Conductive elastomers combining micromechanical sensitivity,lightweight adaptability,and environmental sustainability are critically needed for advanced flexible electronics requiring precise responsiveness and long-t...Conductive elastomers combining micromechanical sensitivity,lightweight adaptability,and environmental sustainability are critically needed for advanced flexible electronics requiring precise responsiveness and long-term wearability;however,the integration of these properties remains a significant challenge.Here,we present a biomass-derived conductive elastomer featuring a rationally engineered dynamic crosslinked network integrated with a tunable microporous architecture.This structural design imparts pronounced micromechanical sensitivity,an ultralow density(~0.25 g cm^(−3)),and superior mechanical compliance for adaptive deformation.Moreover,the unique micro-spring effect derived from the porous architecture ensures exceptional stretchability(>500%elongation at break)and superior resilience,delivering immediate and stable electrical response under both subtle(<1%)and large(>200%)mechanical stimuli.Intrinsic dynamic interactions endow the elastomer with efficient room temperature self-healing and complete recyclability without compromising performance.First-principles simulations clarify the mechanisms behind micropore formation and the resulting functionality.Beyond its facile and mild fabrication process,this work establishes a scalable route toward high-performance,sustainable conductive elastomers tailored for next-generation soft electronics.展开更多
Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side eff...Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side effects.Furthermore,the apoptosis mechanism of tumor cells induced by celastrol has not been exhausted yet.In this study,we developed a reduction sensitive polymeric vector for tumor-targeted celastrol delivery.And our researches indicated that the celastrol could be delivered by reductionsensitive nanomedicine(RSNMs)with a controlled release strategy.Meanwhile,the cell uptake results indicated that excellent reduction-sensitive behavior of RSNMs could effectively accelerate celastrol into the human retinoblastoma(RB)cell.The cell cytotoxicity assay demonstrated that celastrol inhibited proliferation of human RB Y79 cells growth in a dose-dependent manner.Furthermore,the results of flow cytometry and terminal dUTP nick-end labeling(TUNEL)staining showed that celastrol induced apoptosis of the RB Y79 cells,and revealed a time-dependent increase in apoptosis induction of RB Y79 cells.The results of western blotting showed that celastrol induced the apoptosis of human RB Y79 cells involving the activation of caspase-3 and caspase-9.In conclusion,our results revealed that RSNMs may be utilized as a novel therapy for retinoblastoma.展开更多
Semiconductor-noble metal composite has become a research focus due to its superior performance compared with its respective component.Although various methods have been developed to synthesize semiconductor-noble met...Semiconductor-noble metal composite has become a research focus due to its superior performance compared with its respective component.Although various methods have been developed to synthesize semiconductor-noble metal heterostructures,most of them are relatively complex multistep and use toxic reactants of high cost and risk.In this work,a series of Cu_(2)O/Ag heterojunctions were quickly prepared in one step via simple microwave-assisted green route.XRD,SEM,TEM,EDS,XPS,etc.were used to characterize obtained products,and the results indicate a Cu_(2)O/Ag metal-semiconductor heterojunction in micro-nano size was fabricated successfully.In addition,antibacterial behavior of Cu_(2)O/Ag heterojunctions against E.coli and S.aureus were investigated.Owing to the synergistic effect of Cu_(2)O and Ag,the heterojunction exhibits much better antibacterial performance than the pristine Cu_(2)O does.This work provides new insights into the green design and fabrication of surface-modified Cu_(2)O hybrid multifunctional materials for antibacterial applications.展开更多
Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Alt...Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.展开更多
Although porphyrin-based metal-organic frameworks(MOFs)have been widely explored as photosensitizers for photodynamic therapy,how the size will affect the light-induced catalytic activity for generation of reactive ox...Although porphyrin-based metal-organic frameworks(MOFs)have been widely explored as photosensitizers for photodynamic therapy,how the size will affect the light-induced catalytic activity for generation of reactive oxygen species(ROS)still remain unclear.Herein,we first report the size-controlled synthesis of two-dimensional(2D)porphyrin-based PCN-134 MOF nanosheets by a two-step solvothermal method to explore the size effect on its PDT performance,thus yielding enhanced photodynamic antimicrobial therapy.By simply controlling the reaction temperature in the synthesis process,the bulk PCN-134 crystal,large PCN-134(L-PCN-134)nanosheets with a lateral size of 2–3μm and thickness of 33.2–37.5 nm and small PCN-134 nanosheets(S-PCN-134)with a lateral size of 160–180 nm and thickness of 9.1–9.7 nm were successfully prepared.Interestingly,the S-PCN-134 nanosheets exhibit much higher photodynamic activity for ROS generation than that of the bulk 3D PCN-134 crystal and L-PCN-134 nanosheets under a660 nm laser irradiation,suggesting that the photodynamic activity of PCN-134 MOF increases when the size reduces.Therefore,the S-PCN-134 nanosheets show much enhanced performance when used as a photosensitizer for photodynamic antimicrobial activity and wound healing.展开更多
Proton exchange membrane fuel cell(PEMFC)faults,especially dehydration and flooding,cause distinct changes in electrochemical behavior.Consequently,real-time monitoring is essential for early and accurate diagnosis.Ho...Proton exchange membrane fuel cell(PEMFC)faults,especially dehydration and flooding,cause distinct changes in electrochemical behavior.Consequently,real-time monitoring is essential for early and accurate diagnosis.However,acquiring real-world fault data is challenging,and the rarity of such faults results in severe class imbalance.This imbalance limits the performance,reliability,and practical applicability of conventional diag-nostic methods.To address these limitations,this study proposes a unified diagnostic framework that integrates multi-sine AC voltage response,boundary-aware resampling,and attention-guided generative modeling.The key innovations of the proposed approach include:(1)Enhanced fault separability through the first application of multi-sine AC voltage response under data imbalance,enabling real-time extraction of critical electrochemical spectral features for early-stage diagnosis;(2)Improved data balance and clearer class boundaries using synthetic minority oversampling with Tomek links,which oversamples minority classes and removes borderline samples;(3)Realistic minority class synthesis using a dual attention Wasserstein generative adversarial networks,where channel attention focuses on diagnostically relevant spectral features and temporal attention models the dynamic evolution of PEMFC electrochemical behavior,ensuring high-quality,diagnostically informative synthetic fault data.The integrated framework achieves 99.67%overall diagnostic accuracy and,under an extreme 1:200 class imbalance,outperforms state-of-the-art methods by 14%.This approach enables rapid,data-efficient PEMFC fault diagnosis,strengthening fault management and advancing the performance of energy systems.展开更多
Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facil...Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss.展开更多
To achieve better control of the formation of silver sulfide （Ag2S） nanoparticles, ultrasmall Ag nanoclusters protected by thiolate ligands （Ag44（SR）30 and Agla（GSH）9） are used as precursors, which, via delica...To achieve better control of the formation of silver sulfide （Ag2S） nanoparticles, ultrasmall Ag nanoclusters protected by thiolate ligands （Ag44（SR）30 and Agla（GSH）9） are used as precursors, which, via delicate chemistry, can be readily converted to monodisperse Ag2S nanoparticles with controllable sizes （4-16 nm） and switchable solvent affinity （between aqueous and organic solvents）. This new synthetic protocol makes use of the atomic monodispersity and rich surface chemistry of Ag nanoclusters and a novel two-phase protocol design, which results in a well-controlled reaction environment for the formation of Ag2S nanopartides.展开更多
Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy,chemodynamic therapy,and catalytic therapy,their utilization...Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy,chemodynamic therapy,and catalytic therapy,their utilization as photosensitizers for photodynamic therapy(PDT)have been rarely reported so far.Herein,we report the activation of MoO_(3) nanobelts via aqueous co-intercalation of Na+and H_(2)O into their van der Waals gaps as a near-infrared Type I photosensitizer for photodynamic periodontitis treatment.The Na^(+)/H_(2)O intercalation of MoO_(3) nanobelts can shorten its length,generate rich oxygen vacancies,and enlarge its interlayer gaps.Such structural changes thus can induce the color change from white to dark blue with a strong near-infrared(NIR)absorption.When used as a photosensitizer,the I-MoO_(3−x) nanobelts exhibit much higher activities for the generation of superoxide radical(·O_(2)^(−))under an 808 nm laser irradiation than that of the pristine MoO_(3) nanobelts.Therefore,the prepared I-MoO_(3)−x nanobelts show a spectral antibacterial activity against Escherichia coli and Saccharomyces aureus,thus yielding a good clinical therapeutic effect on periodontitis.Our study proves that aqueous intercalation can be a simple but powerful strategy to activate layered MoO_(3) nanomaterials for high-performance PDT.展开更多
基金supported by National Natural Science Foundation of China(No.52103044)Double First-Class Initiative University of Science and Technology of China(KY2400000037)the Young Talent Programme(GG2400007009).
文摘Conductive elastomers combining micromechanical sensitivity,lightweight adaptability,and environmental sustainability are critically needed for advanced flexible electronics requiring precise responsiveness and long-term wearability;however,the integration of these properties remains a significant challenge.Here,we present a biomass-derived conductive elastomer featuring a rationally engineered dynamic crosslinked network integrated with a tunable microporous architecture.This structural design imparts pronounced micromechanical sensitivity,an ultralow density(~0.25 g cm^(−3)),and superior mechanical compliance for adaptive deformation.Moreover,the unique micro-spring effect derived from the porous architecture ensures exceptional stretchability(>500%elongation at break)and superior resilience,delivering immediate and stable electrical response under both subtle(<1%)and large(>200%)mechanical stimuli.Intrinsic dynamic interactions endow the elastomer with efficient room temperature self-healing and complete recyclability without compromising performance.First-principles simulations clarify the mechanisms behind micropore formation and the resulting functionality.Beyond its facile and mild fabrication process,this work establishes a scalable route toward high-performance,sustainable conductive elastomers tailored for next-generation soft electronics.
基金supported by the National Natural Science Foundation of China(Nos.81600775,U1904176 and 21504082)the Science and Technology Program of Henan Province,China(No.202102310072)the Medical Science and Technology Program of Henan Province,China(Nos.2018020398 and SB201902026)。
文摘Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further clinical application of celastrol is restricted by its poor water solubility and serious side effects.Furthermore,the apoptosis mechanism of tumor cells induced by celastrol has not been exhausted yet.In this study,we developed a reduction sensitive polymeric vector for tumor-targeted celastrol delivery.And our researches indicated that the celastrol could be delivered by reductionsensitive nanomedicine(RSNMs)with a controlled release strategy.Meanwhile,the cell uptake results indicated that excellent reduction-sensitive behavior of RSNMs could effectively accelerate celastrol into the human retinoblastoma(RB)cell.The cell cytotoxicity assay demonstrated that celastrol inhibited proliferation of human RB Y79 cells growth in a dose-dependent manner.Furthermore,the results of flow cytometry and terminal dUTP nick-end labeling(TUNEL)staining showed that celastrol induced apoptosis of the RB Y79 cells,and revealed a time-dependent increase in apoptosis induction of RB Y79 cells.The results of western blotting showed that celastrol induced the apoptosis of human RB Y79 cells involving the activation of caspase-3 and caspase-9.In conclusion,our results revealed that RSNMs may be utilized as a novel therapy for retinoblastoma.
基金financially supported by the National Natural Science Foundation of China(Nos.U2004177 and 21504082)Zhongyuan Thousand Talents Plan Project,Outstanding Youth Fund of Henan Province(No.212300410081)Natural Science Research Project of Henan Educational Committee(No.20A43001)。
文摘Semiconductor-noble metal composite has become a research focus due to its superior performance compared with its respective component.Although various methods have been developed to synthesize semiconductor-noble metal heterostructures,most of them are relatively complex multistep and use toxic reactants of high cost and risk.In this work,a series of Cu_(2)O/Ag heterojunctions were quickly prepared in one step via simple microwave-assisted green route.XRD,SEM,TEM,EDS,XPS,etc.were used to characterize obtained products,and the results indicate a Cu_(2)O/Ag metal-semiconductor heterojunction in micro-nano size was fabricated successfully.In addition,antibacterial behavior of Cu_(2)O/Ag heterojunctions against E.coli and S.aureus were investigated.Owing to the synergistic effect of Cu_(2)O and Ag,the heterojunction exhibits much better antibacterial performance than the pristine Cu_(2)O does.This work provides new insights into the green design and fabrication of surface-modified Cu_(2)O hybrid multifunctional materials for antibacterial applications.
基金supported by the National Natural Science Foundation of China(52173143 and 82371108)Natural Science Foundation of Henan Province(232300421176)Basic Science Key Project of Henan Eye Hospital(20JCZD002 and 23JCZD003).
文摘Dry eye disease(DED)is a major ocular pathology worldwide,causing serious ocular discomfort and even visual impairment.The incidence of DED is gradually increasing with the highfrequency use of electronic products.Although inflammation is core cause of the DED vicious cycle,reactive oxygen species(ROS)play a pivotal role in the vicious cycle by regulating inflammation from upstream.Therefore,current therapies merely targeting inflammation show the failure of DED treatment.Here,a novel dual-atom nanozymes(DAN)-based eye drops are developed.The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer.The in vitro and in vivo results demonstrate the DAN is endowed with superior biological activity in scavenging excessive ROS,inhibiting NLRP3 inflammasome activation,decreasing proinflammatory cytokines expression,and suppressing cell apoptosis.Consequently,the DAN effectively alleviate ocular inflammation,promote corneal epithelial repair,recover goblet cell density and tear secretion,thus breaking the DED vicious cycle.Our findings open an avenue to make the DAN as an intervention form to DED and ROSmediated inflammatory diseases.
基金the funding support from the National Natural Science Foundation of China(No.52102348)the funding support from the National Natural Science Foundation of China(No.52173143)+6 种基金the funding support from the National Natural Science Foundation of China(No.22005259)the Science and Technology Innovation Talent Program of University in Henan Province(No.23HASTIT016)the funding support from China Postdoctoral Science Foundation(No.2021M701113)the Start-Up Grant(No.9610495)from City University of Hong Kongthe funding support from the National Natural Science Foundation of China(No.21905195)Natural Science Foundation of Tianjin City(No.20JCYBJC00800)the PEIYANG Young Scholars Program of Tianjin University(No.2020XRX-0023)。
文摘Although porphyrin-based metal-organic frameworks(MOFs)have been widely explored as photosensitizers for photodynamic therapy,how the size will affect the light-induced catalytic activity for generation of reactive oxygen species(ROS)still remain unclear.Herein,we first report the size-controlled synthesis of two-dimensional(2D)porphyrin-based PCN-134 MOF nanosheets by a two-step solvothermal method to explore the size effect on its PDT performance,thus yielding enhanced photodynamic antimicrobial therapy.By simply controlling the reaction temperature in the synthesis process,the bulk PCN-134 crystal,large PCN-134(L-PCN-134)nanosheets with a lateral size of 2–3μm and thickness of 33.2–37.5 nm and small PCN-134 nanosheets(S-PCN-134)with a lateral size of 160–180 nm and thickness of 9.1–9.7 nm were successfully prepared.Interestingly,the S-PCN-134 nanosheets exhibit much higher photodynamic activity for ROS generation than that of the bulk 3D PCN-134 crystal and L-PCN-134 nanosheets under a660 nm laser irradiation,suggesting that the photodynamic activity of PCN-134 MOF increases when the size reduces.Therefore,the S-PCN-134 nanosheets show much enhanced performance when used as a photosensitizer for photodynamic antimicrobial activity and wound healing.
基金supported by Anhui Quality Infrastructure Standardi-zation Project(Grant No.2024MKSO7)Anhui Provincial Natural Sci-ence Foundation(Grant No.2208085UD03)National Natural Science Foundation of China(Grant No.52405142).
文摘Proton exchange membrane fuel cell(PEMFC)faults,especially dehydration and flooding,cause distinct changes in electrochemical behavior.Consequently,real-time monitoring is essential for early and accurate diagnosis.However,acquiring real-world fault data is challenging,and the rarity of such faults results in severe class imbalance.This imbalance limits the performance,reliability,and practical applicability of conventional diag-nostic methods.To address these limitations,this study proposes a unified diagnostic framework that integrates multi-sine AC voltage response,boundary-aware resampling,and attention-guided generative modeling.The key innovations of the proposed approach include:(1)Enhanced fault separability through the first application of multi-sine AC voltage response under data imbalance,enabling real-time extraction of critical electrochemical spectral features for early-stage diagnosis;(2)Improved data balance and clearer class boundaries using synthetic minority oversampling with Tomek links,which oversamples minority classes and removes borderline samples;(3)Realistic minority class synthesis using a dual attention Wasserstein generative adversarial networks,where channel attention focuses on diagnostically relevant spectral features and temporal attention models the dynamic evolution of PEMFC electrochemical behavior,ensuring high-quality,diagnostically informative synthetic fault data.The integrated framework achieves 99.67%overall diagnostic accuracy and,under an extreme 1:200 class imbalance,outperforms state-of-the-art methods by 14%.This approach enables rapid,data-efficient PEMFC fault diagnosis,strengthening fault management and advancing the performance of energy systems.
基金the National Natural Science Foundation of China(U1904176,81600775,and 21504082to J.L.)+3 种基金Zhongyuan Thousand Talents Plan Project(to J.L.)Harvard Medical School/Brigham and Women’s Hospital Department of Anesthesiology-Basic Scientist Grant(2420 BPA075,to W.T.)Center for Nanomedicine Research Fund(2019A014810,to W.T.)Gillian Reny Stepping Strong Center for Trauma Innovation Breakthrough Innovator Award(113548,to W.T.).
文摘Effective osteogenesis remains a challenge in the treatment of bone defects.The emergence of artificial bone scaffolds provides an attractive solution.In this work,a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus(P),calcium(Ca),and silicon(Si).We developed black phosphorus(BP)-based,three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential ions for bone defect treatment.The fibrous scaffolds were fabricated from 3D poly(L-lactic acid)(PLLA)nanofibers(3D NFs),BP nanosheets,and hydroxyapatite(HA)-porous SiO2 nanoparticles.The 3D BP@HA NFs possess three advantages:i)stably connected pores allow the easy entrance of bone marrow-derived mesenchymal stem cells(BMSCs)into the interior of the 3D fibrous scaffolds for bone repair and osteogenesis;ii)plentiful nutrients in the NFs strongly improve osteogenic differentiation in the bone repair area;iii)the photothermal effect of fibrous scaffolds promotes the release of elements necessary for bone formation,thus achieving accelerated osteogenesis.Both in vitro and in vivo results demonstrated that the 3D BP@HA NFs,with the assistance of NIR laser,exhibited good performance in promoting bone regeneration.Furthermore,microfluidic technology makes it possible to obtain high-quality 3D BP@HA NFs with low costs,rapid processing,high throughput and mass production,greatly improving the prospects for clinical application.This is also the first BP-based bone scaffold platform that can self-supply Ca^(2+),which may be the blessedness for older patients with bone defects or patients with damaged bones as a result of calcium loss.
基金This work is financially supported by the National Natural Science Foundation of China （Nos. 21173226, 21376247, and 21573240）, and the Ministry of Education, Singapore （No. R-279-000-409-112）.
文摘To achieve better control of the formation of silver sulfide （Ag2S） nanoparticles, ultrasmall Ag nanoclusters protected by thiolate ligands （Ag44（SR）30 and Agla（GSH）9） are used as precursors, which, via delicate chemistry, can be readily converted to monodisperse Ag2S nanoparticles with controllable sizes （4-16 nm） and switchable solvent affinity （between aqueous and organic solvents）. This new synthetic protocol makes use of the atomic monodispersity and rich surface chemistry of Ag nanoclusters and a novel two-phase protocol design, which results in a well-controlled reaction environment for the formation of Ag2S nanopartides.
基金This study is supported by the National Natural Science Foundation of China(Nos.52173143 and 52102348)the Science and Technology Innovation Talent Program of the University in Henan Province(No.23HASTIT016)Chaoliang Tan thanks the funding support from the National Natural Science Foundation of China-Excellent Young Scientists Fund(Hong Kong and Macao)(No.52122002).
文摘Although molybdenum trioxide nanomaterials have been widely explored as nanoagents for biomedical applications against bacteria through photothermal therapy,chemodynamic therapy,and catalytic therapy,their utilization as photosensitizers for photodynamic therapy(PDT)have been rarely reported so far.Herein,we report the activation of MoO_(3) nanobelts via aqueous co-intercalation of Na+and H_(2)O into their van der Waals gaps as a near-infrared Type I photosensitizer for photodynamic periodontitis treatment.The Na^(+)/H_(2)O intercalation of MoO_(3) nanobelts can shorten its length,generate rich oxygen vacancies,and enlarge its interlayer gaps.Such structural changes thus can induce the color change from white to dark blue with a strong near-infrared(NIR)absorption.When used as a photosensitizer,the I-MoO_(3−x) nanobelts exhibit much higher activities for the generation of superoxide radical(·O_(2)^(−))under an 808 nm laser irradiation than that of the pristine MoO_(3) nanobelts.Therefore,the prepared I-MoO_(3)−x nanobelts show a spectral antibacterial activity against Escherichia coli and Saccharomyces aureus,thus yielding a good clinical therapeutic effect on periodontitis.Our study proves that aqueous intercalation can be a simple but powerful strategy to activate layered MoO_(3) nanomaterials for high-performance PDT.
