Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that f...Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material.To overcome this,compact fibrous DBM/polymer(fDBM)composites were prepared via electrospinning.Then,by exploiting the catalytic decomposition of hydrogen peroxide,oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone(Op-fDBM).These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth.In vivo evaluations reveal that fDBM increased bone volume by 41.7%while Op-fDBM increased bone volume by 68.6%.Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration.展开更多
AIM: To enhance non-technical skills and to analyse participant's experience of a course tailored for orth-opaedic surgeons.METHODS: A Delphi technique was used to develop a course in human factors specific to ort...AIM: To enhance non-technical skills and to analyse participant's experience of a course tailored for orth-opaedic surgeons.METHODS: A Delphi technique was used to develop a course in human factors specific to orthopaedic residents. Twenty-six residents(six per course) participated in total with seven course facilitators all trained in Crisis Resource Management providing structured feedback. Six scenarios recreated challenging real-life situations using high-fidelity mannequins and simulated patients. Environments included a simulated operating suite, clinic room and ward setting. All were undertaken in a purpose built simulation suite utilising actors, mock operating rooms, mock clinical rooms and a high fidelity adult patient simulator organised through a simulation control room. Participants completed a 5-point Likert scale questionnaire(strongly disagree to strongly agree) before and after the course. This assessed their understanding of non-technical skills, scenario validity, relevance to orthopaedic training and predicted impact of the course on future practice. A course evaluation questionnaire was also completed to assess participants' feedback on the value and quality of the course itself.RESULTS: Twenty-six orthopaedic residents participated(24 male, 2 female; post-graduation 5-10 years), mean year of residency program 2.6 out of 6 years required in the United Kingdom. Pre-course questionnaires showedthat while the majority of candidates recognised the importance of non-technical(NT) skills in orthopaedic training they demonstrated poor understanding of non-technical skills and their role. This improved significantly after the course(Likert score 3.0-4.2) and the perceived importance of these skills was reported as good or very good in 100%. The course was reported as enjoyable and provided an unthreatening learning environment with the candidates placing particular value on the learning opportunity provided by reflecting on their performance. All agreed that the course achieved its intended aims with realistic simulation scenarios. Participants believed patient care, patient safety and team working would all improve with further human factors training(4.4-4.6). and felt that NT skills learnt through simulation-based training should become an integral component of their training program.CONCLUSION: Participants demonstrated improved understanding of non-technical performance, recognised its relevance to patient safety and expressed a desire for its integration in training.展开更多
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(Project No.2016R1C1B2008296)It was also partially supported by the Na-tional Research Foundation of Korea(NRF)grant funded by the Korean Ministry of Education(Nos.NRF-2021R1I1A1A01047751 and RS-2023-00240020).
文摘Demineralized bone matrix(DBM)is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures.However,current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material.To overcome this,compact fibrous DBM/polymer(fDBM)composites were prepared via electrospinning.Then,by exploiting the catalytic decomposition of hydrogen peroxide,oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone(Op-fDBM).These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth.In vivo evaluations reveal that fDBM increased bone volume by 41.7%while Op-fDBM increased bone volume by 68.6%.Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration.
文摘AIM: To enhance non-technical skills and to analyse participant's experience of a course tailored for orth-opaedic surgeons.METHODS: A Delphi technique was used to develop a course in human factors specific to orthopaedic residents. Twenty-six residents(six per course) participated in total with seven course facilitators all trained in Crisis Resource Management providing structured feedback. Six scenarios recreated challenging real-life situations using high-fidelity mannequins and simulated patients. Environments included a simulated operating suite, clinic room and ward setting. All were undertaken in a purpose built simulation suite utilising actors, mock operating rooms, mock clinical rooms and a high fidelity adult patient simulator organised through a simulation control room. Participants completed a 5-point Likert scale questionnaire(strongly disagree to strongly agree) before and after the course. This assessed their understanding of non-technical skills, scenario validity, relevance to orthopaedic training and predicted impact of the course on future practice. A course evaluation questionnaire was also completed to assess participants' feedback on the value and quality of the course itself.RESULTS: Twenty-six orthopaedic residents participated(24 male, 2 female; post-graduation 5-10 years), mean year of residency program 2.6 out of 6 years required in the United Kingdom. Pre-course questionnaires showedthat while the majority of candidates recognised the importance of non-technical(NT) skills in orthopaedic training they demonstrated poor understanding of non-technical skills and their role. This improved significantly after the course(Likert score 3.0-4.2) and the perceived importance of these skills was reported as good or very good in 100%. The course was reported as enjoyable and provided an unthreatening learning environment with the candidates placing particular value on the learning opportunity provided by reflecting on their performance. All agreed that the course achieved its intended aims with realistic simulation scenarios. Participants believed patient care, patient safety and team working would all improve with further human factors training(4.4-4.6). and felt that NT skills learnt through simulation-based training should become an integral component of their training program.CONCLUSION: Participants demonstrated improved understanding of non-technical performance, recognised its relevance to patient safety and expressed a desire for its integration in training.
