Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformat...Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformation of hepatocytes. HBV can also sensitize hepatocytes to oncogenic transformation by causing genetic and epigenetic changes of the host chromosomes. HBV DNA can insert into host chromosomes and recent large-scale whole-genome sequencing studies revealed recurrent HBV DNA integrations sites that may play important roles in the initiation of hepatocellular carcinogenesis. HBV can also cause epigenetic changes by altering the methylation status of cellular DNA, the post-translational modification of histones, and the expression of micro RNAs. These changes can also lead to the eventual hepatocellular transformation. These recent findings on the genetic and epigenetic alterations of the host chromosomes induced by HBV opened a new avenue for the development of novel diagnosis and treatments for HBV-induced HCC.展开更多
什么是0SI？OSI参考模型（OSI／RM）的全称是开放系统互连参考模型（Open System Interconnection Reference Model．OSI／RM），它是由国际标准化组织ISO提出的一个网络系统互连模型。它是网络技术的基础，也是分析、评判各种网络技术...什么是0SI？OSI参考模型（OSI／RM）的全称是开放系统互连参考模型（Open System Interconnection Reference Model．OSI／RM），它是由国际标准化组织ISO提出的一个网络系统互连模型。它是网络技术的基础，也是分析、评判各种网络技术的依据，它揭开了网络的神秘面纱，让其有理可依，有据可循。展开更多
基金supported by the NIH grants DK100257 and DK177337
文摘Hepatitis B virus(HBV) is a major cause of hepatocellular carcinoma(HCC). Its chronic infection can lead to chronic liver inflammation and the accumulation of genetic alterations to result in the oncogenic transformation of hepatocytes. HBV can also sensitize hepatocytes to oncogenic transformation by causing genetic and epigenetic changes of the host chromosomes. HBV DNA can insert into host chromosomes and recent large-scale whole-genome sequencing studies revealed recurrent HBV DNA integrations sites that may play important roles in the initiation of hepatocellular carcinogenesis. HBV can also cause epigenetic changes by altering the methylation status of cellular DNA, the post-translational modification of histones, and the expression of micro RNAs. These changes can also lead to the eventual hepatocellular transformation. These recent findings on the genetic and epigenetic alterations of the host chromosomes induced by HBV opened a new avenue for the development of novel diagnosis and treatments for HBV-induced HCC.
文摘什么是0SI？OSI参考模型（OSI／RM）的全称是开放系统互连参考模型（Open System Interconnection Reference Model．OSI／RM），它是由国际标准化组织ISO提出的一个网络系统互连模型。它是网络技术的基础，也是分析、评判各种网络技术的依据，它揭开了网络的神秘面纱，让其有理可依，有据可循。
文摘过去几年,应用材料公司在探索半导体制造业的大数据分析方法上一直走在业界前列。除了赞助美国、亚洲和欧洲先进制程控制(APC)大会[1]等重要的相关技术会议,应用材料公司在此方面的工作还体现在《IEEE半导体制造会刊》(IEEE Transactions in Semiconductor Manufacturing)[2]等同行评审期刊上发表的相关论文。公司在瑞士曼迪匹艾(MDPI)的开放期刊Processes上发表的一篇此类文章,获得了2016年和2017年度“最佳论文奖”[3]。
