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应用OCT及OCTA观察孔源性视网膜脱离巩膜扣带术后的眼底变化 被引量:5
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作者 吴红云 陈贵尚 +5 位作者 叶炜 曾曼 谢莉菲 刘锦荣 唐薇 胡莉群 《国际眼科杂志》 CAS 北大核心 2022年第7期1203-1209,共7页
目的:应用OCT及OCTA观察孔源性视网膜脱离(RRD)行巩膜扣带术(SB)术后的黄斑形态结构、黄斑及视盘血管密度及视网膜神经纤维层厚度变化。方法:横断面病例对照研究。将2014-07/2021-03在赣州市人民医院眼科诊断为RRD的患者25例25眼纳入本... 目的:应用OCT及OCTA观察孔源性视网膜脱离(RRD)行巩膜扣带术(SB)术后的黄斑形态结构、黄斑及视盘血管密度及视网膜神经纤维层厚度变化。方法:横断面病例对照研究。将2014-07/2021-03在赣州市人民医院眼科诊断为RRD的患者25例25眼纳入本研究。对比术后末次随访患眼和健眼黄斑浅层血管(SVC)的血管密度(VD)、黄斑深层血管(DVC)的VD、视盘SVC-VD、视网膜神经纤维层(RNFL)、黄斑中心凹厚度(CMT)、中心凹下脉络膜厚度(SFCT)、黄斑外层结构之间的差异,并分析影响末次随访患眼BCVA(LogMAR)的相关性指标。结果:术后末次随访患眼与健眼黄斑SVC-VD、黄斑DVC-VD、视盘SVC-VD、RNFL、CMT、SFCT无差异(均P>0.05);末次随访患眼与健眼OCT下黄斑外层结构对比显示外界膜(ELM)、肌样体区(MZ)、椭圆体带区(EZ)、光感受器外节(OS)的光带完整性无差异(均P>0.05),嵌合体区(IZ)光带完整性则有差异(P=0.014);末次随访患眼与健眼BCVA有差异(P=0.002)。术后末次随访患眼BCVA与有无波及黄斑、视盘SVC-VD、黄斑外层结构ELM、MZ、EZ、OS、IZ光带完整性有显著相关性,其中与有无波及黄斑呈现正相关(r_(s)=0.401,P=0.047);与视盘SVC-VD、黄斑外层结构ELM、MZ、EZ、OS、IZ光带完整性呈负相关(均P<0.05)。结论:OCT及OCTA用于观察RRD行SB术后眼底改变可获得与视力预后相关的长期随访信息,其术后视力预后取决于视网膜外层结构的恢复情况而定,IZ结构的完整性对于视力恢复更为重要;视盘SVC-VD与视力预后有相关性,视盘SVC-VD的改变与术后眼压是否相关还需要术后连续数据进一步观察验证。 展开更多
关键词 孔源性视网膜脱离 巩膜扣带术 光学相干断层扫描技术(OCT) 光学相干断层扫描血流成像(OCTA)
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橙皮苷对翼状胬肉成纤维细胞增殖及cyclin D表达的影响 被引量:1
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作者 刘琳琳 吴晶 +5 位作者 王辉 刘锦荣 吴维霖 唐爱东 蒋贻平 胡成全 《国际眼科杂志》 CAS 北大核心 2019年第12期2022-2025,共4页
目的:评价橙皮苷对体外培养的人翼状胬肉成纤维细胞(HPF)增殖的抑制作用及对周期蛋白D(cyclin D)表达的影响。方法:将人翼状胬肉新鲜组织进行体外贴壁细胞常规培养,并采用免疫荧光染色法进行鉴定。通过MTT法检测不同浓度丝裂霉素C(MMC)(... 目的:评价橙皮苷对体外培养的人翼状胬肉成纤维细胞(HPF)增殖的抑制作用及对周期蛋白D(cyclin D)表达的影响。方法:将人翼状胬肉新鲜组织进行体外贴壁细胞常规培养,并采用免疫荧光染色法进行鉴定。通过MTT法检测不同浓度丝裂霉素C(MMC)(1.5、7.5、30.0μmol/L)和橙皮苷(24、48、64、72、96、120μmol/L)作用不同时间(24、48、72h)对细胞增殖的抑制,筛选适宜的作用浓度和时间。采用Western blot法检测cyclin D在HPF细胞中的相对表达量。结果:分别采用48、72μmol/L橙皮苷和7.5μmol/L MMC作用于HPF细胞48h,Western blot检测结果显示,空白对照组(正常培养)、MMC组、48μmol/L橙皮苷组、72μmol/L橙皮苷组细胞cyclin D蛋白相对表达量分别为1.20±0.02、0.60±0.03、0.54±0.02、0.45±0.07(F=73.025,P=0.001),MMC组和橙皮苷组细胞cyclin D蛋白相对表达量均低于空白对照组(P<0.05),但MMC组和橙皮苷组(48、72μmol/L)细胞cyclin D蛋白相对表达量均无差异(P>0.05)。结论:橙皮苷能抑制翼状胬肉HPF细胞增殖,该过程与其降低cyclin D的表达有关。 展开更多
关键词 橙皮苷 翼状胬肉 细胞增殖 CYCLIN D
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Field investigation into directional hydraulic fracturing for hard roof in Tashan Coal Mine 被引量:14
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作者 Bina-Xiana HUANG Bin YU +3 位作者 Feng FENG Zhao LI You-Zhuang WANG jin-rong liu 《Journal of Coal Science & Engineering(China)》 2013年第2期153-159,共7页
t Research and development of safe and effective control technology of hard roof is an inevitable trend at present. Directional hydraulic fracturing technology is expected to become a safe and effective way to control... t Research and development of safe and effective control technology of hard roof is an inevitable trend at present. Directional hydraulic fracturing technology is expected to become a safe and effective way to control and manage hard roof. In order to make hard roof fracture in a directional way, a hydraulic fracture field test has been conducted in the third panel district of Tashan Coal Mine in Datong. First, two hydraulic fracturing drilling holes and four observing drilling holes were arranged in the roof, followed by a wedge-shaped ring slot in each hydraulic fracturing drilling hole. The hydraulic fracturing holes were then sealed and, hydraulic fracturing was conducted. The results show that the hard roof is fractured directionally by the hydraulic fracturing function of the two fracturing drilling holes; the sudden drop, or the overall downward trend of hydraulic pressure from hydraulic monitoring is the proof that the rock in the hard roof has been fractured. The required hydraulic pressure to fracture the hard roof in Tashan coal mine, consisting of carboniferous sandstone layer, is 50.09 MPa, and the fracturing radius of a single drilling hole is not less than 10.5 m. The wedge-shaped ring slot made in the bottom of the hydraulic fracturing drilling hole plays a guiding role for crack propagation. After the hydraulic fracturing drill hole is cracked, the propagation of the resulting hydraulic crack, affected mainly by the regional stress field, will turn to other directions. 展开更多
关键词 hard roof hydraulic fracturing wedge-shaped ring slot crack propagation
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Full realization of the RIBLL2 separator at the HIRFL-CSR facility 被引量:1
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作者 Xiao-Dong Xu Yong Zheng +33 位作者 Zhi-Yu Sun Yu-Nan Song Bao-Hua Sun Satoru Terashima Chang-Jian Wang Ge Guo Guang-Shuai Li Xiu-Lin Wei Jun-Yao Xu Ji-Chao Zhang Yong Cao Bing-Shui Gao Jia-Xing Han jin-rong liu Chen-Gui Lu Shu-Ya Jin Hooi Jin Ong Hao-Tian Qi Yun Qin Ya-Zhou Sun Isao Tanihata Lu-Ping Wan Kai-Long Wang Shi-Tao Wang Xin-Xu Wang Tian-Yu Wu Xiao-Tian Wu Mei-Xue Zhang Wen-Wen Zhang Xiao-Bin Zhang Xue-Heng Zhang Jian-Wei Zhao Zi-Cheng Zhou Li-Hua Zhu 《Science Bulletin》 2025年第7期1026-1029,共4页
Since the pioneering use of radioactive ion beams(RIB)in the1980s at Lawrence Berkeley National Laboratory in USA,production and investigation of exotic nuclei far from stability have become possible for a wide range ... Since the pioneering use of radioactive ion beams(RIB)in the1980s at Lawrence Berkeley National Laboratory in USA,production and investigation of exotic nuclei far from stability have become possible for a wide range of nuclear chart.Over the past few decades,the RIB has triggered tremendous advancements in the study of exotic nuclei.For instance,over 3300 nuclides have been discovered[1],with a substantial number of them produced by employing RIBs.Experimentally,there are several methods to generate radioactive nuclei.Among them,the in-flight production methods,specifically projectile fragmentation and in-flight fission,are proven to be two of the most crucial approaches.In-flight methods have been widely used to create the radioactive nuclei lying away from the valley of stability,such as those situated on or close to the r-process path(e.g.,see Refs.[2-4]),thereby allowing scientists to explore the previously inaccessible nuclear territory.In the past few decades,a number of fragment separators have been constructed worldwide in order to produce exotic nuclei utilizing the in-flight techniques[5]. 展开更多
关键词 exotic nuclei flight fission generate radioact radioactive ion beams rib flight production investigation exotic nuclei far stability projectile fragmentation study exotic nucleifor
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