Background:Iron deficiency anemia(IDA)is prevalent among women of reproductive age,leading to adverse effects on health and quality of life.IDA affects an estimated 30%of the global population.While iron supple-mentat...Background:Iron deficiency anemia(IDA)is prevalent among women of reproductive age,leading to adverse effects on health and quality of life.IDA affects an estimated 30%of the global population.While iron supple-mentation remains the standard treatment,adherence to therapy and side effects often limit its effectiveness.Majun-e-khabsul hadeed,a traditional Unani formulation,is believed to have therapeutic effects on anemia.However,scientific evidence on its efficacy remains sparse.Objective:The objective of the study is to evaluate the effect of Majun-e-khabsul hadeed in comparison with standard therapy on iron deficiency anemia in women of reproductive age.Methods:A randomized controlled trial was conducted involving 120 women of reproductive age diagnosed with Iron Deficiency Anemia.Participants were randomly assigned to two groups:one receiving Majun-e-khabsul hadeed 5 g twice daily and the other receiving standard oral iron supplementation,Tab Orofer XT 1 BD.The pri-mary outcomes will include changes in hemoglobin levels and serum ferritin,while secondary outcomes include changes in RBC indices.All parameters were assessed before and after treatment.Results:Significant changes were observed in primary outcome measures i.e.both Hb%and serum ferritin with P<0.05 in both primary and secondary outcome measures.Conclusion:Majun-e-khabsul hadeed group experienced a significant increase in Hb from baseline but had a lower post-treatment haemoglobin compared to the control group,hence demonstrating non-inferiority trend towards Tab Orofer in improving hemoglobin levels and managing iron deficiency anemia.However,since no non-inferiority margin was specified a priori,the results should be interpreted as exploratory rather than confirmatory.Both treatments were well-tolerated,with Majune khabsul hadeed showing a slightly better safety profile.Majune khabsul hadeed can provide comparable efficacy with potentially fewer side effects,supporting its use in iron-deficiency anemia treatment protocols.展开更多
基金supported by RGUHS vide No.21UNA368National Institute of unani Medicine。
文摘Background:Iron deficiency anemia(IDA)is prevalent among women of reproductive age,leading to adverse effects on health and quality of life.IDA affects an estimated 30%of the global population.While iron supple-mentation remains the standard treatment,adherence to therapy and side effects often limit its effectiveness.Majun-e-khabsul hadeed,a traditional Unani formulation,is believed to have therapeutic effects on anemia.However,scientific evidence on its efficacy remains sparse.Objective:The objective of the study is to evaluate the effect of Majun-e-khabsul hadeed in comparison with standard therapy on iron deficiency anemia in women of reproductive age.Methods:A randomized controlled trial was conducted involving 120 women of reproductive age diagnosed with Iron Deficiency Anemia.Participants were randomly assigned to two groups:one receiving Majun-e-khabsul hadeed 5 g twice daily and the other receiving standard oral iron supplementation,Tab Orofer XT 1 BD.The pri-mary outcomes will include changes in hemoglobin levels and serum ferritin,while secondary outcomes include changes in RBC indices.All parameters were assessed before and after treatment.Results:Significant changes were observed in primary outcome measures i.e.both Hb%and serum ferritin with P<0.05 in both primary and secondary outcome measures.Conclusion:Majun-e-khabsul hadeed group experienced a significant increase in Hb from baseline but had a lower post-treatment haemoglobin compared to the control group,hence demonstrating non-inferiority trend towards Tab Orofer in improving hemoglobin levels and managing iron deficiency anemia.However,since no non-inferiority margin was specified a priori,the results should be interpreted as exploratory rather than confirmatory.Both treatments were well-tolerated,with Majune khabsul hadeed showing a slightly better safety profile.Majune khabsul hadeed can provide comparable efficacy with potentially fewer side effects,supporting its use in iron-deficiency anemia treatment protocols.
