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Pharmacological actions of the bioactive compounds of Epimedium on the male reproductive system:current status and future perspective 被引量:2
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作者 Song-Po Liu Yun-Fei Li +10 位作者 Dan Zhang Chun-Yang Li Xiao-Fang Dai Dong-Feng Lan ji cai He Zhou Tao Song Yan-Yu Zhao Zhi-Xu He Jun Tan ji-Dong Zhang 《Asian Journal of Andrology》 2025年第1期20-29,共10页
Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research a... Compounds isolated from Epimedium include the total flavonoids of Epimedium,icariin,and its metabolites(icaritin,icariside Ⅰ,and icariside Ⅱ),which have similar molecular structures.Modern pharmacological research and clinical practice have proved that Epimedium and its active components have a wide range of pharmacological effects,especially in improving sexual function,hormone regulation,anti-osteoporosis,immune function regulation,anti-oxidation,and anti-tumor activity.To date,we still need a comprehensive source of knowledge about the pharmacological effects of Epimedium and its bioactive compounds on the male reproductive system.However,their actions in other tissues have been reviewed in recent years.This review critically focuses on the Epimedium,its bioactive compounds,and the biochemical and molecular mechanisms that modulate vital pathways associated with the male reproductive system.Such intrinsic knowledge will significantly further studies on the Epimedium and its bioactive compounds that protect the male reproductive system and provide some guidances for clinical treatment of related male reproductive disorders. 展开更多
关键词 EPIMEDIUM ICARIIN INFERTILITY male reproductive system TUMOR
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前列腺纤维性增生的差异表达基因筛选及富集研究 被引量:1
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作者 万少平 蔡季 肖靓琨 《中国现代医学杂志》 CAS 北大核心 2021年第22期33-38,共6页
目的筛选和初步鉴定良性前列腺纤维性增生的差异表达基因(DEGs),发现新的良性前列腺纤维性增生的基因片段,为临床监测和治疗前列腺纤维性增生提供潜在的基因位点和标志物依据。方法收集前列腺等离子电切术后组织标本,根据标本病理诊断结... 目的筛选和初步鉴定良性前列腺纤维性增生的差异表达基因(DEGs),发现新的良性前列腺纤维性增生的基因片段,为临床监测和治疗前列腺纤维性增生提供潜在的基因位点和标志物依据。方法收集前列腺等离子电切术后组织标本,根据标本病理诊断结果,将标本分成纤维组和结节组。标本冷冻保存,分别提取前列腺结节性增生标本和纤维性增生标本的组织总RNA,构建转录组文库,通过二代高通量测序,对两组mRNA进行定量及差异分析,再做差异基因的GO、KEGG、网络互作分析。结果两组标本总共发现差异表达基因1598个,与结节组相比,纤维组相对表达量上调基因1063个,相对表达量下调基因535个。通过GO富集分析发现,DGEs主要富集在离子转运、细胞黏附、细胞外基质组等生物学过程中,富集在近端启动子DNA结合转录激活剂、RNA聚合酶Ⅱ、DNA结合转录激活剂、信号受体结合等活性分子功能上,以及富集在细胞膜、细胞外区域、质膜等细胞部位。KEGG通路分析发现,DGEs主要富集在细胞外基质-受体作用、细胞因子与细胞因子受体作用等信号通路上。构建DEGs的PPI网络互作筛选出10个重要基因,发现PPBP、OPRM1、GAL 3个基因在前列腺纤维性增生组织中上调。结论PPBP、OPRM1、GAL等DEGs参与前列腺纤维性增生的发生、发展,可能是良性前列腺纤维性增生监测和治疗的潜在分子标志物。 展开更多
关键词 良性前列腺增生 结节 纤维 MICRORNA 差异表达基因
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静脉用药调配中心药学专业实习带教中目标管理法的构建 被引量:11
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作者 吴园园 叶伟峰 +4 位作者 陆美斐 黄凌斐 高鹏 纪彩 吴妙莲 《中华医学教育探索杂志》 2020年第12期1433-1437,共5页
目的探讨目标管理法(management by objective,MBO)在静脉用药调配中心(pharmacy intravenous admixture services,PIVAS)药学专业实习生培训带教中的应用效果。方法将2015至2017年度某医院PIVAS实习的32名药学实习生随机分为对照组和... 目的探讨目标管理法(management by objective,MBO)在静脉用药调配中心(pharmacy intravenous admixture services,PIVAS)药学专业实习生培训带教中的应用效果。方法将2015至2017年度某医院PIVAS实习的32名药学实习生随机分为对照组和观察组(每组16名),分别予以传统带教和MBO教学模式带教4周。出科前以理论知识考核、操作技能考核、综合能力考核以及教学双方满意度评价教学效果。采用SPSS 19.0进行非参数检验和t检验。结果与对照组相比,观察组实习生的理论成绩[(88.03±5.86)分vs.(80.69±9.74)分,P=0.016]、操作成绩[(96.97±2.62)分vs.(94.14±4.31)分,P=0.034]与综合能力考核成绩[(93.03±3.63)分vs.(89.00±5.54)分,P=0.021]均明显提升,且带教教师对实习生满意度[(92.38±1.88)分vs.(83.75±3.02)分,P=0.023]及实习生对带教教师满意度[(93.75±1.91)分vs.(84.81±3.04)分,P=0.018]也明显提升,差异有统计学意义。结论MBO教学能有效提升PIVAS药学实习生教学效果,值得在PIVAS药学专业实习带教中进行推广应用。 展开更多
关键词 目标管理 静脉用药调配中心 药学专业 实习带教
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Removal of elemental mercury by KI-impregnated clay
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作者 Boxiong SHEN jianhong CHEN ji cai 《Frontiers of Environmental Science & Engineering》 SCIE EI CAS CSCD 2016年第2期236-243,共8页
This study described the use of clay impreg- nated by KI in gas phase elemental mercury (Hg°) removal in flue gas. The effects of KI loading, temperature, 02, SO2 and H20 on Hg°removal were investigated us... This study described the use of clay impreg- nated by KI in gas phase elemental mercury (Hg°) removal in flue gas. The effects of KI loading, temperature, 02, SO2 and H20 on Hg°removal were investigated using a fixed bed reactor. The Hg° removal efficiency of KI-clay with 3% KI loading could maintain at a high level (approxi- mately 80 %) after 3 h. The KI-clay demonstrated to be a potential adsorbent for Hg° removal when compared with activated carbon based adsorbent. 02 was found to be an important factor in improving the Hg° removal. 02 was demonstrated to assist the transfer of KI to I2 on the surface of KI-clay, which could react with Hg° directly. NO and SO2 could slightly improve Hg° removal, while H20 inhibited it greatly. The results indicated that after adsorption, most of the mercury escaped from the surface again. Some of the mercury may have been oxidized as it left the surface. The results demonstrated that the chemical reaction primarily occurred between KI and mercury on the surface of the KI-clay. 展开更多
关键词 CLAY elemental mercury removal efficiency potassium iodide MECHANISM
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