Despite significant advancements in cancer treatment,current therapies often fail to completely eradicate malignant cells.This shortfall underscores the urgent need to explore alternative approaches such as cancer vac...Despite significant advancements in cancer treatment,current therapies often fail to completely eradicate malignant cells.This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines.Leveraging the immune system’s natural ability to target and kill cancer cells holds great ther-apeutic potential.However,the development of cancer vaccines is hindered by several challenges,including low stability,inadequate immune response activa-tion,and the immunosuppressive tumor microenvironment,which limit their efficacy.Recent progress in various fields,such as click chemistry,nanotechnol-ogy,exosome engineering,and neoantigen design,offer innovative solutions to these challenges.These achievements have led to the emergence of smart vaccine platforms(SVPs),which integrate protective carriers for messenger ribonucleic acid(mRNA)with functionalization strategies to optimize targeted delivery.Click chemistry further enhances SVP performance by improving the encapsu-lation of mRNA antigens and facilitating their precise delivery to target cells.This review highlights the latest developments in SVP technologies for cancer therapy,exploring both their opportunities and challenges in advancing these transformative approaches.展开更多
基金National Institutes of Health,Grant/Award Number:R01EB027705。
文摘Despite significant advancements in cancer treatment,current therapies often fail to completely eradicate malignant cells.This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines.Leveraging the immune system’s natural ability to target and kill cancer cells holds great ther-apeutic potential.However,the development of cancer vaccines is hindered by several challenges,including low stability,inadequate immune response activa-tion,and the immunosuppressive tumor microenvironment,which limit their efficacy.Recent progress in various fields,such as click chemistry,nanotechnol-ogy,exosome engineering,and neoantigen design,offer innovative solutions to these challenges.These achievements have led to the emergence of smart vaccine platforms(SVPs),which integrate protective carriers for messenger ribonucleic acid(mRNA)with functionalization strategies to optimize targeted delivery.Click chemistry further enhances SVP performance by improving the encapsu-lation of mRNA antigens and facilitating their precise delivery to target cells.This review highlights the latest developments in SVP technologies for cancer therapy,exploring both their opportunities and challenges in advancing these transformative approaches.
