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Enhanced Long-Distance Weak Signal Transmission Capabilities via Weak Measurement
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作者 Ding Wang Qi Song +3 位作者 Hongjing Li Zhiqiang Liu jingzheng huang Guihua Zeng 《Chinese Physics Letters》 2025年第11期118-125,共8页
Reliable detection of weak phase signals under significant channel loss and complex noise environments is a crucial step for practical applications of optical integrated communication and sensing systems. In this lett... Reliable detection of weak phase signals under significant channel loss and complex noise environments is a crucial step for practical applications of optical integrated communication and sensing systems. In this letter, we propose and experimentally demonstrate an enhanced long-distance weak signal transmission method assisted by weak measurement. Performing heterodyne detection and light intensity compensation on two nearly symmetric post-selected paths, the method enables real-time estimation of a time-varying phase while maintaining robustness against technical noises proportional to light intensity or photon number, detector common-mode noise, and significant attenuation over long-distance transmission. Experimental results indicate a potential phase sensitivity at the level of 10-8rad even with a signal light intensity attenuation of 48.1 d B. Potentially, combining the adaptive adjustment strategy, the method may provide a viable solution in remote weak signal detection and extraction,thereby contributing to optical integrated communication and sensing. 展开更多
关键词 weak measurement detection weak phase signals heterodyne detection optical integrated communication sensing systems light intensity compensation enhanced long distance weak signal transmission
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经动脉化疗栓塞联合仑伐替尼及程序性死亡受体1抑制剂治疗不可切除中晚期肝癌的临床疗效分析 被引量:9
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作者 黄景铮 蔡明岳 +8 位作者 黄文薮 郭永建 黄敬君 周群芳 林立腾 曹碧辉 梁礼聪 周娟 朱康顺 《中华放射学杂志》 CAS CSCD 北大核心 2022年第8期879-885,共7页
目的探讨经动脉化疗栓塞(TACE)联合仑伐替尼(Len)和程序性死亡受体-1抑制剂(PD-1)(TACE+Len+PD-1组)与TACE联合Len(TACE+Len组)治疗不可切除中晚期肝细胞癌(HCC)的疗效和安全性差异。方法收集2019年6月至2021年2月间在广州医科大学附属... 目的探讨经动脉化疗栓塞(TACE)联合仑伐替尼(Len)和程序性死亡受体-1抑制剂(PD-1)(TACE+Len+PD-1组)与TACE联合Len(TACE+Len组)治疗不可切除中晚期肝细胞癌(HCC)的疗效和安全性差异。方法收集2019年6月至2021年2月间在广州医科大学附属第二医院接受TACE+Len+PD-1或TACE+Len治疗的94例中晚期HCC患者的临床资料并进行回顾性分析。其中,TACE+Len+PD-1组44例,TACE术后1周内开始给予Len及PD-1抑制剂。Len 8或12 mg/d,口服;PD-1抑制剂200 mg/3周,静脉滴注。TACE+Len组50例,TACE术后1周内开始给予Len。Len 8或12 mg/d,口服。按照改良实体瘤疗效评价标准评估肿瘤治疗反应。比较两组间客观缓解率(ORR)、疾病控制率(DCR)、无进展生存期(PFS)、总生存期(OS)和不良事件(AEs)的差异,分析PFS和OS的可能影响因素。结果 TACE+Len+PD-1组和TACE+Len组的ORR分别为72.8%(32/44)和52.0%(26/50),DCR分别为86.4%(38/44)和62.0%(31/50),差异具有统计学意义(χ^(2)=4.25,P=0.039;χ^(2)=7.12,P=0.008);两组的中位PFS分别为7.9和5.6个月,中位OS分别为18.5和13.6个月,差异具有统计学意义(χ^(2)=7.91,P=0.005;χ^(2)=4.40,P=0.036)。多因素Cox比例风险回归分析结果显示,TACE+Len(HR=2.184,95%CI 1.366~3.493)、肿瘤包膜不完整(HR=2.002,95%CI 1.294~3.209)和肝外转移(HR=1.765,95%CI 1.095~2.844)是PFS的独立危险因素;而TACE+Len(HR=2.081,95%CI 1.097~3.948)、肿瘤BCLC C期(HR=7.325,95%CI 2.260~23.746)是OS的独立危险因素。TACE+Len+PD-1和TACE+Len组间3级不良事件的发生率分别为38.6%(17/44)和32.0%(16/50),差异无统计学意义(χ^(2)=0.45,P=0.501)。结论相较于TACE+Len,TACE+Len+PD-1可提高中晚期HCC患者的肿瘤治疗反应,延长PFS和OS。 展开更多
关键词 肝肿瘤 经动脉化疗栓塞 仑伐替尼 PD-1抑制剂 临床疗效
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Ultrasensitive measurement of angular rotations via a Hermite–Gaussian pointer 被引量:1
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作者 BINKE XIA jingzheng huang +4 位作者 HONGJING LI MIAOMIAO LIU TAILONG XIAO CHEN FANG GUIHUA ZENG 《Photonics Research》 SCIE EI CAS CSCD 2022年第12期2816-2827,共12页
Exploring high sensitivity on the measurement of angular rotations is an outstanding challenge in optics and metrology.In this work,we employ the mn-order Hermite-Gaussian(HG) beam in the weak measurement scheme with ... Exploring high sensitivity on the measurement of angular rotations is an outstanding challenge in optics and metrology.In this work,we employ the mn-order Hermite-Gaussian(HG) beam in the weak measurement scheme with an angular rotation interaction,where the rotation information is taken by another HG mode state completely after the post-selection.By taking a projective measurement on the final light beam,the precision of angular rotation is improved by a factor of 2mn+m+n.For verification,we perform an optical experiment where the minimum detectable angular rotation improves √15-fold with HG55 mode over that of HG11 mode,and achieves a sub-microradian scale of the measurement precision.Our theoretical framework and experimental results not only provide a more practical and convenient scheme for ultrasensitive measurement of angular rotations but also contribute to a wide range of applications in quantum metrology. 展开更多
关键词 ROTATION ANGULAR scheme
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