Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cance...Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune response.However,inadequate biocompatibility restricts their potential in clinical translation.Therefore,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines.Intrinsic properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future nanomedicines.The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery.This review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination therapy.Herein we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical translation.This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.展开更多
Ecoflex is widely used in bioelectronics due to its outstanding properties of low modulus and large stretchability.For its use as an encapsulation layer in multi-channel wearable devices,a patterning procedure is esse...Ecoflex is widely used in bioelectronics due to its outstanding properties of low modulus and large stretchability.For its use as an encapsulation layer in multi-channel wearable devices,a patterning procedure is essential.However,conventional patterning strategies for Ecoflex,such as soft lithography,punching,and laser ablation,lack sufficient quality and process compatibility.To address this,we propose a process-compatible method of patterning Ecoflex by developing Photo-patternable Ecoflex(PPE).The PPE layer,used as an encapsulation layer,effectively dissipates strain energy at homogeneous interfaces,resulting in a 50%increase in electrical conductance under 250%strain.Using PPE,we fabricated intrinsically stretchable multi-sensors that monitor bio-signals like glucose,lactate,pH,and humidity in sweat.These sensors maintain durable sensitivity under strain up to 50%and for 1000 cycles at 20%strain.Finally,we mounted these stretchable multi-chemical sensors on an arm to monitor glucose and lactate levels in sweat.展开更多
基金National Research Foundation of Korea CRI project(Grant No.2018R1A3B1052702 and 2019M3E5D1A01068998,J.S.K.and NRF-2021R1A2B03002487,S.-G.C.)Basic Science Research Programs(2022R1C1C2007637,SK)of the NRF KoreaThis work was also supported by the Korea University Grant(PJ).
文摘Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area.The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune response.However,inadequate biocompatibility restricts their potential in clinical translation.Therefore,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines.Intrinsic properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future nanomedicines.The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery.This review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination therapy.Herein we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical translation.This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.
基金supported by the Wearable Platform Materials Technology Center(WMC)funded by the National Research Foundation of Korea(NRF)grant by the Korea Government(MSIT)(NRF-2022R1A5A6000846,NRF-2021M3D1A2049869,NRF-2020M3H4A3106405)supported by Nano Material Technology Development Program(2021M3H4A1A04092879)through the National Research Foundation of Korea funded by the Ministry of Science and ICT.
文摘Ecoflex is widely used in bioelectronics due to its outstanding properties of low modulus and large stretchability.For its use as an encapsulation layer in multi-channel wearable devices,a patterning procedure is essential.However,conventional patterning strategies for Ecoflex,such as soft lithography,punching,and laser ablation,lack sufficient quality and process compatibility.To address this,we propose a process-compatible method of patterning Ecoflex by developing Photo-patternable Ecoflex(PPE).The PPE layer,used as an encapsulation layer,effectively dissipates strain energy at homogeneous interfaces,resulting in a 50%increase in electrical conductance under 250%strain.Using PPE,we fabricated intrinsically stretchable multi-sensors that monitor bio-signals like glucose,lactate,pH,and humidity in sweat.These sensors maintain durable sensitivity under strain up to 50%and for 1000 cycles at 20%strain.Finally,we mounted these stretchable multi-chemical sensors on an arm to monitor glucose and lactate levels in sweat.
