BACKGROUND Hemorrhage associated with varices at the site of choledochojejunostomy is an unusual,difficult to treat,and often fatal manifestation of portal hypertension.So far,no treatment guidelines have been establi...BACKGROUND Hemorrhage associated with varices at the site of choledochojejunostomy is an unusual,difficult to treat,and often fatal manifestation of portal hypertension.So far,no treatment guidelines have been established.CASE SUMMARY We reported three patients with jejunal varices at the site of choledochojejun-ostomy managed by endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoacrylate injection at our institution between June 2021 and August 2023.We reviewed all patient records,clinical presentation,endoscopic findings and treatment,outcomes and follow-up.Three patients who underwent pancre-aticoduodenectomy with a Whipple anastomosis were examined using conven-tional upper gastrointestinal endoscopy for suspected hemorrhage from the afferent jejunal loop.Varices with stigmata of recent hemorrhage or active he-morrhage were observed around the choledochojejunostomy site in all three patients.Endoscopic injection of lauromacrogol/α-butyl cyanoacrylate was carried out at jejunal varices for all three patients.The bleeding ceased and patency was observed for 26 and 2 months in two patients.In one patient with multiorgan failure and internal environment disturbance,rebleeding occurred 1 month after endoscopic sclerotherapy,and despite a second endoscopic sclero-therapy,repeated episodes of bleeding and multiorgan failure resulted in eventual death.CONCLUSION We conclude that endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoac-rylate injection can be an easy,effective,safe and low-cost treatment option for jejunal varicose bleeding at the site of choledochojejunostomy.展开更多
Objective:To investigate the effect of vault on conjunctiva combined with fascia sheath suspension on the mobility and aesthetics of eyelid in patients with ptosis.Methods:A total of 80 patients with ptosis who were a...Objective:To investigate the effect of vault on conjunctiva combined with fascia sheath suspension on the mobility and aesthetics of eyelid in patients with ptosis.Methods:A total of 80 patients with ptosis who were admitted to our hospital from January 2017 to January 2019 were selected as the subjects.They were divided into 2 groups with random number table method,40 cases each.The control group was treated with modified single-incision frontalis fascia flap suspension,and the observation group was treated with vault on conjunctiva combined with fascia sheath suspension.The eyelid margin activity,aesthetics and complications were compared between the two groups.Results:The eyelid margin activity of the observation group after treatment was higher than that of the control group,the difference was statistically significant(P<0.05);the aesthetic satisfaction of the observation group after treatment was 95.00%(38/40)higher than that of the control group 70.00%(28/40)The difference was statistically significant(P<0.05);the incidence of complications in the observation group was 2.50%(1/40)lower than that in the control group 20.00%(8/40),and the difference was statistically significant(P<0.05).Conclusion:Patients with ptosis are treated with superior conjunctival fornix combined with fascia sheath suspension,which can improve the mobility of eyelid margin,and it is more beautiful and has less complications.展开更多
Civil aviation is one of the industries facing the greatest challenge in reaching carbon neutrality by the middle of this century,and this sector also contributes to adverse impacts on the regional air quality and hum...Civil aviation is one of the industries facing the greatest challenge in reaching carbon neutrality by the middle of this century,and this sector also contributes to adverse impacts on the regional air quality and human health.China exhibits the second highest air passenger turnover worldwide.Our understanding of civil aviation emissionsmust be urgently enhanced,and themitigation potential should be explored.In this study,on the basis of real domestic flight information for 2019,we built a greenhouse gas and air pollution emission inventory for the civil aviation sector in China with the fuel flowmethod based on the cruise and other phases.We thoroughly analyzed emissions by region,aircraft and engine types,and aircraft age,based on which we designed four measures to evaluate the abatement potential.We found that the hydrocarbon(HC),CO,NO_(x),SO_(2),particulate matter(PM)and CO_(2)emissions in 2019 reached 79.9 kt(95%CI[51.6–114.5]),176.3 kt(95%CI[114.5–248.2]),304.2 kt(95%CI[203.4–420.7]),23.2 kt(95%CI[14.2–33.7]),1.0 kt(95%CI[0.61–1.44])and 87.0 Mt(95%CI[57.4–119.6]),respectively.The cruise phase was the major emission phase,accounting for 67%-87%of the total pollutant emissions.If four measures were jointly implemented,the HC,CO,NO_(x),SO_(2),PM and CO_(2)emissions could be reduced by 61%,54%,55%,45%,32%and 38%,respectively.Utilizing lower-emission aircraft and switching travel modes could substantially reduce civil aviation emissions in China.展开更多
Polyurethane foam,when used as a compressible layer in deep soft rock tunnels,offers a feasible solution to reduce the support pressure on the secondary lining.The foam spraying method using sprayed polyurethane mater...Polyurethane foam,when used as a compressible layer in deep soft rock tunnels,offers a feasible solution to reduce the support pressure on the secondary lining.The foam spraying method using sprayed polyurethane material is convenient for engineering applications;however,the compressive behaviour and feasibility of sprayed polyurethane material as a compressible layer remain unclear.To address this gap,this study conducts uniaxial compression tests and scanning electron microscope(SEM)tests to investigate the compressive behaviour of the rigid foams fabricated from a self-developed polyurethane spray material.A peridynamics model for the composite lining with a polyurethane compressible layer is then established.After validating the proposed method by comparison with two tests,a parametric study is carried out to investigate the damage evolution of the composite lining with a polyurethane compressible layer under various combinations of large deformations and compressible layer parameters.The results indicate that the polyurethane compressible layer effectively reduces the radial deformation and damage index of the secondary lining while increasing the damage susceptibility of the primary lining.The thickness of the polyurethane compressible layer significantly influences the prevention effect of large deformation-induced damage to the secondary lining within the density range of 50e100 kg/m^(3).In accordance with the experimental and simulation results,a simple,yet reasonable and convenient approach for determining the key parameters of the polyurethane compressible layer is proposed,along with a classification scheme for the parameters of the polyurethane compressible layer.展开更多
Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the...Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the damaged area around the tunnel.An in situ microseismic(MS)monitoring system is established in the plateau soft tock tunnel.This technique facilitates spatiotemporal monitoring of the rock mass's fracturing expansion and squeezing deformation,which agree well with field convergence deformation results.The formation mechanisms of progressive failure evolution of soft rock tunnels were discussed and analyzed with MS data and numerical results.The results demonstrate that:(1)Localized stress concentration and layered rock result in significant asymmetry in micro-fractures propagation in the tunnel radial section.As excavation continues,the fracture extension area extends into the deep surrounding rockmass on the east side affected by the weak bedding;(2)Tunnel excavation and long-term deformation can induce tensile shear action on the rock mass,vertical tension fractures(account for 45%)exist in deep rockmass,which play a crucial role in controlling the macroscopic failure of surrounding rock;and(3)Based on the radiated MS energy,a three-dimensional model was created to visualize the damage zone of the tunnel surrounding rock.The model depicted varying degrees of damage,and three high damage zones were identified.Generally,the depth of high damage zone ranged from 4 m to 12 m.This study may be a valuable reference for the warning and controlling of large deformations in similar projects.展开更多
BACKGROUND Inflammatory bowel disease(IBD)is a global health burden that affects millions of individuals worldwide,necessitating extensive patient education.Large language models(LLMs)hold promise for addressing patie...BACKGROUND Inflammatory bowel disease(IBD)is a global health burden that affects millions of individuals worldwide,necessitating extensive patient education.Large language models(LLMs)hold promise for addressing patient information needs.However,LLM use to deliver accurate and comprehensible IBD-related medical information has yet to be thoroughly investigated.AIM To assess the utility of three LLMs(ChatGPT-4.0,Claude-3-Opus,and Gemini-1.5-Pro)as a reference point for patients with IBD.METHODS In this comparative study,two gastroenterology experts generated 15 IBD-related questions that reflected common patient concerns.These questions were used to evaluate the performance of the three LLMs.The answers provided by each model were independently assessed by three IBD-related medical experts using a Likert scale focusing on accuracy,comprehensibility,and correlation.Simultaneously,three patients were invited to evaluate the comprehensibility of their answers.Finally,a readability assessment was performed.RESULTS Overall,each of the LLMs achieved satisfactory levels of accuracy,comprehensibility,and completeness when answering IBD-related questions,although their performance varies.All of the investigated models demonstrated strengths in providing basic disease information such as IBD definition as well as its common symptoms and diagnostic methods.Nevertheless,when dealing with more complex medical advice,such as medication side effects,dietary adjustments,and complication risks,the quality of answers was inconsistent between the LLMs.Notably,Claude-3-Opus generated answers with better readability than the other two models.CONCLUSION LLMs have the potential as educational tools for patients with IBD;however,there are discrepancies between the models.Further optimization and the development of specialized models are necessary to ensure the accuracy and safety of the information provided.展开更多
Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal b...Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.展开更多
Catalytic purification of sulphur-containing malodorous gases has attracted wide attention because of its advantages of high purification efficiency,low energy consumption and lack of secondary pollution.The selection...Catalytic purification of sulphur-containing malodorous gases has attracted wide attention because of its advantages of high purification efficiency,low energy consumption and lack of secondary pollution.The selection of efficient catalysts is the key to the problem,while the preparation and optimisation of catalysts depend on the analysis of experimental results and in-depth mechanistic analysis.By analysing the published literature,bibliometric analysis can identify existing research hotspots,the areas of interest and predict development trends,which can help to identify hot catalysts in the catalytic purification of sulphurcontaining odours and to investigate their catalytic purification mechanisms.Therefore,this paper uses bibliometric analysis,based on Web Of Science and CNKI databases,CiteSpace and VOS viewer software to collate and analyse the literature on the purification of sulphurcontaining odour pollutants,to identify the current research hotspots,to summarise the progress of research on the catalytic purification of different types of sulphur-containing odours,and to analyse their reaction mechanisms and kinetics.On this basis,the research progress of catalytic purification of different kinds of sulfur odour is summarized,and the reaction mechanism and dynamics are summarized.展开更多
Micro-silicon(Si)anode that features high theoretical capacity and fine tap density is ideal for energy-dense lithiumion batteries.However,the substantial localized mechanical strain caused by the large volume expansi...Micro-silicon(Si)anode that features high theoretical capacity and fine tap density is ideal for energy-dense lithiumion batteries.However,the substantial localized mechanical strain caused by the large volume expansion often results in electrode disintegration and capacity loss.Herein,a microporous Si anode with the SiO_(x)/C layer functionalized all-surface and high tap density(~0.65 g cm^(-3))is developed by the hydrolysis-driven strategy that avoids the common use of corrosive etchants and toxic siloxane reagents.The functionalized inner pore with superior structural stability can effectively alleviate the volume change and enhance the electrolyte contact.Simultaneously,the outer particle surface forms a continuous network that prevents electrolyte parasitic decomposition,disperses the interface stress of Si matrix and facilitates electron/ion transport.As a result,the micron-sized Si anode shows only~9.94 GPa average stress at full lithiation state and delivers an impressive capacity of 901.1 mAh g^(-1)after 500 cycles at 1 A g^(-1).It also performs excellent rate performance of 1123.0 mAh g^(-1)at 5 A g^(-1)and 850.4 at 8 A g^(-1),far exceeding most of reported literatures.Furthermore,when paired with a commercial LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),the pouch cell demonstrates high capacity and desirable cyclic performance.展开更多
BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various diseases.AIM To explore the association between pretreatment RDW and short-term outcomes after laparoscopi...BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various diseases.AIM To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively analyzed.Correlations between pretreatment RDW and clinicopathological characteristics and short-term outcomes were investigated.RESULTS Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal RDW.High pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification system.Subgroup analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe hemorrhage.High pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional index.CONCLUSION Pretreatment RDW was a special parameter for patients who underwent LPD.It was associated with malnutrition,severe inflammatory status and poorer short-term outcomes.RDW could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.展开更多
The sodium-iodine(Na-I)battery exhibits significant potential as an alternative energy storage device to the lithium-ion battery.However,its development is hindered by inadequate electrical and thermal stability,as we...The sodium-iodine(Na-I)battery exhibits significant potential as an alternative energy storage device to the lithium-ion battery.However,its development is hindered by inadequate electrical and thermal stability,as well as the dissolution and shuttling of polyiodide.In this study,we report a preparation method for melamine carbon sponge(MC)via carbonizing a commercially available kitchen sponge.It was revealed that the as-prepared MC,composed of unique self-growing carbon nanotubes,could provide both physical and chemical adsorption capabilities for intermediate polyiodides to improve the electrochemical performance of NaI.Consequently,the NaI/MC electrode effectively minimized polyiodide dissolution and reduced the electrochemical impedance.The NaI/MC cathode demonstrated a high average discharge capacity of 92.75 mAh·g^(–1)over 200 cycles while maintaining a coulombic efficiency of 94%.The research findings from our study have promising applications in Na-I batteries.展开更多
The Non-uniform rational B-spline （NURBS） enhanced scaled boundary finite element method in combination with the modified precise integration method is proposed for the transient heat conduction problems in this pap...The Non-uniform rational B-spline （NURBS） enhanced scaled boundary finite element method in combination with the modified precise integration method is proposed for the transient heat conduction problems in this paper. The scaled boundary finite element method is a semi-analytical technique, which weakens the governing differential equations along the circumferential direction and solves those analytically in the radial direction. In this method, only the boundary is discretized in the finite element sense leading to a re- duction of the spatial dimension by one with no fundamental solution required. Neverthe- less, in case of the complex geometry, a huge number of elements are generally required to properly approximate the exact shape of the domain and distorted meshes are often un- avoidable in the conventional finite element approach, which leads to huge computational efforts and loss of accuracy. NURBS are the most popular mathematical tool in CAD industry due to its flexibility to fit any free-form shape. In the proposed methodology, the arbitrary curved boundary of problem domain is exactly represented with NURBS basis functions, while the straight part of the boundary is discretized by the conventional Lagrange shape functions. Both the concepts of isogeometric analysis and scaled boundary finite element method are combined to form the governing equations of transient heat conduction analy- sis and the solution is obtained using the modified precise integration method. The stiffness matrix is obtained from a standard quadratic eigenvalue problem and the mass matrix is determined from the low-frequency expansion. Finally the governing equations become a system of first-order ordinary differential equations and the time domain response is solved numerically by the modified precise integration method. The accuracy and stability of the proposed method to deal with the transient heat conduction problems are demonstrated by numerical examples.展开更多
文摘BACKGROUND Hemorrhage associated with varices at the site of choledochojejunostomy is an unusual,difficult to treat,and often fatal manifestation of portal hypertension.So far,no treatment guidelines have been established.CASE SUMMARY We reported three patients with jejunal varices at the site of choledochojejun-ostomy managed by endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoacrylate injection at our institution between June 2021 and August 2023.We reviewed all patient records,clinical presentation,endoscopic findings and treatment,outcomes and follow-up.Three patients who underwent pancre-aticoduodenectomy with a Whipple anastomosis were examined using conven-tional upper gastrointestinal endoscopy for suspected hemorrhage from the afferent jejunal loop.Varices with stigmata of recent hemorrhage or active he-morrhage were observed around the choledochojejunostomy site in all three patients.Endoscopic injection of lauromacrogol/α-butyl cyanoacrylate was carried out at jejunal varices for all three patients.The bleeding ceased and patency was observed for 26 and 2 months in two patients.In one patient with multiorgan failure and internal environment disturbance,rebleeding occurred 1 month after endoscopic sclerotherapy,and despite a second endoscopic sclero-therapy,repeated episodes of bleeding and multiorgan failure resulted in eventual death.CONCLUSION We conclude that endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoac-rylate injection can be an easy,effective,safe and low-cost treatment option for jejunal varicose bleeding at the site of choledochojejunostomy.
文摘Objective:To investigate the effect of vault on conjunctiva combined with fascia sheath suspension on the mobility and aesthetics of eyelid in patients with ptosis.Methods:A total of 80 patients with ptosis who were admitted to our hospital from January 2017 to January 2019 were selected as the subjects.They were divided into 2 groups with random number table method,40 cases each.The control group was treated with modified single-incision frontalis fascia flap suspension,and the observation group was treated with vault on conjunctiva combined with fascia sheath suspension.The eyelid margin activity,aesthetics and complications were compared between the two groups.Results:The eyelid margin activity of the observation group after treatment was higher than that of the control group,the difference was statistically significant(P<0.05);the aesthetic satisfaction of the observation group after treatment was 95.00%(38/40)higher than that of the control group 70.00%(28/40)The difference was statistically significant(P<0.05);the incidence of complications in the observation group was 2.50%(1/40)lower than that in the control group 20.00%(8/40),and the difference was statistically significant(P<0.05).Conclusion:Patients with ptosis are treated with superior conjunctival fornix combined with fascia sheath suspension,which can improve the mobility of eyelid margin,and it is more beautiful and has less complications.
基金supported by the National Natural Science Foundation of China(Nos.42375171 and 42105157)the Interdisciplinary Research Project for Young Teachers of USTB(No.06600083)+1 种基金Energy Foundation(Nos.G-2109-33379 and G-2306-34754)the Fundamental Research Funds for the Central Universities(No.06500166).
文摘Civil aviation is one of the industries facing the greatest challenge in reaching carbon neutrality by the middle of this century,and this sector also contributes to adverse impacts on the regional air quality and human health.China exhibits the second highest air passenger turnover worldwide.Our understanding of civil aviation emissionsmust be urgently enhanced,and themitigation potential should be explored.In this study,on the basis of real domestic flight information for 2019,we built a greenhouse gas and air pollution emission inventory for the civil aviation sector in China with the fuel flowmethod based on the cruise and other phases.We thoroughly analyzed emissions by region,aircraft and engine types,and aircraft age,based on which we designed four measures to evaluate the abatement potential.We found that the hydrocarbon(HC),CO,NO_(x),SO_(2),particulate matter(PM)and CO_(2)emissions in 2019 reached 79.9 kt(95%CI[51.6–114.5]),176.3 kt(95%CI[114.5–248.2]),304.2 kt(95%CI[203.4–420.7]),23.2 kt(95%CI[14.2–33.7]),1.0 kt(95%CI[0.61–1.44])and 87.0 Mt(95%CI[57.4–119.6]),respectively.The cruise phase was the major emission phase,accounting for 67%-87%of the total pollutant emissions.If four measures were jointly implemented,the HC,CO,NO_(x),SO_(2),PM and CO_(2)emissions could be reduced by 61%,54%,55%,45%,32%and 38%,respectively.Utilizing lower-emission aircraft and switching travel modes could substantially reduce civil aviation emissions in China.
基金financially supported by the National Key Research and Development Program of China(Grant Nos.2023YFB2604005)the National Key Research and Development 451 Program of China(Grant No.2021YFC3100803)the Yangtze River Water Science Research Joint Fund Key Project of National Natural Science Foundation of China(Grant No.U2340231).
文摘Polyurethane foam,when used as a compressible layer in deep soft rock tunnels,offers a feasible solution to reduce the support pressure on the secondary lining.The foam spraying method using sprayed polyurethane material is convenient for engineering applications;however,the compressive behaviour and feasibility of sprayed polyurethane material as a compressible layer remain unclear.To address this gap,this study conducts uniaxial compression tests and scanning electron microscope(SEM)tests to investigate the compressive behaviour of the rigid foams fabricated from a self-developed polyurethane spray material.A peridynamics model for the composite lining with a polyurethane compressible layer is then established.After validating the proposed method by comparison with two tests,a parametric study is carried out to investigate the damage evolution of the composite lining with a polyurethane compressible layer under various combinations of large deformations and compressible layer parameters.The results indicate that the polyurethane compressible layer effectively reduces the radial deformation and damage index of the secondary lining while increasing the damage susceptibility of the primary lining.The thickness of the polyurethane compressible layer significantly influences the prevention effect of large deformation-induced damage to the secondary lining within the density range of 50e100 kg/m^(3).In accordance with the experimental and simulation results,a simple,yet reasonable and convenient approach for determining the key parameters of the polyurethane compressible layer is proposed,along with a classification scheme for the parameters of the polyurethane compressible layer.
基金the funding support from the National Natural Science Foundation of China(Grant Nos.U23A2060,42177143 and 42277461).
文摘Surrounding rock deterioration and large deformation have always been a significant difficulty in designing and constructing tunnels in soft rock.The key lies in real-time perception and quantitative assessment of the damaged area around the tunnel.An in situ microseismic(MS)monitoring system is established in the plateau soft tock tunnel.This technique facilitates spatiotemporal monitoring of the rock mass's fracturing expansion and squeezing deformation,which agree well with field convergence deformation results.The formation mechanisms of progressive failure evolution of soft rock tunnels were discussed and analyzed with MS data and numerical results.The results demonstrate that:(1)Localized stress concentration and layered rock result in significant asymmetry in micro-fractures propagation in the tunnel radial section.As excavation continues,the fracture extension area extends into the deep surrounding rockmass on the east side affected by the weak bedding;(2)Tunnel excavation and long-term deformation can induce tensile shear action on the rock mass,vertical tension fractures(account for 45%)exist in deep rockmass,which play a crucial role in controlling the macroscopic failure of surrounding rock;and(3)Based on the radiated MS energy,a three-dimensional model was created to visualize the damage zone of the tunnel surrounding rock.The model depicted varying degrees of damage,and three high damage zones were identified.Generally,the depth of high damage zone ranged from 4 m to 12 m.This study may be a valuable reference for the warning and controlling of large deformations in similar projects.
基金Supported by the China Health Promotion Foundation Young Doctors'Research Foundation for Inflammatory Bowel Disease,the Taishan Scholars Program of Shandong Province,China,No.tsqn202306343National Natural Science Foundation of China,No.82270578.
文摘BACKGROUND Inflammatory bowel disease(IBD)is a global health burden that affects millions of individuals worldwide,necessitating extensive patient education.Large language models(LLMs)hold promise for addressing patient information needs.However,LLM use to deliver accurate and comprehensible IBD-related medical information has yet to be thoroughly investigated.AIM To assess the utility of three LLMs(ChatGPT-4.0,Claude-3-Opus,and Gemini-1.5-Pro)as a reference point for patients with IBD.METHODS In this comparative study,two gastroenterology experts generated 15 IBD-related questions that reflected common patient concerns.These questions were used to evaluate the performance of the three LLMs.The answers provided by each model were independently assessed by three IBD-related medical experts using a Likert scale focusing on accuracy,comprehensibility,and correlation.Simultaneously,three patients were invited to evaluate the comprehensibility of their answers.Finally,a readability assessment was performed.RESULTS Overall,each of the LLMs achieved satisfactory levels of accuracy,comprehensibility,and completeness when answering IBD-related questions,although their performance varies.All of the investigated models demonstrated strengths in providing basic disease information such as IBD definition as well as its common symptoms and diagnostic methods.Nevertheless,when dealing with more complex medical advice,such as medication side effects,dietary adjustments,and complication risks,the quality of answers was inconsistent between the LLMs.Notably,Claude-3-Opus generated answers with better readability than the other two models.CONCLUSION LLMs have the potential as educational tools for patients with IBD;however,there are discrepancies between the models.Further optimization and the development of specialized models are necessary to ensure the accuracy and safety of the information provided.
基金supported by grants from Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA22096018(to JY)Guangxi Key Research and Development Program,No.AB22080053(to DD)+6 种基金Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA23023004(to MZ)the National Natural Science Foundation of China,Nos.82260021(to MZ),82060315(to DD)the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2021GXNSFBA220007(to GD)Clinical Research Center For Medical Imaging in Hunan Province,No.2020SK4001(to JL)Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection in Hunan Province,No.2020SK3006(to JL)Science and Technology Innovation Program of Hunan Province,No.2021RC4016(to JL)Key Project of the Natural Science Foundation of Hunan Province,No.2024JJ3041(to JL).
文摘Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.
基金supported by the National Natural Science Foundation of China(Nos.21677010 and 51808037)the National Key R&D Program of China(No.2021YFB3500702)the Special fund of Beijing Key Laboratory of Indoor Air Quality Evaluation and Control(No.BZ0344KF21-04).
文摘Catalytic purification of sulphur-containing malodorous gases has attracted wide attention because of its advantages of high purification efficiency,low energy consumption and lack of secondary pollution.The selection of efficient catalysts is the key to the problem,while the preparation and optimisation of catalysts depend on the analysis of experimental results and in-depth mechanistic analysis.By analysing the published literature,bibliometric analysis can identify existing research hotspots,the areas of interest and predict development trends,which can help to identify hot catalysts in the catalytic purification of sulphurcontaining odours and to investigate their catalytic purification mechanisms.Therefore,this paper uses bibliometric analysis,based on Web Of Science and CNKI databases,CiteSpace and VOS viewer software to collate and analyse the literature on the purification of sulphurcontaining odour pollutants,to identify the current research hotspots,to summarise the progress of research on the catalytic purification of different types of sulphur-containing odours,and to analyse their reaction mechanisms and kinetics.On this basis,the research progress of catalytic purification of different kinds of sulfur odour is summarized,and the reaction mechanism and dynamics are summarized.
基金supported by the National Natural Science Foundation of China Projects(Nos.52271213,52202299).
文摘Micro-silicon(Si)anode that features high theoretical capacity and fine tap density is ideal for energy-dense lithiumion batteries.However,the substantial localized mechanical strain caused by the large volume expansion often results in electrode disintegration and capacity loss.Herein,a microporous Si anode with the SiO_(x)/C layer functionalized all-surface and high tap density(~0.65 g cm^(-3))is developed by the hydrolysis-driven strategy that avoids the common use of corrosive etchants and toxic siloxane reagents.The functionalized inner pore with superior structural stability can effectively alleviate the volume change and enhance the electrolyte contact.Simultaneously,the outer particle surface forms a continuous network that prevents electrolyte parasitic decomposition,disperses the interface stress of Si matrix and facilitates electron/ion transport.As a result,the micron-sized Si anode shows only~9.94 GPa average stress at full lithiation state and delivers an impressive capacity of 901.1 mAh g^(-1)after 500 cycles at 1 A g^(-1).It also performs excellent rate performance of 1123.0 mAh g^(-1)at 5 A g^(-1)and 850.4 at 8 A g^(-1),far exceeding most of reported literatures.Furthermore,when paired with a commercial LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2),the pouch cell demonstrates high capacity and desirable cyclic performance.
基金Supported by the National Natural Science Foundation of China,No.81302124.
文摘BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various diseases.AIM To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively analyzed.Correlations between pretreatment RDW and clinicopathological characteristics and short-term outcomes were investigated.RESULTS Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal RDW.High pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,P<0.001)and severe POCs of grade IIIa or higher(hazard ratio=3.138,95%confidence interval:2.042-4.824,P<0.001)based on the Clavien-Dino classification system.Subgroup analysis showed that high pretreatment RDW was an independent risk factor for Clavien-Dino classi-fication grade IIIb or higher POCs,a comprehensive complication index score≥26.2,severe postoperative pancreatic fistula,severe bile leakage and severe hemorrhage.High pretreatment RDW was positively associated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and was negatively associated with albumin and the prognostic nutritional index.CONCLUSION Pretreatment RDW was a special parameter for patients who underwent LPD.It was associated with malnutrition,severe inflammatory status and poorer short-term outcomes.RDW could be a surrogate marker for nutritional and inflammatory status in identifying patients who were at high risk of developing POCs after LPD.
基金supported by Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application(Grant No.ZDSYS20220527171407017).
文摘The sodium-iodine(Na-I)battery exhibits significant potential as an alternative energy storage device to the lithium-ion battery.However,its development is hindered by inadequate electrical and thermal stability,as well as the dissolution and shuttling of polyiodide.In this study,we report a preparation method for melamine carbon sponge(MC)via carbonizing a commercially available kitchen sponge.It was revealed that the as-prepared MC,composed of unique self-growing carbon nanotubes,could provide both physical and chemical adsorption capabilities for intermediate polyiodides to improve the electrochemical performance of NaI.Consequently,the NaI/MC electrode effectively minimized polyiodide dissolution and reduced the electrochemical impedance.The NaI/MC cathode demonstrated a high average discharge capacity of 92.75 mAh·g^(–1)over 200 cycles while maintaining a coulombic efficiency of 94%.The research findings from our study have promising applications in Na-I batteries.
基金support by the National Natural Science Foundation of China(grant No.51779033,51409038)the National Key Research and Development Plan(grant No.2016YFB0201001)the National Natural Science Foundation of China(grant No.51421064)
文摘The Non-uniform rational B-spline （NURBS） enhanced scaled boundary finite element method in combination with the modified precise integration method is proposed for the transient heat conduction problems in this paper. The scaled boundary finite element method is a semi-analytical technique, which weakens the governing differential equations along the circumferential direction and solves those analytically in the radial direction. In this method, only the boundary is discretized in the finite element sense leading to a re- duction of the spatial dimension by one with no fundamental solution required. Neverthe- less, in case of the complex geometry, a huge number of elements are generally required to properly approximate the exact shape of the domain and distorted meshes are often un- avoidable in the conventional finite element approach, which leads to huge computational efforts and loss of accuracy. NURBS are the most popular mathematical tool in CAD industry due to its flexibility to fit any free-form shape. In the proposed methodology, the arbitrary curved boundary of problem domain is exactly represented with NURBS basis functions, while the straight part of the boundary is discretized by the conventional Lagrange shape functions. Both the concepts of isogeometric analysis and scaled boundary finite element method are combined to form the governing equations of transient heat conduction analy- sis and the solution is obtained using the modified precise integration method. The stiffness matrix is obtained from a standard quadratic eigenvalue problem and the mass matrix is determined from the low-frequency expansion. Finally the governing equations become a system of first-order ordinary differential equations and the time domain response is solved numerically by the modified precise integration method. The accuracy and stability of the proposed method to deal with the transient heat conduction problems are demonstrated by numerical examples.
