The combination of U-Pb and Lu-Hf compositions measured in zircon crystals is a remarkably powerful isotopic couplet that provides measures on both the timing of mineral growth and the radiogenic enrichment of the sou...The combination of U-Pb and Lu-Hf compositions measured in zircon crystals is a remarkably powerful isotopic couplet that provides measures on both the timing of mineral growth and the radiogenic enrichment of the source from which the zircon grew.The U-Pb age documents the timing of zircon crystallization/recrystallization and Hf isotopes inform on the degree to which the host melt was derived from a radiogenic reservoir(e.g.depleted mantle) versus an unradiogenic reservoir(e.g.ancient continental crust),or some mixture of these sources.The ease of generating large quantities of zircon U-Pb and Lu-Hf data has been in large part facilitated by instrument advances.However,the dramatic increase in time constrained zircon Lu-Hf analyses in the Earth science community has brought to the fore the importance of careful data collection and reduction workflows,onto which robust geological interpretations may be based.In this work,we discuss the fundamentals of Lu-Hf isotopes in zircon,which then allows us to provide a robust,accessible,methodology for the assessment of data quality.Additionally,we discuss some novel techniques for:data visualization—that facilitates better transparency of data interpretation;integration of geographic information—that may reveal spatial trends where temporal trends were only apparent before;and some novel statistical evaluation tools—that may provide more rigorous interand intra-sample comparisons.展开更多
The Collaborative Initial Glaucoma Treatment Study (CIGTS), funded by the U.S. National Eye Institute, is a prospective, randomized clinical trial designed to determine whether primary filtering surgery or medical the...The Collaborative Initial Glaucoma Treatment Study (CIGTS), funded by the U.S. National Eye Institute, is a prospective, randomized clinical trial designed to determine whether primary filtering surgery or medical therapy should be the initial intervention for patients with open-angle glaucoma Primary open-angle, exfoliative, and pigmentary glaucoma patients with elevated in-展开更多
In the Middle Norway eye-screening study, the prevalence of XFS in both members of 343 married couples (3.2%) was significantly higher (P=0.022) than one would expect. There has been an increasing number of reports of...In the Middle Norway eye-screening study, the prevalence of XFS in both members of 343 married couples (3.2%) was significantly higher (P=0.022) than one would expect. There has been an increasing number of reports of younger patients developing XFS after penetrating keratoplasty from elderly donors.展开更多
基金funded via an Australian Geophysical Observing System grant providedfunding from the Australian Research Council LIEF program(LE150100013)。
文摘The combination of U-Pb and Lu-Hf compositions measured in zircon crystals is a remarkably powerful isotopic couplet that provides measures on both the timing of mineral growth and the radiogenic enrichment of the source from which the zircon grew.The U-Pb age documents the timing of zircon crystallization/recrystallization and Hf isotopes inform on the degree to which the host melt was derived from a radiogenic reservoir(e.g.depleted mantle) versus an unradiogenic reservoir(e.g.ancient continental crust),or some mixture of these sources.The ease of generating large quantities of zircon U-Pb and Lu-Hf data has been in large part facilitated by instrument advances.However,the dramatic increase in time constrained zircon Lu-Hf analyses in the Earth science community has brought to the fore the importance of careful data collection and reduction workflows,onto which robust geological interpretations may be based.In this work,we discuss the fundamentals of Lu-Hf isotopes in zircon,which then allows us to provide a robust,accessible,methodology for the assessment of data quality.Additionally,we discuss some novel techniques for:data visualization—that facilitates better transparency of data interpretation;integration of geographic information—that may reveal spatial trends where temporal trends were only apparent before;and some novel statistical evaluation tools—that may provide more rigorous interand intra-sample comparisons.
文摘The Collaborative Initial Glaucoma Treatment Study (CIGTS), funded by the U.S. National Eye Institute, is a prospective, randomized clinical trial designed to determine whether primary filtering surgery or medical therapy should be the initial intervention for patients with open-angle glaucoma Primary open-angle, exfoliative, and pigmentary glaucoma patients with elevated in-
文摘In the Middle Norway eye-screening study, the prevalence of XFS in both members of 343 married couples (3.2%) was significantly higher (P=0.022) than one would expect. There has been an increasing number of reports of younger patients developing XFS after penetrating keratoplasty from elderly donors.
