Objective:Cardiac hypertrophy and fibrosis are major pathological manifestations observed in left ventricular remodeling induced by angiotensin II(AngII).Low-intensity pulsed ultrasound(LIPUS)has been reported to amel...Objective:Cardiac hypertrophy and fibrosis are major pathological manifestations observed in left ventricular remodeling induced by angiotensin II(AngII).Low-intensity pulsed ultrasound(LIPUS)has been reported to ameliorate cardiac dysfunction and myocardial fibrosis in myocardial infarction(MI)through mechano-transduction and its downstream pathways.In this study,we aimed to investigate whether LIPUS could exert a protective effect by ameliorating AngII-induced cardiac hypertrophy and fibrosis and if so,to further elucidate the underlying molecular mechanisms.Methods:We used AngII to mimic animal and cell culture models of cardiac hypertrophy and fibrosis.LIPUS irradiation was applied in vivo for 20 min every 2 d from one week before mini-pump implantation to four weeks after mini-pump implantation,and in vitro for 20 min on each of two occasions 6 h apart.Cardiac hypertrophy and fibrosis levels were then evaluated by echocardiographic,histopathological,and molecular biological methods.Results:Our results showed that LIPUS could ameliorate left ventricular remodeling in vivo and cardiac fibrosis in vitro by reducing AngII-induced release of inflammatory cytokines,but the protective effects on cardiac hypertrophy were limited in vitro.Given that LIPUS increased the expression of caveolin-1 in response to mechanical stimulation,we inhibited caveolin-1 activity with pyrazolopyrimidine 2(pp2)in vivo and in vitro.LIPUS-induced downregulation of inflammation was reversed and the anti-fibrotic effects of LIPUS were absent.Conclusions:These results indicated that LIPUS could ameliorate AngII-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway,providing new insights for the development of novel therapeutic apparatus in clinical practice.展开更多
Ammonia is an important chemical for pharmaceutical,agriculture,industry,as well as energy production et al.However,the industrial production of ammonia using the Haber-Bosch process is energy-intensive,which stimulat...Ammonia is an important chemical for pharmaceutical,agriculture,industry,as well as energy production et al.However,the industrial production of ammonia using the Haber-Bosch process is energy-intensive,which stimulates us to explore a cost-effective and low-carbon footprint way for the synthesis of ammonia[1–3].Electrochemical(EC)synthesis of ammonia from an aqueous N_(2)reduction reaction(NRR)has gained significant attention in recent years,while the high dissociation energy of the N≡N bond(941 kJ/mol),as well as higher over-potential than hydrogen evolution reaction(HER),cause a lower efficiency[4].展开更多
The original version of this article(Zhao et al.,2021)unfortunately contained two mistakes.(1)In p.826,the hematoxylin eosin(HE)staining figure of the fourth panel(the Ang Ⅱ+LIPUS group)in Fig.3a was incorrect.
Co-free Li-rich Li_(1.2)Ni_(0.2)Mn_(0.6)O_(2)(LR)cathode shows the highest working capacity that can be applied to high-energy density Li-ion batteries(LIBs).However,poor cycle stability and voltage decay caused by ph...Co-free Li-rich Li_(1.2)Ni_(0.2)Mn_(0.6)O_(2)(LR)cathode shows the highest working capacity that can be applied to high-energy density Li-ion batteries(LIBs).However,poor cycle stability and voltage decay caused by phase transition are always hindering its further development.Herein,a novel medium-entropy Li-rich Mn-based cathode material(LRMEF)was synthesized via a simple sol-gel method.The introduction of multivalent ions(Al^(3+)/Cu^(2+)doping at Mn sites and F−doping at O sites)effectively mitigates the Jahn-Teller distortion of Mn ions and suppresses oxygen release.High-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)images confirm that this synergistic doping strategy induces the in-situ formation of an approximately 3 nm-thick spinel surface layer,which significantly enhances structural stability and ion diffusion kinetics.Besides,a series of in-situ/ex-situ characterization methods and density functional theory(DFT)calculations have been carried out to fundamentally shed light on the optimized structure-activity relationship and reaction mechanism.As a result,the LR material with entropy regulation and anion doping exhibits excellent cycling stability(189.2 mAh g^(−1)at 1 C with 84%capacity retention after 300 cycles),rate performance(164.1 mAh g^(−1)at 5 C),and voltage retention(82.7%at 1 C after 300 cycles),demonstrating great application prospects in future high-energy-density LIBs.展开更多
Photoelectrochemical(PEC)organic transformation at the anode coupled with cathodic H_(2) generation is a potentially rewarding strategy for efficient solar energy utilization.Nevertheless,achieving the full conversion ...Photoelectrochemical(PEC)organic transformation at the anode coupled with cathodic H_(2) generation is a potentially rewarding strategy for efficient solar energy utilization.Nevertheless,achieving the full conversion of organic substrates with exceptional product selectivity remains a formidable hurdle in the context of heterogeneous catalysis at the solid/liquid interface.Here,we put forward a quasi-homogeneous catalysis concept by using the reactive oxygen species(ROS),such as·OH,H_(2)O_(2) and SO_(4)^(2-),as a charge transfer mediator instead of direct heterogeneous catalysis at the solid/liquid interface.In the context of glycerol oxidation,all ROS exhibited a preference forfirst-order reaction kinetics.These ROS,however,showcased distinct oxidation mechanisms,offering a range of advantages such as100%conversion ratios and theflexibility to tune the resulting products.Glycerol oxidative formic acid with Faradaic efficiency(FE)of 81.2%was realized by the H_(2)O_(2) and·OH,while SO_(4)^(2-)was preferably for glycerol conversion to C3 products like glyceraldehyde and dihydroxyacetone with a total FE of about 80%.Strikingly,the oxidative coupling of methane to ethanol was successfully achieved in our quasi-homogeneous system,yielding a remarkable production rate of 12.27 lmol h^(-1) and an impressive selectivity of 92.7%.This study is anticipated to pave the way for novel approaches in steering solar-driven organic conversions by manipulating ROS to attain desired products and conversion ratios.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.81627802)the Priority Academic Program Development of Jiangsu Higher Education Institutions(No.PAPD2014-2016)the National Key R&D Program of China(No.2019YFA0210100).
文摘Objective:Cardiac hypertrophy and fibrosis are major pathological manifestations observed in left ventricular remodeling induced by angiotensin II(AngII).Low-intensity pulsed ultrasound(LIPUS)has been reported to ameliorate cardiac dysfunction and myocardial fibrosis in myocardial infarction(MI)through mechano-transduction and its downstream pathways.In this study,we aimed to investigate whether LIPUS could exert a protective effect by ameliorating AngII-induced cardiac hypertrophy and fibrosis and if so,to further elucidate the underlying molecular mechanisms.Methods:We used AngII to mimic animal and cell culture models of cardiac hypertrophy and fibrosis.LIPUS irradiation was applied in vivo for 20 min every 2 d from one week before mini-pump implantation to four weeks after mini-pump implantation,and in vitro for 20 min on each of two occasions 6 h apart.Cardiac hypertrophy and fibrosis levels were then evaluated by echocardiographic,histopathological,and molecular biological methods.Results:Our results showed that LIPUS could ameliorate left ventricular remodeling in vivo and cardiac fibrosis in vitro by reducing AngII-induced release of inflammatory cytokines,but the protective effects on cardiac hypertrophy were limited in vitro.Given that LIPUS increased the expression of caveolin-1 in response to mechanical stimulation,we inhibited caveolin-1 activity with pyrazolopyrimidine 2(pp2)in vivo and in vitro.LIPUS-induced downregulation of inflammation was reversed and the anti-fibrotic effects of LIPUS were absent.Conclusions:These results indicated that LIPUS could ameliorate AngII-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway,providing new insights for the development of novel therapeutic apparatus in clinical practice.
基金supported by the National Natural Science Foundation of China(T2322013)supported by the Ministry of Science and ICT through the National Research Foundation of Korea(2022H1D3A3A01077254,NRF-2019R1A2C3010479)。
文摘Ammonia is an important chemical for pharmaceutical,agriculture,industry,as well as energy production et al.However,the industrial production of ammonia using the Haber-Bosch process is energy-intensive,which stimulates us to explore a cost-effective and low-carbon footprint way for the synthesis of ammonia[1–3].Electrochemical(EC)synthesis of ammonia from an aqueous N_(2)reduction reaction(NRR)has gained significant attention in recent years,while the high dissociation energy of the N≡N bond(941 kJ/mol),as well as higher over-potential than hydrogen evolution reaction(HER),cause a lower efficiency[4].
文摘The original version of this article(Zhao et al.,2021)unfortunately contained two mistakes.(1)In p.826,the hematoxylin eosin(HE)staining figure of the fourth panel(the Ang Ⅱ+LIPUS group)in Fig.3a was incorrect.
基金financially supported by the Research and Development Program of China(2022YFA1505700)the National Natural Science Foundation of China(22475214,22205232,52102216)+5 种基金the Natural Science Foundation of Fujian Province(2023J06044,2022J01625,2022-S-002)the Talent Plan of Shanghai Branch,Chinese Academy of Sciences(CASSHB-QNPD-2023-020)the Self-deployment Project Research Program of Haixi Institutes,Chinese Academy of Sciences(CXZX-2022-JQ06 and CXZX-2022-GH03)the Anhui Key Laboratory of Nanomaterials and Nanotechnology,the Major Science and Technology Projects in Anhui Province(202305a12020006)the Open Project of State Key Laboratory of Inorganic Synthesis and Preparative Chemistry(2025-22)theInnovation Training Program for College Students(2025019300A,20250193008).The authors als0 greatly appreciate support by Transmission Electron Microscope Platform and Highperformance Computing Platform of Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China.
文摘Co-free Li-rich Li_(1.2)Ni_(0.2)Mn_(0.6)O_(2)(LR)cathode shows the highest working capacity that can be applied to high-energy density Li-ion batteries(LIBs).However,poor cycle stability and voltage decay caused by phase transition are always hindering its further development.Herein,a novel medium-entropy Li-rich Mn-based cathode material(LRMEF)was synthesized via a simple sol-gel method.The introduction of multivalent ions(Al^(3+)/Cu^(2+)doping at Mn sites and F−doping at O sites)effectively mitigates the Jahn-Teller distortion of Mn ions and suppresses oxygen release.High-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)images confirm that this synergistic doping strategy induces the in-situ formation of an approximately 3 nm-thick spinel surface layer,which significantly enhances structural stability and ion diffusion kinetics.Besides,a series of in-situ/ex-situ characterization methods and density functional theory(DFT)calculations have been carried out to fundamentally shed light on the optimized structure-activity relationship and reaction mechanism.As a result,the LR material with entropy regulation and anion doping exhibits excellent cycling stability(189.2 mAh g^(−1)at 1 C with 84%capacity retention after 300 cycles),rate performance(164.1 mAh g^(−1)at 5 C),and voltage retention(82.7%at 1 C after 300 cycles),demonstrating great application prospects in future high-energy-density LIBs.
基金financially supported by the National Natural Science Foundation of China(22005149,21975129,and 22172077)the Natural Science Foundation of Jiangsu Province(BK20200777 and BK20211573)+1 种基金the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province,China(20KJB430034)the Science Fund for Distinguished Young Scholars,Nanjing Forestry University(JC2019002)。
基金supported by the National Natural Science Foundation of China(T2322013,22172077)the Natural Science Foundation of Jiangsu Province of China(BK 20211573)+3 种基金the Fundamental Research Funds for the Central Universities(30921011216)C.L was supported by China Scholarship Council(CSC)(202206840088)supported by the Ministry of Science and ICT through the National Research Foundation of Korea(2022H1D3A3A01077254,2021M3H4A1A03049662)the support from Yonsei-KIST Convergence Research Program and the Yonsei Fellow Program,funded by Lee Youn Jae.
文摘Photoelectrochemical(PEC)organic transformation at the anode coupled with cathodic H_(2) generation is a potentially rewarding strategy for efficient solar energy utilization.Nevertheless,achieving the full conversion of organic substrates with exceptional product selectivity remains a formidable hurdle in the context of heterogeneous catalysis at the solid/liquid interface.Here,we put forward a quasi-homogeneous catalysis concept by using the reactive oxygen species(ROS),such as·OH,H_(2)O_(2) and SO_(4)^(2-),as a charge transfer mediator instead of direct heterogeneous catalysis at the solid/liquid interface.In the context of glycerol oxidation,all ROS exhibited a preference forfirst-order reaction kinetics.These ROS,however,showcased distinct oxidation mechanisms,offering a range of advantages such as100%conversion ratios and theflexibility to tune the resulting products.Glycerol oxidative formic acid with Faradaic efficiency(FE)of 81.2%was realized by the H_(2)O_(2) and·OH,while SO_(4)^(2-)was preferably for glycerol conversion to C3 products like glyceraldehyde and dihydroxyacetone with a total FE of about 80%.Strikingly,the oxidative coupling of methane to ethanol was successfully achieved in our quasi-homogeneous system,yielding a remarkable production rate of 12.27 lmol h^(-1) and an impressive selectivity of 92.7%.This study is anticipated to pave the way for novel approaches in steering solar-driven organic conversions by manipulating ROS to attain desired products and conversion ratios.
