Interfacial superconductivity(IS)has been a topic of intense interest in condensed matter physics,due to its unique properties and exotic photoelectrical performance.However,there are few reports about IS systems cons...Interfacial superconductivity(IS)has been a topic of intense interest in condensed matter physics,due to its unique properties and exotic photoelectrical performance.However,there are few reports about IS systems consisting of two insulators.Here,motivated by the emergence of an insulator-metal transition in type-Ⅲ heterostructures and the superconductivity in some“special”two-dimensional(2D)semiconductors via electron doping,we predict that the 2D heterostructure SnSe_(2)/PtTe_(2) is a model system for realizing IS by using firstprinciples calculations.Our results show that due to slight but crucial interlayer charge transfer,SnSe_(2)/PtTe_(2) turns to be a type-Ⅲ heterostructure with metallic properties and shows a superconducting transition with the critical temperature(T_(c))of 3.73 K.Similar to the enhanced electron–phonon coupling(EPC)in the electrondoped SnSe_(2) monolayer,the IS in the SnSe_(2)/PtTe_(2) heterostructure mainly originates from the metallized SnSe_(2) layer.Furthermore,we find that its superconductivity is sensitive to tensile lattice strain,forming a domeshaped superconducting phase diagram.Remarkably,at 7%biaxial tensile strain,the superconducting T_(c) can increase more than twofold(8.80 K),resulting from softened acoustic phonons at the𝑀point and enhanced EPC strength.Our study provides a concrete example for realizing IS in type-Ⅲ heterostructures,which waits for future experimental verification.展开更多
The design and construction of heterojunction photocatalysts,which possess a staggered energy band structure and appropriate interfacial contact,is an effective way to achieve outstanding photocatalytic performance.In...The design and construction of heterojunction photocatalysts,which possess a staggered energy band structure and appropriate interfacial contact,is an effective way to achieve outstanding photocatalytic performance.In this study,2D/2D BiOBr/g‐C_(3)N_(4)heterojunctions were successfully obtained by a convenient in situ self‐assembly route.Under simulated sunlight irradiation,99%of RhB(10 mg·L–1,100 mL)was efficiently degraded by 1.5‐BiOBr/g‐C_(3)N_(4)within 30 min,which is better than the performance of both BiOBr and g‐C_(3)N_(4),and it has superior stability.In addition,the composite also exhibits enhanced photocatalytic activity for H2 production.The enhanced activity can be attributed to the intimate interface contact,the larger surface area,and the highly efficient separation of photoinduced electron–hole pairs.Based on the experimental results,a novel S‐scheme model was proposed to illuminate the transfer process of charge carriers.This study presents a simple way to develop novel step‐scheme photocatalysts for environmental and related applications.展开更多
Ag nanoparticles (NPs) were deposited on the surface of g-C3N4 (CN) by an in situ calcination method. NiS was successfully loaded onto the composites by a hydrothermal method. The results showed that the 10 wt%-NiS/1....Ag nanoparticles (NPs) were deposited on the surface of g-C3N4 (CN) by an in situ calcination method. NiS was successfully loaded onto the composites by a hydrothermal method. The results showed that the 10 wt%-NiS/1.0 wt%-Ag/CN composite exhibits excellent photocatalytic H2 generation performance under solar-light irradiation. An H2 production rate of 9.728 mmol·g^-1·h^-1 was achieved, which is 10.82-, 3.45-, and 2.77-times higher than those of pure g-C3N4, 10 wt%-NiS/CN, and 1.0 wt%-Ag/CN composites, respectively. This enhanced photocatalytic H2 generation can be ascribed to the co-decoration of Ag and NiS on the surface of g-C3N4, which efficiently improves light harvesting capacity, photogenerated charge carrier separation, and photocatalytic H2 production kinetics. Thus, this study demonstrates an effective strategy for constructing excellent g-C3N4-related composite photocatalysts for H2 production by using different co-catalysts.展开更多
Effective bulk phase and surface charge separation is critical for charge utilization during the photo-catalytic energy conversion process.In this work,the ternary Ni_(2)P-NiS/twinned Mn_(0.5)Cd_(0.5)S(T-MCS)nanohybri...Effective bulk phase and surface charge separation is critical for charge utilization during the photo-catalytic energy conversion process.In this work,the ternary Ni_(2)P-NiS/twinned Mn_(0.5)Cd_(0.5)S(T-MCS)nanohybrids were successfully constructed via combining Ni_(2)P-NiS with T-MCS solid solution for visible light photocatalytic H_(2)evolution.T-MCS is composed of zinc blende Mn_(0.5)Cd_(0.5)S(ZB-MCS)and wurtzite Mn_(0.5)Cd_(0.5)S(WZ-MCS)and those two alternatively arranged crystal phases endow T-MCS with excellent bulk phase charge separation performance for the slight energy level difference between ZB-MCS and WZ-MCS.S-scheme carriers transfer route between NiS and T-MCS can accelerate the interfacial charge separation and retain the active electrons and holes,meanwhile,co-catalyst Ni_(2)P as electron receiver and proton reduction center can further optimize the H_(2)evolution reaction kinetics based on the surface Schottky barrier effect.The above-formed homo-heterojunctions can establish multiple charge transfer channels in the bulk phase of T-MCS and interface of T-MCS and Ni_(2)P-NiS.Under the synergistic effect of twinned homojunction,S-scheme heterojunction,and Schottky barrier,the ternary Ni_(2)P-NiS/T-MCS com-posite manifested an H_(2)production rate of 122.5 mmol h^(-1)g^(-1),which was 1.33,1.24,and 2.58 times higher than those of the NiS/T-MCS(92.4 mmol h^(-1)g^(-1)),Ni_(2)P/T-MCS(98.4 mmol h^(-1)g^(-1)),and T-MCS(47.5 mmol h^(-1)g^(-1)),respectively.This work demonstrates a promising strategy to develop efficient sul-fides photocatalyst toward targeted solar-driven H_(2)evolution through homo-heterojunction engineering.展开更多
Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of pho-tocatalyst.In this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for ...Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of pho-tocatalyst.In this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for organic pollutants degradation.This Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction exhibited much higher pho-tocatalytic activity towards Rhodamine B(92.24%,expose to visible light for 60 min),norfloxacin(81.73%,expose to visible light for 90 min)and levofloxacin(87.46%,expose to visible light for 90 min)than pure Bi_(2)WO_(6)and pure AgInS_(2).Toxicity analysis indicated the low environmental toxicity of Rhodamine B degradation intermediates for Rye seeds and Sudangrass seeds germination and growth.Mechanism study displayed that AgInS_(2)and Bi_(2)WO_(6)work as the primary photocatalyst to form·O_(2)−and ·OH,respectively.The improved photocatalytic activity of the Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was due to the im-proved light response range and intensified carrier separation capability.Additionally,a S-scheme charge transfer mechanism including multiple charge transfer channels was proposed.This work could provide an effective strategy for organic pollutants degradation in wastewater.展开更多
Developing machine learning frameworks with predictive power,interpretability,and transferability is crucial,yet it faces challenges in the field of electrocatalysis.To achieve this,we employed rigorous feature engine...Developing machine learning frameworks with predictive power,interpretability,and transferability is crucial,yet it faces challenges in the field of electrocatalysis.To achieve this,we employed rigorous feature engineering to establish a finely tuned gradient boosting regressor(GBR)model,which adeptly captures the physical complexity from feature space to target variables.We demonstrated that environmental electron effects and atomic number significantly govern the success of the mapping process via global and local explanations.The finely tuned GBR model exhibits exceptional robustness in predicting CO adsorption energies(R_(ave)^(2)=0.937,RMSE=0.153 eV).Moreover,the model demonstrated remarkable transfer learning ability,showing excellent predictive power for OH,NO,and N_(2) adsorption.Importantly,the GBR model exhibits exceptional predictive capability across an extensive search space,thereby demonstrating profound adaptability and versatility.Our research framework significantly enhances the interpretability and transferability of machine learning in electrocatalysis,offering vital insights for further advancements.展开更多
This study investigated the removal of dissolved organic matter（DOM） from real dyeing bio-treatment effluents（DBEs） with the use of a novel magnetic anion exchange resin（NDMP）.DOMs in two typical DBEs were fract...This study investigated the removal of dissolved organic matter（DOM） from real dyeing bio-treatment effluents（DBEs） with the use of a novel magnetic anion exchange resin（NDMP）.DOMs in two typical DBEs were fractionized using DAX-8/XAD-4 resin and ultrafiltration membranes. The hydrophilic fractions and the low molecular weight（MW）（〈3 kDa） DOM fractions constituted a major portion（〉50%） of DOMs for the two effluents. The hydrophilic and low MW fractions of both effluents were the greatest contributors of specific UV254absorbance（SUVA254）,and the SUVA254 of DOM fractions decreased with hydrophobicity and MW. Two DBEs exhibited acute and chronic biotoxicities. Both acute and chronic toxicities of DOM fractions increased linearly with the increase of SUVA254 value. Kinetics of dissolved organic carbon（DOC） removal via NDMP treatment was performed by comparing it with that of particle active carbon（PAC）. Results indicated that the removal of DOC from DBEs via NDMP was 60%,whereas DOC removals by PAC were lower than 15%. Acidic organics could be significantly removed with the use of NDMP. DOM with large MW in DBE could be removed significantly by using the same means. Removal efficiency of NDMP for DOM decreased with the decrease of MW. Compared with PAC,NDMP could significantly reduce the acute and chronic bio-toxicities of DBEs. NaCl/NaOH mixture regenerants,with selected concentrations of 10% NaCl（m/m）/1%NaOH（m/m）,could improve desorption efficiency.展开更多
Two-dimensional mesoporous ultrathin Cd0.5Zn0.5S nanosheets with a thickness of~1.5 nm were fabricated using a multistep chemical transformation strategy involving inorganic–organic hybrid ZnS-ethylenediamine(denoted...Two-dimensional mesoporous ultrathin Cd0.5Zn0.5S nanosheets with a thickness of~1.5 nm were fabricated using a multistep chemical transformation strategy involving inorganic–organic hybrid ZnS-ethylenediamine(denoted as ZnS(en)0.5)as a hard template.Inorganic–organic hybrid ZnS(en)0.5,Cd0.5Zn0.5S(en)x,and Cd0.5Zn0.5S nanosheets were sequentially fabricated,and their transformation processes were analyzed in detail.The fabricated Cd0.5Zn0.5S nanosheets exhibited high photocatalytic hydrogen evolution reaction activity in the presence of a sacrificial agent.The Cd0.5Zn0.5S nanosheets exhibited remarkably high H2 production activity of~1395μmol∙h^−1∙g^−1 in pure water with no co-catalyst,which is the highest value reported thus far for bare photocatalysts,to the best of our knowledge.The high activity of these nanosheets is attributed to their distinct nanostructure(e.g.,short transfer distance of photoinduced charge carriers,large number of unsaturated surface atoms,and large surface area).Moreover,ternary NiCo2S4 nanoparticles were employed to facilitate the charge separation and enhance the surface kinetics of H2 evolution.The H2 production rate reached~62.2 and~2436μmol∙h^−1∙g^−1 in triethanolamine and pure water,respectively,over the NiCo2S4/Cd0.5Zn0.5S heterojunctions.The result indicated that the Schottky junction was critical to the enhanced activity.The proposed method can be used for fabricating other highly efficient CdZnS-based photocatalysts for solar-energy conversion or other applications.展开更多
In this work,a novel plasmon-assisted UV-vis-NIR-driven W_(18)O_(49)/Cd_(0.5)Zn_(0.5)S heterostructure photocatalyst was obtained by a facile ultrasonic-assisted electrostatic self-assembly strategy.The hybrid exhibit...In this work,a novel plasmon-assisted UV-vis-NIR-driven W_(18)O_(49)/Cd_(0.5)Zn_(0.5)S heterostructure photocatalyst was obtained by a facile ultrasonic-assisted electrostatic self-assembly strategy.The hybrid exhibits extraordinary H2 evolution activity of 147.7 mmol·g^(-1)·h^(-1) at room temperature due to the efficient charge separation and expanded light absorption.Our investigation shows that the unique Step-scheme(S-scheme)charge transfer and the‘hot electron’injection are both responsible for the extraordinary H2 evolution process,depending on the wavelength of the incident light.Moreover,by accelerating the surface reaction kinetics,the activity can be further elevated to 306.1 mmol·g^(-1)·h^(-1),accompanied by a high apparent quantum yield of 45.3% at 365±7.5 nm.This work provides us a potential strategy for the highly efficient conversion of the solar energy by elaborately combining a nonstoichiometric ratio plasmonic material with an appropriate active photocatalyst.展开更多
Optimal use of water and fertilizers can enhance winter wheat yield and increase the efficiencies of water and fertilizer usage in dryland agricultural systems. In order to optimize water and nitrogen （N） management...Optimal use of water and fertilizers can enhance winter wheat yield and increase the efficiencies of water and fertilizer usage in dryland agricultural systems. In order to optimize water and nitrogen （N） management for winter wheat, we conducted field experiments from 2006 to 2008 at the Changwu Agro-ecological Experimental Station of the Chinese Academy of Sciences on the Loess Plateau, China. Regression models of wheat yield and evapotranspiration （ET） were established in this study to evaluate the water and fertilizer coupling effects and to determine the optimal coupling domain. The results showed that there was a positive effect of water and N fertilizer on crop yield, and optimal irrigation and N inputs can significantly increase the yield of winter wheat. In the drought year （2006-2007）, the maximum yield （Yma~） of winter wheat was 9.211 t/hm2 for the treatment with 324 mm irriga- tion and 310 kg/hm2 N input, and the highest water use efficiency （WUE） of 16.335 kg/（hm2.mm） was achieved with 198 mm irrigation and 274 kg/hm2 N input. While in the normal year （2007-2008）, the maximum winter wheat yield of 10.715 t/hm2 was achieved by applying 318 mm irrigation and 291 kg/hm2 N, and the highest WUE was 18.69 kg/（hm2.mm） with 107 mm irrigation and 256 kg/hm2 N input. Crop yield and ET response to irrigation and N inputs followed a quadratic and a line function, respectively. The optimal coupling domain was determined using the elas- ticity index （El） and its expression in the water-N dimensions, and was represented by an ellipse, such that the global maximum WUE （WUErnax） and Ymax values corresponded to the left and right end points of the long axis, respectively. Considering the aim to get the greatest profit in practice, the optimal coupling domain was represented by the lower half of the ellipse, with the Yma~ and WUE^ax on the two end points of the long axis. Overall, we found that the total amount of irrigation for winter wheat should not exceed 324 ram. In addition, our optimal coupling domain visually reflects the optimal range of water and N inputs for the maximum winter wheat yield on the Loess Plateau, and it may also provide a useful reference for identifying appropriate water and N inputs in agricultural applications.展开更多
In large continental orogens, an important research topic is the behavior of deep crustal and upper mantle deformation, and the flow styles of ductile material. The morphology of the eastern margin of the Tibetan plat...In large continental orogens, an important research topic is the behavior of deep crustal and upper mantle deformation, and the flow styles of ductile material. The morphology of the eastern margin of the Tibetan plateau, adjacent to the Sichuan basin, is characterized by very steep relief with high mountain ranges. The crust beneath this region slows the velocities in the middle and lower crust. We have adopted a relatively dense network to inverse the detailed structure of the crust and upper mantle along the eastern margin of the Tibetan plateau and Sichuan basin, using teleseismic data via receiver function analysis. The results are in-line with the hypothesis that viscous crustal material is flowing beneath the eastern margin of the Tibetan plateau and that this process drives overlying crustal material around the strong and rigid Sichuan basin. When the viscous material hits this obstruction, flows are divided into two or more branches with different directions. The upper part of the upwelling viscous flow produces the pressure to intrude the upper crust, thereby driving uplift of mountain ranges and high peaks. In contrast, the lower part of the downwelling viscous flow produces the pressure to intrude the lower crust and upper mantle to deepen the Moho discontinuity, causing observed crustal thickening.展开更多
The incidence of colorectal cancer(CRC)is increasing in China,with high mortality.Here,we aimed to evaluate the latest clinicopathological features and prognostic value of the KRAS/NRAS/BRAF mutation status in CRC pat...The incidence of colorectal cancer(CRC)is increasing in China,with high mortality.Here,we aimed to evaluate the latest clinicopathological features and prognostic value of the KRAS/NRAS/BRAF mutation status in CRC patients in Central China.The clinical data of 1549 CRC patients with stage I-IV disease diagnosed at Union Hospital,Tongji Medical College of Huazhong University of Science and Technology from 2015 to 2017 were collected and analyzed retrospectively.KRAS/NRAS/BRAF mutations were detected by real-time quantitative polymerase chain reaction(q-PCR)in 410 CRC patients,with mutation frequencies of KRAS,NRAS and BRAF of 47.56%,2.93%and 4.15%,respectively.The gene mutation status and clinicopathological characteristics of 410 patients with CRC who underwent qPCR were analyzed.The KRAS and BRAF gene mutations were related to the pathological differentiation and number of metastatic lymph nodes.The BRAF gene mutation was also associated with cancer thrombosis in blood vessels.Cox regression analysis showed that there was no statistically significant difference in the overall survival(OS)between patients with KRAS,NRAS mutants and wild-type CRC patients,while the BRAF gene mutation was negatively correlated with the OS rate of CRC patients.It is suggested that the BRAF gene mutation may be an independent risk factor for the prognosis of CRC.展开更多
A numerical triangulation and transformation into the time domain of a Kirchhoff approximation(KA)method is proposed for the modeling of bistatic scattering from an underwater non-penetrable target.The time domain sol...A numerical triangulation and transformation into the time domain of a Kirchhoff approximation(KA)method is proposed for the modeling of bistatic scattering from an underwater non-penetrable target.The time domain solution in this approximation can be split up into two parts:the solution of reflected field,contributing around the specular direction,and the solution of shadow radiation,contributing around the forward direction.An average solution in the time domain satisfying the reciprocity principle is presented.The solution is expressed in terms of non-singular functions.The proposed method is validated against a normal mode method for bistatic scattering from a rigid sphere.Moreover,the reflected and shadow highlights on the surface of the sphere are shown to verify the integration surface of the reflected field and shadow radiation.It is also tested against a finite element method and an experiment involving a scaled Benchmark Target Strength Simulation Submarine model.The time-angle bistatic spectra for the model are evaluated by the direct and transformed average solutions of KA,and the former accelerates its speed of calculation.The results are good,and show that this method can be used to predict the bistatic scattered field of a non-penetrable target.展开更多
Optomagnetic multifunctional composite has attracted much attention in recent years because of its promising application prospect in bioimaging,analysis,detection,disease diagnosis,and targeted drug delivery.To explor...Optomagnetic multifunctional composite has attracted much attention in recent years because of its promising application prospect in bioimaging,analysis,detection,disease diagnosis,and targeted drug delivery.To explore a dual-targeted therapy for cancer,a novel class of optomagnetic multifunctional composite(UCNP-Fe_(3)O_(4)@MSNs-FA)was successfully synthesized by using upconversion nanoparticles(UCNPs)as nucleus,embedding Fe_(3)O_(4)nanoparticles into the SiO_(2)coating layer,and modifying the surface with folic acid(FA)to strengthen its tumor targeting performance.The properties of the composite were extensively studied.The obtained composite possesses excellent upconversion fluorescence,good dispersion,high specific surface area(229.347 m^(2)/g),and saturation magnetization value(10.9 A m^(2)/g).Its drug loading co ntent and encapsulation efficiency can reach as high as 14.2%and 47.3%,respectively,using doxorubicin hydrochloride(DOX)as model drug.The DOX-UCNP-Fe_(3)O_(4)@MSNs-FA system shows excellent sustained drug release and strong pH-dependent performance,in which the drug release would be accelerated at the slightly acidic microenvironment in the tumor;thus,the system can realize the targeted treatment of cancers.The viability of L929 cells demonstrates the good biocompatibility of the composite.Furthermore,DOX-UCNP-Fe_(3)O_(4)@MSNs-FA exhibits specific cytotoxicity to folate receptor(FR)positive tumor cells,whereas DOX has weak toxicity to FR-negative cells.Therefore,the as-prepared UCNP-Fe_(3)O_(4)@MSNs-FA can potentially be used as an anti-cancer targeted drug delivery system and enhance the therapeutic efficacy against FR-positive tumor cells.展开更多
Influenza A virus(IAV),responsible for seasonal epidemics and recurring pandemics,represents a global threat to public health.Given the risk of a potential IAV pandemic,it is increasingly important to better understan...Influenza A virus(IAV),responsible for seasonal epidemics and recurring pandemics,represents a global threat to public health.Given the risk of a potential IAV pandemic,it is increasingly important to better understand virushost interactions and develop new anti-viral strategies.Here,we reported nonmuscle myosin IIA(MYH9)-mediated regulation of IAV infection.MYH9 depletion caused a profound inhibition of IAV infection by reducing viral attachment and internalization in human lung epithelial cells.Surprisingly,overexpression of MYH9 also led to a significant reduction in viral productive infection.Interestingly,overexpression of MYH9 retained viral attachment,internalization,or uncoating,but suppressed the viral ribonucleoprotein(vRNP)activity in a minigenome system.Further analyses found that excess MYH9 might interrupt the formation of vRNP by interacting with the viral nucleoprotein(NP)and result in the reduction of the completed vRNP in the nucleus,thereby inhibiting subsequent viral RNA transcription and replication.Together,we discovered that MYH9 can interact with IAV NP protein and engage in the regulation of vRNP complexes,thereby involving viral replication.These findings enlighten new mechanistic insights into the complicated interface of host-IAV interactions,ultimately making it an attractive target for the generation of antiviral drugs.展开更多
BACKGROUND： Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained b...BACKGROUND： Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE： This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN： A case-control observation. SETTING： Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS： Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition （insomnia is defined by a Pittsburgh Sleep Quality Index score 〉 7）, the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received examinations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The protocol was approved by the Hospital＇s Ethics Committee. METHODS： Following admission, each subject＇s neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an autonomic nerve analyzer （Weijin Science and Technology Co., Ltd., Taiwan）. Each frequency spectrum parameter of heart rate variability was obtained, including very low frequency, low frequency, high frequency, total power, R-R interval, and its mean square. In addition, percentage of low frequency, high frequency, and ratio of low frequency to high frequency were calculated. For each heart rate frequency spectrum parameter, the difference between groups was analyzed. Moreover, correlations of each frequency spectrum parameter with insomnia and disease condition were analyzed. Data from each index, which were not normally distributed, were processed by logarithmic transformation. The t-test was used for the comparison of intergroup differences. Single-factor linear regression analysis and t-test were used for the analysis of factor-factor correlation and coefficient of correlation, respectively. MAIN OUTCOME MEASURES： （1） Differences of scores in the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index between the simple cerebral infarction group and the cerebral infarction complicated by insomnia group. （2） Differences of heart rate variability parameters between the simple cerebral infarction group and the control group. （3） Correlation of heart rate variability parameters, the Pittsburgh Sleep Quality Index score, and the neurological impairment score. RESULTS： Sixty patients and thirty healthy controls were included in the final analysis. （1） The scores of the Pittsburgh Sleep Quality Index and the neurological impairment were significantly higher in the cerebral infarction complicated by insomnia group compared to the simple cerebral infarction group （P 〈 0.05-0.01）. （2） R-R interval was significantly longer in the simple cerebral infarction group than in the control group, while R-R interval variance and high-frequency band were significantly lower in the simple cerebral infarction group compared to the control group （P 〈 0.05）. （3） For cerebral infarction patients with insomnia, the Pittsburgh Sleep Quality Index score was significantly positively correlated with neurological impairment （r = 0.54, P 〈 0.01）. The low-frequency band, very low-frequency band, high-frequency band, R-R interval variance, total power, R-R interval, and the percentage of high-frequency were significantly negatively correlated with the National Institutes of Health Stroke Scale score （r =4）.45 to 4）.90, P 〈 0.054）.01） and with the Pittsburgh Sleep Quality Index scores （r = 4）.56 to 4）.36, P 〈 0.054）.01）. CONCLUSION： Each heart rate variability parameter can be used as an index for assessing dyssomnia and neurologic impairment （r =4）.56 to 4）.36, P 〈 0.054）.01）.展开更多
基金supported by the National Key R&D Program of China (Grant Nos.2022YFA1403103 and 2019YFA0308603)the National Natural Science Foundation of China (Grant No.12304167)the Shandong Provincial Natural Science Foundation of China (Grant No.ZR2023QA020)。
文摘Interfacial superconductivity(IS)has been a topic of intense interest in condensed matter physics,due to its unique properties and exotic photoelectrical performance.However,there are few reports about IS systems consisting of two insulators.Here,motivated by the emergence of an insulator-metal transition in type-Ⅲ heterostructures and the superconductivity in some“special”two-dimensional(2D)semiconductors via electron doping,we predict that the 2D heterostructure SnSe_(2)/PtTe_(2) is a model system for realizing IS by using firstprinciples calculations.Our results show that due to slight but crucial interlayer charge transfer,SnSe_(2)/PtTe_(2) turns to be a type-Ⅲ heterostructure with metallic properties and shows a superconducting transition with the critical temperature(T_(c))of 3.73 K.Similar to the enhanced electron–phonon coupling(EPC)in the electrondoped SnSe_(2) monolayer,the IS in the SnSe_(2)/PtTe_(2) heterostructure mainly originates from the metallized SnSe_(2) layer.Furthermore,we find that its superconductivity is sensitive to tensile lattice strain,forming a domeshaped superconducting phase diagram.Remarkably,at 7%biaxial tensile strain,the superconducting T_(c) can increase more than twofold(8.80 K),resulting from softened acoustic phonons at the𝑀point and enhanced EPC strength.Our study provides a concrete example for realizing IS in type-Ⅲ heterostructures,which waits for future experimental verification.
文摘The design and construction of heterojunction photocatalysts,which possess a staggered energy band structure and appropriate interfacial contact,is an effective way to achieve outstanding photocatalytic performance.In this study,2D/2D BiOBr/g‐C_(3)N_(4)heterojunctions were successfully obtained by a convenient in situ self‐assembly route.Under simulated sunlight irradiation,99%of RhB(10 mg·L–1,100 mL)was efficiently degraded by 1.5‐BiOBr/g‐C_(3)N_(4)within 30 min,which is better than the performance of both BiOBr and g‐C_(3)N_(4),and it has superior stability.In addition,the composite also exhibits enhanced photocatalytic activity for H2 production.The enhanced activity can be attributed to the intimate interface contact,the larger surface area,and the highly efficient separation of photoinduced electron–hole pairs.Based on the experimental results,a novel S‐scheme model was proposed to illuminate the transfer process of charge carriers.This study presents a simple way to develop novel step‐scheme photocatalysts for environmental and related applications.
基金supported by the National Natural Science Foundation of China(21676213,21476183,51372201)the China Postdoctoral Science Foundation(2016M600809)the Natural Science Basic Research Plan in Shaanxi Province of China(2017JM2026)~~
文摘Ag nanoparticles (NPs) were deposited on the surface of g-C3N4 (CN) by an in situ calcination method. NiS was successfully loaded onto the composites by a hydrothermal method. The results showed that the 10 wt%-NiS/1.0 wt%-Ag/CN composite exhibits excellent photocatalytic H2 generation performance under solar-light irradiation. An H2 production rate of 9.728 mmol·g^-1·h^-1 was achieved, which is 10.82-, 3.45-, and 2.77-times higher than those of pure g-C3N4, 10 wt%-NiS/CN, and 1.0 wt%-Ag/CN composites, respectively. This enhanced photocatalytic H2 generation can be ascribed to the co-decoration of Ag and NiS on the surface of g-C3N4, which efficiently improves light harvesting capacity, photogenerated charge carrier separation, and photocatalytic H2 production kinetics. Thus, this study demonstrates an effective strategy for constructing excellent g-C3N4-related composite photocatalysts for H2 production by using different co-catalysts.
基金supported by the National Natu-ral Science Foundation of China(Nos.22078261,21676213,and 11974276)Natural Science Basic Research Program of Shaanxi(No.2023-JC-YB-115)+1 种基金Shaanxi Key Science and Technology Innovation Team Project(No.2022TD-33)National College Student Inno-vation and Entrepreneurship Training Program(No.202210697069)for the financial support of this work.
文摘Effective bulk phase and surface charge separation is critical for charge utilization during the photo-catalytic energy conversion process.In this work,the ternary Ni_(2)P-NiS/twinned Mn_(0.5)Cd_(0.5)S(T-MCS)nanohybrids were successfully constructed via combining Ni_(2)P-NiS with T-MCS solid solution for visible light photocatalytic H_(2)evolution.T-MCS is composed of zinc blende Mn_(0.5)Cd_(0.5)S(ZB-MCS)and wurtzite Mn_(0.5)Cd_(0.5)S(WZ-MCS)and those two alternatively arranged crystal phases endow T-MCS with excellent bulk phase charge separation performance for the slight energy level difference between ZB-MCS and WZ-MCS.S-scheme carriers transfer route between NiS and T-MCS can accelerate the interfacial charge separation and retain the active electrons and holes,meanwhile,co-catalyst Ni_(2)P as electron receiver and proton reduction center can further optimize the H_(2)evolution reaction kinetics based on the surface Schottky barrier effect.The above-formed homo-heterojunctions can establish multiple charge transfer channels in the bulk phase of T-MCS and interface of T-MCS and Ni_(2)P-NiS.Under the synergistic effect of twinned homojunction,S-scheme heterojunction,and Schottky barrier,the ternary Ni_(2)P-NiS/T-MCS com-posite manifested an H_(2)production rate of 122.5 mmol h^(-1)g^(-1),which was 1.33,1.24,and 2.58 times higher than those of the NiS/T-MCS(92.4 mmol h^(-1)g^(-1)),Ni_(2)P/T-MCS(98.4 mmol h^(-1)g^(-1)),and T-MCS(47.5 mmol h^(-1)g^(-1)),respectively.This work demonstrates a promising strategy to develop efficient sul-fides photocatalyst toward targeted solar-driven H_(2)evolution through homo-heterojunction engineering.
基金supported by the Specialized Research Fund of Education Department of Shaanxi Province(No.22JY015)the College Students Innovation and Entrepreneurship Plan Training Program(No.S202211396006).
文摘Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of pho-tocatalyst.In this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for organic pollutants degradation.This Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction exhibited much higher pho-tocatalytic activity towards Rhodamine B(92.24%,expose to visible light for 60 min),norfloxacin(81.73%,expose to visible light for 90 min)and levofloxacin(87.46%,expose to visible light for 90 min)than pure Bi_(2)WO_(6)and pure AgInS_(2).Toxicity analysis indicated the low environmental toxicity of Rhodamine B degradation intermediates for Rye seeds and Sudangrass seeds germination and growth.Mechanism study displayed that AgInS_(2)and Bi_(2)WO_(6)work as the primary photocatalyst to form·O_(2)−and ·OH,respectively.The improved photocatalytic activity of the Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was due to the im-proved light response range and intensified carrier separation capability.Additionally,a S-scheme charge transfer mechanism including multiple charge transfer channels was proposed.This work could provide an effective strategy for organic pollutants degradation in wastewater.
基金supported by the Research Grants Council of Hong Kong(CityU 11305919 and 11308620)and NSFC/RGC Joint Research Scheme N_CityU104/19Hong Kong Research Grant Council Collaborative Research Fund:C1002-21G and C1017-22Gsupported by the Hong Kong Research Grant Council Collaborative Research Fund:C6021-19E.
文摘Developing machine learning frameworks with predictive power,interpretability,and transferability is crucial,yet it faces challenges in the field of electrocatalysis.To achieve this,we employed rigorous feature engineering to establish a finely tuned gradient boosting regressor(GBR)model,which adeptly captures the physical complexity from feature space to target variables.We demonstrated that environmental electron effects and atomic number significantly govern the success of the mapping process via global and local explanations.The finely tuned GBR model exhibits exceptional robustness in predicting CO adsorption energies(R_(ave)^(2)=0.937,RMSE=0.153 eV).Moreover,the model demonstrated remarkable transfer learning ability,showing excellent predictive power for OH,NO,and N_(2) adsorption.Importantly,the GBR model exhibits exceptional predictive capability across an extensive search space,thereby demonstrating profound adaptability and versatility.Our research framework significantly enhances the interpretability and transferability of machine learning in electrocatalysis,offering vital insights for further advancements.
基金supported by the Program for Changjiang Scholars and Innovative Research Team in University (Nos.51208249,51290282)Natural Science Foundation of China (Nos.51178215,51308283)+1 种基金the Jiangsu Nature Science Fund,China (Nos.BK2010006,BK2011032)the Joint Innovation Project for Production-Study-Research in Jiangsu Province,China (No.BY2013061)
文摘This study investigated the removal of dissolved organic matter（DOM） from real dyeing bio-treatment effluents（DBEs） with the use of a novel magnetic anion exchange resin（NDMP）.DOMs in two typical DBEs were fractionized using DAX-8/XAD-4 resin and ultrafiltration membranes. The hydrophilic fractions and the low molecular weight（MW）（〈3 kDa） DOM fractions constituted a major portion（〉50%） of DOMs for the two effluents. The hydrophilic and low MW fractions of both effluents were the greatest contributors of specific UV254absorbance（SUVA254）,and the SUVA254 of DOM fractions decreased with hydrophobicity and MW. Two DBEs exhibited acute and chronic biotoxicities. Both acute and chronic toxicities of DOM fractions increased linearly with the increase of SUVA254 value. Kinetics of dissolved organic carbon（DOC） removal via NDMP treatment was performed by comparing it with that of particle active carbon（PAC）. Results indicated that the removal of DOC from DBEs via NDMP was 60%,whereas DOC removals by PAC were lower than 15%. Acidic organics could be significantly removed with the use of NDMP. DOM with large MW in DBE could be removed significantly by using the same means. Removal efficiency of NDMP for DOM decreased with the decrease of MW. Compared with PAC,NDMP could significantly reduce the acute and chronic bio-toxicities of DBEs. NaCl/NaOH mixture regenerants,with selected concentrations of 10% NaCl（m/m）/1%NaOH（m/m）,could improve desorption efficiency.
文摘Two-dimensional mesoporous ultrathin Cd0.5Zn0.5S nanosheets with a thickness of~1.5 nm were fabricated using a multistep chemical transformation strategy involving inorganic–organic hybrid ZnS-ethylenediamine(denoted as ZnS(en)0.5)as a hard template.Inorganic–organic hybrid ZnS(en)0.5,Cd0.5Zn0.5S(en)x,and Cd0.5Zn0.5S nanosheets were sequentially fabricated,and their transformation processes were analyzed in detail.The fabricated Cd0.5Zn0.5S nanosheets exhibited high photocatalytic hydrogen evolution reaction activity in the presence of a sacrificial agent.The Cd0.5Zn0.5S nanosheets exhibited remarkably high H2 production activity of~1395μmol∙h^−1∙g^−1 in pure water with no co-catalyst,which is the highest value reported thus far for bare photocatalysts,to the best of our knowledge.The high activity of these nanosheets is attributed to their distinct nanostructure(e.g.,short transfer distance of photoinduced charge carriers,large number of unsaturated surface atoms,and large surface area).Moreover,ternary NiCo2S4 nanoparticles were employed to facilitate the charge separation and enhance the surface kinetics of H2 evolution.The H2 production rate reached~62.2 and~2436μmol∙h^−1∙g^−1 in triethanolamine and pure water,respectively,over the NiCo2S4/Cd0.5Zn0.5S heterojunctions.The result indicated that the Schottky junction was critical to the enhanced activity.The proposed method can be used for fabricating other highly efficient CdZnS-based photocatalysts for solar-energy conversion or other applications.
文摘In this work,a novel plasmon-assisted UV-vis-NIR-driven W_(18)O_(49)/Cd_(0.5)Zn_(0.5)S heterostructure photocatalyst was obtained by a facile ultrasonic-assisted electrostatic self-assembly strategy.The hybrid exhibits extraordinary H2 evolution activity of 147.7 mmol·g^(-1)·h^(-1) at room temperature due to the efficient charge separation and expanded light absorption.Our investigation shows that the unique Step-scheme(S-scheme)charge transfer and the‘hot electron’injection are both responsible for the extraordinary H2 evolution process,depending on the wavelength of the incident light.Moreover,by accelerating the surface reaction kinetics,the activity can be further elevated to 306.1 mmol·g^(-1)·h^(-1),accompanied by a high apparent quantum yield of 45.3% at 365±7.5 nm.This work provides us a potential strategy for the highly efficient conversion of the solar energy by elaborately combining a nonstoichiometric ratio plasmonic material with an appropriate active photocatalyst.
基金National Natural Science Foundation of China (51239009)National Science and Technology Support Program of China (2011BAD29B05)+1 种基金Key Discipline Foundation of Water Resources and Hydropower Engineering of Xinjiang Province (XJZDXK-2002-10-05)Natural Science Foundation of Shandong Province (ZR2010EM042)
文摘Optimal use of water and fertilizers can enhance winter wheat yield and increase the efficiencies of water and fertilizer usage in dryland agricultural systems. In order to optimize water and nitrogen （N） management for winter wheat, we conducted field experiments from 2006 to 2008 at the Changwu Agro-ecological Experimental Station of the Chinese Academy of Sciences on the Loess Plateau, China. Regression models of wheat yield and evapotranspiration （ET） were established in this study to evaluate the water and fertilizer coupling effects and to determine the optimal coupling domain. The results showed that there was a positive effect of water and N fertilizer on crop yield, and optimal irrigation and N inputs can significantly increase the yield of winter wheat. In the drought year （2006-2007）, the maximum yield （Yma~） of winter wheat was 9.211 t/hm2 for the treatment with 324 mm irriga- tion and 310 kg/hm2 N input, and the highest water use efficiency （WUE） of 16.335 kg/（hm2.mm） was achieved with 198 mm irrigation and 274 kg/hm2 N input. While in the normal year （2007-2008）, the maximum winter wheat yield of 10.715 t/hm2 was achieved by applying 318 mm irrigation and 291 kg/hm2 N, and the highest WUE was 18.69 kg/（hm2.mm） with 107 mm irrigation and 256 kg/hm2 N input. Crop yield and ET response to irrigation and N inputs followed a quadratic and a line function, respectively. The optimal coupling domain was determined using the elas- ticity index （El） and its expression in the water-N dimensions, and was represented by an ellipse, such that the global maximum WUE （WUErnax） and Ymax values corresponded to the left and right end points of the long axis, respectively. Considering the aim to get the greatest profit in practice, the optimal coupling domain was represented by the lower half of the ellipse, with the Yma~ and WUE^ax on the two end points of the long axis. Overall, we found that the total amount of irrigation for winter wheat should not exceed 324 ram. In addition, our optimal coupling domain visually reflects the optimal range of water and N inputs for the maximum winter wheat yield on the Loess Plateau, and it may also provide a useful reference for identifying appropriate water and N inputs in agricultural applications.
基金supported by National Natural Science Foundation of China under grant Nos. 40839909,41074062, and 40674040
文摘In large continental orogens, an important research topic is the behavior of deep crustal and upper mantle deformation, and the flow styles of ductile material. The morphology of the eastern margin of the Tibetan plateau, adjacent to the Sichuan basin, is characterized by very steep relief with high mountain ranges. The crust beneath this region slows the velocities in the middle and lower crust. We have adopted a relatively dense network to inverse the detailed structure of the crust and upper mantle along the eastern margin of the Tibetan plateau and Sichuan basin, using teleseismic data via receiver function analysis. The results are in-line with the hypothesis that viscous crustal material is flowing beneath the eastern margin of the Tibetan plateau and that this process drives overlying crustal material around the strong and rigid Sichuan basin. When the viscous material hits this obstruction, flows are divided into two or more branches with different directions. The upper part of the upwelling viscous flow produces the pressure to intrude the upper crust, thereby driving uplift of mountain ranges and high peaks. In contrast, the lower part of the downwelling viscous flow produces the pressure to intrude the lower crust and upper mantle to deepen the Moho discontinuity, causing observed crustal thickening.
基金the National Natural Science Foundation of China(No.81472707)Chinese South Western Oncology Group(CSWOG-CCET005).
文摘The incidence of colorectal cancer(CRC)is increasing in China,with high mortality.Here,we aimed to evaluate the latest clinicopathological features and prognostic value of the KRAS/NRAS/BRAF mutation status in CRC patients in Central China.The clinical data of 1549 CRC patients with stage I-IV disease diagnosed at Union Hospital,Tongji Medical College of Huazhong University of Science and Technology from 2015 to 2017 were collected and analyzed retrospectively.KRAS/NRAS/BRAF mutations were detected by real-time quantitative polymerase chain reaction(q-PCR)in 410 CRC patients,with mutation frequencies of KRAS,NRAS and BRAF of 47.56%,2.93%and 4.15%,respectively.The gene mutation status and clinicopathological characteristics of 410 patients with CRC who underwent qPCR were analyzed.The KRAS and BRAF gene mutations were related to the pathological differentiation and number of metastatic lymph nodes.The BRAF gene mutation was also associated with cancer thrombosis in blood vessels.Cox regression analysis showed that there was no statistically significant difference in the overall survival(OS)between patients with KRAS,NRAS mutants and wild-type CRC patients,while the BRAF gene mutation was negatively correlated with the OS rate of CRC patients.It is suggested that the BRAF gene mutation may be an independent risk factor for the prognosis of CRC.
基金the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(project number SL2021PT108)。
文摘A numerical triangulation and transformation into the time domain of a Kirchhoff approximation(KA)method is proposed for the modeling of bistatic scattering from an underwater non-penetrable target.The time domain solution in this approximation can be split up into two parts:the solution of reflected field,contributing around the specular direction,and the solution of shadow radiation,contributing around the forward direction.An average solution in the time domain satisfying the reciprocity principle is presented.The solution is expressed in terms of non-singular functions.The proposed method is validated against a normal mode method for bistatic scattering from a rigid sphere.Moreover,the reflected and shadow highlights on the surface of the sphere are shown to verify the integration surface of the reflected field and shadow radiation.It is also tested against a finite element method and an experiment involving a scaled Benchmark Target Strength Simulation Submarine model.The time-angle bistatic spectra for the model are evaluated by the direct and transformed average solutions of KA,and the former accelerates its speed of calculation.The results are good,and show that this method can be used to predict the bistatic scattered field of a non-penetrable target.
基金Project supported by the Key Research and Development Plan of Shaanxi Province(2020GY-313)the Specialized Research Fund of Education Department of Shaanxi Province(19JK0255)+1 种基金the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang(18YSZX001)the Science and Technology Innovation Team of Shangluo(SK2017-45),China。
文摘Optomagnetic multifunctional composite has attracted much attention in recent years because of its promising application prospect in bioimaging,analysis,detection,disease diagnosis,and targeted drug delivery.To explore a dual-targeted therapy for cancer,a novel class of optomagnetic multifunctional composite(UCNP-Fe_(3)O_(4)@MSNs-FA)was successfully synthesized by using upconversion nanoparticles(UCNPs)as nucleus,embedding Fe_(3)O_(4)nanoparticles into the SiO_(2)coating layer,and modifying the surface with folic acid(FA)to strengthen its tumor targeting performance.The properties of the composite were extensively studied.The obtained composite possesses excellent upconversion fluorescence,good dispersion,high specific surface area(229.347 m^(2)/g),and saturation magnetization value(10.9 A m^(2)/g).Its drug loading co ntent and encapsulation efficiency can reach as high as 14.2%and 47.3%,respectively,using doxorubicin hydrochloride(DOX)as model drug.The DOX-UCNP-Fe_(3)O_(4)@MSNs-FA system shows excellent sustained drug release and strong pH-dependent performance,in which the drug release would be accelerated at the slightly acidic microenvironment in the tumor;thus,the system can realize the targeted treatment of cancers.The viability of L929 cells demonstrates the good biocompatibility of the composite.Furthermore,DOX-UCNP-Fe_(3)O_(4)@MSNs-FA exhibits specific cytotoxicity to folate receptor(FR)positive tumor cells,whereas DOX has weak toxicity to FR-negative cells.Therefore,the as-prepared UCNP-Fe_(3)O_(4)@MSNs-FA can potentially be used as an anti-cancer targeted drug delivery system and enhance the therapeutic efficacy against FR-positive tumor cells.
基金supported by the National Natural Science Foundation of China(82071788,81901598,81771704,and 82041015)National Key R&D Program of China(2022YFC2604100).
文摘Influenza A virus(IAV),responsible for seasonal epidemics and recurring pandemics,represents a global threat to public health.Given the risk of a potential IAV pandemic,it is increasingly important to better understand virushost interactions and develop new anti-viral strategies.Here,we reported nonmuscle myosin IIA(MYH9)-mediated regulation of IAV infection.MYH9 depletion caused a profound inhibition of IAV infection by reducing viral attachment and internalization in human lung epithelial cells.Surprisingly,overexpression of MYH9 also led to a significant reduction in viral productive infection.Interestingly,overexpression of MYH9 retained viral attachment,internalization,or uncoating,but suppressed the viral ribonucleoprotein(vRNP)activity in a minigenome system.Further analyses found that excess MYH9 might interrupt the formation of vRNP by interacting with the viral nucleoprotein(NP)and result in the reduction of the completed vRNP in the nucleus,thereby inhibiting subsequent viral RNA transcription and replication.Together,we discovered that MYH9 can interact with IAV NP protein and engage in the regulation of vRNP complexes,thereby involving viral replication.These findings enlighten new mechanistic insights into the complicated interface of host-IAV interactions,ultimately making it an attractive target for the generation of antiviral drugs.
文摘BACKGROUND： Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE： This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN： A case-control observation. SETTING： Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS： Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition （insomnia is defined by a Pittsburgh Sleep Quality Index score 〉 7）, the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received examinations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The protocol was approved by the Hospital＇s Ethics Committee. METHODS： Following admission, each subject＇s neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an autonomic nerve analyzer （Weijin Science and Technology Co., Ltd., Taiwan）. Each frequency spectrum parameter of heart rate variability was obtained, including very low frequency, low frequency, high frequency, total power, R-R interval, and its mean square. In addition, percentage of low frequency, high frequency, and ratio of low frequency to high frequency were calculated. For each heart rate frequency spectrum parameter, the difference between groups was analyzed. Moreover, correlations of each frequency spectrum parameter with insomnia and disease condition were analyzed. Data from each index, which were not normally distributed, were processed by logarithmic transformation. The t-test was used for the comparison of intergroup differences. Single-factor linear regression analysis and t-test were used for the analysis of factor-factor correlation and coefficient of correlation, respectively. MAIN OUTCOME MEASURES： （1） Differences of scores in the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index between the simple cerebral infarction group and the cerebral infarction complicated by insomnia group. （2） Differences of heart rate variability parameters between the simple cerebral infarction group and the control group. （3） Correlation of heart rate variability parameters, the Pittsburgh Sleep Quality Index score, and the neurological impairment score. RESULTS： Sixty patients and thirty healthy controls were included in the final analysis. （1） The scores of the Pittsburgh Sleep Quality Index and the neurological impairment were significantly higher in the cerebral infarction complicated by insomnia group compared to the simple cerebral infarction group （P 〈 0.05-0.01）. （2） R-R interval was significantly longer in the simple cerebral infarction group than in the control group, while R-R interval variance and high-frequency band were significantly lower in the simple cerebral infarction group compared to the control group （P 〈 0.05）. （3） For cerebral infarction patients with insomnia, the Pittsburgh Sleep Quality Index score was significantly positively correlated with neurological impairment （r = 0.54, P 〈 0.01）. The low-frequency band, very low-frequency band, high-frequency band, R-R interval variance, total power, R-R interval, and the percentage of high-frequency were significantly negatively correlated with the National Institutes of Health Stroke Scale score （r =4）.45 to 4）.90, P 〈 0.054）.01） and with the Pittsburgh Sleep Quality Index scores （r = 4）.56 to 4）.36, P 〈 0.054）.01）. CONCLUSION： Each heart rate variability parameter can be used as an index for assessing dyssomnia and neurologic impairment （r =4）.56 to 4）.36, P 〈 0.054）.01）.
