Depression is a prevalent mental disorder with limited effective treatments,posing a significant global issue.This study explored L-theanine and geniposide,key components in“food-medicine homology”materials,to deter...Depression is a prevalent mental disorder with limited effective treatments,posing a significant global issue.This study explored L-theanine and geniposide,key components in“food-medicine homology”materials,to determine if their combination(TG)could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress(CUMS)mouse model.Male C57BL/6J mice were divided into control,CUMS model,and CUMS+TG groups with varying doses.The CUMS group displayed depressionlike behaviors,including reduced activity and sucrose preference.TG treatment partially reversed these changes,significantly increasing antioxidant enzyme activities,decreasing pro-inflammatory cytokine levels,and improving neuromodulator levels.RNA-seq analysis identified the transthyretin(TTR)gene,upregulated in the model group but downregulated after TG treatment.TG treatment modulated intestinal microbiota composition compared to the CUMS group,including increased Firmicutes,reduced Bacteroidetes and Prevotella,and variable changes in Bifidobacterium abundance.In conclusion,our study indicates that CUMS exposure upregulates stress hormones and TTR expression,associated with neuroinflammation,oxidative stress,monoamine depletion,depression-like behaviors,and intestinal microbiota dysbiosis.TG treatment alleviates these effects and modulates intestinal microbiota,suggesting L-theanine and geniposide's potential as a novel depression therapy.展开更多
[Objectives]This study aimed to optimize the chelation process for complex microelement iron supplement derived from pig blood by response surface methodology.[Methods]On the basis of single-factor test,p H value,conc...[Objectives]This study aimed to optimize the chelation process for complex microelement iron supplement derived from pig blood by response surface methodology.[Methods]On the basis of single-factor test,p H value,concentration of polypeptide solution and volume ratio of polypeptide solution to FeCl_2 solution were selected as influencing factors with Fe(II)chelation rate as the indicator for Box-Behnken central composite experimental design with three factors and three levels.The effects of three factors on the response value were analyzed by response surface methodology.[Results]The optimized chelation process for complex microelement iron supplement derived from pig blood by response surface methodology was as follows:pH 5.40,polypeptide solution concentration 2.27%,volume ratio of polypeptide solution to FeCl_2 solution 2.16∶1.Under this condition,the predictive Fe(II)chelation rate of iron supplement was 79.37%,while the actual value was 79.41%.[Conclusions]The optimized process may provide new thoughts for the development and utilization of complex microelement iron supplement derived from pig blood.展开更多
In this paper, a generalized preconditioned Hermitian and skew-Hermitian splitting （GPHSS） iteration method for a non-Hermitian positive-definite matrix is studied, which covers standard Hermitian and skew-Hermitian...In this paper, a generalized preconditioned Hermitian and skew-Hermitian splitting （GPHSS） iteration method for a non-Hermitian positive-definite matrix is studied, which covers standard Hermitian and skew-Hermitian splitting （HSS） iteration and also many existing variants. Theoretical analysis gives an upper bound for the spectral radius of the iteration matrix. From practical point of view, we have analyzed and implemented inexact generalized preconditioned Hermitian and skew-Hermitian splitting （IGPHSS） iteration, which employs Krylov subspace methods as its inner processes. Numerical experiments from three-dimensional convection-diffusion iterations are efficient and competitive with equation show that the GPHSS and IGPHSS standard HSS iteration and AHSS iteration.展开更多
In this paper,we construct and analyze a Crank-Nicolson fitted finite volume scheme for pricing European options under regime-switching Kou’s jumpdiffusion model which is governed by a system of partial integro-diffe...In this paper,we construct and analyze a Crank-Nicolson fitted finite volume scheme for pricing European options under regime-switching Kou’s jumpdiffusion model which is governed by a system of partial integro-differential equations(PIDEs).We show that this scheme is consistent,stable and monotone as the mesh sizes in space and time approach zero,hence it ensures the convergence to the solution of continuous problem.Finally,numerical experiments are performed to demonstrate the efficiency,accuracy and robustness of the proposed method.展开更多
The discretization of the fractional regime-switching option pricing model leads to the linear system with the block diagonal and Kronecker product structure.A fast matrix splitting iteration method is presented to so...The discretization of the fractional regime-switching option pricing model leads to the linear system with the block diagonal and Kronecker product structure.A fast matrix splitting iteration method is presented to solve the discrete system.Theoretical analyses prove the convergence of the proposed iteration method.Numerical experiments show that the new method is efficient and outperforms the existing methods in terms of the number of iteration steps and the elapsed CPU time.展开更多
基金funded by Innovation Project for Chinese Academy of Agricultural Sciences(CAAS-ASTIP-TRI)China Agriculture Research System of MOF and MARA(CARS-19)。
文摘Depression is a prevalent mental disorder with limited effective treatments,posing a significant global issue.This study explored L-theanine and geniposide,key components in“food-medicine homology”materials,to determine if their combination(TG)could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress(CUMS)mouse model.Male C57BL/6J mice were divided into control,CUMS model,and CUMS+TG groups with varying doses.The CUMS group displayed depressionlike behaviors,including reduced activity and sucrose preference.TG treatment partially reversed these changes,significantly increasing antioxidant enzyme activities,decreasing pro-inflammatory cytokine levels,and improving neuromodulator levels.RNA-seq analysis identified the transthyretin(TTR)gene,upregulated in the model group but downregulated after TG treatment.TG treatment modulated intestinal microbiota composition compared to the CUMS group,including increased Firmicutes,reduced Bacteroidetes and Prevotella,and variable changes in Bifidobacterium abundance.In conclusion,our study indicates that CUMS exposure upregulates stress hormones and TTR expression,associated with neuroinflammation,oxidative stress,monoamine depletion,depression-like behaviors,and intestinal microbiota dysbiosis.TG treatment alleviates these effects and modulates intestinal microbiota,suggesting L-theanine and geniposide's potential as a novel depression therapy.
基金Supported by Youth Fund of National Natural Science Foundation of China(31801673)Talent Development Fund of Anhui Academy of Agricultural Sciences(17F1205)+2 种基金Youth Innovation Fund of President of Anhui Academy of Agricultural Sciences(17B1220)Team Building Project of Anhui Academy of Agricultural Sciences(18C1225)Youth Fund of Natural Science Foundation of Anhui Province(1808085QC94)
文摘[Objectives]This study aimed to optimize the chelation process for complex microelement iron supplement derived from pig blood by response surface methodology.[Methods]On the basis of single-factor test,p H value,concentration of polypeptide solution and volume ratio of polypeptide solution to FeCl_2 solution were selected as influencing factors with Fe(II)chelation rate as the indicator for Box-Behnken central composite experimental design with three factors and three levels.The effects of three factors on the response value were analyzed by response surface methodology.[Results]The optimized chelation process for complex microelement iron supplement derived from pig blood by response surface methodology was as follows:pH 5.40,polypeptide solution concentration 2.27%,volume ratio of polypeptide solution to FeCl_2 solution 2.16∶1.Under this condition,the predictive Fe(II)chelation rate of iron supplement was 79.37%,while the actual value was 79.41%.[Conclusions]The optimized process may provide new thoughts for the development and utilization of complex microelement iron supplement derived from pig blood.
文摘In this paper, a generalized preconditioned Hermitian and skew-Hermitian splitting （GPHSS） iteration method for a non-Hermitian positive-definite matrix is studied, which covers standard Hermitian and skew-Hermitian splitting （HSS） iteration and also many existing variants. Theoretical analysis gives an upper bound for the spectral radius of the iteration matrix. From practical point of view, we have analyzed and implemented inexact generalized preconditioned Hermitian and skew-Hermitian splitting （IGPHSS） iteration, which employs Krylov subspace methods as its inner processes. Numerical experiments from three-dimensional convection-diffusion iterations are efficient and competitive with equation show that the GPHSS and IGPHSS standard HSS iteration and AHSS iteration.
基金supported by the National Natural Science Foundation of China(Nos.11971354,and 11701221)the Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities’Association(No.2019FH001-079)the Fundamental Research Funds for the Central Universities(No.22120210555).
文摘In this paper,we construct and analyze a Crank-Nicolson fitted finite volume scheme for pricing European options under regime-switching Kou’s jumpdiffusion model which is governed by a system of partial integro-differential equations(PIDEs).We show that this scheme is consistent,stable and monotone as the mesh sizes in space and time approach zero,hence it ensures the convergence to the solution of continuous problem.Finally,numerical experiments are performed to demonstrate the efficiency,accuracy and robustness of the proposed method.
基金supported by the National Natural Science Foundation of China(No.11971354).
文摘The discretization of the fractional regime-switching option pricing model leads to the linear system with the block diagonal and Kronecker product structure.A fast matrix splitting iteration method is presented to solve the discrete system.Theoretical analyses prove the convergence of the proposed iteration method.Numerical experiments show that the new method is efficient and outperforms the existing methods in terms of the number of iteration steps and the elapsed CPU time.
