Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to i...Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.展开更多
Carotenoids are naturally occurring pigments found in various fruits,vegetables,algae,insects,fungi,etc.As nutritional supplements,carotenoids have gained considerable attention for their potential therapeutic and hea...Carotenoids are naturally occurring pigments found in various fruits,vegetables,algae,insects,fungi,etc.As nutritional supplements,carotenoids have gained considerable attention for their potential therapeutic and health-promoting effects,making them significant components of alternative and traditional medicine worldwide.Carotenoids have many health benefits,particularly disease prevention.Carotenoids such as lutein,lycopene,and beta-carotene possess strong antioxidant properties,which help mitigate oxidative stress and reduce the risk of chronic diseases,including cancer,cardiovascular diseases,and eye disorders.Carotenoids play a vital role in various health conditions,including coronavirus disease-19(COVID-19),vision disorders,Alzheimer’s disease,reproductive health,cosmetic applications,diabetes management,infant formula,and animal nutrition.In alternative medicine,carotenoids are valued for enhancing immune function,reducing oxidative damage,and lowering the risk of chronic illnesses.Their benefits extend to improving cognitive function and potentially delaying the progression of Alzheimer’s disease,protecting against age-related macular degeneration and other vision problems,and supporting COVID-19 treatment.In skin care,carotenoids contribute to skin health and beauty,while in diabetes management,they aid in blood glucose regulation.This review especially emphasizes the potential of carotenoids as vital components in health management strategies within alternative medicine and underscores the need for further research to optimize their use in nutraceutical applications.展开更多
文摘Background:Epidemiological studies have confirmed that longer exposure to insecticides like cypermethrin(CYP)significantly increases the risk of male reproductive toxicity.Crocus sativus L.has been recognized due to its therapeutic properties,but its exact role and molecular mechanisms in treatment of reproductive dysfunction remain unclear.Methods:During this study,36 rats were randomly divided into six groups(n=6):control,CYP-induced(60 mg/kg),standard(leuprolide 3 mg/kg)and three treatment groups receiving aqueous,ethanolic,and oil extracts(50 mg/kg or 20 mL/kg)for post-toxicity induction.Results:The finding represented that exposure of CYP significantly increased oxidative stress,disrupted testicular architecture,and markedly reduced testosterone levels(P<0.05).Importantly,Crocus sativus L.treatment alleviated these changes by increasing the expression of Nrf2(nuclear factor erythroid 2-related factor 2),restoring the activity of antioxidant enzymes,and enhancing testicular histomorphology.Surprisingly,molecular docking established a high binding affinity of Crocus sativus L.phytoconstituents such as gallic acid,cinnamic acid and quercetin to the Nrf2-Keap1 complex.It is worth noting that,Crocus sativus L.exhibited a high level of protection against reproductive toxicity caused by CYP in male rats,which was mediated by the activation of Nrf2 pathway,reduction of oxidative damage,and favorable ADMET characteristics.Conclusion:Notably,this research provides a more valid,safe,and effective method of developing new drugs for reproductive disorders,however,further investigation is needed to support the research findings and implement it in clinical practice.
文摘Carotenoids are naturally occurring pigments found in various fruits,vegetables,algae,insects,fungi,etc.As nutritional supplements,carotenoids have gained considerable attention for their potential therapeutic and health-promoting effects,making them significant components of alternative and traditional medicine worldwide.Carotenoids have many health benefits,particularly disease prevention.Carotenoids such as lutein,lycopene,and beta-carotene possess strong antioxidant properties,which help mitigate oxidative stress and reduce the risk of chronic diseases,including cancer,cardiovascular diseases,and eye disorders.Carotenoids play a vital role in various health conditions,including coronavirus disease-19(COVID-19),vision disorders,Alzheimer’s disease,reproductive health,cosmetic applications,diabetes management,infant formula,and animal nutrition.In alternative medicine,carotenoids are valued for enhancing immune function,reducing oxidative damage,and lowering the risk of chronic illnesses.Their benefits extend to improving cognitive function and potentially delaying the progression of Alzheimer’s disease,protecting against age-related macular degeneration and other vision problems,and supporting COVID-19 treatment.In skin care,carotenoids contribute to skin health and beauty,while in diabetes management,they aid in blood glucose regulation.This review especially emphasizes the potential of carotenoids as vital components in health management strategies within alternative medicine and underscores the need for further research to optimize their use in nutraceutical applications.
