BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis th...BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.展开更多
As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap forward.In particular,three-dimensional(3D)bioprinting stands...As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap forward.In particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ regeneration.Curated by the editorial board of Bio-Design and Manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable organs.We further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control measures.Finally,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.展开更多
Fractional-N phase-locked loops(PLLs)are widely deployed in high-speed communication systems to generate local oscillator(LO)or clock signals with precise frequency.To support sophisticated modulations for increasing ...Fractional-N phase-locked loops(PLLs)are widely deployed in high-speed communication systems to generate local oscillator(LO)or clock signals with precise frequency.To support sophisticated modulations for increasing the data rate,the PLL needs to generate low-jitter output[1].展开更多
Industrial decarbonization is critical for achieving net-zero goals.The carbon dioxide electrochemical reduction reaction(CO_(2)RR)is a promising approach for converting CO_(2)into high-value chemicals,offering the po...Industrial decarbonization is critical for achieving net-zero goals.The carbon dioxide electrochemical reduction reaction(CO_(2)RR)is a promising approach for converting CO_(2)into high-value chemicals,offering the potential for decarbonizing industrial processes toward a sustainable,carbon-neutral future.However,developing CO_(2)RR catalysts with high selectivity and activity remains a challenge due to the complexity of finding such catalysts and the inefficiency of traditional computational or experimental approaches.Here,we present a methodology integrating density functional theory(DFT)calculations,deep learning models,and an active learning strategy to rapidly screen high-performance catalysts.The proposed methodology is then demonstrated on graphene-based single-atom catalysts for selective CO_(2)electroreduction to methanol.First,we conduct systematic binding energy calculations for 3045 single-atom catalysts to identify thermodynamically stable catalysts as the design space.We then use a graph neural network,fine-tuned with a specialized adsorption energy database,to predict the relative activity and selectivity of the candidate catalysts.An autonomous active learning framework is used to facilitate the exploration of designs.After six learning cycles and 2180 adsorption calculations across 15 intermediates,we develop a surrogate model that identifies four novel catalysts on the Pareto front of activity and selectivity.Our work demonstrates the effectiveness of leveraging a domain foundation model with an active learning framework and holds potential to significantly accelerate the discovery of high-performance CO_(2)RR catalysts.展开更多
Diseases associated with bacterial infection,especially those caused by gram-negative bacteria,have been posing a serious threat to human health.Photodynamic therapy based on aggregation-induced emission(AIE)photosens...Diseases associated with bacterial infection,especially those caused by gram-negative bacteria,have been posing a serious threat to human health.Photodynamic therapy based on aggregation-induced emission(AIE)photosensitizer have recently emerged and provided a promising approach for bacterial discrimination and efficient photodynamic antimicrobial applications.However,they often suffer from the shorter excitation wavelength and lower molar extinction coefficients in the visible region,severely limiting their further applications.Herein,three novel BF_(2)-curcuminoid-based AIE photosensitizers,TBBC,TBC and TBBC-C8,have been rationally designed and successfully developed,in which OCH_(3)-and OC_(8)H_(17)-substituted tetraphenylethene(TPE)groups serve as both electron donor(D)and AIE active moieties,BF_(2)bdk group functions as electron acceptor(A),and styrene(or ethylene)group asπ-bridge in this D-π-A-π-D system,respectively.As expected,these resulting BF_(2)-curcuminoids presented solvent-dependent photophysical properties with large molar extinction coefficients in solutions and excellent AIE properties.Notably,TBBC showed an effective singlet oxygen generation efficiency thanks to the smaller singlet-triplet energy gap(△E_(ST)),and remarkable photostability under green light exposure at 530nm(8.9 mW/cm^(2)).More importantly,TBBC was demonstrated effectiveness in selective staining and photodynamic killing of Escherichia coli(E.coli)in vitro probably due to its optimal molecular size compared with TBC and TBBC-C8.Therefore,TBBC will have great potential as a novel AIE photosensitizer to apply in the discrimination and selective sterilization between Gram-positive and Gram-negative bacteria.展开更多
This study reviews the hepatotoxic chemicals,mechanisms of toxicity,and detoxification methods of Toosendan Fructus(TF).Limonin-type triterpenoids,as primary hepatotoxic components,mediate toxicity though inflammation...This study reviews the hepatotoxic chemicals,mechanisms of toxicity,and detoxification methods of Toosendan Fructus(TF).Limonin-type triterpenoids,as primary hepatotoxic components,mediate toxicity though inflammation,oxidative stress,mitochondrial dysfunction,ferroptosis,and apoptosis.Hepatotoxicity can be mitigated by controlling dosage,using processed forms of the herbs,and through rational herbal compatibility.The review provides insights for enhancing the safety and clinical application of TF.展开更多
Combining optical tweezers with fluorescence microscopy is a powerful tool for single-cell analysis,playing a pivotal role in disease diagnosis,cell sorting,and the investigation of cellular dynamics.However,fluoresce...Combining optical tweezers with fluorescence microscopy is a powerful tool for single-cell analysis,playing a pivotal role in disease diagnosis,cell sorting,and the investigation of cellular dynamics.However,fluorescence detection faces challenges such as blinking,photobleaching and autofluorescence in biotissues.To address these limitations,we developed a magnetic detection strategy by integrating quantum magnetometry using nitrogen-vacancy centers into optical tweezers,demonstrating precise trapping and manipulation of individual cells in microfluidic environment.We detected a magnetic signal of 89μT from a single cell labeled with magnetic nanoparticles,compared to a noise floor of 3.9μT observed in unlabeled cells.This platform provides a promising approach for high-precision single-cell analysis and holds significant potential for probing cellular activities within biological microenvironments.展开更多
Currently,perovskite solar cells have achieved commendable progresses in power conversion efficiency(PCE)and operational stability.However,some conventional laboratory-scale fabrication methods become challenging when...Currently,perovskite solar cells have achieved commendable progresses in power conversion efficiency(PCE)and operational stability.However,some conventional laboratory-scale fabrication methods become challenging when scaling up material syntheses or device production.Particularly,the prolonged high-temperature annealing process for the crystallization of perovskites requires a substantial amount of energy consumption and impact the modules’throughput.Here,we report a modified near-infrared annealing(NIRA)process,which involves the excess PbI_(2)engineered crystallization,efficiently reduces the preparation time for perovskite active layer to within 20 s compared to dozens of min in conventional hot plate annealing(HPA)process.The study showed that the incorporated PbI_(2)promoted the consistent nucleation of the perovskite film,leading to the subsequent rapid and homogeneous crystallization at the NIRA stage.Thus,highly crystalized perovskite film was realized with even better crystallization performance than conventional HPA-based film.Ultimately,efficient perovskite solar modules of 36 and 100 cm^(2)were readily fabricated with the optimal PCEs of 22.03%and 20.18%,respectively.This study demonstrates,for the first time,the successful achievement of homogeneous and high-quality crystallization in large-area perovskite films through rapid NIRA processing.This approach not only significantly reduces energy consumption during production,but also substantially shortens the manufacturing cycle,paving a new path toward the commercial-scale application of perovskite solar modules.展开更多
As the Chinese Lunar New Year-Spring Festival 2025 begins,we take an opportunity to look back at the journal Bio-Design and Manufacturing(BDM for short).The journal BDM,first published in 2018,is related not only to h...As the Chinese Lunar New Year-Spring Festival 2025 begins,we take an opportunity to look back at the journal Bio-Design and Manufacturing(BDM for short).The journal BDM,first published in 2018,is related not only to human life and health but also to the frontier disciplines of global scientific and technological development.Today we highlight a few points of interest from the past year in order to encourage more readers to pay attention to this exciting field.展开更多
Objective: To study the expression of CA125 in the serum of patients with CHF and the relationship between CA125 level and the occurrence of adverse cardiovascular events. Methods: The clinical data of 132 patients wi...Objective: To study the expression of CA125 in the serum of patients with CHF and the relationship between CA125 level and the occurrence of adverse cardiovascular events. Methods: The clinical data of 132 patients with CHF admitted to Shizuishan Second People’s Hospital from January 2023 to December 2023 were collected and divided into heart function II group, heart function III group, heart function IV group according to cardiac function. 44 healthy subjects who underwent physical examination during the same period were selected as the control group. The clinical data of CA125, NT-proBNP, echocardiography and other clinical data of the four groups were compared, and the incidence of major adverse cardiovascular events was followed up for 12 months. Results: Compared with the control group, the CA125 level in the CHF group was significantly increased (P Conclusion: Serum CA125 level is related to the cardiac function level in CHF patients and increases with the deterioration of cardiac function. The increase of the index is related to the mortality rate and re-hospitalization rate, suggesting that CA125 can be used as an indicator to reflect the severity of heart failure and prognosis monitoring.展开更多
BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to ...BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation.展开更多
Formaldehyde, as one of the simplest reactive carbonyl species（RCS）, is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may res...Formaldehyde, as one of the simplest reactive carbonyl species（RCS）, is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may result in cognitive decline and spatial memory deficits, asthmatic symptoms,Alzheimer＇s disease, and cancer. Due to the harmfulness of high levels of formaldehyde in nature and humans, it is of great significance to further elucidate the roles and functions of formaldehyde by a noninvasive detection approach. Fluorescence imaging has become a powerful and popular tool in monitoring bio-species owing to their high sensitivity and selectivity, excellent spatiotemporal resolution and non-invasion nature. Therefore, fluorescent probes are widely applied to track and detect formaldehyde in vitro and in vivo which have attracted more and more interest recently. This review focuses on various strategies to design the fluorescent probes for detecting formaldehyde based on different recognition groups.展开更多
Photodynamic therapy(PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared(NIR)fluorescent dy...Photodynamic therapy(PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared(NIR)fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3 a,4 a-diaza-s-indacene(BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues.展开更多
基金Supported by The National Natural Science Foundation of China,No.82350127 and No.82241013the Shanghai Natural Science Foundation,No.20ZR1411600+2 种基金the Shanghai Shenkang Hospital Development Center,No.SHDC2020CR4039the Bethune Ethicon Excellent Surgery Foundation,No.CESS2021TC04Xuhui District Medical Research Project of Shanghai,No.SHXH201805.
文摘BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and metastasis.Activin A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent ligands.AIM To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han population.METHODS In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were enrolled.Five SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction method.Hardy-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were conducted.RESULTS Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male smokers.In the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to ESCC.CONCLUSION ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.
基金supported by the National Natural Science Foundation of China(Nos.52325504,52235007,and T2121004).
文摘As surgical procedures transition from conventional resection to advanced tissue-regeneration technologies,human disease therapy has witnessed a great leap forward.In particular,three-dimensional(3D)bioprinting stands as a landmark in this setting,by promising the precise integration of biomaterials,cells,and bioactive molecules,thus opening up a novel avenue for tissue/organ regeneration.Curated by the editorial board of Bio-Design and Manufacturing,this review brings together a cohort of leading young scientists in China to dissect the core functionalities and evolutionary trajectory of 3D bioprinting,by elucidating the intricate challenges encountered in the manufacturing of transplantable organs.We further delve into the translational pathway from scientific research to clinical application,emphasizing the imperativeness of establishing a regulatory framework and rigorously enforcing quality-control measures.Finally,this review outlines the strategic landscape and innovative achievements of China in this field and provides a comprehensive roadmap for researchers worldwide to propel this field collectively to even greater heights.
基金supported by the University of Macao Research Fund under Grant MYRG-GRG2024-00298-IMEby the Macao Science and Technology Development Fund(FDCT)under Grant 0103/2022/AFJ.
文摘Fractional-N phase-locked loops(PLLs)are widely deployed in high-speed communication systems to generate local oscillator(LO)or clock signals with precise frequency.To support sophisticated modulations for increasing the data rate,the PLL needs to generate low-jitter output[1].
基金supported by the National Key Research and Development Program of China(2022ZD0117501)the Scientific Research Innovation Capability Support Project for Young Faculty(ZYGXQNJSKYCXNLZCXM-E7)the Tsinghua University Initiative Scientific Research Program and the Carbon Neutrality and Energy System Transformation(CNEST)Program led by Tsinghua University.
文摘Industrial decarbonization is critical for achieving net-zero goals.The carbon dioxide electrochemical reduction reaction(CO_(2)RR)is a promising approach for converting CO_(2)into high-value chemicals,offering the potential for decarbonizing industrial processes toward a sustainable,carbon-neutral future.However,developing CO_(2)RR catalysts with high selectivity and activity remains a challenge due to the complexity of finding such catalysts and the inefficiency of traditional computational or experimental approaches.Here,we present a methodology integrating density functional theory(DFT)calculations,deep learning models,and an active learning strategy to rapidly screen high-performance catalysts.The proposed methodology is then demonstrated on graphene-based single-atom catalysts for selective CO_(2)electroreduction to methanol.First,we conduct systematic binding energy calculations for 3045 single-atom catalysts to identify thermodynamically stable catalysts as the design space.We then use a graph neural network,fine-tuned with a specialized adsorption energy database,to predict the relative activity and selectivity of the candidate catalysts.An autonomous active learning framework is used to facilitate the exploration of designs.After six learning cycles and 2180 adsorption calculations across 15 intermediates,we develop a surrogate model that identifies four novel catalysts on the Pareto front of activity and selectivity.Our work demonstrates the effectiveness of leveraging a domain foundation model with an active learning framework and holds potential to significantly accelerate the discovery of high-performance CO_(2)RR catalysts.
基金National Natural Science Foundation of China(No.32101150)Key Scientific Research Project of Higher Education of Henan Province(No.22A430007)+2 种基金Natural Science Foundation of Henan Province(No.222300420501)the Science and Technology Project of Henan Province(No.242102230119)Innovation and Entrepreneurship Training Program for College students in China(No.202310482001).
文摘Diseases associated with bacterial infection,especially those caused by gram-negative bacteria,have been posing a serious threat to human health.Photodynamic therapy based on aggregation-induced emission(AIE)photosensitizer have recently emerged and provided a promising approach for bacterial discrimination and efficient photodynamic antimicrobial applications.However,they often suffer from the shorter excitation wavelength and lower molar extinction coefficients in the visible region,severely limiting their further applications.Herein,three novel BF_(2)-curcuminoid-based AIE photosensitizers,TBBC,TBC and TBBC-C8,have been rationally designed and successfully developed,in which OCH_(3)-and OC_(8)H_(17)-substituted tetraphenylethene(TPE)groups serve as both electron donor(D)and AIE active moieties,BF_(2)bdk group functions as electron acceptor(A),and styrene(or ethylene)group asπ-bridge in this D-π-A-π-D system,respectively.As expected,these resulting BF_(2)-curcuminoids presented solvent-dependent photophysical properties with large molar extinction coefficients in solutions and excellent AIE properties.Notably,TBBC showed an effective singlet oxygen generation efficiency thanks to the smaller singlet-triplet energy gap(△E_(ST)),and remarkable photostability under green light exposure at 530nm(8.9 mW/cm^(2)).More importantly,TBBC was demonstrated effectiveness in selective staining and photodynamic killing of Escherichia coli(E.coli)in vitro probably due to its optimal molecular size compared with TBC and TBBC-C8.Therefore,TBBC will have great potential as a novel AIE photosensitizer to apply in the discrimination and selective sterilization between Gram-positive and Gram-negative bacteria.
文摘This study reviews the hepatotoxic chemicals,mechanisms of toxicity,and detoxification methods of Toosendan Fructus(TF).Limonin-type triterpenoids,as primary hepatotoxic components,mediate toxicity though inflammation,oxidative stress,mitochondrial dysfunction,ferroptosis,and apoptosis.Hepatotoxicity can be mitigated by controlling dosage,using processed forms of the herbs,and through rational herbal compatibility.The review provides insights for enhancing the safety and clinical application of TF.
基金Project supported by the the National Key R&D Program of China(Grant Nos.2019YFA0709300 and 2021YFB3202800)the National Natural Science Foundation of China(Grant Nos.T2125011 and 12174377)+4 种基金the Chinese Academy of Sciences(Grant No.YSBR-068)Innovation Program for Quantum Science and Technology(GrantNos.2021ZD0302200 and 2021ZD0303204)New Cornerstone Science Foundation through the XPLORER PRIZEScience and Technology Department of Zhejiang Province(Grant No.2025C01041)the Fundamental Research Funds for the Central Universities(Grant No.226-2024-00142)。
文摘Combining optical tweezers with fluorescence microscopy is a powerful tool for single-cell analysis,playing a pivotal role in disease diagnosis,cell sorting,and the investigation of cellular dynamics.However,fluorescence detection faces challenges such as blinking,photobleaching and autofluorescence in biotissues.To address these limitations,we developed a magnetic detection strategy by integrating quantum magnetometry using nitrogen-vacancy centers into optical tweezers,demonstrating precise trapping and manipulation of individual cells in microfluidic environment.We detected a magnetic signal of 89μT from a single cell labeled with magnetic nanoparticles,compared to a noise floor of 3.9μT observed in unlabeled cells.This platform provides a promising approach for high-precision single-cell analysis and holds significant potential for probing cellular activities within biological microenvironments.
基金supported by China Huaneng Group Key R&D Program(HNKJ22-H104)the Science and Technology Programs of Fujian Province(2022H0005)+1 种基金the Fundamental Research Funds for the Central Universities(20720240067)Technology Projects of Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(RD2020020101 and RD2022040601).
文摘Currently,perovskite solar cells have achieved commendable progresses in power conversion efficiency(PCE)and operational stability.However,some conventional laboratory-scale fabrication methods become challenging when scaling up material syntheses or device production.Particularly,the prolonged high-temperature annealing process for the crystallization of perovskites requires a substantial amount of energy consumption and impact the modules’throughput.Here,we report a modified near-infrared annealing(NIRA)process,which involves the excess PbI_(2)engineered crystallization,efficiently reduces the preparation time for perovskite active layer to within 20 s compared to dozens of min in conventional hot plate annealing(HPA)process.The study showed that the incorporated PbI_(2)promoted the consistent nucleation of the perovskite film,leading to the subsequent rapid and homogeneous crystallization at the NIRA stage.Thus,highly crystalized perovskite film was realized with even better crystallization performance than conventional HPA-based film.Ultimately,efficient perovskite solar modules of 36 and 100 cm^(2)were readily fabricated with the optimal PCEs of 22.03%and 20.18%,respectively.This study demonstrates,for the first time,the successful achievement of homogeneous and high-quality crystallization in large-area perovskite films through rapid NIRA processing.This approach not only significantly reduces energy consumption during production,but also substantially shortens the manufacturing cycle,paving a new path toward the commercial-scale application of perovskite solar modules.
文摘As the Chinese Lunar New Year-Spring Festival 2025 begins,we take an opportunity to look back at the journal Bio-Design and Manufacturing(BDM for short).The journal BDM,first published in 2018,is related not only to human life and health but also to the frontier disciplines of global scientific and technological development.Today we highlight a few points of interest from the past year in order to encourage more readers to pay attention to this exciting field.
文摘Objective: To study the expression of CA125 in the serum of patients with CHF and the relationship between CA125 level and the occurrence of adverse cardiovascular events. Methods: The clinical data of 132 patients with CHF admitted to Shizuishan Second People’s Hospital from January 2023 to December 2023 were collected and divided into heart function II group, heart function III group, heart function IV group according to cardiac function. 44 healthy subjects who underwent physical examination during the same period were selected as the control group. The clinical data of CA125, NT-proBNP, echocardiography and other clinical data of the four groups were compared, and the incidence of major adverse cardiovascular events was followed up for 12 months. Results: Compared with the control group, the CA125 level in the CHF group was significantly increased (P Conclusion: Serum CA125 level is related to the cardiac function level in CHF patients and increases with the deterioration of cardiac function. The increase of the index is related to the mortality rate and re-hospitalization rate, suggesting that CA125 can be used as an indicator to reflect the severity of heart failure and prognosis monitoring.
基金the National Natural Science Foundation of China(81471840,81171837)the Shanghai Traditional Medicine Development Project(ZY3-CCCX3-3018,ZHYY-ZXYJH-201615)the Key Project of Shanghai Municipal Health Bureau(2016ZB0202).
文摘BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation.
基金support from National Natural Science Foundation of China (Nos. 21676113, 21402057, 21472059, 81671803) Youth Chen-Guang Project of Wuhan(2016070204010098)+2 种基金 the 111 Project B17019the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Shenzhensupported by self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (No. CCNU16A02004)
文摘Formaldehyde, as one of the simplest reactive carbonyl species（RCS）, is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may result in cognitive decline and spatial memory deficits, asthmatic symptoms,Alzheimer＇s disease, and cancer. Due to the harmfulness of high levels of formaldehyde in nature and humans, it is of great significance to further elucidate the roles and functions of formaldehyde by a noninvasive detection approach. Fluorescence imaging has become a powerful and popular tool in monitoring bio-species owing to their high sensitivity and selectivity, excellent spatiotemporal resolution and non-invasion nature. Therefore, fluorescent probes are widely applied to track and detect formaldehyde in vitro and in vivo which have attracted more and more interest recently. This review focuses on various strategies to design the fluorescent probes for detecting formaldehyde based on different recognition groups.
基金the Natural Science Foundation Committee of China (NSFC,No.81671803)the National Key Research and Development Program (No.2017YFC0107700)+6 种基金the Outstanding Youth Foundation of Jiangsu Province (Nos.GX20171114003, BK20170030)Fok Ying Tung Education Foundation (No.161033)"Double First-Class" University Project (Nos.CPU2018GY06 and CPU2018GY24)the Priority Academic Program Development of Jiangsu Higher Education Institutions for their financial supportthe National Natural Science Foundation of China (Nos.21676113,21402057,21772054,21472059)Distinguished Young Scholar of Hubei Province (No.2018CFA079) for the financial supportsupported by the 111 Project (No.B17019)
文摘Photodynamic therapy(PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared(NIR)fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3 a,4 a-diaza-s-indacene(BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues.
