BACKGROUND The current method of cleaning and changing dressings for non-healing lumbar incisions post-radiotherapy is time-consuming and laborious,with very poor results.We here report a patient with radiation dermat...BACKGROUND The current method of cleaning and changing dressings for non-healing lumbar incisions post-radiotherapy is time-consuming and laborious,with very poor results.We here report a patient with radiation dermatitis who developed a nonhealing wound after lumbar spinal surgery.The wound was successfully treated with vacuum sealing drainage therapy,confirming its feasibility in complex wound healing.CASE SUMMARY The patient was a 76-year-old female with lung cancer,positron emission tomography/computed tomography showed bone metastasis in L2 and L3 vertebrae.After 2 months of local radiotherapy to the lumbar spine,symptoms did not improve and pain worsened.She had lumbar lesion clearance and internal fixation surgery,but developed a nonhealing wound of approximately 15 cm postoperatively.After 12 rounds of clearing necrotic and unhealthy tissue,78 days of negative pressure therapy promoted granulation tissue growth and wound healing,resulting in wound healing.CONCLUSION Vacuum sealing drainage therapy has shown efficacy in treating nonhealing wounds after radiotherapy,promoting wound healing and reducing infection risk.展开更多
AIM:To report on the clinical features of patients with retinal amyloid angiopathy(RAA)who were identified to be caused by the transthyretin(TTR)Gly83Arg variant.METHODS:Case series of five patients diagnosed with RAA...AIM:To report on the clinical features of patients with retinal amyloid angiopathy(RAA)who were identified to be caused by the transthyretin(TTR)Gly83Arg variant.METHODS:Case series of five patients diagnosed with RAA was collected at Affiliated Hospital of Zunyi Medical University from January 2010 to December 2021.The clinical features,therapeutic strategies,and prognoses of all patients were reviewed.RESULTS:Five patients with a mean age of 52.00±7.23y were diagnosed as RAA.These patients were previously diagnosed with hereditary transthyretin amyloidosis caused by the TTR Gly83Arg variant.Vitreous opacity was found in all 10 eyes,and 7 eyes developed RAA 2 to 20y after the onset of hereditary transthyretin amyloidosis.The clinical manifestations were recurrent vitreous hemorrhage in 2 eyes(29%),neovascular glaucoma in 2 eyes(29%),and iris neovascularization in 1 eye(14%).Microangioma lesions were found in all affected eyes that underwent fundus fluorescein angiography(FFA)in this group of cases,and the incidence of the retinal non-perfusion area was 67%.Although no cases of retinal neovascularization were found,the prognosis of visual acuity was not ideal.CONCLUSION:This is the first report of RAA in patients with the TTR Gly83Arg variant.Complications such as RAA and glaucoma will seriously affect the visual prognosis of patients.Thereafter,regular ophthalmic follow-up of patients with hereditary transthyretin amyloidosis is essential.And FFA after vitrectomy is very important,which can help ophthalmologists detect RAA earlier and treat it in time.展开更多
文摘BACKGROUND The current method of cleaning and changing dressings for non-healing lumbar incisions post-radiotherapy is time-consuming and laborious,with very poor results.We here report a patient with radiation dermatitis who developed a nonhealing wound after lumbar spinal surgery.The wound was successfully treated with vacuum sealing drainage therapy,confirming its feasibility in complex wound healing.CASE SUMMARY The patient was a 76-year-old female with lung cancer,positron emission tomography/computed tomography showed bone metastasis in L2 and L3 vertebrae.After 2 months of local radiotherapy to the lumbar spine,symptoms did not improve and pain worsened.She had lumbar lesion clearance and internal fixation surgery,but developed a nonhealing wound of approximately 15 cm postoperatively.After 12 rounds of clearing necrotic and unhealthy tissue,78 days of negative pressure therapy promoted granulation tissue growth and wound healing,resulting in wound healing.CONCLUSION Vacuum sealing drainage therapy has shown efficacy in treating nonhealing wounds after radiotherapy,promoting wound healing and reducing infection risk.
基金Supported by the National Natural Science Foundation of China(No.31871261)the Guizhou Science and Technology Cooperation Foundation[No.ZK(2021)general 423]the Research Initiation Fund for Masters in Affiliated Hospital of Zunyi Medical University(No.2016-43)。
文摘AIM:To report on the clinical features of patients with retinal amyloid angiopathy(RAA)who were identified to be caused by the transthyretin(TTR)Gly83Arg variant.METHODS:Case series of five patients diagnosed with RAA was collected at Affiliated Hospital of Zunyi Medical University from January 2010 to December 2021.The clinical features,therapeutic strategies,and prognoses of all patients were reviewed.RESULTS:Five patients with a mean age of 52.00±7.23y were diagnosed as RAA.These patients were previously diagnosed with hereditary transthyretin amyloidosis caused by the TTR Gly83Arg variant.Vitreous opacity was found in all 10 eyes,and 7 eyes developed RAA 2 to 20y after the onset of hereditary transthyretin amyloidosis.The clinical manifestations were recurrent vitreous hemorrhage in 2 eyes(29%),neovascular glaucoma in 2 eyes(29%),and iris neovascularization in 1 eye(14%).Microangioma lesions were found in all affected eyes that underwent fundus fluorescein angiography(FFA)in this group of cases,and the incidence of the retinal non-perfusion area was 67%.Although no cases of retinal neovascularization were found,the prognosis of visual acuity was not ideal.CONCLUSION:This is the first report of RAA in patients with the TTR Gly83Arg variant.Complications such as RAA and glaucoma will seriously affect the visual prognosis of patients.Thereafter,regular ophthalmic follow-up of patients with hereditary transthyretin amyloidosis is essential.And FFA after vitrectomy is very important,which can help ophthalmologists detect RAA earlier and treat it in time.
