γδT cells play important roles in the immunosurveillance of infection,cellular stress,and malignant transformation.In contrast to conventionalαβT cells,the T-cell receptor(TCR)ofγδT cells does not recognize anti...γδT cells play important roles in the immunosurveillance of infection,cellular stress,and malignant transformation.In contrast to conventionalαβT cells,the T-cell receptor(TCR)ofγδT cells does not recognize antigen-derived peptides in the context of MHC class I or class II molecules but rather senses stress-inducible surface molecules and microbe-derived or endogenous metabolites.You et al.discovered that certain nuclear proteins,such as nucleolin,can be ectopically expressed on the surface of tumor cells and then serve as ligands for humanγδT cells[1].The demonstration thatγδT cells recognize intracellular proteins that are ectopically expressed on the surface of somatic cells represents a new paradigm for the immunosurveillance function ofγδT cells.展开更多
A characteristic feature of the adaptive immune system is immunological memory,which is the more rapid and more potent response to antigenic challenge upon re-encountering the antigen–even years after the primary ant...A characteristic feature of the adaptive immune system is immunological memory,which is the more rapid and more potent response to antigenic challenge upon re-encountering the antigen–even years after the primary antigen contact.CD8 T cells are essential players in the adaptive immune response to viruses and intracellular microbes.Upon infection,antigen-responsive naive CD8 T cells are activated and they clonally expand to give rise to sufficient effector cell numbers to execute an adequate immune response.Effector cells are deleted after the clearance of infection,but some T cells survive and are maintained as memory T cells in a non-proliferative state in secondary lymphoid tissues and bone marrow.1 Complex transcriptional programs regulate CD8 T-cell differentiation from antigen-inexperienced naive cells via the effector cell stage towards long-term memory cells.展开更多
The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being ...The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and thrombocytopenia.It is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic agents.Notably,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.展开更多
文摘γδT cells play important roles in the immunosurveillance of infection,cellular stress,and malignant transformation.In contrast to conventionalαβT cells,the T-cell receptor(TCR)ofγδT cells does not recognize antigen-derived peptides in the context of MHC class I or class II molecules but rather senses stress-inducible surface molecules and microbe-derived or endogenous metabolites.You et al.discovered that certain nuclear proteins,such as nucleolin,can be ectopically expressed on the surface of tumor cells and then serve as ligands for humanγδT cells[1].The demonstration thatγδT cells recognize intracellular proteins that are ectopically expressed on the surface of somatic cells represents a new paradigm for the immunosurveillance function ofγδT cells.
文摘A characteristic feature of the adaptive immune system is immunological memory,which is the more rapid and more potent response to antigenic challenge upon re-encountering the antigen–even years after the primary antigen contact.CD8 T cells are essential players in the adaptive immune response to viruses and intracellular microbes.Upon infection,antigen-responsive naive CD8 T cells are activated and they clonally expand to give rise to sufficient effector cell numbers to execute an adequate immune response.Effector cells are deleted after the clearance of infection,but some T cells survive and are maintained as memory T cells in a non-proliferative state in secondary lymphoid tissues and bone marrow.1 Complex transcriptional programs regulate CD8 T-cell differentiation from antigen-inexperienced naive cells via the effector cell stage towards long-term memory cells.
基金supported by the Deutsche Forschungsgemeinschaft(DFG)through the Cluster of Excellence“Inflammation-at-Interfaces”EXC306-PN and EXC306-PM(D.K.,O.A.and C.K.)the Werner-und-Klara-Kreitz Foundation(JB).
文摘The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and thrombocytopenia.It is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic agents.Notably,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.
