Aiming at the scale adaptation of automatic driving target detection algorithms in low illumination environments and the shortcomings in target occlusion processing,this paper proposes a YOLO-LKSDS automatic driving d...Aiming at the scale adaptation of automatic driving target detection algorithms in low illumination environments and the shortcomings in target occlusion processing,this paper proposes a YOLO-LKSDS automatic driving detection model.Firstly,the Contrast-Limited Adaptive Histogram Equalisation(CLAHE)image enhancement algorithm is improved to increase the image contrast and enhance the detailed features of the target;then,on the basis of the YOLOv5 model,the Kmeans++clustering algorithm is introduced to obtain a suitable anchor frame,and SPPELAN spatial pyramid pooling is improved to enhance the accuracy and robustness of the model for multi-scale target detection.Finally,an improved SEAM(Separated and Enhancement Attention Module)attention mechanism is combined with the DIOU-NMS algorithm to optimize the model’s performance when dealing with occlusion and dense scenes.Compared with the original model,the improved YOLO-LKSDS model achieves a 13.3%improvement in accuracy,a 1.7%improvement in mAP,and 240,000 fewer parameters on the BDD100K dataset.In order to validate the generalization of the improved algorithm,we selected the KITTI dataset for experimentation,which shows that YOLOv5’s accuracy improves by 21.1%,recall by 36.6%,and mAP50 by 29.5%,respectively,on the KITTI dataset.The deployment of this paper’s algorithm is verified by an edge computing platform,where the average speed of detection reaches 24.4 FPS while power consumption remains below 9 W,demonstrating high real-time capability and energy efficiency.展开更多
The study of the shear behavior of bonded rock-cement interface is important for understanding the strength and stability of grouted rock masses.This research aims to reveal the failure mechanism behind the shear prop...The study of the shear behavior of bonded rock-cement interface is important for understanding the strength and stability of grouted rock masses.This research aims to reveal the failure mechanism behind the shear property of bonded rock-cement interfaces.For the study,sandstone and granite joint blocks with specific morphology were fabricated by using a three-dimensional(3D)engraving technique.Bonded rock-cement joints with asperity inclination angles of 15°,30°,and 45°were prepared.Shear tests were performed on these bonded rock-cement joints to investigate the shear response and failure modes considering the effect of applied normal stress and interface morphology.Meanwhile,the two-dimensional particle flow code(PFC2D)was utilized to model the entire shear process of bonded rock-cement interfaces.The macroscopic shear behavior and mesoscopic failure mechanism were comprehensively investigated by the laboratory test and numerical simulation.The results showed that the shear stress-displacement curves of bonded rock-cement joints exhibit two distinct peaks,and the shear stress evolution can be categorized into four stages including elastic growth,rapid stress drop,secondary stress growth,and progressive softening.Significantly,the number of acoustic emission events also exhibits two distinct peaks related to the double peak of the shear stress curves.The failure of bonded rock-cement interfaces is mainly induced by shear fractures,while the failure of rock and cement blocks is primarily caused by tensile fractures.The number of shear cracks in the bonded rock-cement interfaces reaches the peak when the shear stress reaches the primary peak;whereas as the shear stress continuously approaches the residual stage,the fracture of the bonded rock-cement joints is primarily characterized by tensile cracks in the blocks.展开更多
The microstructural characteristics of austenite in Ti microalloyed steel during continuous casting significantly influence thethermoplasticity,thereby affecting the quality of the slab.In this work,a prediction model...The microstructural characteristics of austenite in Ti microalloyed steel during continuous casting significantly influence thethermoplasticity,thereby affecting the quality of the slab.In this work,a prediction model for two-stage austenite growth under varyingcooling rates was established by incorporating the effect of second-phase pinning and high-temperature ferrite-austenite phase transform-ation and growth theory.The results indicate that with 0.02wt%Ti,the high-temperature ferrite growth exhibits typical parabolic growthcharacteristics.When the Ti content increases to 0.04wt%,the high-temperature ferrite grain boundary migration rate significantly slowsduring the initial solidification stage.The predicted austenite grain sizes for 0.02wt%Ti microalloyed steel at the center,quarter,and sur-face of the slab are 5592,3529,and 1524μm,respectively.For 0.04wt%Ti microalloyed steel,the austenite grain sizes are 4074,2942,and 1179μm at the same positions.The average error is within 5%.As the Ti content increases from 0.02wt% to 0.04wt%,the austenitegrain refinement at the center is most significant,with an average grain size reduction of 27.14%.展开更多
Background:This study aimed to discover whether Cistanche tubulosa affects the AKT/CASP3 pathway by regulating m6A methylation,to exert a protective effect against peripheral nerve injury in a Parkinson's Disease(...Background:This study aimed to discover whether Cistanche tubulosa affects the AKT/CASP3 pathway by regulating m6A methylation,to exert a protective effect against peripheral nerve injury in a Parkinson's Disease(PD)mouse model.Methods:In this study,network pharmacology analysis and the molecular docking virtual screening technique was used to filter Acteoside(Act),a potential neuroprotective agent of active components in Cistanche tubulosa.A PD-related peripheral neuropathy mouse model was established by MPTP induction,followed by 21 days treatment of oral Act(25,50,and 100 mg kg^(−1)).Pole climbing,automatic avoidance ability and hot plate sensory tests were evaluated to determine behavioral changes caused by central and peripheral nerve injury.The pathological alterations of dorsal root ganglion tissue and the protein levels of IL-6,AKT,and CASP3 under Act intervention,as well as the dynamic changes of FTO,METTL3,and YTHDF2 which are closely related to m6A methylation,were comprehensively analyzed to observe the peripheral nerve protective efficacy of Act.Results:The results showed that peripheral neuropathy occurring with PD in the mouse model,which could be verified by behavioral tests and pathological histological changes.In addition to the previously established protective effect of Act on dopaminergic neurons in substantia nigra(SN),extensive follow-up studies demonstrated that Act effectively induced m6A methylation,which could further regulate the AKT/CASP3 pathway to play a therapeutic role.In this study,medium and high doses of Act played more obvious therapeutic roles.Conclusion:These findings suggest that Act may regulate the severity of peripheral nerve injury under the activation of the AKT/CASP3 signaling pathway by balancing the methylation level of m6A.These results provide a theoretical basis and experimental evidence for further research on the protective effect of Cistanche tubulosa on both the central and peripheral nerves in the treatment of PD.展开更多
Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental monitoring.Gas sensors based on conventional bulk materials often suffer from their poor surfa...Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental monitoring.Gas sensors based on conventional bulk materials often suffer from their poor surface-sensitive sites,leading to a very low gas adsorption ability.Moreover,the charge transportation efficiency is usually inhibited by the low defect density of surface-sensitive area than that in the interior.In this work,a gas sensing structure model based on CuS quantum dots/Bi_(2)S_(3) nanosheets(CuS QDs/Bi_(2)S_(3) NSs)inspired by artificial neuron network is constructed.Simulation analysis by density functional calculation revealed that CuS QDs and Bi_(2)S_(3) NSs can be used as the main adsorption sites and charge transport pathways,respectively.Thus,the high-sensitivity sensing of NO_(2) can be realized by designing the artificial neuron-like sensor.The experimental results showed that the CuS QDs with a size of about 8 nm are highly adsorbable,which can enhance the NO_(2) sensitivity due to the rich sensitive sites and quantum size effect.The Bi_(2)S_(3) NSs can be used as a charge transfer network channel to achieve efficient charge collection and transmission.The neuron-like sensor that simulates biological smell shows a significantly enhanced response value(3.4),excellent responsiveness(18 s)and recovery rate(338 s),low theoretical detection limit of 78 ppb,and excellent selectivity for NO_(2).Furthermore,the developed wearable device can also realize the visual detection of NO2 through real-time signal changes.展开更多
Zeolite membranes offer outstanding potentials in separation of many molecular mixtures due to their molecular sieving selectivity and the high thermal and mechanical stability that allow them to operate at harsh cond...Zeolite membranes offer outstanding potentials in separation of many molecular mixtures due to their molecular sieving selectivity and the high thermal and mechanical stability that allow them to operate at harsh conditions.Development of durable and high separation performance membranes with lower fabrication and operation cost are highly demanded for industrial applications. Zeolite T membrane possesses good acid-resistance with excellent hydrophilic properties as compared to NaA zeolite membrane and can be extended to industrial organic dehydrations under an acidic environment. In the present review the research advances in development of zeolite T membranes for the dehydration of organic mixtures in acidic conditions are summarized. Especially the low temperature synthesis, and epitaxial growth of the zeolite membrane with high performance are well addressed, besides emphasis is particularly placed on ensemble synthesis of hollow fiber zeolite T membrane module and its future prospects for industrial separations.展开更多
Human metabolite moisture detection is important in health monitoring and non-invasive diagnosis.However,ultra-sensitive quantitative extraction of respiration information in real-time remains a great challenge.Herein...Human metabolite moisture detection is important in health monitoring and non-invasive diagnosis.However,ultra-sensitive quantitative extraction of respiration information in real-time remains a great challenge.Herein,chemiresistors based on imine-linked covalent organic framework(COF)films with dual-active sites are fabricated to address this issue,which demonstrates an amplified humidity-sensing signal performance.By regulation of monomers and functional groups,these COF films can be pre-engineered to achieve high response,wide detection range,fast response,and recovery time.Under the condition of relative humidity ranging from 13 to 98%,the COFTAPB-DHTA film-based humidity sensor exhibits outstanding humidity sensing perfor-mance with an expanded response value of 390 times.Furthermore,the response values of the COF film-based sensor are highly linear to the relative humidity in the range below 60%,reflecting a quantitative sensing mechanism at the molecular level.Based on the dual-site adsorption of the(-C=N-)and(C-N)stretching vibrations,the revers-ible tautomerism induced by hydrogen bonding with water molecules is demonstrated to be the main intrinsic mechanism for this effective humidity detection.In addition,the synthesized COF films can be further exploited to effectively detect human nasal and oral breathing as well as fabric permeability,which will inspire novel designs for effective humidity-detection devices.展开更多
As a combination device for a step-up pulse transformer and a magnetic switch,the saturable pulse transformer is widely used in pulsed-power and plasma technology.A fractional-turn ratio saturable pulse transformer is...As a combination device for a step-up pulse transformer and a magnetic switch,the saturable pulse transformer is widely used in pulsed-power and plasma technology.A fractional-turn ratio saturable pulse transformer is constructed and analyzed in this paper.Preliminary experimental results show that if the primary energy storage capacitors are charged to 300 V,an output voltage of about 19 kV can be obtained across the capacitor connected to the secondary windings of a fractional-tum ratio saturable pulse transformer.Theoretical and experimental results reveal that this kind of pulse transformer is not only able to integrate a step-up transformer and a magnetic switch into one device,but can also lower the saturable inductance of its secondary windings,thus leading to the relatively high step-up ratio of the pulse transformer.Meanwhile,the application of the fractional-turn ratio saturable pulse transformer in a μs range pulse modulator as a voltage step-up device and main switch is also included in this paper.The demonstrated experiments display that an output voltage with an amplitude of about 29 kV,and a 1.6 μs pulse width can be obtained across a 3500 Ω resistive load,based on a pulse modulator,if the primary energy storage capacitors are charged to 300 V.This compact fractional-turn ratio saturable pulse transformer can be applied in many other fields such as surface treatment,corona plasma generation and dielectric barrier discharge.展开更多
This paper provides a review of the compact intense electron-beam accelerators (IEBAs) based on liquid pulse forming lines (PFLs) that havebeen developed at the National University of Defense Technology (NUDT) in Chin...This paper provides a review of the compact intense electron-beam accelerators (IEBAs) based on liquid pulse forming lines (PFLs) that havebeen developed at the National University of Defense Technology (NUDT) in China. The history and roadmap of the compact IEBAs used todrive high-power microwave (HPM) devices at NUDT are reviewed. The properties of both de-ionized water and glycerin as energy storagemedia are presented. Research into the breakdown properties of liquid dielectrics and the desire to maximize energy storage have resulted in theinvention of several coaxial PFLs with different electromagnetic structures, which are detailed in this paper. These high energy density liquidPFLs have been used to increase the performance of IEBA subsystems, based on which the SPARK (Single Pulse Accelerator with spark gaps)and HEART (High Energy-density Accelerator with Repetitive Transformer) series of IEBAs were constructed. This paper also discusses howthese compact IEBAs have been used to drive typical HPM devices and concludes by summarizing the associated achievements and theconclusions that can be drawn from the results.展开更多
The double pulse sources （DPS） method is presented for linear track estimation in this work. In the field of noise identification of underwater moving target, the Doppler will distort the frequency and amplitude of ...The double pulse sources （DPS） method is presented for linear track estimation in this work. In the field of noise identification of underwater moving target, the Doppler will distort the frequency and amplitude of the radiated noise. To eliminate this, the track estimation is necessary. In the DPS method, we first estimate bearings of two sinusoidal pulse sources installed in the moving target through baseline positioning method. Meanwhile, the emitted and recorded time of each pulse are also acquired. Then the linear track parameters will be achieved based on the geometry pattern with the help of double sources spacing. The simulated results confirm that the DPS improves the performance of the previous double source spacing method. The simulated experiments were carried out using a moving battery car to further evaluate its performance. When the target is 40-60m away, the experiment results show that biases of track azimuth and abeam distance of DPS are under 0.6° and 3.4m, respectively. And the average deviation of estimated velocity is around 0.25m/s.展开更多
CAU-1 is one of aluminum-based amine-functionalized Metal-Organic Frameworks(MOFs).Gas permeation and separation behaviors through CAU-1 membrane were simulated by the dual-control plane nonequilibrium molecular dynam...CAU-1 is one of aluminum-based amine-functionalized Metal-Organic Frameworks(MOFs).Gas permeation and separation behaviors through CAU-1 membrane were simulated by the dual-control plane nonequilibrium molecular dynamics(DCP-NEMD)method.The thickness of membrane was 3.55 nm.Gases CO_(2),N_(2),CH_(4),H_(2),He,Kr and Xe were chosen for the calculation in both single component and binary mixtures.The permeation process was calculated in grand canonical(μVT)ensemble with periodic boundary conditions(PBC)in x-and y-directions at different temperatures.The calculated permeance of H_(2),CH_(4),N_(2),CO_(2) and Kr decreased with increasing temperature in both single and binary system,while that of Xe with kinetic molecule of 0.41 nm increased with increasing temperature.It shows Xe permeation is governed by activated diffusion.The simulated separation factors of CO_(2)/N_(2) and CO_(2)/CH_(4) of 4.2 and 1.3 respectively were lower than the experimental ones when only considering van der Waals interaction.Further consideration of electrostatic potential leads to improved calculation CO_(2)/N_(2) and CO_(2)/CH_(4) separation factor of 23.0 and 12.9 respectively that were consistent with the experimental ones of 26.2 and 14.8.It suggests the necessity of considering the Coulomb interactions between CO_(2) and NH_(2)-on the pore wall of CAU-1 for permeation of CO_(2).For H_(2)/N_(2) and H_(2)/CH_(4) the ideal selectivities also keep consistent with our experimental results.Interestingly,the simulated separation factor for noble Kr/Xe reaches infinite,predicting that CAU-1 membrane possesses potential separation properties for radioactive Kr/Xe.展开更多
Tungsten (W) incorporated mobil-type eleven (MEL) zeolite membrane (referred to as W-MEL membrane) with high separation performance was firstly explored for the separation of oil/water mixtures under the influence of ...Tungsten (W) incorporated mobil-type eleven (MEL) zeolite membrane (referred to as W-MEL membrane) with high separation performance was firstly explored for the separation of oil/water mixtures under the influence of gravity.W-MEL membranes were grown on stainless steel (SS) meshes through in-situ hydrothermal growth method facilitated with (3-aminopropyl)triethoxysilane (APTES) modification of stainless steel meshes,which promote the heterogeneous nucleation and crystal growth of W-MEL zeolites onto the mesh surface.W-MEL membranes were grown on different mesh size supports to investigate the effect of mesh size on the separation performance of the membrane.The assynthesized W-MEL membrane supported on 500 mesh (25μm)(W-MEL-500) exhibit the hydrophilic nature with a water contact angle of 11.8°and delivers the best hexane/water mixture separation with a water flux and separation efficiency of 46247 L·m^(-2)·h^(-1)and 99.5%,respectively.The wettability of W-MEL membranes was manipulated from hydrophilic to hydrophobic nature by chemically modifying with the fluorine-free compounds (hexadecyltrimethoxysilane (HDTMS) and dodecyltrimethoxysilane(DDTMS)) to achieve efficient oil-permselective separation of heavy oils from water.Among the hydrophobically modified W-MEL membranes,W-MEL-500-HDTMS having a water contact angle of146.4°delivers the best separation performance for dichloromethane/water mixtures with a constant oil flux and separation efficiency of 61490 L·m^(-2)·h^(-1)and 99.2%,respectively along with the stability tested up to 20 cycles.Both W-MEL-500-HDTMS and W-MEL-500-DDTMS membranes also exhibit similar separation performances for the separation of heavy oil from sea water along with a 20-fold lower corrosion rate in comparison with the bare stainless-steel mesh,indicating their excellent stability in seawater.Compared to the reported zeolite membranes for oil/water separation,the as-synthesized and hydrophobically modified W-MEL membranes shows competitive separation performances in terms of flux and separation efficiency,demonstrating the good potentiality for oil/water separation.展开更多
Significant challenges are posed by the limitations of gas sensing mechanisms for trace-level detection of ammonia(NH3).In this study,we propose to exploit single-atom catalytic activation and targeted adsorption prop...Significant challenges are posed by the limitations of gas sensing mechanisms for trace-level detection of ammonia(NH3).In this study,we propose to exploit single-atom catalytic activation and targeted adsorption properties to achieve highly sensitive and selective NH3 gas detection.Specifically,Ni singleatom active sites based on N,C coordination(Ni-N-C)were interfacially confined on the surface of two-dimensional(2D)MXene nanosheets(Ni-N-C/Ti_(3)C_(2)Tx),and a fully flexible gas sensor(MNPE-Ni-N-C/Ti_(3)C_(2)Tx)was integrated.The sensor demonstrates a remarkable response value to 5 ppm NH3(27.3%),excellent selectivity for NH3,and a low theoretical detection limit of 12.1 ppb.Simulation analysis by density functional calculation reveals that the Ni single-atom center with N,C coordination exhibits specific targeted adsorption properties for NH3.Additionally,its catalytic activation effect effectively reduces the Gibbs free energy of the sensing elemental reaction,while its electronic structure promotes the spill-over effect of reactive oxygen species at the gas-solid interface.The sensor has a dual-channel sensing mechanism of both chemical and electronic sensitization,which facilitates efficient electron transfer to the 2D MXene conductive network,resulting in the formation of the NH3 gas molecule sensing signal.Furthermore,the passivation of MXene edge defects by a conjugated hydrogen bond network enhances the long-term stability of MXene-based electrodes under high humidity conditions.This work achieves highly sensitive room-temperature NH3 gas detection based on the catalytic mechanism of Ni single-atom active center with N,C coordination,which provides a novel gas sensing mechanism for room-temperature trace gas detection research.展开更多
The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions.Among emerging strategies,extracellular vesicles(EVs)have shown promise as an acellular ap...The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions.Among emerging strategies,extracellular vesicles(EVs)have shown promise as an acellular approach for bone regeneration.However,their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection.To address this challenge,EV-functionalized scaffolds have recently been proposed as an alternative delivery strategy to enhance EV retention and subsequent healing efficacy.This review aims to consolidate recent advancements in the development of EV-functionalized scaffolds for augmenting bone regeneration.It explores various sources of EVs and different strategies for integrating them into biomaterials.Furthermore,the mechanisms underlying their therapeutic effects in bone regeneration are elucidated.Current limitations in clinical translation and perspectives on the design of more efficient EVs for improved therapeutic efficacy are also presented.Overall,this review can provide inspiration for the development of novel EV-assisted grafts with superior bone regeneration potential.展开更多
The influence of a molybdenum dust buildup on plasma edge turbulence has been studied in the EAST tokamak.The motion of the dust from the upper divertor region is detected by a fast visible CCD camera,the XUV spectrom...The influence of a molybdenum dust buildup on plasma edge turbulence has been studied in the EAST tokamak.The motion of the dust from the upper divertor region is detected by a fast visible CCD camera,the XUV spectrometer arrays,and the EUV spectrometer.The MoXV emission intensity sharply increases compared with the spectral lines of various ionization states of other elements,which implies that the dust particles are the molybdenum impurities.The radial distribution of Mo^(14+)ion simulated by a simplified 1 D transport model indicates that the molybdenum dust mainly deposits in the pedestal bottom region.Moreover,it is observed that the coherent mode(CM)appears atρ=0.94 after the molybdenum impurities enter the main plasma region.The influx of molybdenum impurities results in increasing pedestal electron density and decreasing pedestal electron temperature in contrast to that before the event of impurities dropping.It is also found that the electron density gradient in the pedestal increases when the ablation of the molybdenum impurities is observed in the pedestal region.The qualitative experimental results indicate that the onset of CM is likely related to the increase of the density gradient and edge collisionality in the pedestal.In comparison to the density gradient,the enhancement of CM amplitude largely depends on the increase of the edge collisionality.展开更多
A new multi-band and high-speed endoscope diagnostic for the observation of visible light has been successfully developed on the Experimental Advanced Superconducting Tokamak.The mirror with an aperture is designed at...A new multi-band and high-speed endoscope diagnostic for the observation of visible light has been successfully developed on the Experimental Advanced Superconducting Tokamak.The mirror with an aperture is designed at the head of the optical system.Based on two dichroic mirrors,the system is divided into three imaging mirror groups with different bands,i.e.B(380-500 nm),G(500-580 nm)and R(580-750 nm)bands,and its focal length is 16 mm with a relatively large aperture of D/f=1:4.The spatial resolution is less than 5 mm near the object distance of 1750 mm with the camera NAC ACS-1 M60.This optical system will be used to contrastively study both the spatial distribution and time evolution of different impurities in the same field of view.The experimental results confirm that it can be applied to the recognition of plasma boundary and related physical research.展开更多
Objective:Pelvic organ prolapse(POP)is a common gynecological disease in middle-aged and older women that seriously affects patients'physical health and quality of life,increases the financial burden for patients,...Objective:Pelvic organ prolapse(POP)is a common gynecological disease in middle-aged and older women that seriously affects patients'physical health and quality of life,increases the financial burden for patients,and becomes a major public health concern.The aim of this study was to investigate the medium-term outcomes of laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with a posterior approach for patients with severe POP.Methods:Patients with severe POP quantitation stage III-IV who underwent laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with a posterior approach at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine between September 2016 and December 2020 were enrolled in this study.The results and complications were recorded.Data were retrospectively reviewed.Results:In total,124 patients were analyzed.Patients were followed up for 32.2712.90 months.The objective cure rate for patients who underwent hysterectomy was 917%(100/109),with 7(6.4%)patients had anterior vaginal wall prolapse and 2(1.8%)patients had posterior vaginal wall prolapse.The objective cure rate for patients who retained uterus was 66.7%(10/15).All 5 patients with recurrence had uterine prolapse,and 3(20.0%)of them also had anterior vaginal wall prolapse.Conchusions:Laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with the posterior approach is a safe,minimally invasive,and effective method for patients with severe POP.Long-term follow-up is needed to confirm the clinical effects.展开更多
Objective:Laparoscopic pelvic lymph node dissection(LPND),which is an effective therapy for endometrial cancer,is challenging because of the complexity of the procedure and the occurrence of postoperative complication...Objective:Laparoscopic pelvic lymph node dissection(LPND),which is an effective therapy for endometrial cancer,is challenging because of the complexity of the procedure and the occurrence of postoperative complications.This study aimed to explore whether indocyanine green(ICG)-enhanced nearinfrared(NIR)fluorescence-guided LPND is superior to LPND in the context of early-stage endometrial carcinoma.Methods:In this retrospective study,we included the medical records of 190 patients with early-stage endometrioid adenocarcinoma who underwent LPND at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine between January 2019 and January 2021.Depending on whether ICG-enhanced NIR fluorescence guidance was used,the patients were assigned to the ICG group or non-ICG group.Patients were followed-up for one year after surgery.Data on demographic characteristics,pathological results,operative outcomes,and complications were collected and analyzed.Results:The baseline characteristics were comparable between the ICG group and non-ICG group,including age,BMI,pregnancy history,and preoperative hemoglobin.For surgical outcomes,the patients in ICG group had significantly lower intraoperative blood loss(50 mL vs.120 mL,p<0.001),less postoperative pelvic drainage time(4.14±1.44 d vs.5.70±1.89 d,p¼0.001),shorter duration of hospital stay(5.26±1.41 d vs.7.37±1.85 d,p¼0.003),higher number of positive pelvic lymph nodes(PLNs)(1 vs.0,p¼0.003),and more PLN-positive cases(16.0%vs.3.6%,p¼0.003)than the patients in non-ICG group.However,no significant differences were noted in blood transfusion requirement,operative time,hemoglobin level decreases,number of PLNs harvested,or the presence of lymphocysts between the two groups.Conclusion:Our study showed that ICG-enhanced NIR fluorescence-guided operation may improve the accuracy and safety of LPND.展开更多
基金supported by the Key R&D Program of Shaanxi Province(No.2025CYYBXM-078).
文摘Aiming at the scale adaptation of automatic driving target detection algorithms in low illumination environments and the shortcomings in target occlusion processing,this paper proposes a YOLO-LKSDS automatic driving detection model.Firstly,the Contrast-Limited Adaptive Histogram Equalisation(CLAHE)image enhancement algorithm is improved to increase the image contrast and enhance the detailed features of the target;then,on the basis of the YOLOv5 model,the Kmeans++clustering algorithm is introduced to obtain a suitable anchor frame,and SPPELAN spatial pyramid pooling is improved to enhance the accuracy and robustness of the model for multi-scale target detection.Finally,an improved SEAM(Separated and Enhancement Attention Module)attention mechanism is combined with the DIOU-NMS algorithm to optimize the model’s performance when dealing with occlusion and dense scenes.Compared with the original model,the improved YOLO-LKSDS model achieves a 13.3%improvement in accuracy,a 1.7%improvement in mAP,and 240,000 fewer parameters on the BDD100K dataset.In order to validate the generalization of the improved algorithm,we selected the KITTI dataset for experimentation,which shows that YOLOv5’s accuracy improves by 21.1%,recall by 36.6%,and mAP50 by 29.5%,respectively,on the KITTI dataset.The deployment of this paper’s algorithm is verified by an edge computing platform,where the average speed of detection reaches 24.4 FPS while power consumption remains below 9 W,demonstrating high real-time capability and energy efficiency.
基金supported by the National Natural Science Foundation of China(Grant Nos.52369019,52004127)the Young Elite Scientists Sponsorship Program by JXAST(Grant No.2023QT06).
文摘The study of the shear behavior of bonded rock-cement interface is important for understanding the strength and stability of grouted rock masses.This research aims to reveal the failure mechanism behind the shear property of bonded rock-cement interfaces.For the study,sandstone and granite joint blocks with specific morphology were fabricated by using a three-dimensional(3D)engraving technique.Bonded rock-cement joints with asperity inclination angles of 15°,30°,and 45°were prepared.Shear tests were performed on these bonded rock-cement joints to investigate the shear response and failure modes considering the effect of applied normal stress and interface morphology.Meanwhile,the two-dimensional particle flow code(PFC2D)was utilized to model the entire shear process of bonded rock-cement interfaces.The macroscopic shear behavior and mesoscopic failure mechanism were comprehensively investigated by the laboratory test and numerical simulation.The results showed that the shear stress-displacement curves of bonded rock-cement joints exhibit two distinct peaks,and the shear stress evolution can be categorized into four stages including elastic growth,rapid stress drop,secondary stress growth,and progressive softening.Significantly,the number of acoustic emission events also exhibits two distinct peaks related to the double peak of the shear stress curves.The failure of bonded rock-cement interfaces is mainly induced by shear fractures,while the failure of rock and cement blocks is primarily caused by tensile fractures.The number of shear cracks in the bonded rock-cement interfaces reaches the peak when the shear stress reaches the primary peak;whereas as the shear stress continuously approaches the residual stage,the fracture of the bonded rock-cement joints is primarily characterized by tensile cracks in the blocks.
基金financially supported by the National Natural Science Foundation of China(No.52474355)the Liaoning Province Science and Technology Plan Joint Program(Key Research and Development Program Project,Nos.2022JH25/10200003 and 2023JH2/101800058)the Fundamental Research Funds for the Central Universities(Nos.N25YJS003 and N25DCG006)。
文摘The microstructural characteristics of austenite in Ti microalloyed steel during continuous casting significantly influence thethermoplasticity,thereby affecting the quality of the slab.In this work,a prediction model for two-stage austenite growth under varyingcooling rates was established by incorporating the effect of second-phase pinning and high-temperature ferrite-austenite phase transform-ation and growth theory.The results indicate that with 0.02wt%Ti,the high-temperature ferrite growth exhibits typical parabolic growthcharacteristics.When the Ti content increases to 0.04wt%,the high-temperature ferrite grain boundary migration rate significantly slowsduring the initial solidification stage.The predicted austenite grain sizes for 0.02wt%Ti microalloyed steel at the center,quarter,and sur-face of the slab are 5592,3529,and 1524μm,respectively.For 0.04wt%Ti microalloyed steel,the austenite grain sizes are 4074,2942,and 1179μm at the same positions.The average error is within 5%.As the Ti content increases from 0.02wt% to 0.04wt%,the austenitegrain refinement at the center is most significant,with an average grain size reduction of 27.14%.
基金Xinjiang Uygur Autonomous Region Science and Technology Department-Tianshan Innovation Team Program Project,Grant/Award Number:2023D14006Xinjiang Uygur Autonomous Region Science and Technology Department-Natural Science Foundation,Grant/Award Number:2023D01C115。
文摘Background:This study aimed to discover whether Cistanche tubulosa affects the AKT/CASP3 pathway by regulating m6A methylation,to exert a protective effect against peripheral nerve injury in a Parkinson's Disease(PD)mouse model.Methods:In this study,network pharmacology analysis and the molecular docking virtual screening technique was used to filter Acteoside(Act),a potential neuroprotective agent of active components in Cistanche tubulosa.A PD-related peripheral neuropathy mouse model was established by MPTP induction,followed by 21 days treatment of oral Act(25,50,and 100 mg kg^(−1)).Pole climbing,automatic avoidance ability and hot plate sensory tests were evaluated to determine behavioral changes caused by central and peripheral nerve injury.The pathological alterations of dorsal root ganglion tissue and the protein levels of IL-6,AKT,and CASP3 under Act intervention,as well as the dynamic changes of FTO,METTL3,and YTHDF2 which are closely related to m6A methylation,were comprehensively analyzed to observe the peripheral nerve protective efficacy of Act.Results:The results showed that peripheral neuropathy occurring with PD in the mouse model,which could be verified by behavioral tests and pathological histological changes.In addition to the previously established protective effect of Act on dopaminergic neurons in substantia nigra(SN),extensive follow-up studies demonstrated that Act effectively induced m6A methylation,which could further regulate the AKT/CASP3 pathway to play a therapeutic role.In this study,medium and high doses of Act played more obvious therapeutic roles.Conclusion:These findings suggest that Act may regulate the severity of peripheral nerve injury under the activation of the AKT/CASP3 signaling pathway by balancing the methylation level of m6A.These results provide a theoretical basis and experimental evidence for further research on the protective effect of Cistanche tubulosa on both the central and peripheral nerves in the treatment of PD.
基金supported by the National Natural Science Foundation of China(61971284)the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(SL2020ZD203 and SL2020MS031)+2 种基金Scientific Research Fund of Second Institute of Oceanography,Ministry of Natural Resources of P.R.China(SL2003)Shanghai Sailing Program(21YF1421400)Startup Fund for Youngman Research at Shanghai Jiao Tong University.
文摘Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental monitoring.Gas sensors based on conventional bulk materials often suffer from their poor surface-sensitive sites,leading to a very low gas adsorption ability.Moreover,the charge transportation efficiency is usually inhibited by the low defect density of surface-sensitive area than that in the interior.In this work,a gas sensing structure model based on CuS quantum dots/Bi_(2)S_(3) nanosheets(CuS QDs/Bi_(2)S_(3) NSs)inspired by artificial neuron network is constructed.Simulation analysis by density functional calculation revealed that CuS QDs and Bi_(2)S_(3) NSs can be used as the main adsorption sites and charge transport pathways,respectively.Thus,the high-sensitivity sensing of NO_(2) can be realized by designing the artificial neuron-like sensor.The experimental results showed that the CuS QDs with a size of about 8 nm are highly adsorbable,which can enhance the NO_(2) sensitivity due to the rich sensitive sites and quantum size effect.The Bi_(2)S_(3) NSs can be used as a charge transfer network channel to achieve efficient charge collection and transmission.The neuron-like sensor that simulates biological smell shows a significantly enhanced response value(3.4),excellent responsiveness(18 s)and recovery rate(338 s),low theoretical detection limit of 78 ppb,and excellent selectivity for NO_(2).Furthermore,the developed wearable device can also realize the visual detection of NO2 through real-time signal changes.
基金Supported by the Fundamental Research Funds of Panjin Industrial Technology Institute(PJYJY2016A004)the National Natural Science Foundation of China(No.21776032)+2 种基金Natural Science Foundation of Anhui Province(1808085QB51)the Key Research and Development Plan of Anhui Province(1804a09020072)the Natural Science Research Project of Anhui Colleges and Universities(KJ2017A397)
文摘Zeolite membranes offer outstanding potentials in separation of many molecular mixtures due to their molecular sieving selectivity and the high thermal and mechanical stability that allow them to operate at harsh conditions.Development of durable and high separation performance membranes with lower fabrication and operation cost are highly demanded for industrial applications. Zeolite T membrane possesses good acid-resistance with excellent hydrophilic properties as compared to NaA zeolite membrane and can be extended to industrial organic dehydrations under an acidic environment. In the present review the research advances in development of zeolite T membranes for the dehydration of organic mixtures in acidic conditions are summarized. Especially the low temperature synthesis, and epitaxial growth of the zeolite membrane with high performance are well addressed, besides emphasis is particularly placed on ensemble synthesis of hollow fiber zeolite T membrane module and its future prospects for industrial separations.
基金supported by the National Key Research and Development Program of China(2022YFB3205500,and 2022YFC3104700)the National Natural Science Foundation of China(62101329 and 61971284)+4 种基金the Shanghai Sailing Program(21YF1421400)the Natural Science Foundation of Shanghai(23ZR1430100)the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(SL2020ZD203,SL2021MS006 and SL2020MS031)Scientific Research Fund of Second Institute of Oceanography,Ministry of Natural Resources of P.R.China(SL2003)Startup Fund for Youngman Research at Shanghai Jiao Tong University.
文摘Human metabolite moisture detection is important in health monitoring and non-invasive diagnosis.However,ultra-sensitive quantitative extraction of respiration information in real-time remains a great challenge.Herein,chemiresistors based on imine-linked covalent organic framework(COF)films with dual-active sites are fabricated to address this issue,which demonstrates an amplified humidity-sensing signal performance.By regulation of monomers and functional groups,these COF films can be pre-engineered to achieve high response,wide detection range,fast response,and recovery time.Under the condition of relative humidity ranging from 13 to 98%,the COFTAPB-DHTA film-based humidity sensor exhibits outstanding humidity sensing perfor-mance with an expanded response value of 390 times.Furthermore,the response values of the COF film-based sensor are highly linear to the relative humidity in the range below 60%,reflecting a quantitative sensing mechanism at the molecular level.Based on the dual-site adsorption of the(-C=N-)and(C-N)stretching vibrations,the revers-ible tautomerism induced by hydrogen bonding with water molecules is demonstrated to be the main intrinsic mechanism for this effective humidity detection.In addition,the synthesized COF films can be further exploited to effectively detect human nasal and oral breathing as well as fabric permeability,which will inspire novel designs for effective humidity-detection devices.
基金supported by National Natural Science Foundation of China under Grant Nos.51477177 and 51641707
文摘As a combination device for a step-up pulse transformer and a magnetic switch,the saturable pulse transformer is widely used in pulsed-power and plasma technology.A fractional-turn ratio saturable pulse transformer is constructed and analyzed in this paper.Preliminary experimental results show that if the primary energy storage capacitors are charged to 300 V,an output voltage of about 19 kV can be obtained across the capacitor connected to the secondary windings of a fractional-tum ratio saturable pulse transformer.Theoretical and experimental results reveal that this kind of pulse transformer is not only able to integrate a step-up transformer and a magnetic switch into one device,but can also lower the saturable inductance of its secondary windings,thus leading to the relatively high step-up ratio of the pulse transformer.Meanwhile,the application of the fractional-turn ratio saturable pulse transformer in a μs range pulse modulator as a voltage step-up device and main switch is also included in this paper.The demonstrated experiments display that an output voltage with an amplitude of about 29 kV,and a 1.6 μs pulse width can be obtained across a 3500 Ω resistive load,based on a pulse modulator,if the primary energy storage capacitors are charged to 300 V.This compact fractional-turn ratio saturable pulse transformer can be applied in many other fields such as surface treatment,corona plasma generation and dielectric barrier discharge.
基金This work was supported by the National Natural Science Foundation of China under Grant No.51677190the Hunan Provincial Natural Science Foundation of China under Grant No.2017JJ1005.
文摘This paper provides a review of the compact intense electron-beam accelerators (IEBAs) based on liquid pulse forming lines (PFLs) that havebeen developed at the National University of Defense Technology (NUDT) in China. The history and roadmap of the compact IEBAs used todrive high-power microwave (HPM) devices at NUDT are reviewed. The properties of both de-ionized water and glycerin as energy storagemedia are presented. Research into the breakdown properties of liquid dielectrics and the desire to maximize energy storage have resulted in theinvention of several coaxial PFLs with different electromagnetic structures, which are detailed in this paper. These high energy density liquidPFLs have been used to increase the performance of IEBA subsystems, based on which the SPARK (Single Pulse Accelerator with spark gaps)and HEART (High Energy-density Accelerator with Repetitive Transformer) series of IEBAs were constructed. This paper also discusses howthese compact IEBAs have been used to drive typical HPM devices and concludes by summarizing the associated achievements and theconclusions that can be drawn from the results.
文摘The double pulse sources （DPS） method is presented for linear track estimation in this work. In the field of noise identification of underwater moving target, the Doppler will distort the frequency and amplitude of the radiated noise. To eliminate this, the track estimation is necessary. In the DPS method, we first estimate bearings of two sinusoidal pulse sources installed in the moving target through baseline positioning method. Meanwhile, the emitted and recorded time of each pulse are also acquired. Then the linear track parameters will be achieved based on the geometry pattern with the help of double sources spacing. The simulated results confirm that the DPS improves the performance of the previous double source spacing method. The simulated experiments were carried out using a moving battery car to further evaluate its performance. When the target is 40-60m away, the experiment results show that biases of track azimuth and abeam distance of DPS are under 0.6° and 3.4m, respectively. And the average deviation of estimated velocity is around 0.25m/s.
基金the financial support from the China Scholarship Council (CSC)the National Natural Science Foundation of China (21776032)+2 种基金the Fundamental Research Funds of Panjin Industrial Technology Institute (PJYJY2016A004)the National High Technology Research and Development Program of China (2015AA03A602)the Innovation Team of Dalian University of Technology (DUT2017TB01)
文摘CAU-1 is one of aluminum-based amine-functionalized Metal-Organic Frameworks(MOFs).Gas permeation and separation behaviors through CAU-1 membrane were simulated by the dual-control plane nonequilibrium molecular dynamics(DCP-NEMD)method.The thickness of membrane was 3.55 nm.Gases CO_(2),N_(2),CH_(4),H_(2),He,Kr and Xe were chosen for the calculation in both single component and binary mixtures.The permeation process was calculated in grand canonical(μVT)ensemble with periodic boundary conditions(PBC)in x-and y-directions at different temperatures.The calculated permeance of H_(2),CH_(4),N_(2),CO_(2) and Kr decreased with increasing temperature in both single and binary system,while that of Xe with kinetic molecule of 0.41 nm increased with increasing temperature.It shows Xe permeation is governed by activated diffusion.The simulated separation factors of CO_(2)/N_(2) and CO_(2)/CH_(4) of 4.2 and 1.3 respectively were lower than the experimental ones when only considering van der Waals interaction.Further consideration of electrostatic potential leads to improved calculation CO_(2)/N_(2) and CO_(2)/CH_(4) separation factor of 23.0 and 12.9 respectively that were consistent with the experimental ones of 26.2 and 14.8.It suggests the necessity of considering the Coulomb interactions between CO_(2) and NH_(2)-on the pore wall of CAU-1 for permeation of CO_(2).For H_(2)/N_(2) and H_(2)/CH_(4) the ideal selectivities also keep consistent with our experimental results.Interestingly,the simulated separation factor for noble Kr/Xe reaches infinite,predicting that CAU-1 membrane possesses potential separation properties for radioactive Kr/Xe.
基金Financial support from the Science Fund for Creative Research Groups of the National Science Foundation of China (22021005)the National Natural Science Foundation of China (21776032)the Innovation Team of Dalian University of Technology (DUT2017TB01)。
文摘Tungsten (W) incorporated mobil-type eleven (MEL) zeolite membrane (referred to as W-MEL membrane) with high separation performance was firstly explored for the separation of oil/water mixtures under the influence of gravity.W-MEL membranes were grown on stainless steel (SS) meshes through in-situ hydrothermal growth method facilitated with (3-aminopropyl)triethoxysilane (APTES) modification of stainless steel meshes,which promote the heterogeneous nucleation and crystal growth of W-MEL zeolites onto the mesh surface.W-MEL membranes were grown on different mesh size supports to investigate the effect of mesh size on the separation performance of the membrane.The assynthesized W-MEL membrane supported on 500 mesh (25μm)(W-MEL-500) exhibit the hydrophilic nature with a water contact angle of 11.8°and delivers the best hexane/water mixture separation with a water flux and separation efficiency of 46247 L·m^(-2)·h^(-1)and 99.5%,respectively.The wettability of W-MEL membranes was manipulated from hydrophilic to hydrophobic nature by chemically modifying with the fluorine-free compounds (hexadecyltrimethoxysilane (HDTMS) and dodecyltrimethoxysilane(DDTMS)) to achieve efficient oil-permselective separation of heavy oils from water.Among the hydrophobically modified W-MEL membranes,W-MEL-500-HDTMS having a water contact angle of146.4°delivers the best separation performance for dichloromethane/water mixtures with a constant oil flux and separation efficiency of 61490 L·m^(-2)·h^(-1)and 99.2%,respectively along with the stability tested up to 20 cycles.Both W-MEL-500-HDTMS and W-MEL-500-DDTMS membranes also exhibit similar separation performances for the separation of heavy oil from sea water along with a 20-fold lower corrosion rate in comparison with the bare stainless-steel mesh,indicating their excellent stability in seawater.Compared to the reported zeolite membranes for oil/water separation,the as-synthesized and hydrophobically modified W-MEL membranes shows competitive separation performances in terms of flux and separation efficiency,demonstrating the good potentiality for oil/water separation.
基金supported by the National Key Research and Development Program of China(2022YFB3205500)the National Natural Science Foundation of China(62371299,62301314 and 62101329)+2 种基金the China Postdoctoral Science Foundation(2023M732198)the Natural Science Foundation of Shanghai(23ZR1430100)supported by the Center for High-Performance Computing at Shanghai Jiao Tong University.
文摘Significant challenges are posed by the limitations of gas sensing mechanisms for trace-level detection of ammonia(NH3).In this study,we propose to exploit single-atom catalytic activation and targeted adsorption properties to achieve highly sensitive and selective NH3 gas detection.Specifically,Ni singleatom active sites based on N,C coordination(Ni-N-C)were interfacially confined on the surface of two-dimensional(2D)MXene nanosheets(Ni-N-C/Ti_(3)C_(2)Tx),and a fully flexible gas sensor(MNPE-Ni-N-C/Ti_(3)C_(2)Tx)was integrated.The sensor demonstrates a remarkable response value to 5 ppm NH3(27.3%),excellent selectivity for NH3,and a low theoretical detection limit of 12.1 ppb.Simulation analysis by density functional calculation reveals that the Ni single-atom center with N,C coordination exhibits specific targeted adsorption properties for NH3.Additionally,its catalytic activation effect effectively reduces the Gibbs free energy of the sensing elemental reaction,while its electronic structure promotes the spill-over effect of reactive oxygen species at the gas-solid interface.The sensor has a dual-channel sensing mechanism of both chemical and electronic sensitization,which facilitates efficient electron transfer to the 2D MXene conductive network,resulting in the formation of the NH3 gas molecule sensing signal.Furthermore,the passivation of MXene edge defects by a conjugated hydrogen bond network enhances the long-term stability of MXene-based electrodes under high humidity conditions.This work achieves highly sensitive room-temperature NH3 gas detection based on the catalytic mechanism of Ni single-atom active center with N,C coordination,which provides a novel gas sensing mechanism for room-temperature trace gas detection research.
基金This work was supported by the National Natural Science Foundation of China(No.31900966&82001105)the Guangdong Provincial Basic and Applied Basic Research(No.2019A1515110415)+2 种基金Shenzhen Medical Academy of Research and Translation(A2303069)the Shenzhen Basic Research Program General Project(JCYJ20220530162206012)Medicine Plus Project of Shenzhen University.
文摘The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions.Among emerging strategies,extracellular vesicles(EVs)have shown promise as an acellular approach for bone regeneration.However,their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection.To address this challenge,EV-functionalized scaffolds have recently been proposed as an alternative delivery strategy to enhance EV retention and subsequent healing efficacy.This review aims to consolidate recent advancements in the development of EV-functionalized scaffolds for augmenting bone regeneration.It explores various sources of EVs and different strategies for integrating them into biomaterials.Furthermore,the mechanisms underlying their therapeutic effects in bone regeneration are elucidated.Current limitations in clinical translation and perspectives on the design of more efficient EVs for improved therapeutic efficacy are also presented.Overall,this review can provide inspiration for the development of novel EV-assisted grafts with superior bone regeneration potential.
基金supported by Shenzhen Clean Energy Research Institutesupported by the National Key R&D Program of China (No. 2017YFE0301205)National Natural Science Foundation of China (Nos. 11875289, 11975271, 11605244, 11675211, 12075284, 12075283, 12075155 and 11875294)
文摘The influence of a molybdenum dust buildup on plasma edge turbulence has been studied in the EAST tokamak.The motion of the dust from the upper divertor region is detected by a fast visible CCD camera,the XUV spectrometer arrays,and the EUV spectrometer.The MoXV emission intensity sharply increases compared with the spectral lines of various ionization states of other elements,which implies that the dust particles are the molybdenum impurities.The radial distribution of Mo^(14+)ion simulated by a simplified 1 D transport model indicates that the molybdenum dust mainly deposits in the pedestal bottom region.Moreover,it is observed that the coherent mode(CM)appears atρ=0.94 after the molybdenum impurities enter the main plasma region.The influx of molybdenum impurities results in increasing pedestal electron density and decreasing pedestal electron temperature in contrast to that before the event of impurities dropping.It is also found that the electron density gradient in the pedestal increases when the ablation of the molybdenum impurities is observed in the pedestal region.The qualitative experimental results indicate that the onset of CM is likely related to the increase of the density gradient and edge collisionality in the pedestal.In comparison to the density gradient,the enhancement of CM amplitude largely depends on the increase of the edge collisionality.
基金supported by National Natural Science Foundation of China(No.12075281)the National Magnetic Confinement Fusion Research Program of China(Nos.2017YFE0301104 and 2017YFE0301105)Important Projects of Collaborative Innovation of the Hefei Science Center,CAS(No.2021HSC-CIP007)。
文摘A new multi-band and high-speed endoscope diagnostic for the observation of visible light has been successfully developed on the Experimental Advanced Superconducting Tokamak.The mirror with an aperture is designed at the head of the optical system.Based on two dichroic mirrors,the system is divided into three imaging mirror groups with different bands,i.e.B(380-500 nm),G(500-580 nm)and R(580-750 nm)bands,and its focal length is 16 mm with a relatively large aperture of D/f=1:4.The spatial resolution is less than 5 mm near the object distance of 1750 mm with the camera NAC ACS-1 M60.This optical system will be used to contrastively study both the spatial distribution and time evolution of different impurities in the same field of view.The experimental results confirm that it can be applied to the recognition of plasma boundary and related physical research.
基金supported by the National Key Research and Development Program of China(2018YFC1004800)the Scien-tific Research Fund of Zhejiang Provincial Education Department(Y2020433-40)。
文摘Objective:Pelvic organ prolapse(POP)is a common gynecological disease in middle-aged and older women that seriously affects patients'physical health and quality of life,increases the financial burden for patients,and becomes a major public health concern.The aim of this study was to investigate the medium-term outcomes of laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with a posterior approach for patients with severe POP.Methods:Patients with severe POP quantitation stage III-IV who underwent laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with a posterior approach at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine between September 2016 and December 2020 were enrolled in this study.The results and complications were recorded.Data were retrospectively reviewed.Results:In total,124 patients were analyzed.Patients were followed up for 32.2712.90 months.The objective cure rate for patients who underwent hysterectomy was 917%(100/109),with 7(6.4%)patients had anterior vaginal wall prolapse and 2(1.8%)patients had posterior vaginal wall prolapse.The objective cure rate for patients who retained uterus was 66.7%(10/15).All 5 patients with recurrence had uterine prolapse,and 3(20.0%)of them also had anterior vaginal wall prolapse.Conchusions:Laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with the posterior approach is a safe,minimally invasive,and effective method for patients with severe POP.Long-term follow-up is needed to confirm the clinical effects.
基金supported by the Medical and Health Research Project of Zhejiang Province(2018RC008,2018KY113,and WKJ-ZJ-2125)Zhejiang Provincial Natural Science Foundation(LQ20H040011).
文摘Objective:Laparoscopic pelvic lymph node dissection(LPND),which is an effective therapy for endometrial cancer,is challenging because of the complexity of the procedure and the occurrence of postoperative complications.This study aimed to explore whether indocyanine green(ICG)-enhanced nearinfrared(NIR)fluorescence-guided LPND is superior to LPND in the context of early-stage endometrial carcinoma.Methods:In this retrospective study,we included the medical records of 190 patients with early-stage endometrioid adenocarcinoma who underwent LPND at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine between January 2019 and January 2021.Depending on whether ICG-enhanced NIR fluorescence guidance was used,the patients were assigned to the ICG group or non-ICG group.Patients were followed-up for one year after surgery.Data on demographic characteristics,pathological results,operative outcomes,and complications were collected and analyzed.Results:The baseline characteristics were comparable between the ICG group and non-ICG group,including age,BMI,pregnancy history,and preoperative hemoglobin.For surgical outcomes,the patients in ICG group had significantly lower intraoperative blood loss(50 mL vs.120 mL,p<0.001),less postoperative pelvic drainage time(4.14±1.44 d vs.5.70±1.89 d,p¼0.001),shorter duration of hospital stay(5.26±1.41 d vs.7.37±1.85 d,p¼0.003),higher number of positive pelvic lymph nodes(PLNs)(1 vs.0,p¼0.003),and more PLN-positive cases(16.0%vs.3.6%,p¼0.003)than the patients in non-ICG group.However,no significant differences were noted in blood transfusion requirement,operative time,hemoglobin level decreases,number of PLNs harvested,or the presence of lymphocysts between the two groups.Conclusion:Our study showed that ICG-enhanced NIR fluorescence-guided operation may improve the accuracy and safety of LPND.
