The pace-of-life syndrome(POLS) hypothesis predicts that most variation in life history, physiology,and behavior among individuals, popula tions, and species falls along a continuum from slow to fast pace of life. Whi...The pace-of-life syndrome(POLS) hypothesis predicts that most variation in life history, physiology,and behavior among individuals, popula tions, and species falls along a continuum from slow to fast pace of life. While there is evidence for climatic gradientmediated POLS patterns among species, this approach has rarely been explicitly used to study POLS patterns among-and within-populations. In addition, the roles of sex in POLS evolution among-or within-populations are largely unknown. In this study, we investigated the effects of altitudinal gradient and sex on the covariations between growth rate and several physiological traits closely associated with POLS(blood glucose, baselineand stress-induced glucocorticoids(GCs), hemolysis and hemagglutination) in the Asiatic toad Bufo gargarizans.Contrary to our expectation, altitudinal gradient had no influence on the covariations between growth rate and physiological traits, neither at the among-nor withinpopulation level, indicating that these trait integrations have similar fitness payoffs across hierarchical levels.In contrast, we found evidence for sex-specific POLS composition: there was a negative covariance structure between growth rate and baseline GCs-but only in females, and a positive covariance structure between growth rate and baseline GCs-but only in females, and a positive covariance structure between growth rate and hemagglutination-but only in males. This observation indicates that these trait associations differ dramatically in advancing fitness for each sex, and supports the idea that sex-specific POLS composition could evolve in species in which the reproductive roles largely differ between the sexes.展开更多
How nutritional conditions during early development affect an organism’s phenotype at adulthood is still poorly understood despite a plethora of research on developmental plasticity.The"environmental matching&qu...How nutritional conditions during early development affect an organism’s phenotype at adulthood is still poorly understood despite a plethora of research on developmental plasticity.The"environmental matching"hypothesis predicts that individuals will have high fitness providing that their adult environment"matches"what they experienced during development.In contrast,the"silver spoon"hypothesis predicts that individuals who obtain better developmental resources will be generally superior.Here we tested these two hypotheses and examined the underlying hormonal mechanisms by manipulating the early dietary protein content of African clawed frogs(Xenopus laevis)for a year with a 2×2 factorial experimental design.We found that only a lowprotein food during development enhanced the vocal competition ability of male X.laevis,and that vocal dominance was associated with higher cortisol levels but not related with testosterone content.These results were not congruent with the"environmental matching"hypothesis or with the"silver spoon"hypothesis,suggesting the behavioral plasticity during development is more complex than our expectation in amphibians.展开更多
A huge volume of digitized clinical data is generated and accumulated rapidly since the widespread adoption of Electronic Medical Records (EMRs).These big data in healthcare hold the promise of propelling healthcare e...A huge volume of digitized clinical data is generated and accumulated rapidly since the widespread adoption of Electronic Medical Records (EMRs).These big data in healthcare hold the promise of propelling healthcare evolving from a proficiency-based art to a data-driven science,from a reactive mode to a proactive mode,from one-size-fits-all medicine to personalized medicine.This paper first discusses the research background-big data analytics in healthcare,the research framework of big data analytics in healthcare,analysis of medical process,and the literature summary of treatment pattern mining.Then the challenges for data-driven typical treatment pattern mining are highlighted,including similarity measure between treatment records,typical treatment pattern extraction,evaluation and recommendation,when considering the rich temporal and heterogeneous medical information in EMRs.Furthermore,three categories of typical treatment patterns are mined from doctor order content,duration,and sequence view respectively,which can provide a data-driven guideline to achieve the "5R" goal for rational drug use and clinical pathways.展开更多
Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effec...Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effects and adverse reactions of medicines.This paper proposes a data-driven method to mine typical treatment duration patterns for rational drug use from electronic medical records (EMRs).Firstly,a quintuple is defined to describe drug use duration statistics (DUDS) for each drug and treatment record is further represented with DUDS vector (DUDSV).Next a similarity measure method is adopted to compute the similarity between treatment records.Meanwhile,a clustering algorithm is used to cluster all patient treatment records to extract typical treatment duration patterns including typical drug sets,effective drug use day sets,and the DUDSs of each typical drug.Then the extracted typical treatment duration patterns are evaluated and annotated based on patients' demographic information,disease severity scores,treatment outcome and diagnostic information.Finally,a real-world EMR dataset is performed to indicate that the approach we proposed can effectively mine typical treatment duration patterns from EMRs and recommend the appropriate treatment regimens for patients based on their admission information.展开更多
In this paper, a novel anti-interference direction finding(DF)method for amplitude comparison method based on cyclostationarity is proposed. With the periodic properties of the communication signals, the desired signa...In this paper, a novel anti-interference direction finding(DF)method for amplitude comparison method based on cyclostationarity is proposed. With the periodic properties of the communication signals, the desired signal’s amplitude value can be effectively obtained even though there is an interference signal whose frequency spectrum overlaps with the desired signal in the environment,and the corresponding incident angle can be estimated accurately with the amplitude comparison method. The influence of interference signal on the amplitude comparison method is discussed and the proposed method’s theoretical feasibility is also analyzed. Compared with the conventional method,simulations are provided to demonstrate the anti-interference capability of the proposed method. The amplitude comparison DF system working at 2.44 GHz and 5.8 GHz is also constructed to verify its feasibility.展开更多
With the rapid development of modern electronic technologies,antenna arrays typically operate in very complex electromagnetic environments.However,owing to the various errors such as systematic errors and random error...With the rapid development of modern electronic technologies,antenna arrays typically operate in very complex electromagnetic environments.However,owing to the various errors such as systematic errors and random errors,conventional antenna arrays have relatively high sidelobes.Time modulated arrays(TMAs),also known as four-dimensional(4-D)antenna arrays,introduce time as an additional dimension for generating ultra-low sidelobes at fundamental component and realizing real-time beam scanning by harmonic components.Recently,the harmonic components can also be developed for various new applications including wireless communications and radar systems.In this review,we introduce comprehensively the fundamental methodologies and recent applications of TMAs.This aims to stimulate continuing efforts for the understanding of TMAs and explore their applications in various aspects.The methods mentioned in this review include three aspects:sideband radiation suppression,power efficiency of TMAs,and applications of harmonic components.These methods either improve the existing TMAs or promote the practical applications of TMAs.First,to suppress the sideband radiation,a method using non-uniform periodical modulation is introduced.The proposed method has an advantage of low computation and can be easily used for synthesizing a real-time radiation pattern according to the environmental need.Next,a TMA structure using reconfigurable power dividers/combiner is introduced to improve the power efficiency of feeding network.Finally,three applications of harmonic component including direction finding,calibration method,and space division multiple access are separately introduced to illustrate the development potential of TMAs.展开更多
基金financially supported by grants for the Biodiversity Survey and Assessment Project of the Ministry of Ecology and Environment of China (2019HJ2096001006) to J. F. CHENthe National Natural Science Foundation of China (31370431) to,the National Natural Science Foundation of China (31729003) to J. F. CHENthe Sichuan Provincial Science and Technology Department (2018JY0617) to J. F. CHEN。
文摘The pace-of-life syndrome(POLS) hypothesis predicts that most variation in life history, physiology,and behavior among individuals, popula tions, and species falls along a continuum from slow to fast pace of life. While there is evidence for climatic gradientmediated POLS patterns among species, this approach has rarely been explicitly used to study POLS patterns among-and within-populations. In addition, the roles of sex in POLS evolution among-or within-populations are largely unknown. In this study, we investigated the effects of altitudinal gradient and sex on the covariations between growth rate and several physiological traits closely associated with POLS(blood glucose, baselineand stress-induced glucocorticoids(GCs), hemolysis and hemagglutination) in the Asiatic toad Bufo gargarizans.Contrary to our expectation, altitudinal gradient had no influence on the covariations between growth rate and physiological traits, neither at the among-nor withinpopulation level, indicating that these trait integrations have similar fitness payoffs across hierarchical levels.In contrast, we found evidence for sex-specific POLS composition: there was a negative covariance structure between growth rate and baseline GCs-but only in females, and a positive covariance structure between growth rate and baseline GCs-but only in females, and a positive covariance structure between growth rate and hemagglutination-but only in males. This observation indicates that these trait associations differ dramatically in advancing fitness for each sex, and supports the idea that sex-specific POLS composition could evolve in species in which the reproductive roles largely differ between the sexes.
基金financially supported by grants for the National Natural Science Foundation of China(31370431)to JFCthe Sichuan Provincial Science and Technology Department(2018JY0617)to JFCthe Biodiversity Survey and Assessment Project of the Ministry of Ecology and Environment,China(2019HJ2096001006)to JFC。
文摘How nutritional conditions during early development affect an organism’s phenotype at adulthood is still poorly understood despite a plethora of research on developmental plasticity.The"environmental matching"hypothesis predicts that individuals will have high fitness providing that their adult environment"matches"what they experienced during development.In contrast,the"silver spoon"hypothesis predicts that individuals who obtain better developmental resources will be generally superior.Here we tested these two hypotheses and examined the underlying hormonal mechanisms by manipulating the early dietary protein content of African clawed frogs(Xenopus laevis)for a year with a 2×2 factorial experimental design.We found that only a lowprotein food during development enhanced the vocal competition ability of male X.laevis,and that vocal dominance was associated with higher cortisol levels but not related with testosterone content.These results were not congruent with the"environmental matching"hypothesis or with the"silver spoon"hypothesis,suggesting the behavioral plasticity during development is more complex than our expectation in amphibians.
基金supported in part by the National Natural Science Foundation of China under GTant Nos.71771034 and 71421001Science and Technology Program of Jieyang under Grant No.2017xm041.
文摘A huge volume of digitized clinical data is generated and accumulated rapidly since the widespread adoption of Electronic Medical Records (EMRs).These big data in healthcare hold the promise of propelling healthcare evolving from a proficiency-based art to a data-driven science,from a reactive mode to a proactive mode,from one-size-fits-all medicine to personalized medicine.This paper first discusses the research background-big data analytics in healthcare,the research framework of big data analytics in healthcare,analysis of medical process,and the literature summary of treatment pattern mining.Then the challenges for data-driven typical treatment pattern mining are highlighted,including similarity measure between treatment records,typical treatment pattern extraction,evaluation and recommendation,when considering the rich temporal and heterogeneous medical information in EMRs.Furthermore,three categories of typical treatment patterns are mined from doctor order content,duration,and sequence view respectively,which can provide a data-driven guideline to achieve the "5R" goal for rational drug use and clinical pathways.
基金The authors would like to thank the anonymous referees for their help to improve the quality of the paper. This research was supported in part by the National Natural Science Foundation of China under Grant Nos. 71771034 and 71421001Science and Technology Program of Jieyang under Grant No. 2017xm041+1 种基金China Postdoctoral Science Foundation under Grant No. 2017M620054, and the Scientific and Technological Innovation Foundation of Dalian under Grant No. 2018J11CY009This paper is a significantly extended and revised version of the conference paper presented at KSS-2018.
文摘Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effects and adverse reactions of medicines.This paper proposes a data-driven method to mine typical treatment duration patterns for rational drug use from electronic medical records (EMRs).Firstly,a quintuple is defined to describe drug use duration statistics (DUDS) for each drug and treatment record is further represented with DUDS vector (DUDSV).Next a similarity measure method is adopted to compute the similarity between treatment records.Meanwhile,a clustering algorithm is used to cluster all patient treatment records to extract typical treatment duration patterns including typical drug sets,effective drug use day sets,and the DUDSs of each typical drug.Then the extracted typical treatment duration patterns are evaluated and annotated based on patients' demographic information,disease severity scores,treatment outcome and diagnostic information.Finally,a real-world EMR dataset is performed to indicate that the approach we proposed can effectively mine typical treatment duration patterns from EMRs and recommend the appropriate treatment regimens for patients based on their admission information.
基金the National Natural Science Foundation of China(62001291)the National Natural Science Foundation of China(61901263)+1 种基金the Joint Foundation of Key Laboratory of Shanghai Jiao Tong universityXidian University,Ministry of Education(LHJJ/2021-09)the Shanghai Science and Technology Innovation Action Plan(20511106605)。
文摘In this paper, a novel anti-interference direction finding(DF)method for amplitude comparison method based on cyclostationarity is proposed. With the periodic properties of the communication signals, the desired signal’s amplitude value can be effectively obtained even though there is an interference signal whose frequency spectrum overlaps with the desired signal in the environment,and the corresponding incident angle can be estimated accurately with the amplitude comparison method. The influence of interference signal on the amplitude comparison method is discussed and the proposed method’s theoretical feasibility is also analyzed. Compared with the conventional method,simulations are provided to demonstrate the anti-interference capability of the proposed method. The amplitude comparison DF system working at 2.44 GHz and 5.8 GHz is also constructed to verify its feasibility.
基金This work is supported by the National Natural Science Foundation of China(No.61571298).
文摘With the rapid development of modern electronic technologies,antenna arrays typically operate in very complex electromagnetic environments.However,owing to the various errors such as systematic errors and random errors,conventional antenna arrays have relatively high sidelobes.Time modulated arrays(TMAs),also known as four-dimensional(4-D)antenna arrays,introduce time as an additional dimension for generating ultra-low sidelobes at fundamental component and realizing real-time beam scanning by harmonic components.Recently,the harmonic components can also be developed for various new applications including wireless communications and radar systems.In this review,we introduce comprehensively the fundamental methodologies and recent applications of TMAs.This aims to stimulate continuing efforts for the understanding of TMAs and explore their applications in various aspects.The methods mentioned in this review include three aspects:sideband radiation suppression,power efficiency of TMAs,and applications of harmonic components.These methods either improve the existing TMAs or promote the practical applications of TMAs.First,to suppress the sideband radiation,a method using non-uniform periodical modulation is introduced.The proposed method has an advantage of low computation and can be easily used for synthesizing a real-time radiation pattern according to the environmental need.Next,a TMA structure using reconfigurable power dividers/combiner is introduced to improve the power efficiency of feeding network.Finally,three applications of harmonic component including direction finding,calibration method,and space division multiple access are separately introduced to illustrate the development potential of TMAs.
