Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD f...Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice.展开更多
The change of coastal wetland vulnerability affects the ecological environment and the economic development of the estuary area.In the past,most of the assessment studies on the vulnerability of coastal ecosystems sta...The change of coastal wetland vulnerability affects the ecological environment and the economic development of the estuary area.In the past,most of the assessment studies on the vulnerability of coastal ecosystems stayed in static qualitative research,lacking predictability,and the qualitative and quantitative relationship was not objective enough.In this study,the“Source-Pathway-Receptor-Consequence”model and the Intergovernmental Panel on Climate Change vulnerability definition were used to analyze the main impact of sea level rise caused by climate change on coastal wetland ecosystem in Minjiang River Estuary.The results show that:(1)With the increase of time and carbon emission,the area of high vulnerability and the higher vulnerability increased continuously,and the area of low vulnerability and the lower vulnerability decreased.(2)The eastern and northeastern part of the Culu Island in the Minjiang River Estuary of Fujian Province and the eastern coastal wetland of Meihua Town in Changle District are areas with high vulnerability risk.The area of high vulnerability area of coastal wetland under high emission scenario is wider than that under low emission scenario.(3)Under different sea level rise scenarios,elevation has the greatest impact on the vulnerability of coastal wetlands,and slope has less impact.The impact of sea level rise caused by climate change on the coastal wetland ecosystem in the Minjiang River Estuary is mainly manifested in the sea level rise,which changes the habitat elevation and daily flooding time of coastal wetlands,and then affects the survival and distribution of coastal wetland ecosystems.展开更多
BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in pr...BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute STEMI.METHODS: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.Patients were randomly assigned to control group(n=20) or post-dilatation group(n=21) in which a non-compliant balloon was inflated to >16 atm pressure.Strut apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month follow-up.The primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after pPCI.RESULTS: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation vs.control group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE rate.Larger and longer term studies are warranted to further assess safety(Clinical Trials.gov identifier: NCT02121223).展开更多
Organofluorines play a crucial role in medicine,agrochemicals,and materials science.Adding fluorine to molecules creates structures with specific beneficial properties or tunes properties through interactions with the...Organofluorines play a crucial role in medicine,agrochemicals,and materials science.Adding fluorine to molecules creates structures with specific beneficial properties or tunes properties through interactions with their environment.Many popular pharmaceuticals and agrochemicals contain fluorine because it enhances hydrogen bonding at protein’s active sites.展开更多
The Landé g factors of Ba+are very important in high-precision measurement physics.The wave functions,energy levels,and Landég factors for the 6s ^(2)S_(1/2) and 5d 2D_(3/2,5/2) states of Ba+ions were calcul...The Landé g factors of Ba+are very important in high-precision measurement physics.The wave functions,energy levels,and Landég factors for the 6s ^(2)S_(1/2) and 5d 2D_(3/2,5/2) states of Ba+ions were calculated using the multi-configuration Dirac-Hartree-Fock method and the model-quantum electrodynamics(QED)method.The contributions of the electron correlation effects and QED effects were discussed in detail.The transition energies are in excellent agreement with the experimental results,with differences of approximately 5 cm^(−1).The presently calculated g factor of 2.0024905(16)for the 6S1/2 agrees very well with the available experimental and theoretical results,with a difference at a level of 10^(−6).For the 5D_(3/2,5/2) states,the present results of 0.7993961(126)and 1.2003942(190)agree with the experimental results of 0.7993278(3)[Phys.Rev.A 541199(1996)]and 1.20036739(14)[Phys.Rev.Lett.124193001(2020)]very well,with differences at the level of 10−5.展开更多
BACKGROUND Delayed wound healing is a common clinical complication following gastric cancer radical surgery,adversely affecting patient prognosis.With advances in artificial intelligence,machine learning offers a prom...BACKGROUND Delayed wound healing is a common clinical complication following gastric cancer radical surgery,adversely affecting patient prognosis.With advances in artificial intelligence,machine learning offers a promising approach for developing predictive models that can identify high-risk patients and support early clinical intervention.AIM To construct machine learning-based risk prediction models for delayed wound healing after gastric cancer surgery to support clinical decision-making.METHODS We reviewed a total of 514 patients who underwent gastric cancer radical surgery under general anesthesia from January 1,2014 to December 30,2023.Seventy percent of the dataset was selected as the training set and 30%as the validation set.Decision trees,support vector machines,and logistic regression were used to construct a risk prediction model.The performance of the model was evaluated using accuracy,recall,precision,F1 index,and area under the receiver operating characteristic curve and decision curve.RESULTS This study included five variables:Sex,elderly,duration of abdominal drainage,preoperative white blood cell(WBC)count,and absolute value of neutrophils.These variables were selected based on their clinical relevance and statistical significance in predicting delayed wound healing.The results showed that the decision tree model outperformed the logistic regression and support vector machine models in both the training and validation sets.Specifically,the decision tree model achieved higher accuracy,F1 index,recall,and area under the curve(AUC)values.The support vector machine model also demonstrated better performance than logistic regression,with higher accuracy,recall,and F1 index,but a slightly lower AUC.The key variables of sex,elderly,duration of abdominal drainage,preoperative WBC count,and absolute value of neutrophils were found to be strong predictors of delayed wound healing.Patients with longer duration of abdominal drainage had a significantly higher risk of delayed wound healing,with a risk ratio of 1.579 compared to those with shorter duration of abdominal drainage.Similarly,preoperative WBC count,sex,elderly,and absolute value of neutrophils were associated with a higher risk of delayed wound healing,highlighting the importance of these variables in the model.CONCLUSION The model is able to identify high-risk patients based on sex,elderly,duration of abdominal drainage,preoperative WBC count,and absolute value of neutrophils can provide valuable insights for clinical decision-making.展开更多
Aflatoxins B1(AFB1)contamination in agro-food holds great threaten to human and animal health.Conventional test strips for rapid AFB1 visualized monitoring remains challenged by improvement of sensitivity and matrix i...Aflatoxins B1(AFB1)contamination in agro-food holds great threaten to human and animal health.Conventional test strips for rapid AFB1 visualized monitoring remains challenged by improvement of sensitivity and matrix interference resistance.In this case,we developed a portable electrochemiluminescence(ECL)imaging test strip with dual-signal outputs for AFB1 quantification in corn samples.RuPEI@SiO_(2)@Au nanospheres were synthesized for bonding with anti-AFB1 antibody and then colorimetrical signal-reported on test line through the capillary flow at strips.Meanwhile,ECL imaging signal of the constructed carbon-ink-based working electrode on polyvinyl chloride substrate of strips was exported under an applied potential of 1.25 V.The whole ECL test strips not only endowed convenient colorimetric responses but guaranteed quick-witted ECL image distinguishment even at extremely low AFB1 content.The detection limit of this ECL imaging-integrated mode was 10-fold lower than that of only colorimetric mode.Furthermore,satisfactory selectivity,reliability and practicability of the as-proposed ECL test strips were demonstrated.This work offered a promising platform for on-site,accurate and sensitive detection of pollutants in foods.展开更多
Soil bioaccessible and labile As were extracted using in vitro,diffusive gradients in thin films(DGT)and chemical extraction methods.The results showed that As(Ⅲ)was readily converted to As(Ⅴ)in the soils,which was ...Soil bioaccessible and labile As were extracted using in vitro,diffusive gradients in thin films(DGT)and chemical extraction methods.The results showed that As(Ⅲ)was readily converted to As(Ⅴ)in the soils,which was promoted by alkaline conditions and higher content of easily reducible Mn.As(Ⅴ)was not readily reduced to As(Ⅲ)in these soils.The effect of soil pH on bioaccessible As content by in vitro method and labile As content by DGT methodwere inconsistent among different soils due to the coincidence of As(Ⅲ)and As(Ⅴ),with As(Ⅲ)being more readily mobilized in acidic environment while the opposite was true for As(Ⅴ).The labile As extracted by phosphate was significantly correlated with that extracted by in vitro method,while the labile As extracted by the DGT was correlated with that extracted by the CaCl_(2) method.The labile As extracted by the DGT was much lower than that by the in vitro and phosphate methods.The in vitro and phosphate methods extracted As in soils which is tightly bound to Fe oxides through dissolution,complexation and ion exchange.In contrast,the DGT method relied on the adsorption of soil labile As onto ZrO-based binding layer.The higher contents of soil Fe oxides and greater adsorption capacity for As led to the lower content of As measured by the DGT method.In conclusion,the in vitro and phosphate extraction are potential to be used to predict soil bioaccessible As.The DGT method is more suitable for ecological risk prediction.展开更多
Track irregularity from rail alternate side wear is manifested as uneven rail wear waveforms alternating in the left and right rails with equal intervals,which will cause carbody sway behaviour of railway vehicles and...Track irregularity from rail alternate side wear is manifested as uneven rail wear waveforms alternating in the left and right rails with equal intervals,which will cause carbody sway behaviour of railway vehicles and greatly influences the passenger comfort.In this work,the carbody sway behaviour and mechanism due to track irregularity from rail alternate side wear and possible solutions to this issue were studied by the field testing and numerical calculation approaches.First,the carbody sway of an urban rail transit train is introduced with full-scale field tests,through which the rail alternate side wear is characterized and the formatted track irregularity are presented.Then,multibody vehicle dynamic models are developed to reproduce the carbody sway behaviour induced by the track irregularity from the rail alternate side wear.The creep forces acting on the wheel and rail are preliminarily discussed to study the influence of the carbody sway on the wear of the wheel flange and the rail corner.Finally,some potential solutions,e.g.improving the damping ratio of carbody rigid mode and rail grinding,are proposed to relieve this issue.It is concluded that an increased damping ratio of the carbody mode can alleviate the carbody sway and wheel–rail interactions,while properly maintaining track conditions can improve the vehicle performance.展开更多
Landslide susceptibility evaluation plays an important role in disaster prevention and reduction.Feature-based transfer learning(TL)is an effective method for solving landslide susceptibility mapping(LSM)in target reg...Landslide susceptibility evaluation plays an important role in disaster prevention and reduction.Feature-based transfer learning(TL)is an effective method for solving landslide susceptibility mapping(LSM)in target regions with no available samples.However,as the study area expands,the distribution of land-slide types and triggering mechanisms becomes more diverse,leading to performance degradation in models relying on landslide evaluation knowledge from a single source domain due to domain feature shift.To address this,this study proposes a Multi-source Domain Adaptation Convolutional Neural Network(MDACNN),which combines the landslide prediction knowledge learned from two source domains to perform cross-regional LSM in complex large-scale areas.The method is validated through case studies in three regions located in southeastern coastal China and compared with single-source domain TL models(TCA-based models).The results demonstrate that MDACNN effectively integrates transfer knowledge from multiple source domains to learn diverse landslide-triggering mechanisms,thereby significantly reducing prediction bias inherent to single-source domain TL models,achieving an average improvement of 16.58%across all metrics.Moreover,the landslide susceptibility maps gener-ated by MDACNN accurately quantify the spatial distribution of landslide risks in the target area,provid-ing a powerful scientific and technological tool for landslide disaster management and prevention.展开更多
Background Cetobacterium somerae,a symbiotic microorganism resident in various fish intestines,is recognized for its beneficial effects on fish gut health.However,the mechanisms underlying the effects of C.somerae on ...Background Cetobacterium somerae,a symbiotic microorganism resident in various fish intestines,is recognized for its beneficial effects on fish gut health.However,the mechanisms underlying the effects of C.somerae on gut health remain unclear.In this experiment,we investigated the influence of C.somerae(CGMCC No.28843)on the growth performance,intestinal digestive and absorptive capacity,and intestinal structural integrity of juvenile grass carp(Ctenopharyngodon idella)and explored its potential mechanisms.Methods A cohort of 2,160 juvenile grass carp with an initial mean body weight of 11.30±0.01 g were randomly allocated into 6 treatment groups,each comprising 6 replicates(60 fish per replicate).The experimental diets were supplemented with C.somerae at graded levels of 0.00(control),0.68×10^(9),1.35×10^(9),2.04×10^(9),2.70×10^(9),and 3.40×10^(9)cells/kg feed.Following a 10-week experimental period,biological samples were collected for subsequent analyses.Results Dietary supplementation with C.somerae at 1.35×10^(9)cells/kg significantly enhanced growth performance,intestinal development,and nutrient retention rate in juvenile grass carp(P<0.05).The treatment resulted in increased intestinal acetic acid concentration and enhanced activities of digestive enzymes and brush border enzymes(P<0.05).Furthermore,it reduced intestinal permeability(P<0.05),preserved tight junctions(TJ)ultrastructural integrity,and increased the expression of TJ and adherens junctions(AJ)biomarkers at both protein and transcriptional levels(P<0.05).Mechanistically,these effects may be correlated with enhanced antioxidant capacity and coordinated modulation of the RhoA/ROCK,Sirt1,and PI3K/AKT signaling pathways.The appropriate supplementation levels,based on weight gain rate,feed conversion ratio,the activity of serum diamine oxidase and the content of lipopolysaccharide,were 1.27×10^(9),1.27×10^(9),1.34×10^(9)and 1.34×10^(9)cells/kg,respectively.Conclusions C.somerae improved intestinal digestive and absorptive capacity of juvenile grass carp,maintained intestinal structural integrity,and thus promoted their growth and development.This work demonstrates the potential of C.somerae as a probiotic for aquatic animals and provides a theoretical basis for its utilization in aquaculture.展开更多
In this paper,we investigate analytical numerical iterative strategies for the pursuit-evasion game involving spacecraft with leader–follower information.In the proposed problem,the interplay between two spacecraft g...In this paper,we investigate analytical numerical iterative strategies for the pursuit-evasion game involving spacecraft with leader–follower information.In the proposed problem,the interplay between two spacecraft gives rise to a dynamic and real-time game,complicated further by the presence of perturbation.The primary challenge lies in crafting control strategies that are both efficient and applicable to real-time game problems within a nonlinear system.To overcome this challenge,we introduce the model prediction and iterative correction technique proposed in model predictive static programming,enabling the generation of strategies in analytical iterative form for nonlinear systems.Subsequently,we proceed by integrating this model predictive framework into a simplified Stackelberg equilibrium formulation,tailored to address the practical complexities of leader–follower pursuit-evasion scenarios.Simulation results validate the effectiveness and exceptional efficiency of the proposed solution within a receding horizon framework.展开更多
基金supported by grants from the Clinical Research Founding of Southwest Hospital (Grant No. SWH2016BZGFKJ-30), Technological Innovation for Intelligent Medicine of Southwest Hospital (Grant No. SWH2016ZDCX4403) Talents Training Program of Third Military Medical University (Grant No. 2017MPRC18)
文摘Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice.
基金The National Natural Science Foundation of China under contract No.U22A20585the Education Research Project of Fujian Education Department under contract No.JAT200019.
文摘The change of coastal wetland vulnerability affects the ecological environment and the economic development of the estuary area.In the past,most of the assessment studies on the vulnerability of coastal ecosystems stayed in static qualitative research,lacking predictability,and the qualitative and quantitative relationship was not objective enough.In this study,the“Source-Pathway-Receptor-Consequence”model and the Intergovernmental Panel on Climate Change vulnerability definition were used to analyze the main impact of sea level rise caused by climate change on coastal wetland ecosystem in Minjiang River Estuary.The results show that:(1)With the increase of time and carbon emission,the area of high vulnerability and the higher vulnerability increased continuously,and the area of low vulnerability and the lower vulnerability decreased.(2)The eastern and northeastern part of the Culu Island in the Minjiang River Estuary of Fujian Province and the eastern coastal wetland of Meihua Town in Changle District are areas with high vulnerability risk.The area of high vulnerability area of coastal wetland under high emission scenario is wider than that under low emission scenario.(3)Under different sea level rise scenarios,elevation has the greatest impact on the vulnerability of coastal wetlands,and slope has less impact.The impact of sea level rise caused by climate change on the coastal wetland ecosystem in the Minjiang River Estuary is mainly manifested in the sea level rise,which changes the habitat elevation and daily flooding time of coastal wetlands,and then affects the survival and distribution of coastal wetland ecosystems.
基金funded by grants from National Natural Science Foundation of China(81100141 and 81570322 for JJ,81320108003 for JW)jointly supported by Boston Scientific
文摘BACKGROUND: Stent failure is more likely in the lipid rich and thrombus laden culprit lesions underlying ST-segment elevation myocardial infarction(STEMI).This study assessed the effectiveness of post-dilatation in primary percutaneous coronary intervention(pPCI) for acute STEMI.METHODS: The multi-center POST-STEMI trial enrolled 41 consecutive STEMI patients with symptom onset <12 hours undergoing manual thrombus aspiration and Promus Element stent implantation.Patients were randomly assigned to control group(n=20) or post-dilatation group(n=21) in which a non-compliant balloon was inflated to >16 atm pressure.Strut apposition and coverage were evaluated by optical coherence tomography(OCT) after intracoronary verapamil administration via thrombus aspiration catheter, post pPCI and at 7-month follow-up.The primary endpoint was rate of incomplete strut apposition(ISA) at 7 months after pPCI.RESULTS: There were similar baseline characteristics except for stent length(21.9 [SD 6.5] mm vs.26.0 [SD 5.8] mm, respectively, P=0.03).In post-dilatation vs.control group, ISA rate was lower(2.5% vs.4.5%, P=0.04) immediately after pPCI without affecting final TIMI flow 3 rate(95.2% vs.95.0%, P>0.05) or corrected TIMI frame counts(22.6±9.4 vs.22.0±9.7, P>0.05); and at 7-month follow-up(0.7% vs.1.8%, P<0.0001), the primary study endpoint, with similar strut coverage(98.5% vs.98.4%, P=0.63) and 1-year rate of major adverse cardiovascular events(MACE).CONCLUSION: In STEMI patients, post-dilatation after stent implantation and thrombus aspiration improved strut apposition up to 7 months without affecting coronary blood flow or 1-year MACE rate.Larger and longer term studies are warranted to further assess safety(Clinical Trials.gov identifier: NCT02121223).
文摘Organofluorines play a crucial role in medicine,agrochemicals,and materials science.Adding fluorine to molecules creates structures with specific beneficial properties or tunes properties through interactions with their environment.Many popular pharmaceuticals and agrochemicals contain fluorine because it enhances hydrogen bonding at protein’s active sites.
基金supported by the National key Research and Development Program of China under Grant No.2022YFA1602500the National Natural Science Foundation of China under Grant Nos.12174316 and 1236040286,and 12404306。
文摘The Landé g factors of Ba+are very important in high-precision measurement physics.The wave functions,energy levels,and Landég factors for the 6s ^(2)S_(1/2) and 5d 2D_(3/2,5/2) states of Ba+ions were calculated using the multi-configuration Dirac-Hartree-Fock method and the model-quantum electrodynamics(QED)method.The contributions of the electron correlation effects and QED effects were discussed in detail.The transition energies are in excellent agreement with the experimental results,with differences of approximately 5 cm^(−1).The presently calculated g factor of 2.0024905(16)for the 6S1/2 agrees very well with the available experimental and theoretical results,with a difference at a level of 10^(−6).For the 5D_(3/2,5/2) states,the present results of 0.7993961(126)and 1.2003942(190)agree with the experimental results of 0.7993278(3)[Phys.Rev.A 541199(1996)]and 1.20036739(14)[Phys.Rev.Lett.124193001(2020)]very well,with differences at the level of 10−5.
基金Supported by the Shandong Province Traditional Chinese Medicine Technology Project,No.Q-2023147the Weifang Health Commission Research Project,No.WFWSJK-2023-033+3 种基金the Weifang City Science and Technology Development Plan(Medical Category),No.2023YX057the Weifang Medical University 2022 Campus Level Education and Teaching Reform and Research Project,No.2022YB051Norman Bethune Public Welfare Foundation,No.ezmr2023-037Special Research Project on Optimized Management of Acute Pain,Wu Jieping Medical Foundation.
文摘BACKGROUND Delayed wound healing is a common clinical complication following gastric cancer radical surgery,adversely affecting patient prognosis.With advances in artificial intelligence,machine learning offers a promising approach for developing predictive models that can identify high-risk patients and support early clinical intervention.AIM To construct machine learning-based risk prediction models for delayed wound healing after gastric cancer surgery to support clinical decision-making.METHODS We reviewed a total of 514 patients who underwent gastric cancer radical surgery under general anesthesia from January 1,2014 to December 30,2023.Seventy percent of the dataset was selected as the training set and 30%as the validation set.Decision trees,support vector machines,and logistic regression were used to construct a risk prediction model.The performance of the model was evaluated using accuracy,recall,precision,F1 index,and area under the receiver operating characteristic curve and decision curve.RESULTS This study included five variables:Sex,elderly,duration of abdominal drainage,preoperative white blood cell(WBC)count,and absolute value of neutrophils.These variables were selected based on their clinical relevance and statistical significance in predicting delayed wound healing.The results showed that the decision tree model outperformed the logistic regression and support vector machine models in both the training and validation sets.Specifically,the decision tree model achieved higher accuracy,F1 index,recall,and area under the curve(AUC)values.The support vector machine model also demonstrated better performance than logistic regression,with higher accuracy,recall,and F1 index,but a slightly lower AUC.The key variables of sex,elderly,duration of abdominal drainage,preoperative WBC count,and absolute value of neutrophils were found to be strong predictors of delayed wound healing.Patients with longer duration of abdominal drainage had a significantly higher risk of delayed wound healing,with a risk ratio of 1.579 compared to those with shorter duration of abdominal drainage.Similarly,preoperative WBC count,sex,elderly,and absolute value of neutrophils were associated with a higher risk of delayed wound healing,highlighting the importance of these variables in the model.CONCLUSION The model is able to identify high-risk patients based on sex,elderly,duration of abdominal drainage,preoperative WBC count,and absolute value of neutrophils can provide valuable insights for clinical decision-making.
基金financially supported by China Postdoctoral Science Foundation(No.2022T150708)National Key Research and Development Program of China(No.2023YFF1104600)National Natural Science Foundation of China(Nos.32072305,32102089)。
文摘Aflatoxins B1(AFB1)contamination in agro-food holds great threaten to human and animal health.Conventional test strips for rapid AFB1 visualized monitoring remains challenged by improvement of sensitivity and matrix interference resistance.In this case,we developed a portable electrochemiluminescence(ECL)imaging test strip with dual-signal outputs for AFB1 quantification in corn samples.RuPEI@SiO_(2)@Au nanospheres were synthesized for bonding with anti-AFB1 antibody and then colorimetrical signal-reported on test line through the capillary flow at strips.Meanwhile,ECL imaging signal of the constructed carbon-ink-based working electrode on polyvinyl chloride substrate of strips was exported under an applied potential of 1.25 V.The whole ECL test strips not only endowed convenient colorimetric responses but guaranteed quick-witted ECL image distinguishment even at extremely low AFB1 content.The detection limit of this ECL imaging-integrated mode was 10-fold lower than that of only colorimetric mode.Furthermore,satisfactory selectivity,reliability and practicability of the as-proposed ECL test strips were demonstrated.This work offered a promising platform for on-site,accurate and sensitive detection of pollutants in foods.
基金supported by the National Key R&D Program of China(No.2020YFC1806801).
文摘Soil bioaccessible and labile As were extracted using in vitro,diffusive gradients in thin films(DGT)and chemical extraction methods.The results showed that As(Ⅲ)was readily converted to As(Ⅴ)in the soils,which was promoted by alkaline conditions and higher content of easily reducible Mn.As(Ⅴ)was not readily reduced to As(Ⅲ)in these soils.The effect of soil pH on bioaccessible As content by in vitro method and labile As content by DGT methodwere inconsistent among different soils due to the coincidence of As(Ⅲ)and As(Ⅴ),with As(Ⅲ)being more readily mobilized in acidic environment while the opposite was true for As(Ⅴ).The labile As extracted by phosphate was significantly correlated with that extracted by in vitro method,while the labile As extracted by the DGT was correlated with that extracted by the CaCl_(2) method.The labile As extracted by the DGT was much lower than that by the in vitro and phosphate methods.The in vitro and phosphate methods extracted As in soils which is tightly bound to Fe oxides through dissolution,complexation and ion exchange.In contrast,the DGT method relied on the adsorption of soil labile As onto ZrO-based binding layer.The higher contents of soil Fe oxides and greater adsorption capacity for As led to the lower content of As measured by the DGT method.In conclusion,the in vitro and phosphate extraction are potential to be used to predict soil bioaccessible As.The DGT method is more suitable for ecological risk prediction.
基金supported by the National Natural Science Foundation of China(Grant Nos.52002344,U2034210,and 61960206010)the Development Project of State Key Laboratory of Rail Transit Vehicle System(Grant No.2022TPL_T09)。
文摘Track irregularity from rail alternate side wear is manifested as uneven rail wear waveforms alternating in the left and right rails with equal intervals,which will cause carbody sway behaviour of railway vehicles and greatly influences the passenger comfort.In this work,the carbody sway behaviour and mechanism due to track irregularity from rail alternate side wear and possible solutions to this issue were studied by the field testing and numerical calculation approaches.First,the carbody sway of an urban rail transit train is introduced with full-scale field tests,through which the rail alternate side wear is characterized and the formatted track irregularity are presented.Then,multibody vehicle dynamic models are developed to reproduce the carbody sway behaviour induced by the track irregularity from the rail alternate side wear.The creep forces acting on the wheel and rail are preliminarily discussed to study the influence of the carbody sway on the wear of the wheel flange and the rail corner.Finally,some potential solutions,e.g.improving the damping ratio of carbody rigid mode and rail grinding,are proposed to relieve this issue.It is concluded that an increased damping ratio of the carbody mode can alleviate the carbody sway and wheel–rail interactions,while properly maintaining track conditions can improve the vehicle performance.
基金the National Natural Science Foundation of China(Grant No.42301002,and 52109118)Fujian Provincial Water Resources Science and Technology Project(Grant No.MSK202524)Guidance fund for Science and Technology Program,Fujian province(Grant No.2024Y0002).
文摘Landslide susceptibility evaluation plays an important role in disaster prevention and reduction.Feature-based transfer learning(TL)is an effective method for solving landslide susceptibility mapping(LSM)in target regions with no available samples.However,as the study area expands,the distribution of land-slide types and triggering mechanisms becomes more diverse,leading to performance degradation in models relying on landslide evaluation knowledge from a single source domain due to domain feature shift.To address this,this study proposes a Multi-source Domain Adaptation Convolutional Neural Network(MDACNN),which combines the landslide prediction knowledge learned from two source domains to perform cross-regional LSM in complex large-scale areas.The method is validated through case studies in three regions located in southeastern coastal China and compared with single-source domain TL models(TCA-based models).The results demonstrate that MDACNN effectively integrates transfer knowledge from multiple source domains to learn diverse landslide-triggering mechanisms,thereby significantly reducing prediction bias inherent to single-source domain TL models,achieving an average improvement of 16.58%across all metrics.Moreover,the landslide susceptibility maps gener-ated by MDACNN accurately quantify the spatial distribution of landslide risks in the target area,provid-ing a powerful scientific and technological tool for landslide disaster management and prevention.
基金financially supported by the earmarked fund for the earmarked fund for CARS(CARS-45)National Science Fund for Distinguished Young Scholars of China(32425056)+1 种基金the National Key R&D Program of China(2023YFD2400600)Sichuan Innovation Team of National Modern Agricultural Industry Technology System(SCCXTD-2024-16).
文摘Background Cetobacterium somerae,a symbiotic microorganism resident in various fish intestines,is recognized for its beneficial effects on fish gut health.However,the mechanisms underlying the effects of C.somerae on gut health remain unclear.In this experiment,we investigated the influence of C.somerae(CGMCC No.28843)on the growth performance,intestinal digestive and absorptive capacity,and intestinal structural integrity of juvenile grass carp(Ctenopharyngodon idella)and explored its potential mechanisms.Methods A cohort of 2,160 juvenile grass carp with an initial mean body weight of 11.30±0.01 g were randomly allocated into 6 treatment groups,each comprising 6 replicates(60 fish per replicate).The experimental diets were supplemented with C.somerae at graded levels of 0.00(control),0.68×10^(9),1.35×10^(9),2.04×10^(9),2.70×10^(9),and 3.40×10^(9)cells/kg feed.Following a 10-week experimental period,biological samples were collected for subsequent analyses.Results Dietary supplementation with C.somerae at 1.35×10^(9)cells/kg significantly enhanced growth performance,intestinal development,and nutrient retention rate in juvenile grass carp(P<0.05).The treatment resulted in increased intestinal acetic acid concentration and enhanced activities of digestive enzymes and brush border enzymes(P<0.05).Furthermore,it reduced intestinal permeability(P<0.05),preserved tight junctions(TJ)ultrastructural integrity,and increased the expression of TJ and adherens junctions(AJ)biomarkers at both protein and transcriptional levels(P<0.05).Mechanistically,these effects may be correlated with enhanced antioxidant capacity and coordinated modulation of the RhoA/ROCK,Sirt1,and PI3K/AKT signaling pathways.The appropriate supplementation levels,based on weight gain rate,feed conversion ratio,the activity of serum diamine oxidase and the content of lipopolysaccharide,were 1.27×10^(9),1.27×10^(9),1.34×10^(9)and 1.34×10^(9)cells/kg,respectively.Conclusions C.somerae improved intestinal digestive and absorptive capacity of juvenile grass carp,maintained intestinal structural integrity,and thus promoted their growth and development.This work demonstrates the potential of C.somerae as a probiotic for aquatic animals and provides a theoretical basis for its utilization in aquaculture.
基金supported,in part,by the National Natural Science Foundation of China(Nos.12372050 and 62088101)the Zhejiang Provincial Natural Science Foundation of China(No.LR20F030003).
文摘In this paper,we investigate analytical numerical iterative strategies for the pursuit-evasion game involving spacecraft with leader–follower information.In the proposed problem,the interplay between two spacecraft gives rise to a dynamic and real-time game,complicated further by the presence of perturbation.The primary challenge lies in crafting control strategies that are both efficient and applicable to real-time game problems within a nonlinear system.To overcome this challenge,we introduce the model prediction and iterative correction technique proposed in model predictive static programming,enabling the generation of strategies in analytical iterative form for nonlinear systems.Subsequently,we proceed by integrating this model predictive framework into a simplified Stackelberg equilibrium formulation,tailored to address the practical complexities of leader–follower pursuit-evasion scenarios.Simulation results validate the effectiveness and exceptional efficiency of the proposed solution within a receding horizon framework.
