Background Vitamin E is the most abundant lipid-soluble antioxidants present in plasma;however,the relationship between serum vitamin E and change in body mass index(BMI)-for-age Z scores in adolescents has not been w...Background Vitamin E is the most abundant lipid-soluble antioxidants present in plasma;however,the relationship between serum vitamin E and change in body mass index(BMI)-for-age Z scores in adolescents has not been well described.Methods This study is a cross-sectional study.Data were analyzed from 4014 adolescents who participated in the National Health and Nutrition Examination Survey.The nutritional status was calculated by BMI Z scores and was classifed into nor-mal weight,overweight,and obese.Multivariable-adjusted logistic regression was used to examine the association between serum vitamin E levels with overweight/obesity.Besides,the interaction effects between potential confounders and vitamin E on obesity were further evaluated.Results After adjusting potential confounders,serum vitamin E levels were negatively associated with overweight/obesity in girls but not in boys.Per standard deviation increment in vitamin E concentrations was associated with a 92%decreased risk of obesity in females.Besides,lower quartiles of serum vitamin E were associated with a higher risk of overweight/obesity in girls.Moreover,the inverse association between serum vitamin E levels and obesity was also found in most subgroups through subgroup analysis.Conclusions Our study supports the negative association between serum vitamin E levels and overweight/obesity in ado-lescents.A higher serum vitamin E level may be associated with a reduced probability of obesity in girls,but not in boys.展开更多
基金supported by the China Postdoctoral Science Foundation(2019M651904)the Key Project supported by the Medical Science and Technology Development Foundation,Nanjing Municipality Health Bureau(ZKX19039)+1 种基金the National Key Research and Development Program of China(2017YFC1308105,2016YFC1101001)the National Natural Science Foundation of China(81970265,82000303).
文摘Background Vitamin E is the most abundant lipid-soluble antioxidants present in plasma;however,the relationship between serum vitamin E and change in body mass index(BMI)-for-age Z scores in adolescents has not been well described.Methods This study is a cross-sectional study.Data were analyzed from 4014 adolescents who participated in the National Health and Nutrition Examination Survey.The nutritional status was calculated by BMI Z scores and was classifed into nor-mal weight,overweight,and obese.Multivariable-adjusted logistic regression was used to examine the association between serum vitamin E levels with overweight/obesity.Besides,the interaction effects between potential confounders and vitamin E on obesity were further evaluated.Results After adjusting potential confounders,serum vitamin E levels were negatively associated with overweight/obesity in girls but not in boys.Per standard deviation increment in vitamin E concentrations was associated with a 92%decreased risk of obesity in females.Besides,lower quartiles of serum vitamin E were associated with a higher risk of overweight/obesity in girls.Moreover,the inverse association between serum vitamin E levels and obesity was also found in most subgroups through subgroup analysis.Conclusions Our study supports the negative association between serum vitamin E levels and overweight/obesity in ado-lescents.A higher serum vitamin E level may be associated with a reduced probability of obesity in girls,but not in boys.
