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An Improved Bionic Piezoelectric Actuator for Eliminating the Backward Motion
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作者 Nen Wan junjie cai +7 位作者 Lidong He Jianping Li Yili Hu Jijie Ma Kang Chen Yingting Wang Yigang Shen Jianming Wen 《Journal of Bionic Engineering》 2025年第2期703-712,共10页
Piezoelectric actuators are widely utilized in positioning systems to realize nano-scale resolution. However, the backward motion always generates for some piezoelectric actuators, which reduces the working efficiency... Piezoelectric actuators are widely utilized in positioning systems to realize nano-scale resolution. However, the backward motion always generates for some piezoelectric actuators, which reduces the working efficiency. Bionic motions have already been employed in the field of piezoelectric actuators to realize better performance. By imitating the movement form of seals, seal type piezoelectric actuator is capable to realize large operating strokes easily. Nevertheless, the conventional seal type piezoelectric actuator has a complicated structure and control system, which limits further applications. Hence, an improved bionic piezoelectric actuator is proposed to realize a long motion stroke and eliminate backward movement with a simplified structure and control method in this study. The composition and motion principle of the designed actuator are discussed, and the performance is investigated with simulations and experiments. Results confirm that the presented actuator effectively realizes the linear movement that has a large working stroke stably without backward motion. The smallest stepping displacement ΔL is 0.2 μm under 1 Hz and 50 V. The largest motion speed is 900 μm/s with 900 Hz and 120 V. The largest vertical and horizontal load are 250 g and 12 g, respectively. This work shows that the improved bionic piezoelectric actuator is feasible for eliminating backward motion and has a great working ability. 展开更多
关键词 PIEZOELECTRIC ACTUATOR SEAL BIONIC Flexure Backward motion
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Signal cascade amplification of streptavidin-biotin-modified immunofluorescence nanocapsules for ultrasensitive detection of glial fibrillary acidic protein
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作者 Bo Liu Shuaiqiang Shao +4 位作者 junjie cai Zijian Zhang Feng Tian Kun Yang Fan Li 《Chinese Chemical Letters》 2025年第3期316-321,共6页
Glial fibrillary acidic protein(GFAP)is one of the discriminative biomarkers for diagnosing traumatic brain injury(TBI),and accurate determination of GFAP is clinically significant.In this study,a novel fluorescence i... Glial fibrillary acidic protein(GFAP)is one of the discriminative biomarkers for diagnosing traumatic brain injury(TBI),and accurate determination of GFAP is clinically significant.In this study,a novel fluorescence immunoassay system was designed.We encapsulated carbon dots with a high fluorescence quantum yield(QY=92.5%)inside silicon nanocapsules to serve as fluorescent markers.These markers were then integrated with the streptavidin(SA)-biotin biomagnification system and immunomagnetic separation technology for the sensitive detection of GFAP.Based on the signal cascade amplification effect of the silicon nanocapsules and SA-biotin,the fluorescence signal of the SA-biotin-modified immunofluorescence nanocapsules increased 3.6-fold compared to the carbon dot-based immunoprobe.The fluorescence immunoassay system was constructed for GFAP using SA-biotin-modified immunocapsules as the sensing probe and immunomagnetic nanoparticles as the immunorecognition probe.The fluorescence immunoassay system can specifically and ultra-sensitively quantify GFAP in blood samples,with a detection range of 10 pg/mL–10 ng/mL and detection limits of 3.2 pg/mL(serum)and 3.6 pg/mL(plasma).Moreover,the fluorescence immunoassay system exhibited prominent recoveries of 99.4%–100.4%(phosphate buffered saline),96%–102.6%(serum),and 93.2%–110.2%(plasma),with favorable specificity and excellent stabilization.The novel fluorescence immunoassay system provides a new approach to the clinical analysis of GFAP and may serve as a potential tool for screening and diagnosing TBI. 展开更多
关键词 Carbon dots NANOCAPSULES Signal amplification Traumatic brain injury Fluorescence immunoassay system
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Effect of Low-Intensity Focused Ultrasound on CaN and NFAT Expression Following Spinal Cord Injury in Rats
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作者 Zhuorui HE junjie cai +4 位作者 Wanxin SUN Chenyu ZHANG Shupeng ZHU Fanyi WU Liqun REN 《Medicinal Plant》 2025年第6期75-79,共5页
[Objectives]To investigate the effect of low-intensity focused ultrasound(LIFU)on rats with spinal cord injury(SCI)by examining the expression of calcineurin(CaN)and nuclear factor of activated T-cells(NFAT)in the inj... [Objectives]To investigate the effect of low-intensity focused ultrasound(LIFU)on rats with spinal cord injury(SCI)by examining the expression of calcineurin(CaN)and nuclear factor of activated T-cells(NFAT)in the injured spinal cord region following LIFU intervention.[Methods]Twenty-four specific pathogen-free(SPF)female Wistar rats,aged 7-8 weeks(160-180 g),were selected.Six rats were randomly assigned to the sham-operated group(SHAM),undergoing laminectomy only without spinal cord injury.Spinal cord injury models were established in the remaining rats using a modified Allen s weight-drop method at the T10 thoracic vertebral level.The 18 rats with successful modeling were then randomly divided into the spinal cord injury model group(SCI group),LIFU treatment group 1(T1 group),and LIFU treatment group 2(T2 group),with six rats in each group.LIFU treatment(for T1 and T2 groups)commenced on day 4 after injury,administered once daily for 20 min per session,for a total of 11 consecutive days.Tissues were harvested on day 14.Changes in CaN and NFAT4 mRNA expression were assessed using quantitative polymerase chain reaction(qPCR).Changes in CaN and NFAT4 protein expression were evaluated by Western blot analysis.[Results]qPCR analysis revealed that compared to the SHAM group,mRNA expression levels of both CaN and NFAT4 were decreased in the SCI group;compared to the SCI group,mRNA expression levels of CaN and NFAT4 were increased in both the T1 and T2 groups;furthermore,compared to the T1 group,mRNA expression levels of CaN and NFAT4 were higher in the T2 group.Western Blot analysis showed that compared to the SHAM group,protein expression levels of both CaN and NFAT4 were downregulated in the SCI group;compared to the SCI group,protein expression levels of CaN and NFAT4 were increased in both the T1 and T2 groups;moreover,compared to the T1 group,protein expression levels of CaN and NFAT4 were higher in the T2 group.[Conclusions]LIFU may contribute to functional recovery in SCI rats by modulating the expression levels of CaN and NFAT4. 展开更多
关键词 Spinal cord injury Low-intensity focused ultrasound CALCINEURIN Nuclear factor of activated T-cells
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Study on the evolution of solid–liquid–gas in multi-scale pore methane in tectonic coal 被引量:1
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作者 junjie cai Xijian Li +1 位作者 Hao Sui Honggao Xie 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第7期122-131,共10页
The rich accumulation of methane(CH_(4))in tectonic coal layers poses a significant obstacle to the safe and efficient extraction of coal seams and coalbed methane.Tectonic coal samples from three geologically complex... The rich accumulation of methane(CH_(4))in tectonic coal layers poses a significant obstacle to the safe and efficient extraction of coal seams and coalbed methane.Tectonic coal samples from three geologically complex regions were selected,and the main results obtained by using a variety of research tools,such as physical tests,theoretical analyses,and numerical simulations,are as follows:22.4–62.5 nm is the joint segment of pore volume,and 26.7–100.7 nm is the joint segment of pore specific surface area.In the dynamic gas production process of tectonic coal pore structure,the adsorption method of methane molecules is“solid–liquid adsorption is the mainstay,and solid–gas adsorption coexists”.Methane stored in micropores with a pore size smaller than the jointed range is defined as solid-state pores.Pores within the jointed range,which transition from micropore filling to surface adsorption,are defined as gaseous pores.Pores outside the jointed range,where solid–liquid adsorption occurs,are defined as liquid pores.The evolution of pore structure affects the methane adsorption mode,which provides basic theoretical guidance for the development of coal seam resources. 展开更多
关键词 Tectonic coal Multiscale pore structure Methane adsorption Micropore filling MONOLAYER Molecular simulation
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A Novel Bionic Piezoelectric Actuator Based on the Walrus Motion 被引量:1
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作者 Jianping Li junjie cai +5 位作者 Nen Wan Yili Hu Jianming Wen Junwu Kan Song Chen Hongwei Zhao 《Journal of Bionic Engineering》 SCIE EI CSCD 2021年第5期1117-1125,共9页
A novel bionic piezoelectric actuator based on the walrus motion to achieve high performance on large working stroke for micro/nano positioning systems is first proposed in this study.The structure of the proposed wal... A novel bionic piezoelectric actuator based on the walrus motion to achieve high performance on large working stroke for micro/nano positioning systems is first proposed in this study.The structure of the proposed walrus type piezoelectric actuator is described,and its motion principle is presented in details.An experimental system is set up to verify its feasibility and explore its working performances.Experimental results indicate that the proposed walrus type piezoelectric actuator could realize large working stroke with only one driving unit and one coupled clamping unit;the maximum stepping displacement isΔL max=19.5μm in the case that the frequency f=1 Hz and the voltage U=120 V;the maximum speed V max=2275.2μm·s^(-1) when the frequency f=900 Hz and the voltage U=120 V;the maximum vertical load m max=350 g while the voltage U=120 V and the frequency f=1 Hz.This study shows the feasibility of mimicking the bionic motion of the real walrus animal to the design of piezoelectric actuators,which is hopeful for the real application of micro/nano positioning systems to achieve large working stroke and high performance. 展开更多
关键词 Piezoelectric actuator Bionic actuator Walrus motion Flexure mechanism
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Effect of hUC-MSCs on the NLRP3/Caspase-1 Pathway in APP/PS1 Mice
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作者 junjie cai Fuhong LI +4 位作者 Tianyu WANG Zhuorui HE Kaiyue LI Yufan ZANG Liqun REN 《Medicinal Plant》 2024年第6期75-78,共4页
[Objectives] To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on the NOD-like receptor protein 3 (NLRP3)/cysteinyl aspartate specific proteinase (Caspase-1) pathway within the cerebr... [Objectives] To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on the NOD-like receptor protein 3 (NLRP3)/cysteinyl aspartate specific proteinase (Caspase-1) pathway within the cerebral cortex of a mouse model of Alzheimer s disease (AD).[Methods] Twelve 6-month-old female APP/PS1 mice were randomly assigned to two groups: the model group (MOD, n =6) and the hUC-MSCs treatment group (MSC, n =6). Six 6-month-old C57BL/6N mice were utilized as a control group (CON, n =6). All mice underwent caudal vein injections of hUC-MSCs. Following a 4-week treatment, the mice from each group were euthanized. The expression levels of NLRP3, Caspase-1 protein, and mRNA in the cerebral cortex of each group were assessed using Western blotting and real-time fluorescence quantitative PCR assays.[Results] The results of immunoblotting showed that the expression levels of NLRP3 and Caspase-1 proteins in the MOD group were significantly higher than those observed in the CON group. Furthermore, the expression levels of NLRP3 and Caspase-1 proteins in the MSC group were found to be lower than those in the MOD group. Additionally, the findings from real-time fluorescence quantitative PCR assay demonstrated that the mRNA levels of NLRP3 and Caspase-1 in the MOD group were elevated compared to the CON group. Conversely, the mRNA levels of NLRP3 and Caspase-1 in the MSC group were reduced in comparison to the MOD group.[Conclusions] hUC-MSCs have the capacity to modulate the expression of the NLRP3/Caspase-1 pathway within the cerebral cortex of APP/PS1 mice. This modulation may be associated with the neuroinflammatory processes mediated by hUC-MSCs in the brains of APP/PS1 mice. 展开更多
关键词 Alzheimer s disease(AD) Human umbilical cord mesenchymal stem cells(hUC-MSCs) APP/PS1 mice NLRP3 inflammasome
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Effect of Human Umbilical Cord Mesenchymal Stem Cells on GRP78/ATF4 Pathway in Alzheimer s Disease Model Mice
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作者 Fuhong LI Tianyu WANG +3 位作者 junjie cai Zhuorui HE Yufan ZANG Liqun REN 《Medicinal Plant》 2023年第6期67-70,共4页
[Objectives]To study the effect of human umbilical cord mesenchymal stem cells(hUC-MSCs)on GRP78/ATF4 pathway in APP/PS1 mice.[Methods]Twelve 6-month-old female APP/PS1 mice were randomly divided into model group(MOD,... [Objectives]To study the effect of human umbilical cord mesenchymal stem cells(hUC-MSCs)on GRP78/ATF4 pathway in APP/PS1 mice.[Methods]Twelve 6-month-old female APP/PS1 mice were randomly divided into model group(MOD,n=6)and human umbilical cord mesenchymal stem cell treatment group(MSC,n=6);six 6-month-old C57BL/6N mice were used as control group(CON,n=6).The mice in each group were treated with the fourth generation of human umbilical cord mesenchymal stem cells through tail vein.Four weeks later,the mice in each group were killed.The expression of GFP78 and ATF4 in the cortex of mice in each group was detected by Western blotting and real-time fluorescence quantitative PCR.[Results]The results of immunoblotting and real-time fluorescence quantitative PCR showed that the expression of GRP78 in MOD group was lower than that in CON group and the expression of ATF4 increased.The expression of GRP78 protein in MSC group was higher than that in MOD group,but the expression of ATF4 protein was lower.The results of real-time fluorescence quantitative PCR showed that the mRNA level of GRP78 decreased and the mRNA level of ATF4 increased in MOD group compared with CON group.The mRNA level of GRP78 in MSC group was higher than that in MOD group,while the mRNA level of ATF4 in MSC group was lower than that in MOD group.[Conclusions]Human umbilical cord mesenchymal stem cells can regulate the expression of GRP78/ATF4 pathway in APP/PSI mice,which may be related to the stress level of endoplasmic reticulum in the brain of APP/PS1 mice mediated by human umbilical cord mesenchymal stem cells. 展开更多
关键词 Alzheimer s disease Human umbilical cord mesenchymal stem cells APP/PS1 mice Endoplasmic reticulum stress
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Progress in niobium-based oxides as anode for fast-charging Li-ion batteries 被引量:2
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作者 Fuqiang Xie Junling Xu +7 位作者 Qizhong Liao Qingqing Zhang Binyun Liu Lianyi Shao junjie cai Xiaoyan Shi Zhipeng Sun Ching-Ping Wong 《Energy Reviews》 2023年第2期62-79,共18页
With the increasing popularity of electric/hybrid vehicles and the rapid development of 3C electronics,there is a growing interest in high-rate energy storage systems.The rapid development and widespread adoption of l... With the increasing popularity of electric/hybrid vehicles and the rapid development of 3C electronics,there is a growing interest in high-rate energy storage systems.The rapid development and widespread adoption of lithiumion batteries(LIBs)can be attributed to their numerous advantages,including high energy density,high operating voltage,environmental friendliness,and lack of memory effect.However,the progress of LIBs is currently hindered by the limitations of energy storage materials,which serve as vital components.Therefore,there is an urgent need to address the development of a new generation of high-rate energy storage materials in order to overcome these limitations and further advance LIB technology.Niobium-based oxides have emerged as promising candidates for the fabrication of fast-charging Li-ion batteries due to their excellent rate capability and long lifespan.This review paper provides a comprehensive analysis of the fundamentals,methodologies,and electrochemistries of niobium-based oxides,with a specific focus on the evolution and creation of crystal phases of Nb_(2)O_(5),fundamental electrochemical behavior,and modification methods including morphology modulation,composite technology,and carbon coating.Furthermore,the review explores Nb_(2)O_(5)-derived compounds and related advanced characterization techniques.Finally,the challenges and issues in the development of niobiumbased oxides for high-rate energy storage batteries are discussed,along with future research perspectives. 展开更多
关键词 Energy storage materials Fast-charging Li-ion batteries Niobium-based oxides Modification Nb_(2)O_(5)-Derived compounds Advanced characterization techniques
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Enhancing the ability of single-pixel imaging against the source's energy fluctuation by complementary detection
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作者 蔡俊杰 龚文林 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第3期19-24,共6页
The source's energy fluctuation has a great effect on the quality of single-pixel imaging(SPI).When the method of complementary detection is introduced into an SPI camera system and the echo signal is corrected wi... The source's energy fluctuation has a great effect on the quality of single-pixel imaging(SPI).When the method of complementary detection is introduced into an SPI camera system and the echo signal is corrected with the summation of the light intensities recorded by two complementary detectors,we demonstrate,by both experiments and simulations,that complementary single-pixel imaging(CSPI)is robust to the source's energy fluctuation.The superiority of the CSPI structure is also discussed in comparison with previous SPI via signal monitoring. 展开更多
关键词 computational imaging image reconstruction complementary detection correlation function
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