Skin wound healing is an important aspect of regenerative medicine.Metal-organic frameworks(MOFs)have attracted considerable attention as promising nanomaterials for skin wound healing due to their remarkable versatil...Skin wound healing is an important aspect of regenerative medicine.Metal-organic frameworks(MOFs)have attracted considerable attention as promising nanomaterials for skin wound healing due to their remarkable versatility,tunable pore size,surface area,targeted delivery of various therapeutic agents,and controlled release properties.The combination of these materials with biocompatible and synthetic polymers can help improve their performance in wound regeneration.This review examines the potential of MOF-polymer composites in skin wound healing.Physical and biological chemical properties and methods of making MOFs and their composites have been investigated.In the final section of this review,challenges and future prospects for the development of MOF-polymer composites are stated.展开更多
Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical ...Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy.Hierarchical nanostructure construction involves coupling liganded nanoscale isotropic/anisotropic Au(comparable to few integrin molecules-scale)to the surface of microscale isotropic/anisotropic magnetic Fe3O4(comparable to integrin cluster-scale)and then elastically tethering them to a substrate.Systematic independent tailoring of nanoscale or microscale ligand isotropy versus anisotropy in four different hierarchical nanostructures with constant liganded surface area demonstrates similar levels of integrin molecule bridging and macrophage adhesion on the nanoscale ligand isotropy versus anisotropy.Conversely,the levels of integrin cluster bridging across hierarchical nanostructures and macrophage adhesion are significantly promoted by microscale ligand anisotropy compared with microscale ligand isotropy.Furthermore,microscale ligand anisotropy dominantly activates the host macrophage adhesion and pro-regenerative M2 polarization in vivo over the nanoscale ligand anisotropy,which can be cyclically reversed by substrate-proximate versus substrate-distant magnetic manipulation.This unprecedented scale-specific regulation of cells can be diversified by unlimited tuning of the scale,anisotropy,dimension,shape,and magnetism of hierarchical structures to decipher scale-specific dynamic cell-material interactions to advance immunoengineering strategies.展开更多
基金A.Hasan acknowledges the partial financial support from the Grant(No.NPRP12S-0310-190276)。
文摘Skin wound healing is an important aspect of regenerative medicine.Metal-organic frameworks(MOFs)have attracted considerable attention as promising nanomaterials for skin wound healing due to their remarkable versatility,tunable pore size,surface area,targeted delivery of various therapeutic agents,and controlled release properties.The combination of these materials with biocompatible and synthetic polymers can help improve their performance in wound regeneration.This review examines the potential of MOF-polymer composites in skin wound healing.Physical and biological chemical properties and methods of making MOFs and their composites have been investigated.In the final section of this review,challenges and future prospects for the development of MOF-polymer composites are stated.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2023-00208427)supported by the Korea Basic Science Institute(National research Facilities and Equipment Center)grant fun-ded by the Korea government(MSIT)(No.RS-2024-00402412)+1 种基金supported by the Nano&Material Technology Develop-ment Program through the National Research Foundation of Korea(NRF)funded by Ministry of Science and ICT(RS-2024-00407093)supported by a Korea University Grant.
文摘Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation.In this study,remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy.Hierarchical nanostructure construction involves coupling liganded nanoscale isotropic/anisotropic Au(comparable to few integrin molecules-scale)to the surface of microscale isotropic/anisotropic magnetic Fe3O4(comparable to integrin cluster-scale)and then elastically tethering them to a substrate.Systematic independent tailoring of nanoscale or microscale ligand isotropy versus anisotropy in four different hierarchical nanostructures with constant liganded surface area demonstrates similar levels of integrin molecule bridging and macrophage adhesion on the nanoscale ligand isotropy versus anisotropy.Conversely,the levels of integrin cluster bridging across hierarchical nanostructures and macrophage adhesion are significantly promoted by microscale ligand anisotropy compared with microscale ligand isotropy.Furthermore,microscale ligand anisotropy dominantly activates the host macrophage adhesion and pro-regenerative M2 polarization in vivo over the nanoscale ligand anisotropy,which can be cyclically reversed by substrate-proximate versus substrate-distant magnetic manipulation.This unprecedented scale-specific regulation of cells can be diversified by unlimited tuning of the scale,anisotropy,dimension,shape,and magnetism of hierarchical structures to decipher scale-specific dynamic cell-material interactions to advance immunoengineering strategies.
