Conductive polymer composites(CPCs)strain sensors exhibit promising applications in flexible electronics,people’s health monitoring,etc.It remains a big challenge to develop a simple and cost-effective method to prep...Conductive polymer composites(CPCs)strain sensors exhibit promising applications in flexible electronics,people’s health monitoring,etc.It remains a big challenge to develop a simple and cost-effective method to prepare CPCs with high conductivity,corrosion resistance,strong interfacial adhesion and high sensitivity.Here,we propose a facile“drop-casting and fluorination”strategy to fabricate superhydrophobic and highly electrically conductive coating by Ag precursor adsorption onto a commercially available elastic tape,subsequent chemical reduction and final fluorination.The Ag nanoparticles could not only construct the electrically conductive network but also greatly enhance the surface roughness.The contact angle and electrical conductivity of the coating can reach as high as 156°and 126 S/cm,respectively.When used for strain sensing,the superhydrophobic and conductive coating shows a high gauger factor(up to 7631 with the strain from 44%to 50%)and outstanding recyclability.The strain sensor could monitor different body joint motions with the stable and reliable sensing signals even after long time treatment in a corrosive solution.展开更多
Electrically conductive fibric composites(CFCs)have been widely used as electromagnetic interference(EMI)shielding materials;however,it is still difficult to achieve combination of strong interfacial adhesion,outstand...Electrically conductive fibric composites(CFCs)have been widely used as electromagnetic interference(EMI)shielding materials;however,it is still difficult to achieve combination of strong interfacial adhesion,outstanding water proof performance,multi-functionality and superb EMI shielding performance for the CFCs.Herein,we report a novel“photo-thermally induced interfacial sintering”method to prepare flexible and superhydrophobic CFCs with excellent interfacial adhesion.The CFC possesses dual conductive network composed of carbon nanofiber and silver nanoparticles(Ag NPs),and a conductivity of 112.1 S/cm,imparting to the material excellent Joule heating performance,revealing an large SE and SSE(59.4 dB and 333.9 dB mm^(-1))of the CFC in the X band,respectively.In addition,the CFC can maintain its superhydrophobicity,high conductivity and excellent EMI shielding performance after cyclic abrasion,stretching and ultrasonication washing.This“interfacial sintering”strategy provides a new way to fabricating multi-functional and durable conductive polymer composite.展开更多
Precise mapping of leukemic cells onto the known hematopoietic hierarchy is important for understanding the cell-of-origin and mechanisms underlying disease initiation and development.However,this task remains challen...Precise mapping of leukemic cells onto the known hematopoietic hierarchy is important for understanding the cell-of-origin and mechanisms underlying disease initiation and development.However,this task remains challenging because of the high interpatient and intrapatient heterogeneity of leukemia cell clones as well as the differences that exist between leukemic and normal hematopoietic cells.Using single-cell RNA sequencing(scRNA-seq)data with a curated clustering approach,we constructed a comprehensive reference hierarchy of normal hematopoiesis.This reference hierarchy was accomplished through multistep clustering and annotating over 100,000 bone marrow mononuclear cells derived from 25 healthy donors.We further employed the cosine distance algorithm to develop a likelihood score to determine the similarities of leukemic cells to their putative normal counterparts.Using our scoring strategies,we mapped the cells of acute myeloid leukemia(AML)and B cell precursor acute lymphoblastic leukemia(BCP-ALL)samples to their corresponding counterparts.The reference hierarchy also facilitated bulk RNA sequencing(RNA-seq)analysis,enabling the development of a least absolute shrinkage and selection operator(LASSO)score model to reveal subtle differences in lineage aberrancy within AML or BCP-ALL patients.To facilitate interpretation and application,we established an R-based package(HematoMap)that offers a fast,convenient,and user-friendly tool for identifying and visualizing lineage aberrations in leukemia from scRNA-seq and bulk RNA-seq data.Our tool provides curated resources and data analytics for understanding leukemogenesis,with the potential to enhance leukemia risk stratification and personalized treatments.The HematoMap is available at https://github.com/NRCTM-bioinfo/HematoMap.展开更多
基金Natural Science Foundation of China(No.51873178)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University)(No.sklpme2020-4-03)+1 种基金Qing Lan Project of Yangzhou University and Jiangsu Province,High-end Talent Project of Yangzhou University,the Priority Academic Program Development of Jiangsu Higher Education Institutions,Postgraduate Research&Practice Innovation Program of Jiangsu province(No.KYCX18_2364,No.KYCX20_2977)Outstanding Doctoral Dissertation Fund of Yangzhou University.
文摘Conductive polymer composites(CPCs)strain sensors exhibit promising applications in flexible electronics,people’s health monitoring,etc.It remains a big challenge to develop a simple and cost-effective method to prepare CPCs with high conductivity,corrosion resistance,strong interfacial adhesion and high sensitivity.Here,we propose a facile“drop-casting and fluorination”strategy to fabricate superhydrophobic and highly electrically conductive coating by Ag precursor adsorption onto a commercially available elastic tape,subsequent chemical reduction and final fluorination.The Ag nanoparticles could not only construct the electrically conductive network but also greatly enhance the surface roughness.The contact angle and electrical conductivity of the coating can reach as high as 156°and 126 S/cm,respectively.When used for strain sensing,the superhydrophobic and conductive coating shows a high gauger factor(up to 7631 with the strain from 44%to 50%)and outstanding recyclability.The strain sensor could monitor different body joint motions with the stable and reliable sensing signals even after long time treatment in a corrosive solution.
基金financially supported by National Natural Science Foundation of China(No.51873178,No.21673203)the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan Unversity)(No.sklpme2020-4-03)+4 种基金Qing Lan Project of Yangzhou University and Jiangsu ProvinceHigh-end Talent Project of Yangzhou Universitythe Priority Academic Program Development of Jiangsu Higher Education InstitutionsPostgraduate Research&Practice Innovation Program of Jiangsu province(No.KYCX18_2364,No.KYCX20_2977)Outstanding Doctoral Dissertation Fund of Yangzhou University
文摘Electrically conductive fibric composites(CFCs)have been widely used as electromagnetic interference(EMI)shielding materials;however,it is still difficult to achieve combination of strong interfacial adhesion,outstanding water proof performance,multi-functionality and superb EMI shielding performance for the CFCs.Herein,we report a novel“photo-thermally induced interfacial sintering”method to prepare flexible and superhydrophobic CFCs with excellent interfacial adhesion.The CFC possesses dual conductive network composed of carbon nanofiber and silver nanoparticles(Ag NPs),and a conductivity of 112.1 S/cm,imparting to the material excellent Joule heating performance,revealing an large SE and SSE(59.4 dB and 333.9 dB mm^(-1))of the CFC in the X band,respectively.In addition,the CFC can maintain its superhydrophobicity,high conductivity and excellent EMI shielding performance after cyclic abrasion,stretching and ultrasonication washing.This“interfacial sintering”strategy provides a new way to fabricating multi-functional and durable conductive polymer composite.
基金supported by the National Natural Science Foundation of China(Grant No.82200153 to Yuting Dai,Grant Nos.82350710226 and 82370178 to Kankan Wang,Grant No.32170663 to Hai Fang,Grant No.82200116 to Fan Zhang)the National Key R&D Program of China(Grant No.2023YFA1800401 to Kankan Wang)+1 种基金the Interdisciplinary Program of Shanghai Jiao Tong University(Grant No.YG2022QN008 to Yuting Dai)the Innovative Research Team of High-Level Local Universities in Shanghai,China.
文摘Precise mapping of leukemic cells onto the known hematopoietic hierarchy is important for understanding the cell-of-origin and mechanisms underlying disease initiation and development.However,this task remains challenging because of the high interpatient and intrapatient heterogeneity of leukemia cell clones as well as the differences that exist between leukemic and normal hematopoietic cells.Using single-cell RNA sequencing(scRNA-seq)data with a curated clustering approach,we constructed a comprehensive reference hierarchy of normal hematopoiesis.This reference hierarchy was accomplished through multistep clustering and annotating over 100,000 bone marrow mononuclear cells derived from 25 healthy donors.We further employed the cosine distance algorithm to develop a likelihood score to determine the similarities of leukemic cells to their putative normal counterparts.Using our scoring strategies,we mapped the cells of acute myeloid leukemia(AML)and B cell precursor acute lymphoblastic leukemia(BCP-ALL)samples to their corresponding counterparts.The reference hierarchy also facilitated bulk RNA sequencing(RNA-seq)analysis,enabling the development of a least absolute shrinkage and selection operator(LASSO)score model to reveal subtle differences in lineage aberrancy within AML or BCP-ALL patients.To facilitate interpretation and application,we established an R-based package(HematoMap)that offers a fast,convenient,and user-friendly tool for identifying and visualizing lineage aberrations in leukemia from scRNA-seq and bulk RNA-seq data.Our tool provides curated resources and data analytics for understanding leukemogenesis,with the potential to enhance leukemia risk stratification and personalized treatments.The HematoMap is available at https://github.com/NRCTM-bioinfo/HematoMap.
