Background:Placenta specific 8(PLAC8)is a candidate oncogene involved in the development and progression of solid tumors.However,the status of PLAC8 in lung cancer(LC),especially non-small cell lung cancer(NSCLC)is st...Background:Placenta specific 8(PLAC8)is a candidate oncogene involved in the development and progression of solid tumors.However,the status of PLAC8 in lung cancer(LC),especially non-small cell lung cancer(NSCLC)is still not lucid.Methods:Tissue microarray analysis(TMA)was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines.Then a series of cellular experiments were performed fto assess cell proliferation,cell cycle profiles,and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines:H1299 and A549.Results:TMA results showed that PLAC8 played complex and even contradictory roles in different LC samples.Detailed cell-based experiments confirmed that PLAC8 could promote cell viability,alter the cell cycle,and accelerate cell mobility by regulating cell cyclins or cadherins,respectively.Conclusions:The study findings indicate that PLAC8 might participate in LC,especially NSCLC,by affecting cellular physiological processes.The outcomes also shed new light on the potential role of PLAC8 as a therapeutic biomarker in NSCLC.展开更多
基金supported by the Fund for Key Laboratory Construction of Hubei Province(Grant No.2018BFC360)the National Natural Science Foundation of China(Grant No.31101047 to Lu Xue)“the Fundamental Research Funds for the Central Universities”,South-Central Minzu University(Grant Number:CZQ22013).
文摘Background:Placenta specific 8(PLAC8)is a candidate oncogene involved in the development and progression of solid tumors.However,the status of PLAC8 in lung cancer(LC),especially non-small cell lung cancer(NSCLC)is still not lucid.Methods:Tissue microarray analysis(TMA)was performed to detect the expression patterns of PLAC8 in LC tissues and cell lines.Then a series of cellular experiments were performed fto assess cell proliferation,cell cycle profiles,and cell motility to explore the role of PLAC8 in NSCLC-derived cell lines:H1299 and A549.Results:TMA results showed that PLAC8 played complex and even contradictory roles in different LC samples.Detailed cell-based experiments confirmed that PLAC8 could promote cell viability,alter the cell cycle,and accelerate cell mobility by regulating cell cyclins or cadherins,respectively.Conclusions:The study findings indicate that PLAC8 might participate in LC,especially NSCLC,by affecting cellular physiological processes.The outcomes also shed new light on the potential role of PLAC8 as a therapeutic biomarker in NSCLC.
