Several popular time-frequency techniques,including the Wigner-Ville distribution,smoothed pseudo-Wigner-Ville distribution,wavelet transform,synchrosqueezing transform,Hilbert-Huang transform,and Gabor-Wigner transfo...Several popular time-frequency techniques,including the Wigner-Ville distribution,smoothed pseudo-Wigner-Ville distribution,wavelet transform,synchrosqueezing transform,Hilbert-Huang transform,and Gabor-Wigner transform,are investigated to determine how well they can identify damage to structures.In this work,a synchroextracting transform(SET)based on the short-time Fourier transform is proposed for estimating post-earthquake structural damage.The performance of SET for artificially generated signals and actual earthquake signals is examined with existing methods.Amongst other tested techniques,SET improves frequency resolution to a great extent by lowering the influence of smearing along the time-frequency plane.Hence,interpretation and readability with the proposed method are improved,and small changes in the time-varying frequency characteristics of the damaged buildings are easily detected through the SET method.展开更多
Graphene quantum dots(GQDs)have emerged as promising nanomaterials in cancer therapy because of their unique physicochemical properties.This review comprehensively analyzes the roles of GQDs in cancer diagnostics and ...Graphene quantum dots(GQDs)have emerged as promising nanomaterials in cancer therapy because of their unique physicochemical properties.This review comprehensively analyzes the roles of GQDs in cancer diagnostics and treatment,highlighting their biocompatibility,tunable photoluminescence,and surface functionalization capabilities.GQDs exhibit minimal toxicity,efficient cellular uptake,and favorable biodistribution,making them suitable for targeted drug delivery,photothermal therapy(PTT),and photodynamic therapy(PDT).Their intrinsic fluorescence also enables real-time bioimaging,supporting theranostic applications.This study explores their mechanisms of action,including reactive oxygen species(ROS)generation,heat-induced ablation,and pH-responsive drug release.GQDs have demonstrated efficacy across various cancers,such as breast,lung,brain,liver,and pancreatic cancers,through enhanced drug/gene delivery,biosensing,and image-guided therapy.Despite encouraging preclinical results,challenges related to toxicity profiling,standardization,regulatory frameworks,and scalability remain significant barriers to clinical translation.This review emphasizes the therapeutic versatility of GQDs and underscores the need for further research to overcome translational hurdles and realize their full potential in personalized cancer care.展开更多
文摘Several popular time-frequency techniques,including the Wigner-Ville distribution,smoothed pseudo-Wigner-Ville distribution,wavelet transform,synchrosqueezing transform,Hilbert-Huang transform,and Gabor-Wigner transform,are investigated to determine how well they can identify damage to structures.In this work,a synchroextracting transform(SET)based on the short-time Fourier transform is proposed for estimating post-earthquake structural damage.The performance of SET for artificially generated signals and actual earthquake signals is examined with existing methods.Amongst other tested techniques,SET improves frequency resolution to a great extent by lowering the influence of smearing along the time-frequency plane.Hence,interpretation and readability with the proposed method are improved,and small changes in the time-varying frequency characteristics of the damaged buildings are easily detected through the SET method.
文摘Graphene quantum dots(GQDs)have emerged as promising nanomaterials in cancer therapy because of their unique physicochemical properties.This review comprehensively analyzes the roles of GQDs in cancer diagnostics and treatment,highlighting their biocompatibility,tunable photoluminescence,and surface functionalization capabilities.GQDs exhibit minimal toxicity,efficient cellular uptake,and favorable biodistribution,making them suitable for targeted drug delivery,photothermal therapy(PTT),and photodynamic therapy(PDT).Their intrinsic fluorescence also enables real-time bioimaging,supporting theranostic applications.This study explores their mechanisms of action,including reactive oxygen species(ROS)generation,heat-induced ablation,and pH-responsive drug release.GQDs have demonstrated efficacy across various cancers,such as breast,lung,brain,liver,and pancreatic cancers,through enhanced drug/gene delivery,biosensing,and image-guided therapy.Despite encouraging preclinical results,challenges related to toxicity profiling,standardization,regulatory frameworks,and scalability remain significant barriers to clinical translation.This review emphasizes the therapeutic versatility of GQDs and underscores the need for further research to overcome translational hurdles and realize their full potential in personalized cancer care.
