Economic growth and environmental pollution have become the bases of geopolitical competition due to the multiple constraints of growth in energy consumption and environmental protection in recent decades.Whether the ...Economic growth and environmental pollution have become the bases of geopolitical competition due to the multiple constraints of growth in energy consumption and environmental protection in recent decades.Whether the coordinated development of inward foreign direct investment(IFDI)and outward foreign direct investment(OFDI)promote economic growth while reducing environmental pollution and realizing high-quality development affects the overall socialist modernization under China’s“Dual Circulation”policy.Using China’s provincial panel data from 2005 to 2020,this paper first measured green total factor productivity(GTFP)and the coordinated development index(CDIFDI)of IFDI and OFDI via the slacks-based measureglobal Malmquist–Luenberger(SBM-GML)model and the capacity coupling model.A panel threshold model with interactive effects(PTIFEs)was then applied to explore the nonlinear impact of the CDIFDI on China’s GTFP.Finally,a regional heterogeneity analysis was conducted for China’s eastern,central and western regions of China.Results show that(1)GTFP in China kept rising with small fluctuations during the sample period,with the increasing range of GTFP decreasing from east to west.(2)CDIFDI had a significant“U”-shaped threshold effect on GTFP,and the main threshold variables were the industrial structure and the level of economic development.(3)CDIFDI played a positive role in promoting GTFP growth in the eastern region,while the effects of CDIFDI on GTFP in the central and western regions were not significant.Policy-makers and enterprises should comprehensively consider promoting regional industrial upgrading and economic growth to achieve a greater positive impact of CDIFDI on GTFP.Scientifically measuring GTFP and exploring the nonlinear impact of the CDIFDI on GTFP and regional heterogeneity provide helpful references for policy-makers to coordinate the high-quality development of regional economies.展开更多
Methylene bis(thiocyanate)(MBT) is insoluble in water, so suspension concentrate(SC) of MBT is extremely relied on surfactants. In this paper, SC of MBT was prepared with wet-grinding technology, and the effect of sur...Methylene bis(thiocyanate)(MBT) is insoluble in water, so suspension concentrate(SC) of MBT is extremely relied on surfactants. In this paper, SC of MBT was prepared with wet-grinding technology, and the effect of surfactants,such as Morwet D425(D425) and Morwet EFW(EFW)(two kinds of dispersant), on the Zeta potential and rheology behavior of MBT SC were investigated. The results showed that the Zeta potential absolute value of MBT SC increased with the increasing content of D425, and it decreased with the increasing content of EFW at acidic solution(pH = 4.5). In the combination system of D425 and EFW, Zeta potential of MBT SC decreased first and then increased with the increasing content of EFW. The relationship between shear rate(γ) and viscosity(η) was studied according to Herschel–Bulkley model: η = η0+ k/γ, and the relationship between shear rate(γ) and shear force(τ) was investigated according to:τ = τ0+Kγ~n. It was revealed that the mixed fluid belonged to Yield Pseudoplastic Fluid.展开更多
Infectious diseases such as coronavirus disease 2019(COVID-19)continue to pose significant global health challenges.Effective management of reinfection risks depends on sustained levels of binding and neutralizing ant...Infectious diseases such as coronavirus disease 2019(COVID-19)continue to pose significant global health challenges.Effective management of reinfection risks depends on sustained levels of binding and neutralizing antibodies.However,conventional methods—such as enzyme-linked immunosorbent assays(ELISA)and virus neutralization tests(VNT)—are limited by complex workflows,long assay durations,and high sample volume requirements,making them less suit-able for routine,decentralized,or time-sensitive surveillance.This study presents a custom-developed tip optofluidic immunoassay(TOI)platform that enables rapid,multiplexed antibody profiling using only 1 mL offingertip blood.The system integrates batch-fabricated microfluidic immunoreactors with a portable chemiluminescent imaging station,completing both binding and neutralization capability assessments within 40 min.TOI achieves a broad dynamic range(3–4 orders of magnitude),high signal-to-noise ratio(10,000),and excellent sensitivity for immunoglobulin G(IgG)detection.A renovated version of the rapid in vitro inhibition assay(RIVIA)is incorporated to evaluate neutralizing an-tibodies against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with greater speed and cost-effi-ciency.In clinical studies,TOI successfully quantified antibody protection against multiple variants,identifying individ-uals with broad-spectrum immunity to both wild-type and XBB strains.With its high-precision,rapid turnaround,and minimal sample requirement,TOI offers a valuable tool for decentralized immune surveillance and personalized immu-nization strategy development.展开更多
基金supported by the Key Project of National Philosophy and Social Science Foundation of China(Grant No.24AGL007).
文摘Economic growth and environmental pollution have become the bases of geopolitical competition due to the multiple constraints of growth in energy consumption and environmental protection in recent decades.Whether the coordinated development of inward foreign direct investment(IFDI)and outward foreign direct investment(OFDI)promote economic growth while reducing environmental pollution and realizing high-quality development affects the overall socialist modernization under China’s“Dual Circulation”policy.Using China’s provincial panel data from 2005 to 2020,this paper first measured green total factor productivity(GTFP)and the coordinated development index(CDIFDI)of IFDI and OFDI via the slacks-based measureglobal Malmquist–Luenberger(SBM-GML)model and the capacity coupling model.A panel threshold model with interactive effects(PTIFEs)was then applied to explore the nonlinear impact of the CDIFDI on China’s GTFP.Finally,a regional heterogeneity analysis was conducted for China’s eastern,central and western regions of China.Results show that(1)GTFP in China kept rising with small fluctuations during the sample period,with the increasing range of GTFP decreasing from east to west.(2)CDIFDI had a significant“U”-shaped threshold effect on GTFP,and the main threshold variables were the industrial structure and the level of economic development.(3)CDIFDI played a positive role in promoting GTFP growth in the eastern region,while the effects of CDIFDI on GTFP in the central and western regions were not significant.Policy-makers and enterprises should comprehensively consider promoting regional industrial upgrading and economic growth to achieve a greater positive impact of CDIFDI on GTFP.Scientifically measuring GTFP and exploring the nonlinear impact of the CDIFDI on GTFP and regional heterogeneity provide helpful references for policy-makers to coordinate the high-quality development of regional economies.
基金Supported by Guangzhou Science Technology and Innovation Commission(201508030019)China Scholarship Council(201506155073)National Undergraduate Innovative and Entrepreneurial Training Program(201610561089)
文摘Methylene bis(thiocyanate)(MBT) is insoluble in water, so suspension concentrate(SC) of MBT is extremely relied on surfactants. In this paper, SC of MBT was prepared with wet-grinding technology, and the effect of surfactants,such as Morwet D425(D425) and Morwet EFW(EFW)(two kinds of dispersant), on the Zeta potential and rheology behavior of MBT SC were investigated. The results showed that the Zeta potential absolute value of MBT SC increased with the increasing content of D425, and it decreased with the increasing content of EFW at acidic solution(pH = 4.5). In the combination system of D425 and EFW, Zeta potential of MBT SC decreased first and then increased with the increasing content of EFW. The relationship between shear rate(γ) and viscosity(η) was studied according to Herschel–Bulkley model: η = η0+ k/γ, and the relationship between shear rate(γ) and shear force(τ) was investigated according to:τ = τ0+Kγ~n. It was revealed that the mixed fluid belonged to Yield Pseudoplastic Fluid.
基金supported by the Outstanding Young Innovator Fund,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences(to X.T.)the State Key Laboratory of Biomedical Imaging Science and System+5 种基金Shenzhen Basic Research Project of Natural Science Foundation(JCYJ20230808105701004 to Y.C.)Shenzhen Science and Technology Innovations Committee(JSGGZD20220822095200001 to H.Y.)National Science Foundation of China(32270937 to F.Y.)Ministry of Science and Technology of China(2021D0102 to Y.C.)Guangdong Basic and Applied Basic Research Foundation(2025A1515012136 to H.L.)Medicine Plus Program of Shenzhen University(2024YG015 to Y.C.).
文摘Infectious diseases such as coronavirus disease 2019(COVID-19)continue to pose significant global health challenges.Effective management of reinfection risks depends on sustained levels of binding and neutralizing antibodies.However,conventional methods—such as enzyme-linked immunosorbent assays(ELISA)and virus neutralization tests(VNT)—are limited by complex workflows,long assay durations,and high sample volume requirements,making them less suit-able for routine,decentralized,or time-sensitive surveillance.This study presents a custom-developed tip optofluidic immunoassay(TOI)platform that enables rapid,multiplexed antibody profiling using only 1 mL offingertip blood.The system integrates batch-fabricated microfluidic immunoreactors with a portable chemiluminescent imaging station,completing both binding and neutralization capability assessments within 40 min.TOI achieves a broad dynamic range(3–4 orders of magnitude),high signal-to-noise ratio(10,000),and excellent sensitivity for immunoglobulin G(IgG)detection.A renovated version of the rapid in vitro inhibition assay(RIVIA)is incorporated to evaluate neutralizing an-tibodies against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with greater speed and cost-effi-ciency.In clinical studies,TOI successfully quantified antibody protection against multiple variants,identifying individ-uals with broad-spectrum immunity to both wild-type and XBB strains.With its high-precision,rapid turnaround,and minimal sample requirement,TOI offers a valuable tool for decentralized immune surveillance and personalized immu-nization strategy development.
