Objective:To investigate the prevalence and risk factors of brucellosis in human and animal’s communities in southern Saudi Arabia.Methods:A cross-sectional sero-epidemiological study was conducted in Aseer and Jazan...Objective:To investigate the prevalence and risk factors of brucellosis in human and animal’s communities in southern Saudi Arabia.Methods:A cross-sectional sero-epidemiological study was conducted in Aseer and Jazan,Saudi Arabia(October 2017-October 2018).Human serum samples(n=339)were initially screened for Brucella antibodies and positive samples were further titrated for Brucella antibodies by immunocapture assay(titer of≥1:320 as positive).Animal samples(n=828)were screened using the Rose Bengal test.Relationship status was dichotomized to measure and predict independent contributions to variations in human using univariate and multivariate stepwise binary logistic regression model.Results:The rate of brucellosis among the 339 human samples in the two regions was 33.9%,and the rate of acute brucellosis was 12.4%.The rate of brucellosis in animals was 4.7%.Human brucellosis among the target groups was higher in northwestern Aseer(53.3%)compared to Southeastern Aseer(25.9%)and Jazan region(20.6%).The disease was more prevalent among non-Saudi nationals(35.2%)compared to Saudis(30.5%).The rate of brucellosis among butchers and shepherds was 37.5%and 37.2%,respectively.The rate of brucellosis was 37.8%in people over 30 years of age.Our univariate analysis showed that residing in Aseer region(OR:2.60,95%CI:1.50-4.40),especially residing in northwestern Aseer region(OR:4.40,95%CI:2.40-7.90),frequent consumption of raw meat(OR:2.90,95%CI:1.50-5.50),shepherds(OR:2.10,95%CI:0.80-5.30),owning sheep(OR:2.20,95%CI:1.10-4.40),daily contact with animals(OR:2.10,95%CI:0.75-5.80),and those>30-year-old(OR:1.50,95%CI:1.00-2.40)were significantly associated with increased risks of brucellosis.Our multivariate analysis further showed that residing in northwestern Aseer(OR:9.16,95%CI:3.39-24.76)and having sheep(OR:1.16,95%CI:1.00-1.35)were significant and independent risks of brucellosis while residing in agricultural region(OR:0.28,95%CI:0.10-0.78)was a significant and independent protector against brucellosis.Conclusions:The study concluded that residing in northwestern Aseer area and having animals(sheep)are associated with significantly increased risks of brucellosis.展开更多
基金funded by a grant from the Deanship for Scientific Research,King Khalid University(Project#GRP-4-1439).
文摘Objective:To investigate the prevalence and risk factors of brucellosis in human and animal’s communities in southern Saudi Arabia.Methods:A cross-sectional sero-epidemiological study was conducted in Aseer and Jazan,Saudi Arabia(October 2017-October 2018).Human serum samples(n=339)were initially screened for Brucella antibodies and positive samples were further titrated for Brucella antibodies by immunocapture assay(titer of≥1:320 as positive).Animal samples(n=828)were screened using the Rose Bengal test.Relationship status was dichotomized to measure and predict independent contributions to variations in human using univariate and multivariate stepwise binary logistic regression model.Results:The rate of brucellosis among the 339 human samples in the two regions was 33.9%,and the rate of acute brucellosis was 12.4%.The rate of brucellosis in animals was 4.7%.Human brucellosis among the target groups was higher in northwestern Aseer(53.3%)compared to Southeastern Aseer(25.9%)and Jazan region(20.6%).The disease was more prevalent among non-Saudi nationals(35.2%)compared to Saudis(30.5%).The rate of brucellosis among butchers and shepherds was 37.5%and 37.2%,respectively.The rate of brucellosis was 37.8%in people over 30 years of age.Our univariate analysis showed that residing in Aseer region(OR:2.60,95%CI:1.50-4.40),especially residing in northwestern Aseer region(OR:4.40,95%CI:2.40-7.90),frequent consumption of raw meat(OR:2.90,95%CI:1.50-5.50),shepherds(OR:2.10,95%CI:0.80-5.30),owning sheep(OR:2.20,95%CI:1.10-4.40),daily contact with animals(OR:2.10,95%CI:0.75-5.80),and those>30-year-old(OR:1.50,95%CI:1.00-2.40)were significantly associated with increased risks of brucellosis.Our multivariate analysis further showed that residing in northwestern Aseer(OR:9.16,95%CI:3.39-24.76)and having sheep(OR:1.16,95%CI:1.00-1.35)were significant and independent risks of brucellosis while residing in agricultural region(OR:0.28,95%CI:0.10-0.78)was a significant and independent protector against brucellosis.Conclusions:The study concluded that residing in northwestern Aseer area and having animals(sheep)are associated with significantly increased risks of brucellosis.
