We report mechanochemically-induced deuteration of Pd-activated aromatic C(sp^(2))–H bonds at ambient temperature under solvent-free conditions.Deuterium was sourced from cysteine-d_(4) to obtain mono-or dideuterated...We report mechanochemically-induced deuteration of Pd-activated aromatic C(sp^(2))–H bonds at ambient temperature under solvent-free conditions.Deuterium was sourced from cysteine-d_(4) to obtain mono-or dideuterated products from various aromatic palladacycles.Next to good deuteration yields,based on time-resolved in situ Raman monitoring and DFT calculations,we present a detailed view of the reaction course in the solid state.The obtained knowledge could lead to the broader application of this methodology for the deuteration of organics.展开更多
基金Financial support was provided by the Croatian Science Foundation(grants IP-2019-04-9951 and IP-2020-02-1419).
文摘We report mechanochemically-induced deuteration of Pd-activated aromatic C(sp^(2))–H bonds at ambient temperature under solvent-free conditions.Deuterium was sourced from cysteine-d_(4) to obtain mono-or dideuterated products from various aromatic palladacycles.Next to good deuteration yields,based on time-resolved in situ Raman monitoring and DFT calculations,we present a detailed view of the reaction course in the solid state.The obtained knowledge could lead to the broader application of this methodology for the deuteration of organics.
