Patients with extensive and deep skin defects treated with dermal scaffolds usually emphasize the importance of rapid angiogenesis,while overlook the crucial role of skin nerves in regenerative repair.Insufficient ear...Patients with extensive and deep skin defects treated with dermal scaffolds usually emphasize the importance of rapid angiogenesis,while overlook the crucial role of skin nerves in regenerative repair.Insufficient early nerve regeneration not only impedes skin reinnervation and angiogenesis,but also damages the synergistic effects among them,eventually hinders healing quality.Nerve growth factor(NGF)has shown potent potential in peripheral nerve regeneration and promotion of angiogenesis.Angiogenin(ANG)is an independent angiogenic factor,supplying microenvironment needed for neurogenesis.This study presents a dermal scaffold with dual gene activity,fabricated by incorporating nanoparticles(NPs)composed of polyethylenimine(PEI)-chimeric plasmids encoding both NGF and ANG(PEI-plasmid NGF/ANG dermal scaffold(NADS)).Specifically,NADS achieves sustained and in situ release of these two factors,and encourages the repair cells to fulfill their regenerative roles.In vivo experiments confirm the efficacy of NADS in promoting fully functional innervated skin regeneration,inducing the fastest healing rates and rapidly facilitating the formation of a mature vascular network,thus resulting in high-quality wound healing.This approach offers an effective and comprehensive strategy for clinical application.展开更多
Recently,the implementation of Industry 4.0 has become a new tendency,and it brings both opportunities and challenges to worldwide manufacturing companies.Thus,many manufacturing companies are attempting to find advan...Recently,the implementation of Industry 4.0 has become a new tendency,and it brings both opportunities and challenges to worldwide manufacturing companies.Thus,many manufacturing companies are attempting to find advanced technologies to launch intelligent manufacturing transformation.In this study,we propose a new model to measure the intelligent manufacturing readiness for the process industry,which aims to guide companies in recognizing their current stage and short slabs when carrying out intelligent manufacturing transformation.Although some models have already been reported to measure Industry 4.0 readiness and maturity,there are no models that are aimed at the process industry.This newly proposed model has six levels to describe different development stages for intelligent manufacturing.In addition,the model consists of four races,nine species,and 25 domains that are relevant to the essential businesses of companies’daily operation and capability requirements of intelligent manufacturing.Furthermore,these 25 domains are divided into 249 characteristic items to evaluate the manufacturing readiness in detail.A questionnaire is also designed based on the proposed model to help process-industry companies easily carry out self-diagnosis.Using the new method,a case including 196 real-world process-industry companies is evaluated to introduce the method of how to use the proposed model.Overall,the proposed model provides a new way to assess the degree of intelligent manufacturing readiness for process-industry companies.展开更多
Pyrolysis is an effective method to treat oily sludge(OS)due to its balance between oil recovery and nonhazardous disposal.However,tank bottom OS contains a high content of heavy fractions,which creates obstacles for ...Pyrolysis is an effective method to treat oily sludge(OS)due to its balance between oil recovery and nonhazardous disposal.However,tank bottom OS contains a high content of heavy fractions,which creates obstacles for pyrolysis due to the high activation energy.The incomplete cracking of macromolecules and secondary polymerization decreases the oil quality and causes coking during the operation process.This study introduced polyethylene(PE)into OS to deploy the H/Ceff ratio of feedstocks for pyrolysis A strong interaction between OS and PE during copyrolysis could be observed from the TG/DTG curves.PE tightly participated in OS degradation,while OS also promoted PE degradation at high temperature.Apparent pits were generated in solid residues from copyrolysis,which was attributed to the uniform and violent gas release.In addition to HCN,other nitrogenous and sulphurous pollutants were inhibited.Accordingly,more gas products were attained after PE addition with more value-added compositions of alkanes and alkenes.Although the oil yield decreased after PE addition,the oil products from copyrolysis possessed higher heating values and higher contents of light fractions with short chains as well as paraffins.Consequently,copyrolysis of OS and PE significantly improved the pyrolysis process and resulted in high oil quality.展开更多
基金supported by grants from the National Key R&D Program of China(Nos.2022YFC2403100 and 2022YFC2403104)the National Natural Science Foundation of China(Nos.81801911,82172198,and 82202443).
文摘Patients with extensive and deep skin defects treated with dermal scaffolds usually emphasize the importance of rapid angiogenesis,while overlook the crucial role of skin nerves in regenerative repair.Insufficient early nerve regeneration not only impedes skin reinnervation and angiogenesis,but also damages the synergistic effects among them,eventually hinders healing quality.Nerve growth factor(NGF)has shown potent potential in peripheral nerve regeneration and promotion of angiogenesis.Angiogenin(ANG)is an independent angiogenic factor,supplying microenvironment needed for neurogenesis.This study presents a dermal scaffold with dual gene activity,fabricated by incorporating nanoparticles(NPs)composed of polyethylenimine(PEI)-chimeric plasmids encoding both NGF and ANG(PEI-plasmid NGF/ANG dermal scaffold(NADS)).Specifically,NADS achieves sustained and in situ release of these two factors,and encourages the repair cells to fulfill their regenerative roles.In vivo experiments confirm the efficacy of NADS in promoting fully functional innervated skin regeneration,inducing the fastest healing rates and rapidly facilitating the formation of a mature vascular network,thus resulting in high-quality wound healing.This approach offers an effective and comprehensive strategy for clinical application.
基金Project supported by the National Key Research and Development Program of China(No.2019YFB1705004)。
文摘Recently,the implementation of Industry 4.0 has become a new tendency,and it brings both opportunities and challenges to worldwide manufacturing companies.Thus,many manufacturing companies are attempting to find advanced technologies to launch intelligent manufacturing transformation.In this study,we propose a new model to measure the intelligent manufacturing readiness for the process industry,which aims to guide companies in recognizing their current stage and short slabs when carrying out intelligent manufacturing transformation.Although some models have already been reported to measure Industry 4.0 readiness and maturity,there are no models that are aimed at the process industry.This newly proposed model has six levels to describe different development stages for intelligent manufacturing.In addition,the model consists of four races,nine species,and 25 domains that are relevant to the essential businesses of companies’daily operation and capability requirements of intelligent manufacturing.Furthermore,these 25 domains are divided into 249 characteristic items to evaluate the manufacturing readiness in detail.A questionnaire is also designed based on the proposed model to help process-industry companies easily carry out self-diagnosis.Using the new method,a case including 196 real-world process-industry companies is evaluated to introduce the method of how to use the proposed model.Overall,the proposed model provides a new way to assess the degree of intelligent manufacturing readiness for process-industry companies.
基金supported by the National Key Research and Deve lopment Program of China(No.2019YFC1903903)Young Elite Scientists Sponsorship Program by Tianjin(China)(No.TJSQNTJ-2020-13).
文摘Pyrolysis is an effective method to treat oily sludge(OS)due to its balance between oil recovery and nonhazardous disposal.However,tank bottom OS contains a high content of heavy fractions,which creates obstacles for pyrolysis due to the high activation energy.The incomplete cracking of macromolecules and secondary polymerization decreases the oil quality and causes coking during the operation process.This study introduced polyethylene(PE)into OS to deploy the H/Ceff ratio of feedstocks for pyrolysis A strong interaction between OS and PE during copyrolysis could be observed from the TG/DTG curves.PE tightly participated in OS degradation,while OS also promoted PE degradation at high temperature.Apparent pits were generated in solid residues from copyrolysis,which was attributed to the uniform and violent gas release.In addition to HCN,other nitrogenous and sulphurous pollutants were inhibited.Accordingly,more gas products were attained after PE addition with more value-added compositions of alkanes and alkenes.Although the oil yield decreased after PE addition,the oil products from copyrolysis possessed higher heating values and higher contents of light fractions with short chains as well as paraffins.Consequently,copyrolysis of OS and PE significantly improved the pyrolysis process and resulted in high oil quality.
