Intravascular large B-cell lymphoma(IVLBCL),a rare subtype of non-Hodgkin lymphoma,is classified as an independent subtype of extranodal diffuse large B-cell lymphoma(DLBCL)in the 2008 World Health Organization(WHO)Cl...Intravascular large B-cell lymphoma(IVLBCL),a rare subtype of non-Hodgkin lymphoma,is classified as an independent subtype of extranodal diffuse large B-cell lymphoma(DLBCL)in the 2008 World Health Organization(WHO)Classification(Turner et al.,2010).The 5th edition of the World Health Organization(WHO 2022)classification of hematolymphoid tumors retains this subtype(Alaggio et al.,2022).IVLBCL,which is characterized by neoplastic lymphocyte proliferation within the lumen of small blood vessels,tends to invade organs,such as the nervous system,skin,bone marrow(BM),and lung(D'Angelo et al.,2019;Satoh et al.,2019;Vasquez et al.,2019;Fukami et al.,2020).展开更多
Neural networks have provided faster and more straightforward solutions for laser modulation.However,their effectiveness when facing diverse structured lights and various output resolutions remains vulnerable because ...Neural networks have provided faster and more straightforward solutions for laser modulation.However,their effectiveness when facing diverse structured lights and various output resolutions remains vulnerable because of the specialized end-to-end training and static model.Here,we propose a redefinable neural network(RediNet),realizing customized modulation on diverse structured light arrays through a single general approach.The network input format features a redefinable dimension designation,which ensures RediNet wide applicability and removes the burden of processing pixel-wise light distributions.The prowess of originally generating arbitrary-resolution holograms with a fixed network is first demonstrated.The versatility is showcased in the generation of 2D/3D foci arrays,Bessel and Airy beam arrays,(perfect)vortex beam arrays,and even snowflake-intensity arrays with arbitrarily built phase functions.A standout application is producing multichannel compound vortex beams,where RediNet empowers a spatial light modulator(SLM)to offer comprehensive multiplexing functionalities for free-space optical communication.Moreover,RediNet has the hitherto highest efficiency,only consuming 12 ms(faster than the mainstream SLM framerate of 60 Hz)for a 1000^(2)-resolution holograph,which is critical in real-time required scenarios.Considering the fine resolution,high speed,and unprecedented universality,RediNet can serve extensive applications,such as next-generation optical communication,parallel laser direct writing,and optical traps.展开更多
Few-shot semantic segmentation aims at training a model that can segment novel classes in a query image with only a few densely annotated support exemplars.It remains a challenge because of large intra-class variation...Few-shot semantic segmentation aims at training a model that can segment novel classes in a query image with only a few densely annotated support exemplars.It remains a challenge because of large intra-class variations between the support and query images.Existing approaches utilize 4D convolutions to mine semantic correspondence between the support and query images.However,they still suffer from heavy computation,sparse correspondence,and large memory.We propose axial assembled correspondence network(AACNet)to alleviate these issues.The key point of AACNet is the proposed axial assembled 4D kernel,which constructs the basic block for semantic correspondence encoder(SCE).Furthermore,we propose the deblurring equations to provide more robust correspondence for the aforementioned SCE and design a novel fusion module to mix correspondences in a learnable manner.Experiments on PASCAL-5~i reveal that our AACNet achieves a mean intersection-over-union score of 65.9%for 1-shot segmentation and 70.6%for 5-shot segmentation,surpassing the state-of-the-art method by 5.8%and 5.0%respectively.展开更多
A composite rubber concrete(CRC)was designed by combining waste tire rubber particles with particle sizes of 3~5 mm,1~3 mm and 20 mesh.Taking the rubber content of different particle sizes as the influencing factors,t...A composite rubber concrete(CRC)was designed by combining waste tire rubber particles with particle sizes of 3~5 mm,1~3 mm and 20 mesh.Taking the rubber content of different particle sizes as the influencing factors,the range and variance analysis of the mechanical and impermeability properties of CRC was carried out by orthogonal test.Through analysis,it is concluded that the optimal proportion of 3~5 mm,1~3 mm,and 20 mesh particle size composite rubber is 1:2.5:5.5 kinds of CRC and 3 kinds of ordinary single-mixed rubber concrete(RC)with a total content of 10%~20%were designed under this ratio,and the salt-freezing cycle test was carried out with a concentration of 5%Na 2 SO4 solution.The physical and mechanical damage laws during 120 salt-freezing cycles are obtained,and the corresponding damage prediction model is established according to the experimental data.The results show that:on the one hand,the composite rubber in CRC produces a more uniform“graded”structure,forms a retractable particle group,and reduces the loss of mechanical properties of CRC.On the other hand,colloidal particles with different particle sizes are used as air entraining agent to improve the pore structure of concrete and introduce evenly dispersed bubbles,which fundamentally improves the durability of concrete.Under the experimental conditions,the CRC performance is the best when the overall content of composite rubber is 15%.展开更多
Background:Generalized pustular psoriasis(GPP),a rare and recurrent autoinflammatory disease,imposes a substantial burden on patients and society.Awareness of GPP in China remains limited.Methods:This cross-sectional ...Background:Generalized pustular psoriasis(GPP),a rare and recurrent autoinflammatory disease,imposes a substantial burden on patients and society.Awareness of GPP in China remains limited.Methods:This cross-sectional survey,conducted between September 2021 and May 2023 across 14 hospitals in China,included GPP patients of all ages and disease phases.Data collected encompassed demographics,clinical characteristics,economic impact,disease severity,quality of life,and treatment-related complications.Risk factors for GPP recurrence were analyzed.Results:Among 127 patients(female/male ratio=1.35:1),the mean age of disease onset was 25 years(1st quartile[Q1]–3rd quartile[Q3]:11–44 years);29.2%had experienced GPP for more than 10 years.Recurrence occurred in 75.6%of patients,and nearly half reported no identifiable triggers.Younger age at disease onset(P=0.021)and transitioning to plaque psoriasis(P=0.022)were associated with higher recurrence rates.The median diagnostic delay was 8 months(Q1–Q3:2–41 months),and 32.3%of patients reported misdiagnoses.Comorbidities were present in 53.5%of patients,whereas 51.1%experienced systemic complications during treatment.Depression and anxiety affected 84.5%and 95.6%of patients,respectively.During GPP flares,the median Dermatology Life Quality Index score was 19.0(Q1–Q3:13.0–23.5).This score showed significant differences between patients with and without systemic symptoms;it demonstrated correlations with both depression and anxiety scores.Treatment costs caused financial hardship in 55.9%of patients,underscoring the burden associated with GPP.Conclusions:The substantial disease and economic burdens among Chinese GPP patients warrant increased attention.Patients with early onset disease and those transitioning to plaque psoriasis require targeted interventions to mitigate the high recurrence risk.展开更多
文摘Intravascular large B-cell lymphoma(IVLBCL),a rare subtype of non-Hodgkin lymphoma,is classified as an independent subtype of extranodal diffuse large B-cell lymphoma(DLBCL)in the 2008 World Health Organization(WHO)Classification(Turner et al.,2010).The 5th edition of the World Health Organization(WHO 2022)classification of hematolymphoid tumors retains this subtype(Alaggio et al.,2022).IVLBCL,which is characterized by neoplastic lymphocyte proliferation within the lumen of small blood vessels,tends to invade organs,such as the nervous system,skin,bone marrow(BM),and lung(D'Angelo et al.,2019;Satoh et al.,2019;Vasquez et al.,2019;Fukami et al.,2020).
基金supported by the Innovation Project of Optics Valley Laboratory(Grant No.OVL2023PY006)the National Natural Science Foundation of China(Grant No.62275097)+1 种基金the Key Research and Development Project of Hubei Province,China(Grant No.2020AAA003)the Major Program(JD)of Hubei Province(Grant No.2023BAA015).
文摘Neural networks have provided faster and more straightforward solutions for laser modulation.However,their effectiveness when facing diverse structured lights and various output resolutions remains vulnerable because of the specialized end-to-end training and static model.Here,we propose a redefinable neural network(RediNet),realizing customized modulation on diverse structured light arrays through a single general approach.The network input format features a redefinable dimension designation,which ensures RediNet wide applicability and removes the burden of processing pixel-wise light distributions.The prowess of originally generating arbitrary-resolution holograms with a fixed network is first demonstrated.The versatility is showcased in the generation of 2D/3D foci arrays,Bessel and Airy beam arrays,(perfect)vortex beam arrays,and even snowflake-intensity arrays with arbitrarily built phase functions.A standout application is producing multichannel compound vortex beams,where RediNet empowers a spatial light modulator(SLM)to offer comprehensive multiplexing functionalities for free-space optical communication.Moreover,RediNet has the hitherto highest efficiency,only consuming 12 ms(faster than the mainstream SLM framerate of 60 Hz)for a 1000^(2)-resolution holograph,which is critical in real-time required scenarios.Considering the fine resolution,high speed,and unprecedented universality,RediNet can serve extensive applications,such as next-generation optical communication,parallel laser direct writing,and optical traps.
基金supported in part by the Key Research and Development Program of Guangdong Province(2021B0101200001)the Guangdong Basic and Applied Basic Research Foundation(2020B1515120071)。
文摘Few-shot semantic segmentation aims at training a model that can segment novel classes in a query image with only a few densely annotated support exemplars.It remains a challenge because of large intra-class variations between the support and query images.Existing approaches utilize 4D convolutions to mine semantic correspondence between the support and query images.However,they still suffer from heavy computation,sparse correspondence,and large memory.We propose axial assembled correspondence network(AACNet)to alleviate these issues.The key point of AACNet is the proposed axial assembled 4D kernel,which constructs the basic block for semantic correspondence encoder(SCE).Furthermore,we propose the deblurring equations to provide more robust correspondence for the aforementioned SCE and design a novel fusion module to mix correspondences in a learnable manner.Experiments on PASCAL-5~i reveal that our AACNet achieves a mean intersection-over-union score of 65.9%for 1-shot segmentation and 70.6%for 5-shot segmentation,surpassing the state-of-the-art method by 5.8%and 5.0%respectively.
基金supported by the National Key Research and Development Program of China under the Grant No.2018YFC0809400.
文摘A composite rubber concrete(CRC)was designed by combining waste tire rubber particles with particle sizes of 3~5 mm,1~3 mm and 20 mesh.Taking the rubber content of different particle sizes as the influencing factors,the range and variance analysis of the mechanical and impermeability properties of CRC was carried out by orthogonal test.Through analysis,it is concluded that the optimal proportion of 3~5 mm,1~3 mm,and 20 mesh particle size composite rubber is 1:2.5:5.5 kinds of CRC and 3 kinds of ordinary single-mixed rubber concrete(RC)with a total content of 10%~20%were designed under this ratio,and the salt-freezing cycle test was carried out with a concentration of 5%Na 2 SO4 solution.The physical and mechanical damage laws during 120 salt-freezing cycles are obtained,and the corresponding damage prediction model is established according to the experimental data.The results show that:on the one hand,the composite rubber in CRC produces a more uniform“graded”structure,forms a retractable particle group,and reduces the loss of mechanical properties of CRC.On the other hand,colloidal particles with different particle sizes are used as air entraining agent to improve the pore structure of concrete and introduce evenly dispersed bubbles,which fundamentally improves the durability of concrete.Under the experimental conditions,the CRC performance is the best when the overall content of composite rubber is 15%.
基金supported by Beijing Natural Science Foundation(No.7242109)CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059)+1 种基金the National High Level Hospital Clinical Research Funding(No.2022-PUMCH-B-092)the Beijing Key Clinical Specialty Construction Project.
文摘Background:Generalized pustular psoriasis(GPP),a rare and recurrent autoinflammatory disease,imposes a substantial burden on patients and society.Awareness of GPP in China remains limited.Methods:This cross-sectional survey,conducted between September 2021 and May 2023 across 14 hospitals in China,included GPP patients of all ages and disease phases.Data collected encompassed demographics,clinical characteristics,economic impact,disease severity,quality of life,and treatment-related complications.Risk factors for GPP recurrence were analyzed.Results:Among 127 patients(female/male ratio=1.35:1),the mean age of disease onset was 25 years(1st quartile[Q1]–3rd quartile[Q3]:11–44 years);29.2%had experienced GPP for more than 10 years.Recurrence occurred in 75.6%of patients,and nearly half reported no identifiable triggers.Younger age at disease onset(P=0.021)and transitioning to plaque psoriasis(P=0.022)were associated with higher recurrence rates.The median diagnostic delay was 8 months(Q1–Q3:2–41 months),and 32.3%of patients reported misdiagnoses.Comorbidities were present in 53.5%of patients,whereas 51.1%experienced systemic complications during treatment.Depression and anxiety affected 84.5%and 95.6%of patients,respectively.During GPP flares,the median Dermatology Life Quality Index score was 19.0(Q1–Q3:13.0–23.5).This score showed significant differences between patients with and without systemic symptoms;it demonstrated correlations with both depression and anxiety scores.Treatment costs caused financial hardship in 55.9%of patients,underscoring the burden associated with GPP.Conclusions:The substantial disease and economic burdens among Chinese GPP patients warrant increased attention.Patients with early onset disease and those transitioning to plaque psoriasis require targeted interventions to mitigate the high recurrence risk.
