Depression manifests as an enduring experience of sorrow and a loss of interest,appetite,and engagement.Currently,no study has systematically reviewed the efficacy of Chinese herbal medicine Banxia-Houpo-Tang(BHT)for ...Depression manifests as an enduring experience of sorrow and a loss of interest,appetite,and engagement.Currently,no study has systematically reviewed the efficacy of Chinese herbal medicine Banxia-Houpo-Tang(BHT)for the treatment of depression in animal experimental research.This systematic review sought to provide evidence regarding the efficacy and molecular mechanism of BHT for depression.Fifteen electronic databases were searched until November 23,2023.Two researchers individually screened abstracts and full texts for inclusion,extracted data,and assessed the quality of included studies using the risk of bias tool from the Systematic Review Center for Laboratory Animal Experimentation.We conducted the meta-analysis for behavior and biological outcomes.Network pharmacology and molecular docking analyses were conducted to predict the key contributors to BHT’s antidepressant effects.We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.This review included 23 studies.The meta-analysis indicated that BHT considerably reduced immobility time in the forced swim test(SMD=−2.89,95%CI:−3.92 to−1.87,P<0.00001,I2=93%),and tail suspended swim test(SMD=−2.70,95%CI:−3.64 to−1.76,P<0.00001,I2=90%),and increased movement in open field tests(SMD=0.62,95%CI:0.25–1.00,P=0.28,I2=21%).Also,BHT markedly increased 5-hydroxytryptamine(SMD=1.39,95%CI=0.61–2.18,P<0.00001,I2=92%),5-hydroxyindoleacetic acid(SMD=1.06,95%CI=0.22–1.90,P<0.00001,I2=93%),and dopamine(SMD=2.07,95%CI=0.35–3.79,P<0.00001,I2=96%).Silico analysis revealed that honokiol,magnolol,and rosmarinic acid were valuable components associated with the mechanisms of BHT.Our study demonstrated that BHT may relieve depression by regulating neurotransmitters,neuro-inflammation,the hypothalamic-pituitary-adrenal axis,and other biological mechanisms.Well-designed pre-clinical studies should be conducted to provide robust evidence for the mechanism and efficacy of BHT.展开更多
基金supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HF21C0036).
文摘Depression manifests as an enduring experience of sorrow and a loss of interest,appetite,and engagement.Currently,no study has systematically reviewed the efficacy of Chinese herbal medicine Banxia-Houpo-Tang(BHT)for the treatment of depression in animal experimental research.This systematic review sought to provide evidence regarding the efficacy and molecular mechanism of BHT for depression.Fifteen electronic databases were searched until November 23,2023.Two researchers individually screened abstracts and full texts for inclusion,extracted data,and assessed the quality of included studies using the risk of bias tool from the Systematic Review Center for Laboratory Animal Experimentation.We conducted the meta-analysis for behavior and biological outcomes.Network pharmacology and molecular docking analyses were conducted to predict the key contributors to BHT’s antidepressant effects.We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.This review included 23 studies.The meta-analysis indicated that BHT considerably reduced immobility time in the forced swim test(SMD=−2.89,95%CI:−3.92 to−1.87,P<0.00001,I2=93%),and tail suspended swim test(SMD=−2.70,95%CI:−3.64 to−1.76,P<0.00001,I2=90%),and increased movement in open field tests(SMD=0.62,95%CI:0.25–1.00,P=0.28,I2=21%).Also,BHT markedly increased 5-hydroxytryptamine(SMD=1.39,95%CI=0.61–2.18,P<0.00001,I2=92%),5-hydroxyindoleacetic acid(SMD=1.06,95%CI=0.22–1.90,P<0.00001,I2=93%),and dopamine(SMD=2.07,95%CI=0.35–3.79,P<0.00001,I2=96%).Silico analysis revealed that honokiol,magnolol,and rosmarinic acid were valuable components associated with the mechanisms of BHT.Our study demonstrated that BHT may relieve depression by regulating neurotransmitters,neuro-inflammation,the hypothalamic-pituitary-adrenal axis,and other biological mechanisms.Well-designed pre-clinical studies should be conducted to provide robust evidence for the mechanism and efficacy of BHT.
