in natural environments.An elastic micro-nano structure was fabricated on a polydimethylsiloxane(PDMS)film via a facile templating method.Leveraging the inherent hydrophobicity and microscale surface roughness of PDMS,our device demonstrates stable and distinct waveform characteristics under natural operating conditions.Importantly,the introduction of a magnetic field generates a Lorentz force,which effectively modulates induced charges within the electrode,yet minimally affects triboelectric charges at the PDMS interface.This selective modulation induces an asymmetric charge distribution inside the electrode,substantially increasing the induced charge density,consequently,subtle waveform features are markedly enhanced.These enriched signal features play a crucial role in elevating material recognition accuracy.As a result,the sensor achieves a remarkable recognition accuracy of 99%when distinguishing among ten different materials under magnetic field assistance.This work provides valuable guidelines for advancing the performance and accuracy of TENG-based tactile sensing systems.展开更多
The principal goal of 1-bit compressive sampling is to decode n-dimensional signals with a sparsity level of s from m binary measurements.This task presents significant challenges due to nonlinearity,noise,and sign fl...The principal goal of 1-bit compressive sampling is to decode n-dimensional signals with a sparsity level of s from m binary measurements.This task presents significant challenges due to nonlinearity,noise,and sign flips.In this paper,we propose the use of the cardinality-constrained least squares decoder as an optimal solution.We establish that,with high probability,the proposed decoder achieves a minimax estimation error,up to a constant c,as long as m≥O(slogn).In terms of computational efficiency,we employ a generalized Newton algorithm(GNA)to solve the cardinality-constrained minimization problem.At each iteration,this approach incurs the cost of solving a least squares problem with a small size.Through rigorous analysis,we demonstrate that,with high probability,theℓ¥norm of the estimation error between the output of GNA and the underlying target diminishes to O√logn/m after at most O(logs)iterations.Furthermore,provided that the target signal is detectable,we can recover the underlying support with high probability within O(logs)steps.To showcase the robustness of our proposed decoder and the efficiency of the GNA algorithm,we present extensive numerical simulations and comparisons with stateof-the-art methods.展开更多
Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers s...Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of these two stereochemical NAF isomers to the α1D receptor remained unclear. Herein, we reported the crystallographic structures of optically pure NAF stereoisomers for the first time and unambiguously determined their absolute configurations. The crystal data of R and S enantiomers matched satisfactorily the pharmacophore model for α1D-selective antagonists. Based on the constructed α1D homology model,molecular docking studies shed light on the molecular mechanism of NAF enantiomers binding to α1D-AR. The results indicated that NAF enantiomers exhibited the very similar binding poses and occupied the same binding pocket.展开更多
Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to ...Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to the truncated L1 regularized linear regression problem and study the support recovery property.Moreover,a primal dual active set algorithm(PDAS)for variable estimation and selection is proposed.Coupled with continuation by a warm-start strategy leads to a primal dual active set with continuation algorithm(PDASC).Data-driven parameter selection rules such as cross validation,BIC or voting method can be applied to select a proper regularization parameter.The application of the proposed method is demonstrated by applying it to simulation data and a breast cancer gene expression data set(bcTCGA).展开更多
基金supported by the National Natural Science Foundation of China(No.51806192)the Fundamental Research Funds for the Central Universities of China(No.2022ZFJH004).
文摘1Introduction The condenser plays a vital role in the operation of a thermal power generation unit.Its primary function is to remove the heat from the steam that is exhausted from the steam turbine,thereby condensing the steam into water.Additionally,it establishes and maintains a specific degree of vacuum at the exhaust port of the steam turbine,facilitating efficient operation of the turbine(Keshvarparast et al.,2020).The vacuum degree of the condenser is affected by physical factors such as steam-side resistance and heat-transfer efficiency.
基金supported by Natural Science Foundation of Guangdong Province(Nos.2021A1515010101,2021A1515011372,2023A1515011895)National Natural Science Foundation of China(Nos.21807017,82273759,32371529)Guangzhou Medical University Scientific Research Capacity Improvement Project(No.02-410-2405104)。
文摘α_(1)-Adrenergic receptor(AR)blockers can be effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms(BPH/LUTS),their usage is limited by cardiovascular-related side effects that are caused by the subtype nonselective nature or low selectivity of many current drugs.We previously reported that phenylpiperazine analogues with amide and propane linker were moderateα_(1D/1A)adrenoceptor antagonists and exhibited better anti-BPH effect than lead compound naftopidil(NAF)in vivo,however,with modestα_(1D/1A)-subtype selectivity.Herein,we replaced propane moiety with2-hydroxypropanol linker and synthesized twenty-seven racemic derivatives with modified aromatic and hetero aromatic groups.Of these new compounds,quinoline surrogate 17 exhibited extremely weak antagonistic affinity onα_(1B)in both cell-based calcium assay and tissue-based functional assay,so that elicited significantα_(1A/1B)andα_(1D/1B)selectivity.Intriguingly,the R enantiomer of 17 preferentially displayed superior anti-BPH effect in rat model compared with S-17,supporting ligand regulates the receptor in a highly stereospecific manner.Finally,the computer-aided modelling research was also performed in order to deeply understand the unique binding mode of R-17 in complex withα_(1A)and the subtype receptor selectivity for R-17 was also rationalized in this study.Taken together,our work enriched the diversity of phenylpiperazines for the treatment of BPH/LUTS,and provided a basis for discovery ofα_(1D/1A)-selective ligands.
基金supports by the Guangxi Science and Technology Base and Talent Special Project(No.AD25069020)Major project of scientific research in colleges and universities of Anhui Province(No.2024AH040211)+3 种基金Department of Education team project(No.2022AH010096)Anhui Province key research and development program(Nos.202423i08050016 and 202304a05020027)the National Natural Science Foundation of China(No.52472190)Beijing Nova Program(Nos.20220484036 and 20240484565).
文摘Triboelectric nanogenerators(TENGs)represent a promising technology for next generation human–computer interaction.The effective enhancement of induced charges are critical factors that determine the recognition accuracy of TENGbased tactile sensors.Here,we propose a magnetic fieldassisted TENG device utilizing waveform feature enrichment strategies to significantly enhance the tactile recognition accuracy in natural environments.An elastic micro-nano structure was fabricated on a polydimethylsiloxane(PDMS)film via a facile templating method.Leveraging the inherent hydrophobicity and microscale surface roughness of PDMS,our device demonstrates stable and distinct waveform characteristics under natural operating conditions.Importantly,the introduction of a magnetic field generates a Lorentz force,which effectively modulates induced charges within the electrode,yet minimally affects triboelectric charges at the PDMS interface.This selective modulation induces an asymmetric charge distribution inside the electrode,substantially increasing the induced charge density,consequently,subtle waveform features are markedly enhanced.These enriched signal features play a crucial role in elevating material recognition accuracy.As a result,the sensor achieves a remarkable recognition accuracy of 99%when distinguishing among ten different materials under magnetic field assistance.This work provides valuable guidelines for advancing the performance and accuracy of TENG-based tactile sensing systems.
基金supported by the National Key Research and Development Program of China(No.2023YFA1000103)by the National Natural Science Foundation of China(No.12125103,No.U24A2002,No.12371424,No.12371441)+1 种基金by the Natural Science Foundation of Hubei Province(No.2025AFA002,No.2024AFE006)by the Fundamental Research Funds for the Central Universities,Chin。
文摘The principal goal of 1-bit compressive sampling is to decode n-dimensional signals with a sparsity level of s from m binary measurements.This task presents significant challenges due to nonlinearity,noise,and sign flips.In this paper,we propose the use of the cardinality-constrained least squares decoder as an optimal solution.We establish that,with high probability,the proposed decoder achieves a minimax estimation error,up to a constant c,as long as m≥O(slogn).In terms of computational efficiency,we employ a generalized Newton algorithm(GNA)to solve the cardinality-constrained minimization problem.At each iteration,this approach incurs the cost of solving a least squares problem with a small size.Through rigorous analysis,we demonstrate that,with high probability,theℓ¥norm of the estimation error between the output of GNA and the underlying target diminishes to O√logn/m after at most O(logs)iterations.Furthermore,provided that the target signal is detectable,we can recover the underlying support with high probability within O(logs)steps.To showcase the robustness of our proposed decoder and the efficiency of the GNA algorithm,we present extensive numerical simulations and comparisons with stateof-the-art methods.
基金supported by grants from the National Science Foundation of Guangdong Province (No. S2013040014088)the Postdoctoral Science Foundation of Guangzhou City (Q188)partially supported by the Guangdong Major Scientific and Technological Special Project for New Drug Development (2013A022100029)
文摘Chiral drug naftopidil(NAF), a specific α1D-adrenoceptor(AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α1D-AR, but the binding mechanism of these two stereochemical NAF isomers to the α1D receptor remained unclear. Herein, we reported the crystallographic structures of optically pure NAF stereoisomers for the first time and unambiguously determined their absolute configurations. The crystal data of R and S enantiomers matched satisfactorily the pharmacophore model for α1D-selective antagonists. Based on the constructed α1D homology model,molecular docking studies shed light on the molecular mechanism of NAF enantiomers binding to α1D-AR. The results indicated that NAF enantiomers exhibited the very similar binding poses and occupied the same binding pocket.
文摘Truncated L1 regularization proposed by Fan in[5],is an approximation to the L0 regularization in high-dimensional sparse models.In this work,we prove the non-asymptotic error bound for the global optimal solution to the truncated L1 regularized linear regression problem and study the support recovery property.Moreover,a primal dual active set algorithm(PDAS)for variable estimation and selection is proposed.Coupled with continuation by a warm-start strategy leads to a primal dual active set with continuation algorithm(PDASC).Data-driven parameter selection rules such as cross validation,BIC or voting method can be applied to select a proper regularization parameter.The application of the proposed method is demonstrated by applying it to simulation data and a breast cancer gene expression data set(bcTCGA).
