OBJECTIVE： To explore the relationship between Renying pulse （carotid） augmentation index （AI） and Cunkou pulse condition in different blood pres- sure groups, and the clinical significance of Reny- ing and Cunko...OBJECTIVE： To explore the relationship between Renying pulse （carotid） augmentation index （AI） and Cunkou pulse condition in different blood pres- sure groups, and the clinical significance of Reny- ing and Cunkou pulse parameters to reflect vascu- lar function. METHODS： Eighty-six patients with essential hyper- tension （EH） and 52 individuals with normal blood pressure （control group） between and January 2012 were included September 2010 this study. Reny- ing pulse AI was examined by a new diagnostic tool （ALOKA ProSound Alpha 10） --wave intensity （Wl） that is calculated as the product of the deriva- tives of the simultaneously recorded blood pres- sure changes （dP/dt） and blood-flow-velocity changes （dU/dt）, while Cunkou pulse condition was detected by DDMX-100 Pulse Apparatus inboth EH and control groups. A multifactorial corre- lation analysis was performed for data analysis. RESULTS： After adjusting for potential confound- ing variables, in the EH group, AI was positively cor- related with ts, w2/t （rts=0.225, P〈0.05; rw2/t=0.230, P〈 0.05） and negatively correlated with hs, hs/hl and w2 （rhs=- 0.393,P〈0.01 ;rhs/l=- 0.444, P〈0.01 ;rw2=- 0.389, P〈0.01）. In the control group, AI was positively cor- related with t3, t4, ts and w, （rt3=0.595, P〈0.01; r,4= 0.292, P〈0.05; rt5=0.318, P〈0.05; rw1=0.541, P〈0.01） and negatively correlated with h1, h2, h3, Ad and A （rh1= - 0.368, P〈0.05; rh2= - 0.330, P〈0.05; rh3= - 0.327, P〈 0.05; rAd=- 0.322, P〈0.05; rA=- 0.410, P〈0.01）. In the total sample group （EH plus control group, n= 138）, AI was positively correlated with t, ts, w1 and w, （rt=0.257, P〈0.01; rt5=0.266, P〈0.01; rw1=0.184, P〈 0.05; rw/t=0.210, P〈0.05） and negatively correlated with hs, hs/hl, w2 and Ad （rhs= - 0.230, P〈0.01; rh5/h1= - 0.218, P〈0.05; rw2= - 0.267, P〈0.01; rAd= - 0.246, P〈0.01）. Multiple linear regression analysis was car- ried out to model the relationship （F=7.887, P〈 0.001）.CONCLUSION： Renying pulse AI can effectively pre- dict arterial stiffness in synchrony with the manifes- tations of Cunkou pulse in elderly patients with hy- pertension. Cunkou pulse apparatus is a valuable tool for evaluating AI in clinical practice, The close correlations reported above reflect the holistic con- cept of Traditional Chinese Medicine.展开更多
Crigler-Najjar syndrome(CNS)and Gilbert syndrome(GS;OMIM:143500)are rare autosomal recessive diseases that cause unconjugated hyperbilirubinemia due to decreased UGT1A1 enzyme activity.Crigler-Najjar syndrome type 2(C...Crigler-Najjar syndrome(CNS)and Gilbert syndrome(GS;OMIM:143500)are rare autosomal recessive diseases that cause unconjugated hyperbilirubinemia due to decreased UGT1A1 enzyme activity.Crigler-Najjar syndrome type 2(CNS2;OMIM:606785)increases the risk of gallbladder stone formation and cholecystitis,while GS seldom causes health issues.We found a 28-year-old male patient with recurring right upper abdomen pain who experienced persistent jaundice from birth.CNS2 with gallbladder stones and cholecystitis was diagnosed after genetic testing revealed rare double homozygous mutations A(TA)7TAA(rs3064744)and P229Q(rs35350960)in the UGT1A1 gene.After pedigree investigation,we found that the patient’s parents with modestly increased bilirubin had compound heterozygous mutations A(TA)7TAA and P229Q,which were GS.Bioinformatics analysis showed that A(TA)7TAA is in the TATA-box region of the gene UGT1A1 promoter,affecting gene transcriptional initiation,whereas P229Q modifies protein three-dimensional structure and may be harmful.In this pedigree,double homozygous mutations have a more severe phenotype than compound heterozygous mutations.Inherited causes of hyperbilirubinemia should be suspected after ruling out biliary obstruction,and early bilirubin reduction(<103µmol/L(6 mg/dL))may reduce the risk of complications like cholecystitis in CNS2 patients,though further studies with longer follow-up are needed to confirm this observation.展开更多
基金Supportedby the Science andTechnology Project of Fujian Province(No.2014Y0007)the Fujian Province Medical Innovation Foundation(No.2009-CXB-13)
文摘OBJECTIVE： To explore the relationship between Renying pulse （carotid） augmentation index （AI） and Cunkou pulse condition in different blood pres- sure groups, and the clinical significance of Reny- ing and Cunkou pulse parameters to reflect vascu- lar function. METHODS： Eighty-six patients with essential hyper- tension （EH） and 52 individuals with normal blood pressure （control group） between and January 2012 were included September 2010 this study. Reny- ing pulse AI was examined by a new diagnostic tool （ALOKA ProSound Alpha 10） --wave intensity （Wl） that is calculated as the product of the deriva- tives of the simultaneously recorded blood pres- sure changes （dP/dt） and blood-flow-velocity changes （dU/dt）, while Cunkou pulse condition was detected by DDMX-100 Pulse Apparatus inboth EH and control groups. A multifactorial corre- lation analysis was performed for data analysis. RESULTS： After adjusting for potential confound- ing variables, in the EH group, AI was positively cor- related with ts, w2/t （rts=0.225, P〈0.05; rw2/t=0.230, P〈 0.05） and negatively correlated with hs, hs/hl and w2 （rhs=- 0.393,P〈0.01 ;rhs/l=- 0.444, P〈0.01 ;rw2=- 0.389, P〈0.01）. In the control group, AI was positively cor- related with t3, t4, ts and w, （rt3=0.595, P〈0.01; r,4= 0.292, P〈0.05; rt5=0.318, P〈0.05; rw1=0.541, P〈0.01） and negatively correlated with h1, h2, h3, Ad and A （rh1= - 0.368, P〈0.05; rh2= - 0.330, P〈0.05; rh3= - 0.327, P〈 0.05; rAd=- 0.322, P〈0.05; rA=- 0.410, P〈0.01）. In the total sample group （EH plus control group, n= 138）, AI was positively correlated with t, ts, w1 and w, （rt=0.257, P〈0.01; rt5=0.266, P〈0.01; rw1=0.184, P〈 0.05; rw/t=0.210, P〈0.05） and negatively correlated with hs, hs/hl, w2 and Ad （rhs= - 0.230, P〈0.01; rh5/h1= - 0.218, P〈0.05; rw2= - 0.267, P〈0.01; rAd= - 0.246, P〈0.01）. Multiple linear regression analysis was car- ried out to model the relationship （F=7.887, P〈 0.001）.CONCLUSION： Renying pulse AI can effectively pre- dict arterial stiffness in synchrony with the manifes- tations of Cunkou pulse in elderly patients with hy- pertension. Cunkou pulse apparatus is a valuable tool for evaluating AI in clinical practice, The close correlations reported above reflect the holistic con- cept of Traditional Chinese Medicine.
基金supported by the Fujian Province Natural Science Fund Project(Nos.2024J011017,2023J011846,2023J011159,2024Y0033,and 2024J08263)Joint Funds for the Innovation of Science and Technology in Fujian Province(Nos.2023Y9284 and 2023Y9305)+3 种基金the Fujian Provincial Health Commission Science and Technology Program(Nos.2024GGA090 and 2024QNA002)the Fujian Province Medical Innovation Foundation(No.2022CXA001)Startup Fund for Scientific Research,Fujian Medical University(Nos.2022QH2042 and 2023QH2038)National Famous and Old Chinese Medicine Experts(Xuemei Zhang,Xiaohua Yan,Shaoguang Lv,and Chunjin Yi)Inheritance Studio Construction Project.
文摘Crigler-Najjar syndrome(CNS)and Gilbert syndrome(GS;OMIM:143500)are rare autosomal recessive diseases that cause unconjugated hyperbilirubinemia due to decreased UGT1A1 enzyme activity.Crigler-Najjar syndrome type 2(CNS2;OMIM:606785)increases the risk of gallbladder stone formation and cholecystitis,while GS seldom causes health issues.We found a 28-year-old male patient with recurring right upper abdomen pain who experienced persistent jaundice from birth.CNS2 with gallbladder stones and cholecystitis was diagnosed after genetic testing revealed rare double homozygous mutations A(TA)7TAA(rs3064744)and P229Q(rs35350960)in the UGT1A1 gene.After pedigree investigation,we found that the patient’s parents with modestly increased bilirubin had compound heterozygous mutations A(TA)7TAA and P229Q,which were GS.Bioinformatics analysis showed that A(TA)7TAA is in the TATA-box region of the gene UGT1A1 promoter,affecting gene transcriptional initiation,whereas P229Q modifies protein three-dimensional structure and may be harmful.In this pedigree,double homozygous mutations have a more severe phenotype than compound heterozygous mutations.Inherited causes of hyperbilirubinemia should be suspected after ruling out biliary obstruction,and early bilirubin reduction(<103µmol/L(6 mg/dL))may reduce the risk of complications like cholecystitis in CNS2 patients,though further studies with longer follow-up are needed to confirm this observation.
