Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug i...Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evidence and global acceptance impede their widespread adoption.Liposomes,nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adaptable systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnostic and imaging agents,enabling precise disease detection and monitoring.While liposomes offer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,energy-based approach to health and organ function,presents distinct challenges regarding formulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how liposomal systems may bridge these approaches.The review analyzes key formulation techniques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.展开更多
With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer diagnosis.Surface-enhanced Raman scattering(SERS)and microfluidic technology have receiv...With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer diagnosis.Surface-enhanced Raman scattering(SERS)and microfluidic technology have received much attention among the various cancer biomarker detection methods.The former has ultrahigh detection sensitivity and can provide a unique fingerprint.In contrast,the latter has the characteristics of miniaturization and integration,which can realize accurate control of the detection samples and high-throughput detection through design.Both have the potential for point-of-care testing(POCT),and their combination(lab-on-a-chip SERS(LoC-SERS))shows good compatibility.In this paper,the basic situation of circulating proteins,circulating tumor cells,exosomes,circulating tumor DNA(ctDNA),and microRNA(miRNA)in the diagnosis of various cancers is reviewed,and the detection research of these biomarkers by the LoC-SERS platform in recent years is described in detail.At the same time,the challenges and future development of the platform are discussed at the end of the review.Summarizing the current technology is expected to provide a reference for scholars engaged in related work and interested in this field.展开更多
基金the Project of Hunan ScienceTechnology(Nos.2020JJ9011、2020JJ9020、2021JJ80078).
文摘Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evidence and global acceptance impede their widespread adoption.Liposomes,nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adaptable systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnostic and imaging agents,enabling precise disease detection and monitoring.While liposomes offer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,energy-based approach to health and organ function,presents distinct challenges regarding formulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how liposomal systems may bridge these approaches.The review analyzes key formulation techniques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.
基金supported by the Natural Science Foundation of Hunan Province,China(Grant No.:2021JJ80078).
文摘With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer diagnosis.Surface-enhanced Raman scattering(SERS)and microfluidic technology have received much attention among the various cancer biomarker detection methods.The former has ultrahigh detection sensitivity and can provide a unique fingerprint.In contrast,the latter has the characteristics of miniaturization and integration,which can realize accurate control of the detection samples and high-throughput detection through design.Both have the potential for point-of-care testing(POCT),and their combination(lab-on-a-chip SERS(LoC-SERS))shows good compatibility.In this paper,the basic situation of circulating proteins,circulating tumor cells,exosomes,circulating tumor DNA(ctDNA),and microRNA(miRNA)in the diagnosis of various cancers is reviewed,and the detection research of these biomarkers by the LoC-SERS platform in recent years is described in detail.At the same time,the challenges and future development of the platform are discussed at the end of the review.Summarizing the current technology is expected to provide a reference for scholars engaged in related work and interested in this field.
