Myopia is a huge health problem due to its high frequency,vision losses and public health cost.According to the World Health Organization,at least 2.2 billion people have vision impairment.Although myopia can be contr...Myopia is a huge health problem due to its high frequency,vision losses and public health cost.According to the World Health Organization,at least 2.2 billion people have vision impairment.Although myopia can be controlled at its early and middle stages,unfortunately,no cure can be achieved so far.Among the methods to control myopia,atropine,a muscarinic receptor antagonist,is the oldest but still the most effective for retardation of myopia progression.Despite such a fact,standard protocols have not been established for clinicians to use atropine for treatment of myopia.In this article,a concise and up to date summary of myopia epidemiology and pathogenesis and summarized therapeutic effects and side effects,possible mechanisms and application methods of atropine were provided in hope for clinical doctors to effectively control this problematic disease.At present,the protocol is recommend:use higher dose(1%)of atropine intermittently to effectively slowdown myopia progression in schoolchildren for 2y,and to significantly reduce side effects of atropine by decrease of atropine frequency for 1y and inhibit myopic rebound by withdrawal of topical atropine gradually for 1y.Application of a lower dose(0.05%)atropine regime should also be considered due to its effectiveness and application at regular basis.展开更多
As an important marine enterprise, marine scientific research serves to national marine strategy. Since the 21st century, with the development of international geopolitics, South Pacific in becoming an important sea a...As an important marine enterprise, marine scientific research serves to national marine strategy. Since the 21st century, with the development of international geopolitics, South Pacific in becoming an important sea area, so the marine scientific research in this sea area is becoming hot points. At present, extraterritorial nations including Germany, America, China and UK are conducting marine scientific research in this sea area mainly because of its abundant deep-sea resources, the need to protect marine environment and serving for marine strategic access. With deep-sea＇s technology improving continually, deep-sea resources in South Pacific will be explored further, marine scientific research cooperation＇s potential for extraterritorial nations will be great, so more and more nations will involve in conducting marine scientific research in South Pacific. As far as China is concerned, marine scientific research is not only the basis for it to practice marine strategy in South Pacific region, but also the important topic for it to cooperate with extraterritorial nations and pacific islands nations.展开更多
基金Supported by the Basic Research Fund for Science and Technology Department of Yunnan Province and Kunming Medical University(No.202401AY070001-289).
文摘Myopia is a huge health problem due to its high frequency,vision losses and public health cost.According to the World Health Organization,at least 2.2 billion people have vision impairment.Although myopia can be controlled at its early and middle stages,unfortunately,no cure can be achieved so far.Among the methods to control myopia,atropine,a muscarinic receptor antagonist,is the oldest but still the most effective for retardation of myopia progression.Despite such a fact,standard protocols have not been established for clinicians to use atropine for treatment of myopia.In this article,a concise and up to date summary of myopia epidemiology and pathogenesis and summarized therapeutic effects and side effects,possible mechanisms and application methods of atropine were provided in hope for clinical doctors to effectively control this problematic disease.At present,the protocol is recommend:use higher dose(1%)of atropine intermittently to effectively slowdown myopia progression in schoolchildren for 2y,and to significantly reduce side effects of atropine by decrease of atropine frequency for 1y and inhibit myopic rebound by withdrawal of topical atropine gradually for 1y.Application of a lower dose(0.05%)atropine regime should also be considered due to its effectiveness and application at regular basis.
文摘As an important marine enterprise, marine scientific research serves to national marine strategy. Since the 21st century, with the development of international geopolitics, South Pacific in becoming an important sea area, so the marine scientific research in this sea area is becoming hot points. At present, extraterritorial nations including Germany, America, China and UK are conducting marine scientific research in this sea area mainly because of its abundant deep-sea resources, the need to protect marine environment and serving for marine strategic access. With deep-sea＇s technology improving continually, deep-sea resources in South Pacific will be explored further, marine scientific research cooperation＇s potential for extraterritorial nations will be great, so more and more nations will involve in conducting marine scientific research in South Pacific. As far as China is concerned, marine scientific research is not only the basis for it to practice marine strategy in South Pacific region, but also the important topic for it to cooperate with extraterritorial nations and pacific islands nations.
