Lung cancer remains the leading cause of cancer death in 2024,with∼80%being non-small cell lung cancer(NSCLC).Anaplastic lymphoma kinase(ALK)rearrangements occur in∼5%of NSCLC cases,typically treated with ALK inhibi...Lung cancer remains the leading cause of cancer death in 2024,with∼80%being non-small cell lung cancer(NSCLC).Anaplastic lymphoma kinase(ALK)rearrangements occur in∼5%of NSCLC cases,typically treated with ALK inhibitors,though resistance often develops[1].Immunotherapy has been explored for advanced or resistant ALK-positive NSCLC,but immune checkpoint blockade(ICB)treatments have shown limited clinical benefits[1].展开更多
Esophageal cancer comprises 2 anatomically shared but histologically different subtypes:esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC).Previous bulk-level genomic and clinical studies have ...Esophageal cancer comprises 2 anatomically shared but histologically different subtypes:esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC).Previous bulk-level genomic and clinical studies have shown that ESCC shares molecular features with head and neck squamous cell carcinoma(HNSCC)[1]and is generally more responsive to immune checkpoint blockade(ICB)therapies than EAC[2],which is similar to gastric adenocarcinoma(GAC)[1].Recent clinical trials have further demonstrated clinical benefits fromvarious ICB therapies,including combination approaches,for ESCC[3].展开更多
Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model c...Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model crop for fruit development and disease resistance.展开更多
Dear Editor Gene networks provide a system-level overview of genetic organizations and enable the dissection of functional modules underlying complex traits.Integration of diverse genomics data based on the Bayesian s...Dear Editor Gene networks provide a system-level overview of genetic organizations and enable the dissection of functional modules underlying complex traits.Integration of diverse genomics data based on the Bayesian statistics framework has been successfully applied to the construction of genome-scale functional networks for major crop species such as rice(Lee et al.,2011),soybean(Kim et al.,2017),and tomato。展开更多
基金supported by the Bio&Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science and ICT(2021R1A2C2094629 and 2017M3A9E9072669 to Hye Ryun Kim,and 2018R1A5A2025079,2022M3A9F3016364,and 2022R1A2C1092062 to Insuk Lee)supported in part by Brain Korea 21(BK21)FOUR program+1 种基金supported by the Technology Innovation Program(20022947)funded by the Ministry of Trade Industry&Energy(MOTIE,Korea)supported by the Yonsei Fellow Program,funded by Lee Youn Jae.
文摘Lung cancer remains the leading cause of cancer death in 2024,with∼80%being non-small cell lung cancer(NSCLC).Anaplastic lymphoma kinase(ALK)rearrangements occur in∼5%of NSCLC cases,typically treated with ALK inhibitors,though resistance often develops[1].Immunotherapy has been explored for advanced or resistant ALK-positive NSCLC,but immune checkpoint blockade(ICB)treatments have shown limited clinical benefits[1].
基金the Bio&Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science and ICT(RS-2021-NR059674,RS-2022-CC125144,2022M3A9F3016364,2022R1A2C1092062,RS-2025-00553825)Brain Korea 21(BK21)FOUR program+3 种基金the Technology Innovation Program(20022947funded by the Ministry of Trade Industry&EnergyMOTIE,Korea)Yonsei Fellow Program funded by Youn Jae Lee.
文摘Esophageal cancer comprises 2 anatomically shared but histologically different subtypes:esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC).Previous bulk-level genomic and clinical studies have shown that ESCC shares molecular features with head and neck squamous cell carcinoma(HNSCC)[1]and is generally more responsive to immune checkpoint blockade(ICB)therapies than EAC[2],which is similar to gastric adenocarcinoma(GAC)[1].Recent clinical trials have further demonstrated clinical benefits fromvarious ICB therapies,including combination approaches,for ESCC[3].
文摘Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model crop for fruit development and disease resistance.
文摘Dear Editor Gene networks provide a system-level overview of genetic organizations and enable the dissection of functional modules underlying complex traits.Integration of diverse genomics data based on the Bayesian statistics framework has been successfully applied to the construction of genome-scale functional networks for major crop species such as rice(Lee et al.,2011),soybean(Kim et al.,2017),and tomato。
