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MXene-based thermoelectric fabric integrated with temperature and strain sensing for health monitoring 被引量:1
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作者 jun peng Fangqing Ge +4 位作者 Weiyi Han Tao Wu Jinglei Tang Yuning Li Chaoxia Wang 《Journal of Materials Science & Technology》 2025年第9期272-280,共9页
Wearable thermoelectric devices hold significant promise in the realm of self-powered wearable electron-ics,offering applications in energy harvesting,movement tracking,and health monitoring.Nevertheless,developing th... Wearable thermoelectric devices hold significant promise in the realm of self-powered wearable electron-ics,offering applications in energy harvesting,movement tracking,and health monitoring.Nevertheless,developing thermoelectric devices with exceptional flexibility,enduring thermoelectric stability,multi-functional sensing,and comfortable wear remains a challenge.In this work,a stretchable MXene-based thermoelectric fabric is designed to accurately discern temperature and strain stimuli.This is achieved by constructing an adhesive polydopamine(PDA)layer on the nylon fabric surface,which facilitates the subsequent MXene attachment through hydrogen bonding.This fusion results in MXene-based thermo-electric fabric that excels in both temperature sensing and strain sensing.The resultant MXene-based thermoelectric fabric exhibits outstanding temperature detection capability and cyclic stability,while also delivering excellent sensitivity,rapid responsiveness(60 ms),and remarkable durability in strain sens-ing(3200 cycles).Moreover,when affixed to a mask,this MXene-based thermoelectric fabric utilizes the temperature difference between the body and the environment to harness body heat,converting it into electrical energy and accurately discerning the body’s respiratory rate.In addition,the MXene-based ther-moelectric fabric can monitor the state of the body’s joint through its own deformation.Furthermore,it possesses the capability to convert solar energy into heat.These findings indicate that MXene-based ther-moelectric fabric holds great promise for applications in power generation,motion tracking,and health monitoring. 展开更多
关键词 Mxene thermoelectric fabric Temperature sensing Strain sensing Energy harvesting
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干眼症患者泪液炎症因子与症状体征相关性研究 被引量:68
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作者 蒋鹏飞 黎冬冬 +2 位作者 彭俊 曾志成 彭清华 《国际眼科杂志》 CAS 北大核心 2020年第4期699-702,共4页
目的:观察干眼症患者泪液炎症因子白细胞介素-1β(IL-1β)和白细胞介素-18(IL-18)与症状体征的相关性。方法:选取2018-09/12在湖南中医药大学第一附属医院眼科干眼门诊就诊的患者131例262眼,根据2013年干眼临床诊疗专家共识中干眼的分... 目的:观察干眼症患者泪液炎症因子白细胞介素-1β(IL-1β)和白细胞介素-18(IL-18)与症状体征的相关性。方法:选取2018-09/12在湖南中医药大学第一附属医院眼科干眼门诊就诊的患者131例262眼,根据2013年干眼临床诊疗专家共识中干眼的分级标准将患者分为无干眼组、轻度干眼组、中度干眼组、重度干眼组,检测所有患者干眼症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠt)、角膜荧光素钠染色评分(FL)的情况,ELISA法检测患者泪液中IL-1β、IL-18的表达,分析干眼炎症因子与症状体征的相关性。结果:各组患者干眼症状评分、BUT、SⅠt、FL及泪液中IL-1β、IL-18表达差异均有统计学意义(P<0.001),炎症因子IL-1β、IL-18与干眼症状评分、FL呈正相关(P<0.05),与BUT、SⅠt呈负相关(P<0.05)。结论:干眼患者泪液中炎症因子与干眼症状体征具有相关性。 展开更多
关键词 干眼 泪液 干眼症状评分 泪膜破裂时间 白细胞介素1-Β 白细胞介素-18
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中医药治疗干眼疗效的Meta分析 被引量:12
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作者 蒋鹏飞 彭俊 +5 位作者 周亚莎 彭晓芳 李翔 李怡琛 彭清华 陈向东 《国际眼科杂志》 CAS 北大核心 2018年第6期1023-1027,共5页
目的:运用Meta分析方法系统评价近5a来中医药治疗干眼的疗效。方法:按Cochrane系统评价方法,计算机检索Medline(2013-01/2017-10)、EMbase(2013/2017年)、Cochrane图书馆(2017年)、万方数据库(2013/2017年)、维普数据库(2013/2017年)、... 目的:运用Meta分析方法系统评价近5a来中医药治疗干眼的疗效。方法:按Cochrane系统评价方法,计算机检索Medline(2013-01/2017-10)、EMbase(2013/2017年)、Cochrane图书馆(2017年)、万方数据库(2013/2017年)、维普数据库(2013/2017年)、中国知网数据库(2013/2017年),纳入近5a中医药治疗干眼的随机对照研究,使用RevMan5.0统计软件进行资料提取与Meta分析。结果:共纳入10个随机对照研究,其中1篇为英文文献,9篇为中文文献,共包括1 229眼。其中9个研究在疗程结束后进行了BUT的测定,结果显示差异有统计学意义(P<0.00001);9个研究在疗程结束后进行了泪液流量的测定,结果显示差异有统计学意义(P<0.0001);2个研究在疗程结束后进行了FL的测定,结果显示差异无统计学意义(P=0.25);3个研究在疗程结束后进行了干眼症状的测定,结果显示差异有统计学意义(P=0.0003);总体疗效比较,两组差异有统计学意义(P<0.00001)。结论:中医药治疗能显著延长患者泪膜破裂时间(breakup time,BUT)和增加泪液流量,在治疗干眼总体疗效上更有优势。 展开更多
关键词 干眼 中医药 META分析 随机对照试验
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青光安对抗青光眼术后滤过道瘢痕化中胶原纤维、α-SMA及FN的影响 被引量:9
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作者 黄学思 彭俊 +3 位作者 蒋鹏飞 李苑碧 喻娟 彭清华 《国际眼科杂志》 CAS 北大核心 2019年第6期906-910,共5页
目的:观察青光安4种有效组份对抗兔眼青光眼术后滤过道胶原纤维、α-平滑肌肌动蛋白(α-SMA)和纤维连接蛋白(FN)的影响。方法:将青光安4种有效组份与青光安中药混悬液应用于滤过手术后D组(有效组份1组)、E组(有效组份2组)、F组(有效组份... 目的:观察青光安4种有效组份对抗兔眼青光眼术后滤过道胶原纤维、α-平滑肌肌动蛋白(α-SMA)和纤维连接蛋白(FN)的影响。方法:将青光安4种有效组份与青光安中药混悬液应用于滤过手术后D组(有效组份1组)、E组(有效组份2组)、F组(有效组份3组)、G组(有效组份4组)、H组(青光安混悬液组),通过与A组(空白对照组)、B组(模型组)和C组(丝裂霉素C组)进行比较,观察青光安4种有效组份与青光安中药混悬液对青光眼术后滤过道瘢痕组织中胶原纤维、α-SMA及FN的影响。结果:C组、E组、F组、H组胶原纤维面积比值、α-SMA的表达、FN的表达与B组比较均有差异(P<0.05)。结论:青光安有效组份2、青光安有效组份3、丝裂霉素C以及青光安混悬液通过抑制胶原纤维、α-SMA及FN的表达,表现出明显的抗青光眼术后滤过道瘢痕化的作用。 展开更多
关键词 青光眼 滤过道瘢痕化 胶原纤维 Α-平滑肌肌动蛋白 纤维连接蛋白
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视网膜色素变性的实验研究进展 被引量:11
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作者 蒋鹏飞 彭俊 +4 位作者 欧晨 姚震 田野 王英 彭清华 《国际眼科杂志》 CAS 北大核心 2020年第6期970-973,共4页
视网膜色素变性是一种遗传性眼病,遗传方式包括常染色体显性遗传、常染色体隐性遗传及性连锁隐性遗传等,目前已知的突变位点超过3000个,造成本病临床治疗困难。眼科学者致力于探索视网膜色素变性的治疗方式,进行了大量实验研究,主要有... 视网膜色素变性是一种遗传性眼病,遗传方式包括常染色体显性遗传、常染色体隐性遗传及性连锁隐性遗传等,目前已知的突变位点超过3000个,造成本病临床治疗困难。眼科学者致力于探索视网膜色素变性的治疗方式,进行了大量实验研究,主要有药物治疗、细胞移植、基因治疗等治疗方式。药物治疗包括中药、抗氧化剂、抗凋亡剂、神经营养因子等,与其它治疗方式相比,无侵入性,且方便价廉,但其作用机制尚需更深入的研究。细胞移植被认为是治疗视网膜色素变性的有效方法,但有可能引起视网膜前膜及黄斑皱褶。基因治疗虽然存在一定的局限性,但随着基因编辑技术和新型基因递送载体的发展,未来会成为视网膜色素变性最有希望的治疗方式之一。本文对近年来视网膜色素变性的实验研究进行了综述与展望。 展开更多
关键词 视网膜色素变性 实验研究 视网膜移植 基因治疗
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密蒙花滴眼液对去势雄兔泪腺细胞炎症因子的影响(英文) 被引量:6
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作者 彭俊 欧阳云 +3 位作者 李文娟 吴权龙 谭涵宇 彭清华 《国际眼科杂志》 CAS 北大核心 2018年第8期1359-1364,共6页
目的:观察不同浓度密蒙花滴眼液对去势雄兔泪腺细胞炎症因子TNF-α、IL-1β的影响,探讨不同浓度密蒙花滴眼液对去势雄兔干眼症模型的疗效。方法:将密蒙花原药材制备成低、中、高3种浓度滴眼液。将42只健康成年新西兰长耳白兔(雄性),随... 目的:观察不同浓度密蒙花滴眼液对去势雄兔泪腺细胞炎症因子TNF-α、IL-1β的影响,探讨不同浓度密蒙花滴眼液对去势雄兔干眼症模型的疗效。方法:将密蒙花原药材制备成低、中、高3种浓度滴眼液。将42只健康成年新西兰长耳白兔(雄性),随机分为A:空白组;B:模型组;C:低浓度密蒙花滴眼液组;D:中浓度密蒙花滴眼液组;E:高浓度密蒙花滴眼液组;F:安慰剂滴眼液组;G:睾酮组等7组,每组6只。除A组外其余6组实验用兔行双侧睾丸及附睾切除术。从术后第3天开始C、D、E、F组分别予相应滴眼液滴双眼。各组实验用兔,分别于术前和术后第4wk各进行一次Schirmer I试验(SIT)和泪膜破裂时间(BUT)测定。采用免疫组化法对泪腺细胞炎症因子TNF-α和IL-1β的表达进行检测。结果:1)SIT与BUT值比较:术后C组与D、E、G组比较,有统计学意义(P<0.01);D、E、G组间相比较,无统计学意义(P>0.05);2)术后各组炎症因子TNF-α、IL-1β比较:C组与D、E、G组比较,有统计学意义(P<0.05);D、E、G组间相比较,无统计学意义(P>0.05)。结论:1)密蒙花滴眼液具有与雄激素相似的抑制细胞炎症因子表达的作用,但其作用弱于雄激素;2)中、高浓度密蒙花滴眼液对TNF-α和IL-1β的抑制作用要强于低浓度密蒙花滴眼液,但中、高浓度密蒙花滴眼液的抑制作用差别不明显。 展开更多
关键词 密蒙花滴眼液 干眼 去势雄兔 泪腺细胞 炎症因子
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蛴螬提取物对视网膜中央静脉阻塞模型兔小胶质细胞CD68表达的影响及机制研究 被引量:6
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作者 蒋鹏飞 董子奕 +3 位作者 彭俊 马俊旭 梁凯霞 彭清华 《中国现代医学杂志》 CAS 2019年第12期7-11,共5页
目的探讨蛴螬提取物对实验性兔视网膜静脉阻塞(RVO)的治疗作用及相关机制。方法选取40 只兔并随机分为空白组、模型组、复方血栓通组及蛴螬组。除空白组外,其余3 组采用光化学动力法复制RVO 动物模型,于给药后7、14 及28 d 行荧光素眼... 目的探讨蛴螬提取物对实验性兔视网膜静脉阻塞(RVO)的治疗作用及相关机制。方法选取40 只兔并随机分为空白组、模型组、复方血栓通组及蛴螬组。除空白组外,其余3 组采用光化学动力法复制RVO 动物模型,于给药后7、14 及28 d 行荧光素眼底血管造影术(FFA),于给药后1、3、7、14及28 d 行免疫组织化学检测白细胞分化抗原68(CD68)的表达。结果 FFA 检查显示,模型组给药7 d后,中央静脉荧光渗漏、出血,出现无灌注区;复方血栓通组与蛴螬组出现无灌注区,但渗漏、出血较模型组少;给药28 d 后,模型组渗漏、出血的静脉周围无灌注区面积增大,并出现新生血管;复方血栓通组渗漏、出血明显减少;蛴螬组渗漏、出血基本吸收。复方血栓通组、蛴螬组与模型组给药后7、14 及28 d 的无灌注区与视盘面积比值比较,差异有统计学意义(P <0.05)。免疫组织化学结果显示,各模型组CD68 表达增加,复方血栓通和蛴螬提取物都使CD68 的阳性表达随时间的延长而减弱,但蛴螬组CD68 表达减弱得更快。复方血栓通组、蛴螬组与模型组3、7、14 及28 d CD68 表达比较,差异有统计学意义(P <0.05)。结论复方血栓通与蛴螬提取物均不同程度抑制视网膜小胶质细胞的活化,而蛴螬提取物的抑制作用更明显,说明其比单纯的活血化瘀药能更快地抑制小胶质细胞活化。 展开更多
关键词 视网膜静脉阻塞 视网膜新生血管 蛴螬提取物 小胶质细胞 白细胞分化抗原68
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活血散结中药复方含药血浆对PDGF干预下兔RPE细胞增殖的影响 被引量:4
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作者 吴权龙 刘晓清 +4 位作者 彭俊 张又玮 潘坤 李建超 彭清华 《国际眼科杂志》 CAS 北大核心 2018年第9期1572-1577,共6页
目的:观察活血散结中药复方含药血浆对血小板源性生长因子(platelet derived growth factor,PDGF)干预下兔RPE细胞增殖的影响。方法:酶消化法获取RPE原代细胞,进行RPE细胞的原代培养和传代;制备活血散结中药复方含药血浆;选取第4代兔RP... 目的:观察活血散结中药复方含药血浆对血小板源性生长因子(platelet derived growth factor,PDGF)干预下兔RPE细胞增殖的影响。方法:酶消化法获取RPE原代细胞,进行RPE细胞的原代培养和传代;制备活血散结中药复方含药血浆;选取第4代兔RPE细胞为实验细胞,PDGF低、中、高剂量(5、10、20μg/L)干预48h后,CCK-8法检测并选取适宜细胞实验干预浓度;建立PDGF干预下RPE细胞增殖模型。实验分组为空白对照组(DMEM)、正常血浆组、PDGF(10μg/L)组、PDGF(10μg/L)+AG1296(10μmol/L)组、PDGF(10μg/L)+10%含药血浆组,PDGF(10μg/L)+20%含药血浆组,分别加入相应处理因素干预24h后,Transwell法测定兔RPE细胞迁移力;而干预48h后,CCK-8法测定兔RPE细胞的细胞活力OD值。结果:10%和20%浓度的活血散结中药复方含药血浆能有效抑制PDGF干预下RPE细胞的细胞活力、细胞迁移。结论:活血散结中药复方含药血浆能够抑制PDGF干预下兔RPE细胞增殖,这可能是其有效治疗增殖性玻璃体视网膜病变的机制之一。 展开更多
关键词 活血散结中药复方 含药血浆 视网膜色素上皮细胞 血小板源性生长因子 细胞活力 细胞迁移力
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双丹明目胶囊对糖尿病大鼠模型视网膜VEGF家族表达的影响 被引量:3
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作者 彭俊 潘坤 +2 位作者 刘峥嵘 秦裕辉 彭清华 《国际眼科杂志》 CAS 北大核心 2018年第11期1958-1962,共5页
目的:观察双丹明目胶囊对糖尿病大鼠模型视网膜VEGF家族因子VEGF-a、VEGF-b、VEGF-c蛋白表达的影响。方法:将40只雄性SD大鼠,采用随机数字法分为A空白组、B模型组、C双丹明目组、D阳性对照组4组,每组10只20眼。将B、C、D三组实验大鼠采... 目的:观察双丹明目胶囊对糖尿病大鼠模型视网膜VEGF家族因子VEGF-a、VEGF-b、VEGF-c蛋白表达的影响。方法:将40只雄性SD大鼠,采用随机数字法分为A空白组、B模型组、C双丹明目组、D阳性对照组4组,每组10只20眼。将B、C、D三组实验大鼠采用STZ 50mg/kg的剂量一次性大鼠尾静脉注射法建立糖尿病视网膜病变大鼠模型,造模后1wk开始连续灌胃用药,灌胃后4wk,处死动物,免疫组化法检测视网膜组织中VEGF-a、VEGF-b、VEGF-c的表达。结果:成模后用药第4wk,模型组、双丹明目组、阳性对照组视网膜中VEGF-a、VEGF-b、VEGF-c蛋白表达平均灰度值均低于正常组,平均光密度均高于正常组,其中模型组与正常组比较,差异均具有统计学意义(P<0. 01);双丹明目组、阳性对照组VEGF-a、VEGF-b、VEGF-c表达的平均灰度值均高于模型组(P<0. 05),平均光密度值均低于模型组(P<0. 01)。结论:双丹明目胶囊能明显降低VEGF家族中VEGF-a、VEGF-b、VEGF-c在糖尿病模型大鼠视网膜中的表达,对其视网膜有一定的保护作用。 展开更多
关键词 双丹明目胶囊 糖尿病大鼠模型 VEGF-A VEGF-B VEGF-C
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Effect of Mo on acicular ferrite transformation and interphase precipitation of Nb–V–N microalloyed steel during a continuous cooling process
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作者 Jing Zhang Wen-bin Xin +3 位作者 Deng-yun Hou jun peng Zhi-bo Zhao Yang Tong 《Journal of Iron and Steel Research International》 2025年第6期1662-1677,共16页
The substantial influences of Mo contents varying from 0 to 0.26 and 0.50 wt.%on the microstructural evolution and MX(M=Nb,V and Mo;X=C and N)precipitation characteristics of Nb–V–N microalloyed steels processed by ... The substantial influences of Mo contents varying from 0 to 0.26 and 0.50 wt.%on the microstructural evolution and MX(M=Nb,V and Mo;X=C and N)precipitation characteristics of Nb–V–N microalloyed steels processed by hot deformation and continuous cooling were studied using a Gleeble 3800 thermomechanical simulator.Metallographic analysis showed that the ferrite microstructure transformed from polygonal ferrite(PF)in 0Mo steel to both acicular ferrite(AF)and PF in 0.26Mo and 0.50Mo steels,and AF content first increased and then decreased.The thermodynamic calculations and the experimental results proved that the quantity of solid solution of Mo in austenite obviously increased,which reduced the austenite(γ)to ferrite(α)transformation temperature,consequently promoting AF formation in 0.26Mo steel and bainite transformation in 0.50Mo steel.Moreover,the submicron Nb-rich MX particles that precipitated at the temperature of the austenite region further induced AF heterogeneous nucleation with an orientation relationship of(100)_(MX)//(100)_(Ferrite)and[■][001]Ferrite.The interphase precipitation of the nanosized V-rich MX particles with Mo partitioning that precipitated duringγ→αtransformation exhibited a Baker–Nutting orientation relationship of(100)_(MX)//(100)Ferrite and[001]_(MX)//[■]_(Ferrite)with respect to the ferrite matrix.With increasing Mo content from 0 to 0.26 and 0.50 wt.%,the sheet spacing decreased from 46.9–49.0 to 34.6–38.6 and 25.7–28.0 nm,respectively,which evidently hindered dislocation movement and greatly enhanced precipitation strengthening.Furthermore,facilitating AF formation and interphase precipitation was beneficial to improving steel properties,and the optimal Mo content was 0.26 wt.%. 展开更多
关键词 Nb-V-Mo-N microalloyed steel Mo content Acicular ferrite Interphase precipitation Secondary ion mass spectrometry
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Microstructure,precipitates and resultant performance in CGHAZ of a high-Nb structural steel
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作者 Jing Zhang Wen-bin Xin +2 位作者 Deng-yun Hou jun peng Li-yong Wang 《Journal of Iron and Steel Research International》 2025年第8期2547-2563,共17页
The effect of high welding heat inputs in the range of 50–200 kJ/cm on the microstructural evolution,MX(M=Ti,Nb and V;X=N and C)precipitation and mechanical properties was investigated in the coarse-grained heat-affe... The effect of high welding heat inputs in the range of 50–200 kJ/cm on the microstructural evolution,MX(M=Ti,Nb and V;X=N and C)precipitation and mechanical properties was investigated in the coarse-grained heat-affected zone(CGHAZ)of a high-Nb(0.10 wt.%)structural steel.The results showed that the primary microconstituents varied from lath bainite(LB)to intragranular acicular ferrite(IAF)+intragranular polygonal ferrite(IPF),and the most content of IAF was acquired at 100 kJ/cm.Moreover,the submicron Ti-and Nb-rich MX precipitates not only pinned prior austenite grain boundaries but also facilitated IAF and IPF nucleation with the Kurdjumov–Sachs orientation relationship of[011]_(MX)//[111]_(Ferrite);the nanoscale V-rich MX precipitates hindered dislocation movement and followed the Baker–Nutting orientation relationship of[001]_(MX)//[001]_(Ferrite)with ferrite matrix,synergistically strengthening and toughening the CGHAZ.In addition,the−20℃impact absorbed energy firstly elevated from 93±5.2 J at 50 kJ/cm to 131±5.4 J at 100 kJ/cm and finally decreased to 59±3.0 J at 200 kJ/cm,being related to the IAF content,while the microhardness decreased from 312±26.1 to 269±12.9 HV0.1,because of the coarsened microstructure and the decreased content of LB and martensite.Compared to the CGHAZ properties with 0.05 wt.%Nb,a higher Nb content produced better low-temperature toughness,as more solid dissolved Nb atoms and precipitated Nb-rich MX particles in austenite limited prior austenite grain growth and promoted IAF formation.Furthermore,the welding process at 100 kJ/cm was most applicable for the high-Nb steel. 展开更多
关键词 High-Nb structural steel Welding heat input MICROSTRUCTURE MX precipitate CGHAZ performance
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Process optimization and application of multi-source industrial solid waste synergistic utilization to prepare functional ceramsite
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作者 Yi-fan Chai Dong-dong Li +2 位作者 Wen-xian Hu jun peng Sheng-li An 《Journal of Iron and Steel Research International》 2025年第7期1978-1989,共12页
The development and utilization of mineral resources are accompanied by the production of a large number of solid wastes such as tailings and smelting slag.Bayan Obo tailings and blast furnace slag were used as the ma... The development and utilization of mineral resources are accompanied by the production of a large number of solid wastes such as tailings and smelting slag.Bayan Obo tailings and blast furnace slag were used as the main raw materials.Coal gangue was used as pore-forming agent to prepare ceramsite which can efficiently treat ammonia nitrogen wastewater.The optimum preparation process parameters were obtained.The mineral evolution process of ceramsite prepared by smelting solid waste during roasting was clarified.The effects of sintering process parameters on the properties of ceramsite and its removal of ammonia nitrogen wastewater were revealed.The results show that,the optimum proportion of raw materials for preparing ceramsite was:25%Bayan Obo tailings,65%blast furnace slag and 10%coal gangue.The reasonable process for preparing ceramsite was:temperature of 400℃,preheating for 20 min,heating rate of 10℃/min,calcination at 1090℃for 15 min,and cooling with the furnace.With the increase in calcination temperature,the main crystal phase changes from dolomite,kaolinite,fluorite and calcite to melilite and Fe2O3.Finally,the ceramsite with porosity of 48.13%,specific surface area of 2.44 m^(2)/g and soluble rate of hydrochloric acid of 1.88%was prepared.The removal rate of ammonia nitrogen wastewater by the ceramsite was 54.13%. 展开更多
关键词 Bayan Obo tailing Blast furnace slag Coal gangue CERAMSITE Utilization of solid waste
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帽状腱膜下引流治疗慢性硬脑膜下血肿的疗效分析 被引量:3
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作者 高灵 陈伟明 +1 位作者 彭俊 夏鹰 《中国现代医学杂志》 CAS 北大核心 2021年第9期41-44,共4页
目的探讨帽状腱膜下引流治疗慢性硬脑膜下血肿(CSDH)的有效性及安全性。方法选取2015年1月—2019年12月中南大学湘雅医学院附属海口医院收治的82例帽状腱膜(实验组)和98例硬脑膜下(对照组)引流的CSDH患者,分析其术后并发症发生率、随访... 目的探讨帽状腱膜下引流治疗慢性硬脑膜下血肿(CSDH)的有效性及安全性。方法选取2015年1月—2019年12月中南大学湘雅医学院附属海口医院收治的82例帽状腱膜(实验组)和98例硬脑膜下(对照组)引流的CSDH患者,分析其术后并发症发生率、随访期内血肿复发、预后及硬脑膜下血肿/积液情况。结果实验组与对照组患者术前、拔管前及6个月复查血肿/积液厚度比较:①两组血肿/积液厚度有差异(F=1.684,P=0.000);②实验组与对照组血肿/积液厚度无差异(F=0.277,P=0.758);③两组的血肿/积液厚度变化趋势无差异(F=2.164,P=0.142)。实验组手术时间短于对照组(P<0.05)。两组患者二次手术、术后感染、癫痫发作、死亡率、随访期内复发率及6个月来院复查MRS评分情况比较,差异无统计学意义(P>0.05)。实验组皮层损伤率低于对照组(P>0.05)。结论帽状腱膜与硬脑膜下引流临床疗效相当,且手术时间更短,更简便、安全,具有临床应用潜力。 展开更多
关键词 慢性硬脑膜下血肿 帽状腱膜下引流 硬脑膜下引流 有效性 安全性
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Effect of B_(2)O_(3) and Na_(2)B_(4)O_(7) on phosphorus enrichment in Ca_(2)SiO_(4)–Ca_(3)(PO_(4))_(2) solid solutions
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作者 Xin Ping Fang Zhang +2 位作者 jun peng Hong-tao Chang Shuang Liu 《Journal of Iron and Steel Research International》 2025年第6期1502-1513,共12页
To separate the phosphorus-containing phase from steel slag,the effects of B_(2)O_(3)and Na_(2)B_(4)O_(7)on the enrichment of phosphorus-containing phases in Ca_(2)SiO_(4)–Ca_(3)(PO_(4))_(2)(C_(2)S–C_(3)P)solid solu... To separate the phosphorus-containing phase from steel slag,the effects of B_(2)O_(3)and Na_(2)B_(4)O_(7)on the enrichment of phosphorus-containing phases in Ca_(2)SiO_(4)–Ca_(3)(PO_(4))_(2)(C_(2)S–C_(3)P)solid solution were comparatively analyzed through theoretical calculations and experimental investigations.The results indicate that the optimum reaction temperature between B_(2)O_(3)and C_(2)S–C_(3)P is 800℃.The phase compositions of C_(2)S–C_(3)P equilibrium system with 5 wt.%B_(2)O_(3)at 800℃ included Ca_(3)(PO_(4))_(2),CaSiO_(3)and Ca11B_(2)Si_(4)O_(22),among which the content of Ca_(3)(PO_(4))_(2)was the highest.For C_(2)S–C_(3)P with 5 wt.%Na_(2)B_(4)O_(7)equilibrium system,Ca_(3)(PO_(4))_(2),CaSiO_(3),Ca11B_(2)Si_(4)O_(22)and Na_(2)Ca_(2)P_(2)O_(8)were independent at 390–690℃.Ca_(3)(PO_(4))_(2)and Ca_(2)SiO_(4)precipitated in the solid solution when the addition of B_(2)O_(3)was more than 6 wt.%,and the content of Ca_(3)(PO_(4))_(2)raised with the increase in the addition of B_(2)O_(3).The main phases in the C_(2)S–C_(3)P solid solution with Na_(2)B_(4)O_(7)were(Ca_(2)SiO_(4))0.05[Ca_(3)(PO_(4))_(2)],Ca_(2)SiO_(4)and Na_(3)Ca_(6)(PO_(4))_(5)at 650℃.And when the addition of Na_(2)B_(4)O_(7)exceeded 6 wt.%,the content of Na_(3)Ca_(6)(PO_(4))_(5)increased significantly.There was no precipitation of Ca_(3)(PO_(4))_(2)or boron-containing phase in the samples with Na_(2)B_(4)O_(7),but a small proportion of Ca_(3)(PO_(4))_(2)transformed into(Ca_(2)SiO_(4))0.05[Ca_(3)(PO_(4))_(2)],and Ca^(2+)was partially replaced by Na^(+)to generate Na_(3)Ca_(6)(PO_(4))_(5).As a result,the temperature for Na_(2)B_(4)O_(7)to enrich the phosphorus-containing phase in C_(2)S–C_(3)P solid solution was lower than that for B_(2)O_(3).However,the grade of the phosphorus-containing phase for Na_(2)B_(4)O_(7)was lower than that for B_(2)O_(3). 展开更多
关键词 B_(2)O_(3) Na_(2)B_(4)O_(7) Ca_(2)SiO_(4)-Ca_(3)(PO_(4))_(2)solid solution Phosphorus enrichment
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Evaluation of MgO on hematite swelling dynamics during CO-driven stepwise reduction
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作者 Fang Zhang jun peng +2 位作者 Shuang Liu Yong-bin Wang Fan Yang 《Journal of Iron and Steel Research International》 2025年第3期564-577,共14页
The significant effect of MgO in inhibiting the reduction swelling of iron ore pellets has been widely recognized.The swelling behaviors of pellets during the stepwise reduction by CO were assessed.The linear expansio... The significant effect of MgO in inhibiting the reduction swelling of iron ore pellets has been widely recognized.The swelling behaviors of pellets during the stepwise reduction by CO were assessed.The linear expansion of strip samples was measured using a linear dilatometer during the staged reduction process at a temperature of 900℃.The existence states of MgO in hematite,magnetite,and wüstite were investigated through thermodynamic calculations.The magnetite strip samples were subjected to oxidizing roasting at 1250℃ for 30 min to produce hematite strip samples.The strip samples with 0.49,1.49,2.49,and 3.49 wt.%MgO were analyzed for length change.It was observed that the sample with 2.49 wt.%MgO exhibited the least significant length change.The lengths of the samples with the initial length being 20 mm before reduction changed during the reduction stages of Fe_(2)O_(3)→Fe_(3)O_(4),Fe_(3)O_(4)→FeO,and FeO→Fe were 615,−25,and−378μm,respectively.The volume expansion of hematite to magnetite was primarily attributed to the crystal transformation.During the reduction stage from wüstite to metallic iron,a substantial contraction occurred,while the slag phase was able to retain its original basic shape.The enclosed areas,as indicated by the expansion change curves of the samples with 0.49,1.49,2.49,and 3.49 wt.%MgO,were measured at 3.76×10^(6),3.23×10^(6),3.05×10^(6),and 3.17×10^(6)μm s,respectively. 展开更多
关键词 MGO HEMATITE Reduction swelling Step-by-step reduction
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Tailored Engineering on the Interface Between Lithium Metal Anode and Solid-State Electrolytes
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作者 Qi Zhou Xiaosong Xiong +7 位作者 jun peng Wenzhuo Wu Weijia Fan Haoyuan Yang Tao Wang Yuan Ma Faxing Wang Yuping Wu 《Energy & Environmental Materials》 2025年第1期1-32,共32页
The replacement of non-aqueous organic electrolytes with solid-state electrolytes(SSEs)in solid-state lithium metal batteries(SLMBs)is considered a promising strategy to address the constraints of lithium-ion batterie... The replacement of non-aqueous organic electrolytes with solid-state electrolytes(SSEs)in solid-state lithium metal batteries(SLMBs)is considered a promising strategy to address the constraints of lithium-ion batteries,especially in terms of energy density and reliability.Nevertheless,few SLMBs can deliver the required cycling performance and long-term stability for practical use,primarily due to suboptimal interface properties.Given the diverse solidification pathways leading to different interface characteristics,it is crucial to pinpoint the source of interface deterioration and develop appropriate remedies.This review focuses on Li|SSE interface issues between lithium metal anode and SSE,discussing recent advancements in the understanding of(electro)chemistry,the impact of defects,and interface evolutions that vary among different SSE species.The state-ofthe-art strategies concerning modified SEI,artificial interlayer,surface architecture,and composite structure are summarized and delved into the internal relationships between interface characteristics and performance enhancements.The current challenges and opportunities in characterizing and modifying the Li|SSE interface are suggested as potential directions for achieving practical SLMBs. 展开更多
关键词 anode instability lithium metal anode solid-state batteries solid-state electrolyte
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中医眼科对疫病的认识及眼科预防新型冠状病毒感染的措施探讨 被引量:1
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作者 蒋鹏飞 刘培 +2 位作者 李书楠 彭俊 彭清华 《TMR经典中医研究》 2020年第2期46-52,共7页
新型冠状病毒肺炎属于中医学“疫病”范畴,中医眼科学将疫病引起的眼病称为天行赤眼,对轻症治疗以疏风清热为主,对重症治疗以泻火解毒为主。目前仍然不能排除结膜传播新型冠状病毒的可能性,因此眼科工作者在临床一线的诊疗中需要加强警... 新型冠状病毒肺炎属于中医学“疫病”范畴,中医眼科学将疫病引起的眼病称为天行赤眼,对轻症治疗以疏风清热为主,对重症治疗以泻火解毒为主。目前仍然不能排除结膜传播新型冠状病毒的可能性,因此眼科工作者在临床一线的诊疗中需要加强警惕。本文探讨了眼科医务工作者在眼科检查、眼科操作、眼科手术等方面预防新型冠状病毒的措施与普通人群家中预防眼病的措施。希望能对预防新型冠状病毒有所帮助。 展开更多
关键词 新型冠状病毒 中医 眼科
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氢气的药理学作用及其给药途径的研究进展
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作者 张慧 张红梅 +1 位作者 彭军 凌云 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2024年第6期571-578,共8页
氢气是自然界中含量最丰富的元素,是无色、无味、无臭的气体,具有很强的还原性。目前的研究证实,氢气具有抗氧化、抗疲劳、抗辐射、抗炎和降糖降脂的作用,可以治疗各种缺血再灌注损伤、器官移植损伤、神经变性疾病、动脉粥样硬化和代谢... 氢气是自然界中含量最丰富的元素,是无色、无味、无臭的气体,具有很强的还原性。目前的研究证实,氢气具有抗氧化、抗疲劳、抗辐射、抗炎和降糖降脂的作用,可以治疗各种缺血再灌注损伤、器官移植损伤、神经变性疾病、动脉粥样硬化和代谢综合征等多种疾病。氢气在水中的溶解度极低,一个大气压下氢气的饱和浓度为只有0.8ppm,因此想要达到理想的氢气治疗浓度,就必须提高氢气的含量和提供合适的给药途径。氢气的给药方式有吸入法给氢、饮用富氢水、饱和氢生理盐水注射、增加体内氢气产生和口服固体释氢药物等。本文总结了氢气的药理学作用及其给药途径,为氢气在治疗应用上提供思路。 展开更多
关键词 氢气 药理作用 给药途径 研究进展
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蠕形螨相关性眼表疾病及其诊治 被引量:17
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作者 陈立浩 李宏哲 +3 位作者 彭俊 王会英 姚小磊 彭清华 《国际眼科杂志》 CAS 北大核心 2020年第9期1547-1550,共4页
眼部蠕形螨感染主要表现为眼表疾病,具体包括睑板腺功能障碍、干眼症、蠕形螨性睑缘炎、霰粒肿、角结膜炎等。其诊断相对简单,在显微镜下就可以实现诊断;但是由于疾病症状相似、检查遗漏、经验诊疗等主客观因素,该病易被误诊。眼部蠕形... 眼部蠕形螨感染主要表现为眼表疾病,具体包括睑板腺功能障碍、干眼症、蠕形螨性睑缘炎、霰粒肿、角结膜炎等。其诊断相对简单,在显微镜下就可以实现诊断;但是由于疾病症状相似、检查遗漏、经验诊疗等主客观因素,该病易被误诊。眼部蠕形螨感染的治疗手段丰富,包括外用茶树油等植物提取物、口服或外用药物、物理疗法(以强脉冲光疗法、艾灸疗法为代表)、联合治疗等。本文就蠕形螨相关性眼表疾病及相应诊断、治疗作一综述,以探讨该病最新研究动态。 展开更多
关键词 蠕形螨 眼表疾病 睑板腺功能障碍 干眼 睑缘炎 结膜炎
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密蒙花滴眼液对去势雄兔干眼结膜炎性因子IL-1β和黏蛋白5AC及P38MAPK表达的影响 被引量:19
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作者 彭晓芳 彭清华 +3 位作者 彭俊 周亚莎 张又玮 覃艮艳 《国际眼科杂志》 CAS 北大核心 2020年第3期426-431,共6页
目的:观察不同浓度的密蒙花滴眼液对去势雄兔干眼结膜炎性因子IL-1β、黏蛋白5AC(MUC5AC)及P38MAPK表达的影响,从而探讨密蒙花滴眼液对干眼的疗效。方法:将36只雄兔随机分为:空白组、模型组、密蒙花滴眼液低浓度组(1mg/mL)、中浓度组(1.... 目的:观察不同浓度的密蒙花滴眼液对去势雄兔干眼结膜炎性因子IL-1β、黏蛋白5AC(MUC5AC)及P38MAPK表达的影响,从而探讨密蒙花滴眼液对干眼的疗效。方法:将36只雄兔随机分为:空白组、模型组、密蒙花滴眼液低浓度组(1mg/mL)、中浓度组(1.5mg/mL)、高浓度组(3mg/mL)、睾酮组。除空白组外各组均行睾丸及附睾切除建立干眼动物模型,造模成功后,空白组和模型组不予以处理,密蒙花滴眼液低浓度组(1mg/mL)、中浓度组(1.5mg/mL)、高浓度组(3mg/mL)给予密蒙花不同浓度滴眼液,3次/d,睾酮组按0.5mL/kg剂量在大腿肌肉处注射丙酸睾酮,每3d 1次,各组分别于造模前和用药4wk后在全身麻醉下检测荧光素染色、SchirmerⅠ试验(SⅠt)和泪膜破裂时间(BUT)。用药4wk后处死兔子,取其双眼球结膜组织,采用免疫组织化学染色法检测结膜中IL-1β、MUC5AC、P38MAPK的表达。结果:密蒙花滴眼液低浓度组、中浓度组、高浓度组用药4wk后,SⅠt值明显高于模型组,BUT值明显长于模型组,角膜荧光素染色阳性较模型组有明显改善(均P<0.01)。密蒙花滴眼液低浓度组、中浓度组、高浓度组结膜IL-1β、P38MAPK的阳性表达低于模型组,MUC5AC的表达高于模型组(P<0.01),密蒙花滴眼液高浓度组优于低浓度、中浓度组。结论:密蒙花滴眼液具有类雄激素效果,对于去势雄兔干眼可以下调干眼结膜组织中IL-1β、P38MAPK的表达,增加MUC5AC的表达,从而减少干眼结膜组织的炎症浸润,维持泪膜稳定性,但其作用弱于雄激素。密蒙花滴眼液中、高浓度组对于干眼治疗作用强于低浓度组,高浓度组优于中浓度组。 展开更多
关键词 干眼 密蒙花滴眼液 白介素-1β 黏蛋白5AC P38丝裂原激活蛋白激酶
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