Background:An epizootic of highly pathogenic avian influenza A(H5N1)has spread worldwide since 2022.Even though this virus has been extensively studied for many decades,little is known about its evolution in South Ame...Background:An epizootic of highly pathogenic avian influenza A(H5N1)has spread worldwide since 2022.Even though this virus has been extensively studied for many decades,little is known about its evolution in South America.Methods:Here,we describe the sequencing and characterization of 13 H5N1 genomes collected from wild birds,poultry,and wild mammals in Peru during the genomic surveillance of this outbreak.Results:The samples belonged to the highly pathogenic avian influenza(H5N1)2.3.4.4b clade.Chilean and Peruvian samples clustered in the same group and therefore share a common ancestor.An analysis of the hemag-glutinin and neuraminidase genes detected new mutations,some dependent upon the host type.Conclusions:The genomic surveillance of highly pathogenic avian influenza is necessary to promote the One Health policy and to overcome the new problems entailed by climate change,which may alter the habitats of resident and migratory birds.展开更多
It has been hypothesized that key lifestyle behaviors of physical activity and sleep worsened in response to the Coronavirus disease(COVID-19)pandemic.However,there have been inconsistencies in findings of changes in ...It has been hypothesized that key lifestyle behaviors of physical activity and sleep worsened in response to the Coronavirus disease(COVID-19)pandemic.However,there have been inconsistencies in findings of changes in these key lifestyle behaviors across populations likely due to the wide variety of assessment methods.The purpose of the study was to compare physical activity and sleep before and after the COVID-19 pandemic using accelerometers and self-reported behaviors.A longitudinal follow-up was conducted on students,faculty,and staff at a university campus in the United States.In the periods before March 2020(covering the academic years of 2018–2019 or 2019–2020)and again in April–June 2021,participants completed surveys to evaluate their physical activity and sleep behaviors and wore an accelerometer.A total of 44 participants completed the survey at both timepoints and 32 completed accelerometer assessment at both timepoints.Fifty-seven percent of participants reported a perceived decline in physical activity,while 30%reported a worsening in sleep.From selfreported data,overall physical activity did not change,but there was a decrease in active transport(p<0.001)and increase in domestic physical activity(p?0.012).Sleep quality decreased as evidenced by an increase in Pittsburgh Sleep Quality Index scores(p?0.045).There were no changes in accelerometer measured physical activity or sleep.There were no changes in physical or mental health.While perceptions of physical activity declined from prior to the COVID-19 pandemic,there were no changes in device-measured physical activity,and changes in self-reported physical activity differed by domain.展开更多
文摘Background:An epizootic of highly pathogenic avian influenza A(H5N1)has spread worldwide since 2022.Even though this virus has been extensively studied for many decades,little is known about its evolution in South America.Methods:Here,we describe the sequencing and characterization of 13 H5N1 genomes collected from wild birds,poultry,and wild mammals in Peru during the genomic surveillance of this outbreak.Results:The samples belonged to the highly pathogenic avian influenza(H5N1)2.3.4.4b clade.Chilean and Peruvian samples clustered in the same group and therefore share a common ancestor.An analysis of the hemag-glutinin and neuraminidase genes detected new mutations,some dependent upon the host type.Conclusions:The genomic surveillance of highly pathogenic avian influenza is necessary to promote the One Health policy and to overcome the new problems entailed by climate change,which may alter the habitats of resident and migratory birds.
文摘It has been hypothesized that key lifestyle behaviors of physical activity and sleep worsened in response to the Coronavirus disease(COVID-19)pandemic.However,there have been inconsistencies in findings of changes in these key lifestyle behaviors across populations likely due to the wide variety of assessment methods.The purpose of the study was to compare physical activity and sleep before and after the COVID-19 pandemic using accelerometers and self-reported behaviors.A longitudinal follow-up was conducted on students,faculty,and staff at a university campus in the United States.In the periods before March 2020(covering the academic years of 2018–2019 or 2019–2020)and again in April–June 2021,participants completed surveys to evaluate their physical activity and sleep behaviors and wore an accelerometer.A total of 44 participants completed the survey at both timepoints and 32 completed accelerometer assessment at both timepoints.Fifty-seven percent of participants reported a perceived decline in physical activity,while 30%reported a worsening in sleep.From selfreported data,overall physical activity did not change,but there was a decrease in active transport(p<0.001)and increase in domestic physical activity(p?0.012).Sleep quality decreased as evidenced by an increase in Pittsburgh Sleep Quality Index scores(p?0.045).There were no changes in accelerometer measured physical activity or sleep.There were no changes in physical or mental health.While perceptions of physical activity declined from prior to the COVID-19 pandemic,there were no changes in device-measured physical activity,and changes in self-reported physical activity differed by domain.
