The high prevalence of obesity and associated nonalcoholic fatty liver disease(NAFLD)in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these p...The high prevalence of obesity and associated nonalcoholic fatty liver disease(NAFLD)in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these patholo-gies.The search for new endogenous bioregulators of lipid metabolism and their inclusion in therapeutic regimens for the treatment of patients is becoming a potentially promising direction in science and medicine.Oleoylethanolamide(OEA)is an endogenous lipid mediator capable of exerting multiple hypolipidemic,anti-inflammatory,and hepato-protective effects mediated by agonism with receptors of the peroxisome proliferator-activated receptor(PPAR)family(PPAR-αand PPAR-γ).This review focuses on a detailed description of the PPAR-dependent mechanisms of the hepatoprotective activity of OEA in the development of NAFLD.The main attention is paid to such topics as reduction of oxidative stress and inflammation,inhibition of liver fibrogenesis,suppression of hepatocyte death,and changes in various parameters of lipid metabolism.展开更多
基金supported by the Russian Science Foundation(project 24-75-00072).
文摘The high prevalence of obesity and associated nonalcoholic fatty liver disease(NAFLD)in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these patholo-gies.The search for new endogenous bioregulators of lipid metabolism and their inclusion in therapeutic regimens for the treatment of patients is becoming a potentially promising direction in science and medicine.Oleoylethanolamide(OEA)is an endogenous lipid mediator capable of exerting multiple hypolipidemic,anti-inflammatory,and hepato-protective effects mediated by agonism with receptors of the peroxisome proliferator-activated receptor(PPAR)family(PPAR-αand PPAR-γ).This review focuses on a detailed description of the PPAR-dependent mechanisms of the hepatoprotective activity of OEA in the development of NAFLD.The main attention is paid to such topics as reduction of oxidative stress and inflammation,inhibition of liver fibrogenesis,suppression of hepatocyte death,and changes in various parameters of lipid metabolism.
