Toll and Toll-like receptors(TLRs)are pivotal components of the innate immune system,playing a crucial role in the early defense against invading pathogens.These receptors basically recognize microbial components and ...Toll and Toll-like receptors(TLRs)are pivotal components of the innate immune system,playing a crucial role in the early defense against invading pathogens.These receptors basically recognize microbial components and thus spread the presence of pathogens to the host and activate signaling pathways that lead to an appropriate immune response.Their discoveries and studies in the late 80s/early90s have initiated the understanding of how organisms detect and respond to microbial infections(Hoffmann et al.,1999;Medzhitov and Janeway,2000;Akira et al.,2006;Nusslein-Volhard,2021).展开更多
基金support has been provided by the University of Strasbourg Institute for Advanced Study(to J.A.H.)the International Science and Technology Innovation Cooperation between Governments for National Key R&D Program Projects(2023YFE0107700)。
文摘Toll and Toll-like receptors(TLRs)are pivotal components of the innate immune system,playing a crucial role in the early defense against invading pathogens.These receptors basically recognize microbial components and thus spread the presence of pathogens to the host and activate signaling pathways that lead to an appropriate immune response.Their discoveries and studies in the late 80s/early90s have initiated the understanding of how organisms detect and respond to microbial infections(Hoffmann et al.,1999;Medzhitov and Janeway,2000;Akira et al.,2006;Nusslein-Volhard,2021).
