To obtain high-performance tissue-adhesive hydrogel embodying excellent mechanical integrity,a supramo-lecular hydrogel patch is fabricated through in situ copolymerization of a liquid-liquid phase separation pre-curs...To obtain high-performance tissue-adhesive hydrogel embodying excellent mechanical integrity,a supramo-lecular hydrogel patch is fabricated through in situ copolymerization of a liquid-liquid phase separation pre-cursor composed of self-complementary 2-2-ureido-4-pyrimidone-based monomer and acrylic acid coupled with subsequent corporation of bioactive epigallocatechin gallate.Remarkably,the prepared supramolecular hydrogel leverages hierarchical multi-strength hydrogen-bonds hinged strategy assisted by alkyl-based hydrophobic pockets,broadening the distribution of binding strength of physical junctions,striking a canonical balance be-tween superb mechanical performance and robust adhesive capacity.Ultimately,the fabricated supramolecular hydrogel patch stands out as a high stretchability(1500%),an excellent tensile strength(2.6 MPa),a superhigh toughness(12.6 MJ m^(-3)),an instant and robust tissue adhesion strength(263.2 kPa for porcine skin),the considerable endurance under cyclic loading and reversible adhesion,a superior burst pressure tolerance(108 kPa)to those of commercially-available tissue sealants,and outstanding anti-swelling behavior.The resultant supramolecular hydrogel patch demonstrates the rapid hemorrhage control within 60 s in liver injury and efficient wound closure and healing effects with alleviated inflammation and reduced scarring in full-thickness skin incision,confirming its medical translation as a promising self-rescue tissue-adhesive patch for hemorrhage prevention and sutureless wound closure.展开更多
基金supported by National Key Research and Develop-ment Program of China(No.2021YFE0105400)the National Nat-ural Science Foundation of China grant(No.32371404).
文摘To obtain high-performance tissue-adhesive hydrogel embodying excellent mechanical integrity,a supramo-lecular hydrogel patch is fabricated through in situ copolymerization of a liquid-liquid phase separation pre-cursor composed of self-complementary 2-2-ureido-4-pyrimidone-based monomer and acrylic acid coupled with subsequent corporation of bioactive epigallocatechin gallate.Remarkably,the prepared supramolecular hydrogel leverages hierarchical multi-strength hydrogen-bonds hinged strategy assisted by alkyl-based hydrophobic pockets,broadening the distribution of binding strength of physical junctions,striking a canonical balance be-tween superb mechanical performance and robust adhesive capacity.Ultimately,the fabricated supramolecular hydrogel patch stands out as a high stretchability(1500%),an excellent tensile strength(2.6 MPa),a superhigh toughness(12.6 MJ m^(-3)),an instant and robust tissue adhesion strength(263.2 kPa for porcine skin),the considerable endurance under cyclic loading and reversible adhesion,a superior burst pressure tolerance(108 kPa)to those of commercially-available tissue sealants,and outstanding anti-swelling behavior.The resultant supramolecular hydrogel patch demonstrates the rapid hemorrhage control within 60 s in liver injury and efficient wound closure and healing effects with alleviated inflammation and reduced scarring in full-thickness skin incision,confirming its medical translation as a promising self-rescue tissue-adhesive patch for hemorrhage prevention and sutureless wound closure.
